K Number
K111606
Date Cleared
2011-10-03

(116 days)

Product Code
Regulation Number
870.1340
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The Pinnacle Precision Access System is used to facilitate placing a catheter through the skin into a vein or artery.

The Entry Needle is an accessory device which is used to gain access to the vein or artery, for placement of the Mini Guide Wire.

The Mini Guide Wire is an accessory device which is used for placement of the sheath into the vein or artery.

Device Description

The Pinnacle Precision Access System consists of an introducer sheath and a dilator which are packaged together with a metallic entry needle, a mini guide wire and a guide wire inserter, prior to sterilization. The Pinnacle Precision Access System is used to facilitate placing a catheter through the skin into a vein or artery. The sheath and dilator contain bismuth, making these devices visible under fluoroscopy

The entry needle (cannula) is an accessory device which is used to gain access to the vein or artery for placement of the mini guide wire.

The mini guide wire is an accessory device which is used for placement of the sheath and dilator into the vein or artery. The mini guide wire is offered in two versions, a stainless steel (spring coil) model and a Palladium tipped Nitinol model.

A guide wire inserter is also provided to assist in insertion of the mini guide wire into the cannula.

AI/ML Overview

The provided text describes the Terumo Medical Corporation's Pinnacle Precision Access System and its premarket notification (510(k) summary) to the FDA. This document is for a medical device (catheter introducer) and therefore does not involve AI or machine learning. As such, many of the requested categories related to AI model evaluation are not applicable.

Here's the information that can be extracted or deduced from the provided text, along with an explanation for categories that are not applicable:

1. A table of acceptance criteria and the reported device performance

The acceptance criteria are generally implied by the successful passing of the listed performance tests. The reported device performance is that it "successfully passed all of the following performance tests." Specific quantitative thresholds for "acceptance" are not explicitly detailed in the summary but are inherent in the "pass" result for each test.

Test CategorySpecific TestAcceptance Criteria (Implied)Reported Device Performance
NeedleNeedle surface free from defectsFree from defectsPassed
Needle ODWithin specified rangePassed
Needle lengthWithin specified rangePassed
Needle IDWithin specified rangePassed
Needle hub conical entry angleWithin specified rangePassed
Bevel indicator visibilityVisiblePassed
Bevel indicator positionCorrect positionPassed
Needle to hub joint strengthMeets strength requirementsPassed
Gauge luer taperConforms to standardPassed
Liquid leakage from fitting assembly under pressureNo liquid leakagePassed
Air leakage into the fitting assembly during aspirationNo air leakagePassed
Separation force of fitting assemblyMeets force requirementsPassed
Unscrewing torque of fitting assemblyMeets torque requirementsPassed
Ease of assemblyEasy to assemblePassed
Resistance to overridingResistant to overridingPassed
Stress crackingNo stress crackingPassed
Tip penetration through thin filmEffective penetrationPassed
Corrosion resistanceResistant to corrosionPassed
GuidewiresGuidewire surface free from defectsFree from defectsPassed
Tip buckling testNo bucklingPassed
Test for resistance of guidewires to damage by flexingResistant to damagePassed
Test for fracture of guidewiresNo fracturePassed
Test for distal tip retention and proximal end retentionTip retention maintainedPassed
Guidewire ODWithin specified rangePassed
Guidewire lengthWithin specified rangePassed
Corrosion resistanceResistant to corrosionPassed
RadiopacityRadiopaquePassed
DilatorDilator surface free from defectsFree from defectsPassed
Dilator tip IDWithin specified rangePassed
Dilator to hub joint strengthMeets strength requirementsPassed
Dilator lengthWithin specified rangePassed
Dilator OD at sheath tip interfaceWithin specified rangePassed
Dilator hub to sheath hub snap fit strengthMeets strength requirementsPassed
Hypotube lengthWithin specified rangePassed
Hypotube to hub joint strengthMeets strength requirementsPassed
Hypotube fall-outNo fall-outPassed
Wire passageSmooth wire passagePassed
SheathCorrosion resistance (hypotube)Resistant to corrosionPassed
Sheath surface free from defectsFree from defectsPassed
Sheath tip IDWithin specified rangePassed
Sheath lengthWithin specified rangePassed
Sheath tip cracksNo cracksPassed
RadiopacityRadiopaquePassed
Simulated UseSystem use in anatomical modelSuccessful deployment and function in modelPassed
Dilator and sheath tip penetrationEffective tip penetrationPassed
BiocompatibilityPhysicochemical profileMeets USP requirementsMeets requirements
CytotoxicityNot considered to have cytotoxic potentialNot considered cytotoxic
HemolysisNon-hemolyticNon-hemolytic
In vitro Hemocompatibility AssayPassPass
Thrombogenicity Study in DogsThrombosis not significantNot considered significant
Complement ActivationMeets requirementsMeets requirements
Unactivated Partial Thromboplastin timeMeets requirementsMeets requirements
Prothrombin TimeNo adverse effect on prothrombin timeNo adverse effect
SensitizationMeets requirementsMeets requirements
Intracutaneous ReactivityMeets requirementsMeets requirements
Acute Systemic ToxicityNegativeNegative
PyrogenicityMeets requirementsMeets requirements
GenotoxicityNot considered mutagenicNot considered mutagenic
Other TestsAnalysis of Metals in Extract by ICP-MS (Echogenic Taper Needle)Meets ISO 7864 requirementsMeets requirements
Biocompatibility (Aged Devices) - Physicochemical profileMeets USP requirementsMeets requirements
Biocompatibility (Aged Devices) - CytotoxicityNot considered to have cytotoxic potentialNot considered cytotoxic
Biocompatibility (Aged Devices) - HemolysisNon-hemolyticNon-hemolytic
SterilizationSterility Assurance Level (SAL)10^-6Achieved SAL of 10^-6
Residual EO/ECHEO < 4mg/device, ECH < 9mg/deviceMeets requirements
Non-pyrogenicNon-pyrogenic in unopened/undamaged packageCertified non-pyrogenic

2. Sample sizes used for the test set and the data provenance

The document does not explicitly state the sample sizes for each performance test. It mentions "Testing was performed on the worse case configuration of the system" for biocompatibility. The tests are general device performance and biocompatibility tests, not clinical studies with patient data.

  • Sample Size for Test Set: Not explicitly stated for each individual test. It mentions "worse case configuration" for biocompatibility testing. These are laboratory/bench tests, not studies on patient data.
  • Data Provenance: Not applicable in the context of patient data for a test set. This refers to laboratory and bench testing performed by the manufacturer, Terumo Medical Corporation.

3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts

This is not applicable. "Ground truth" in this context typically refers to clinical diagnosis or outcomes. The performance tests are objective engineering and biological evaluations, not dependent on expert interpretation of clinical data for a test set.

4. Adjudication method for the test set

This is not applicable. The performance tests are objective measurements against predefined specifications, not subject to adjudication by multiple experts in the way clinical diagnostic interpretations would be.

5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

This is not applicable. The device is a medical instrument (catheter introducer), not an AI-powered diagnostic or assistive tool for human readers.

6. If a standalone (i.e., algorithm only without human-in-the-loop performance) was done

This is not applicable. The device is a physical medical instrument, not an algorithm.

7. The type of ground truth used

For the performance tests, the "ground truth" refers to established engineering standards, material specifications, and biological testing protocols (e.g., ISO, USP, ASTM standards for biocompatibility and physical properties). For example, for "Needle OD," the ground truth would be the specified diameter range from the design documents. For biocompatibility tests, the ground truth is defined by the limits and criteria set forth in the referenced ISO and ASTM standards.

8. The sample size for the training set

This is not applicable. The device is a physical medical instrument, not an AI model requiring a training set.

9. How the ground truth for the training set was established

This is not applicable. The device is a physical medical instrument, not an AI model.

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OCT - 3 2011

K1116.06

Terumo Medical Corporation Premarket Notification - Pinnacle Precision Access System™ Section II. 510(k) Summary

SECTION II. 510(K) SUMMARY

A. Device Name

Proprietary NamePinnacle Precision Access System
Classification NameCatheter Introducer (as per 870.1340)
Common NameIntroducer Sheath
Product CodeDYB

B. Intended Use

The Pinnacle Precision Access System is used to facilitate placing a catheter through the skin into a vein or artery.

The Entry Needle is an accessory device which is used to gain access to the vein or artery, for placement of the Mini Guide Wire.

The Mini Guide Wire is an accessory device which is used for placement of the sheath into the vein or artery.

C. Device Description

The Pinnacle Precision Access System consists of an introducer sheath and a dilator which are packaged together with a metallic entry needle, a mini guide wire and a guide wire inserter, prior to sterilization. The Pinnacle Precision Access System is used to facilitate placing a catheter through the skin into a vein or artery. The sheath and dilator contain bismuth, making these devices visible under fluoroscopy

The entry needle (cannula) is an accessory device which is used to gain access to the vein or artery for placement of the mini guide wire.

The mini guide wire is an accessory device which is used for placement of the sheath and dilator into the vein or artery. The mini guide wire is offered in two versions, a stainless steel (spring coil) model and a Palladium tipped Nitinol model.

A guide wire inserter is also provided to assist in insertion of the mini guide wire into the cannula.

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Terumo Medical Corporation Premarket Notification - Pinnacle Precision Access System™ Section II. 510(k) Summary

D. Principle of Operation / Technology

The Pinnacle Precision Access System and its accessories are operated manually or by a manual process.

The mini guide wire is inserted through a cannula placed in the patient's blood vessel. A guide wire inserter is provided to assist in insertion of the mini guide wire into the cannula. Following guide wire insertion, the cannula is removed and the sheath and dilator are then inserted over the mini guide wire and into the blood vessel. The mini guide wire is then withdrawn from the vessel. The dilator maintains the integrity of the Sheath and dilates the blood vessel during insertion. Once the sheath is situated in the vessel, the dilator is removed and an appropriate catheter can then be inserted through the sheath.

E. Design / Materials and Comparison to Predicate Devices

The primary components of the Pinnacle Precision Access System in this submission (the Sheath and Dilator) are unchanged from those of the Radifocus Introducer II predicate device (K954234). The Pinnacle Precision Access System differs from the Radifocus Introducer II predicate device in the addition of the metallic entry needle and the optional Nitinol Mini Guide Wire. A metallic entry needle and Nitinol Mini Guide Wire are included in the Glidesheath predicate device (K102008).

The Pinnacle Precision Access System submitted in this 510(k), the Radifocus Introducer II (K954234) and the Glidesheath (K102008) have similar components which function in the same manner. Material differences between the devices, as shown in the following table, do not raise any new issues of safety and effectiveness.

ComponentRadifocus Introducer II (K954234)Glidesheath (K102008)Pinnacle Precision Access System
WireStainless SteelNitinol w/Palladiumdistal coilStainless Steel or Nitinolw/Palladium distal coil
NeedleN/AStainless SteelStainless Steel
Needle HubN/AStyrene-ButadienecopolymerStyrene-Butadienecopolymer
Protective SleeveN/APolypropylenePolypropylene
Dilator TubingPolypropylenew/BismuthsubcarbonatePolypropylenew/BismuthsubcarbonatePolypropylenew/Bismuth subcarbonate
Dilator StiffenerN/AN/AStainless Steel (optionalon 4Fr and 5Fr)

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Terumo Medical Corporation Premarket Notification - Pinnacle Precision Access System™ Section II. 510(k) Summary

Dilator CaulkingPinStainless SteelStainless SteelStainless Steel
Dilator HubPolypropylenePolypropylenePolypropylene
Sheath TubingETFE w/15% BiO3,w/2% TiO2ETFE w/15% BiO3,w/2% TiO2ETFE w/15% BiO3,w/2% TiO2
Sheath CaulkingPinStainless SteelStainless SteelStainless Steel
Sheath HousingPolypropylenePolypropylenePolypropylene
Sheath SupportStyrene elastomerStyrene elastomerStyrene elastomer
ValveSilicone rubberSilicone rubberSilicone rubber
CapPolypropylenePolypropylenePolypropylene
SidetubePolybutadienePolybutadienePolybutadiene
3 WSCPolycarbonate,Polyethylene,PolypropylenePolycarbonate,Polyethylene,PolypropylenePolycarbonate,Polyethylene,Polypropylene
Guide wireinserterPolypropylenePolypropylenePolypropylene

F. Specifications and Comparison to Predicate Devices

The Pinnacle Precision Access System submitted in this 510(k), the Radifocus Introducer II (K954234) and the Glidesheath (K102008) have similar device specifications. Differences in specifications between the devices do not raise any new issues of safety and effectiveness.

Radifocus IntroducerII (K954234)Glidesheath(K102008)Pinnacle PrecisionAccess System
Sheath Sizes4Fr - 11Fr5Fr and 6Fr4Fr through 8Fr
Sheath Length5cm - 100cm10 cm10 cm
Sheath CoatingSiliconeHydrophilicSilicone
Dilator Length6cm - 110cm15.5 cm15.5cm or 16.0cm
Guide Wire OD.021" - .038".021".021"
Guide WireLength40cm - 100cm45cm45cm
Entry Needle:SizeN/A21G1.5"21G/19G2.75"

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Terumo Medical Corporation Premarket Notification - Pinnacle Precision Access System™ Section II. 510(k) Summary

G. Performance

.

The Pinnacle Precision Access System successfully passed all of the following performance tests: .

Pinnacle Precision Access System Performance Testing
Needle:Needle surface free from defects
Needle OD
Needle length
Needle ID
Needle hub conical entry angle
Bevel indicator visibility
Bevel indicator position
Needle to hub joint strength
Gauge luer taper
Liquid leakage from fitting assembly under pressure
Air leakage into the fitting assembly during aspiration
Separation force of fitting assembly
Unscrewing torque of fitting assembly
Ease of assembly
Resistance to overriding
Stress cracking
Tip penetration through thin film
Corrosion resistance
Guidewires:Guidewire surface free from defects
Tip buckling test
Test for resistance of guidewires to damage by flexing
Test for fracture of guidewires
Test for distal tip retention and proximal end retention
Guidewire OD
Guidewire length
Corrosion resistance
Radiopacity
Dilator:Dilator surface free from defects
Dilator tip ID
Dilator to hub joint strength
Dilator length
Dilator OD at sheath tip interface
Dilator hub to sheath hub snap fit strength
Hypotube length
Hypotube to hub joint strength
Hypotube fall-out
Wire passage
Sheath:Corrosion resistance (hypotube)
Sheath surface free from defects
Sheath tip ID
Sheath length
Sheath tip cracks
Radiopacity
Simulated Use:System use in anatomical model
Dilator and sheath tip penetration

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Terumo Medical Corporation Premarket Notification - Pinnacle Precision Access System™ Section II. 510(k) Summary

H. Biocompatibility and Sterilization

Biocompatibility testing was conducted in accordance with the FDA General Program memorandum #G95-1 (5/1/95): Use of International Standard ISO 10993, "Biological Evaluation of Medical Devices Part 1: Evaluation and Testing''.

The Pinnacle Precision Access System is classified as an Externally Communicating Device, Circulating Blood, Prolonged Contact (up to 30 days), the same as the Radifocus Introducer II Sheath predicate device. Biocompatibility of the Radifocus Introducer II Sheath, classified as Externally Communicating Device, Circulating Blood, Prolonged Contact (24 hours - 30 days) has been established under K954234. Differences in materials between the Pinnacle Precision Access System and the Radifocus Introducer II Sheath affect only those portions of the system that contact the patient for a short period of time (less than 24 hours). Therefore, the full battery of biocompatibility tests was performed on the whole device for Externally Communicating Devices, Circulating Blood, Limited Contact (up to 24 hours).

Testing was performed on the worse case configuration of the system: Introducer sheath with stiffener, stainless steel guide wire and echogenic step needle. Results are presented in the following table.

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Terumo Medical Corporation Premarket Notification -- Pinnacle Precision Access System™ Section II. 510(k) Summary


: :

Biocompatibility Testing on non aged, 2x EO sterile Pinnacle Precision Access System
TestStandardResult
Physicochemical profileUSPMeets requirements
CytotoxicityISO 10993-5Not considered to have cytotoxic potential
HemolysisASTM F756Non-hemolytic
In vitroHemocompatibility AssayISO 10993-4Pass
Thrombogenicity Study inDogsISO 10993-4Thrombosis was not considered significant
Complement ActivationISO 10993-4Meets requirements
Unactivated PartialThromboplastin timeISO 10993-4Meets requirements
Prothrombin TimeISO 10993-4No adverse effect on the prothrombin time ofhuman plasma
SensitizationISO 10993-10Meets requirements
Intracutaneous ReactivityISO 10993-10Meets requirements
Acute Systemic ToxicityISO 10993-11Negative
PyrogenicityISO 10993-11Meets requirements
GenotoxicityISO 10993-3Not considered to be mutagenic

Alkalinity/acidity and extractables testing was performed per ISO 7864: Sterile Hypodermic Needles for Single Use on 2x EO sterile, non-aged needles.

Pinnacle Precision Access System Echogenic Taper Needle (non-aged, 2xEO sterile)
TestStandardResults
Analysis of Metals inExtract by InductivelyCoupled Plasma MassSpectrometry(ICP-MS) PerISO 7864Meets requirements

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Limited screening tests were conducted on accelerated aged, 2x EO sterile devices to demonstrate that aging does not affect the device's biocompatibility.

TestStandardResults
Physicochemical profileUSPMeets requirements
CytotoxicityISO 10993-5Not considered to have cytotoxic potential
HemolysisASTM F756Non-hemolytic

Sterilization conditions have been validated according to ANSI / AAMI / ISO 11135, Sterilization of Health Care Products-- Part 1: Requirements for development, validation and routine control of a sterilization process for medical devices, to provide a Sterility Assurance Level (SAL) of 10-6.

Residual ethylene oxide (EO) and ethylene chlorohydrin (ECH) residuals will meet requirements for limited exposure devices (contact up to 24 hours) prior to use, based on ISO 10993-7. Biological Evaluation of medical devices- Part 7: Ethylene Oxide Sterilization residuals. Residual EO will not exceed 4 mg per device and residual ECH will not exceed 9 mg per device.

The Pinnacle Precision Access System is certified to be non-pyrogenic in the unopened and undamaged package. Kinetic Turbidimetric Limulus Amebocyte Lysate (LAL) test is performed on each lot of production accordance to the United States Pharmacopoeia (USP) <85> Bacterial Endotoxins Test. Validation was performed in accordance with FDA published "Guideline on Validation of the Limulus Amebocyte Lysate Test as an End-Product Endotoxin Test for Human and Animal Parenteral Drugs, Biological Products, and Medical Devices"; 1987.

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Terumo Medical Corporation Premarket Notification – Pinnacle Precision Access System™ Section II. 510(k) Summary

I. Substantial Equivalence

The performance of the Pinnacle Precision Access System in this submission is substantially equivalent to the performance of the predicate devices. The equivalence was shown through comparison of component materials and specifications, performance and biocompatibility testing and sterilization validation.

The Pinnacle Precision Access System is substantially equivalent in intended use, design, technology/principles of operation, materials and performance to the predicate devices the Radifocus Introducer II (K954234) and the Glidesheath (K102008). Differences between the devices do not raise any significant issues of safety or effectiveness.

J. Submitter Information

Prepared By:Mr. Daniel R. PlonskiRegulatory Affairs Specialist
Prepared For:Terumo Medical Corporation950 Elkton Blvd.Elkton, MD 21921Phone: (410) 392-7395Fax: (410) 398-6079Email: daniel.plonski@terumomedical.com
Date Prepared:June 8, 2011

{8}------------------------------------------------

DEPARTMENT OF HEALTH & HUMAN SERVICES

Image /page/8/Picture/1 description: The image shows the logo for the Department of Health and Human Services. The logo is a circle with the words "DEPARTMENT OF HEALTH & HUMAN SERVICES USA" written around the edge. Inside the circle is a symbol that looks like a stylized human figure with three lines representing the arms and legs. The figure is facing to the right.

Food and Drug Administration 10903 New Flampshire Avenue Document Control Room -WO66-G609 Silver Spring, MD 20993-0002

Terumo Medical Corporation c/o Mr. Daniel R. Plonski, RAČ Regulatory Affairs Specialist 950 Elkton Blvd. Elkton. MD 21921

OCT - 3 2011

Re: K111606

Trade/Device Name: Pinnacle Precision Access System™ Regulation Number: 21 CFR 870.1340 Regulation Name: Catheter Introducer Regulatory Class: Class II Product Code: DYB Dated: September 23, 2011 Received: September 26, 2011

Dear Mr. Plonski:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register. Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing

{9}------------------------------------------------

Page 2 – Mr. Daniel R. Plonski, RAC

(21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting of medical device-related adverse events) (21 CFR 803): good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please go to http://www.fda.gov/AboutFDA/CentersOffices/CDRH/CDRHOffices/ucm115809.htm for the Center for Devices and Radiological Health's (CDRH's) Office of Compliance. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.him for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance,

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (240) 276-3150 or at its Internet address

http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours.

sincerely yours,

Bram D. Zuckerman. M.D. Director Division of Cardiovascular Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known): _

K111606

Pinnacle Precision Access System™ Device Name: _________________________________________________________________________________________________________________________________________________________________

Indications For Use:

The Pinnacle Precision Access System is used to facilitate placing a catheter through the skin into a vein or artery.

The Entry Needle is an accessory device which is used to gain access to the vein or artery, for placement of the Mini Guide Wire.

The Mini Guide Wire is an accessory device which is used for placement of the sheath into the vein or artery.

Prescription Use X (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

(Division Sian-Off) Division of Cardiovascular Devices

510(k) Number K111606

:

§ 870.1340 Catheter introducer.

(a)
Identification. A catheter introducer is a sheath used to facilitate placing a catheter through the skin into a vein or artery.(b)
Classification. Class II (performance standards).