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510(k) Data Aggregation

    K Number
    K223004
    Date Cleared
    2022-12-04

    (66 days)

    Product Code
    Regulation Number
    880.6250
    Reference & Predicate Devices
    Predicate For
    N/A
    AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
    Intended Use

    The Disposable Nitrile Examination Gloves are disposable devices intended for medical purposes that are worn on the examiner's hands to prevent contamination between patient and examiner.

    Device Description

    The subject device is powder free nitrile examination gloves. The subject device is in blue color. It can be available in four specifications: S,M,L and XL. The subject device is non-sterile.

    AI/ML Overview

    The provided document is a 510(k) Premarket Notification for Disposable Nitrile Examination Gloves. It details the non-clinical testing performed to demonstrate substantial equivalence to a predicate device.

    Here's an analysis of the acceptance criteria and study findings based on the provided text:

    1. Table of Acceptance Criteria and Reported Device Performance

    Test MethodPurposeAcceptance CriteriaReported Device Performance
    ASTM D6319Physical Dimensions TestLength(mm): S:≥220; M/L/XL:≥230; Width(mm): S: 80±10; M: 95±10; L: 110±10; XL: 120±10; Thickness (mm): Finger: ≥0.05, Palm: ≥0.05Length: S: >220/Pass; M/L/XL: >230/Pass; Width: S: 82-88 /Pass; M: 95-98/ Pass; L: 106-111/ Pass; XL:111-115/ Pass; Finger Thickness: 0.13-0.15/Pass; Palm Thickness: 0.09-0.12/Pass
    ASTM D5151Watertightness Test for Detection of HolesMeet the requirements of ASTM D5151 AQL=2.50/125/Pass (This implies 0 holes found in 125 samples, meeting the AQL of 2.5)
    ASTM D6124Powder ContentMeet the requirements of ASTM D6124 << 2.0mg/gloveS:0.13 mg/glove; M:0.13 mg/glove; L:0.16 mg/glove; XL:0.11 mg/glove (All below 2.0mg/glove)
    ASTM D412Physical propertiesBefore Aging: Tensile Strength ≥14MPa, Ultimate Elongation ≥500%; After Aging: Tensile Strength ≥14MPa, Ultimate Elongation ≥400%Before Aging: Tensile Strength: 20-34/Pass (vs ≥14MPa); Ultimate Elongation: 521-570/Pass (vs ≥500%); After Aging: Tensile Strength: 15-25/Pass (vs ≥14MPa); Ultimate Elongation: 470-545/Pass (vs ≥400%)
    ISO 10993-5CytotoxicityNon-cytotoxicUnder the condition of the study, the device extract showed cytotoxic / fail. (Note: This is a failure, indicating it did not meet the non-cytotoxic criterion.) Correction: The sentence in the document says "Under conditions of the study, device extract is cytotoxic" for the predicate in the comparison table, and then "Under the condition of the study, the device extract showed cytotoxic / fail" in the results. This indicates that their device extract was indeed cytotoxic according to the test results and it failed this specific criterion as reported. From the context below, it seems the failure was acknowledged and the device was still cleared based on overall safety. (In 510k submissions, sometimes minor failures are accepted if compensated by other factors or if the risk is deemed acceptable for the intended use.)
    ISO 10993-11Acute systemic toxicityNon-acute systemic toxicityUnder conditions of the study, did not show acute systemic toxicity in vivo / Pass
    ISO 10993-10IrritationNon-irritatingUnder the conditions of the study, not an irritant/ Pass
    ISO 10993-10SensitizationNon-sensitizingUnder conditions of the study, not a sensitizer./ Pass

    2. Sample size used for the test set and the data provenance

    • Test Set Sample Sizes:
      • ASTM D5151 (Watertightness): 125 samples (stated as "0/125/Pass")
      • ASTM D6319 (Dimensions), ASTM D6124 (Powder Content), ASTM D412 (Physical Properties): Specific sample sizes for each glove size (S, M, L, XL) are not explicitly stated, but the results are presented for each size.
      • Biocompatibility (ISO 10993-5, -10, -11): Not explicitly stated, but these typically involve a certain number of replicates and control groups for in vitro or in vivo tests.
    • Data Provenance: The document implies that the testing was conducted by or for the manufacturer, Jiangxi Handspro Products Solutions CO., LTD. in China. The data is from non-clinical testing designed to evaluate the physical and biological characteristics of the device. It is prospective in the sense that these tests were conducted intentionally for this 510(k) submission.

    3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts

    This section is not applicable for this type of device and study. The "ground truth" for the non-clinical testing of medical gloves (like dimensions, physical properties, or biocompatibility) is established by adherence to recognized international and national standards (e.g., ASTM, ISO). There are no human experts "establishing ground truth" in the way a radiologist would for medical imaging. The standards themselves define the test methods and acceptance criteria.

    4. Adjudication method for the test set

    This is not applicable for non-clinical performance testing. Adjudication methods like "2+1" are relevant for clinical studies or expert review processes where subjective interpretations might differ. For objective measurements against established standards, the results are determined by the test execution itself.

    5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

    No, an MRMC comparative effectiveness study was not done. This type of study is relevant for AI-powered diagnostic or screening devices, not for disposable examination gloves.

    6. If a standalone (i.e., algorithm only without human-in-the-loop performance) was done

    No, a standalone algorithm performance study was not done. This device is not an AI algorithm.

    7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.)

    The "ground truth" is defined by established international and national consensus standards (ASTM D6319, ASTM D5151, ASTM D6124, ASTM D412, ISO 10993-5, ISO 10993-10, ISO 10993-11). These standards specify the methods for measurement and the acceptable ranges for physical properties and biological responses.

    8. The sample size for the training set

    Not applicable. This device is a physical medical product (disposable gloves), not a machine learning or AI algorithm that requires a training set.

    9. How the ground truth for the training set was established

    Not applicable. As stated above, this device does not utilize a training set.

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    K Number
    K223008
    Date Cleared
    2022-10-08

    (9 days)

    Product Code
    Regulation Number
    880.6250
    Reference & Predicate Devices
    Predicate For
    AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
    Intended Use

    The Disposable Vinyl Examination Glove is a disposable device intended for medical purposes that is worn on the examiner's hands to prevent contamination between patient and examiner.

    Device Description

    The subject device is powder free non-colored vinyl examination glove. It can be available in four specifications: S, M, L and XL. The subject device is non-sterile.

    AI/ML Overview

    The provided text describes the acceptance criteria and the study that proves a "Disposable Vinyl Examination Glove" meets these criteria. It is important to note that this is a Class I medical device (non-AI/ML).

    Here's the breakdown of the requested information:

    1. A table of acceptance criteria and the reported device performance

    Test MethodPurposeAcceptance CriteriaReported Device Performance
    ASTM D5250Physical Dimensions TestLength: S/M/L/XL: ≥230mm Width: S: 85±5mm; M: 95±5mm; L: 105±5mm; XL: 115±5mm Thickness: Finger: ≥0.08mm; Palm: ≥0.08mmLength: >230mm / Pass Width: S: 84-87mm / Pass; M: 92-96mm / Pass; L: 103-106mm / Pass; XL: 112-117mm / Pass Thickness: Finger: 0.13-0.15mm / Pass; Palm: 0.09-0.12mm / Pass
    ASTM D5151Watertightness Test for Detection of HolesAQL 2.50/125 / Pass
    ASTM D6124Powder Content< 2.0mg0.07~0.15mg / Pass
    ASTM D5250Physical properties (Before Aging)Tensile Strength: ≥11MPa Ultimate Elongation: ≥300%Tensile Strength: 1324MPa / Pass Ultimate Elongation: 347579% / Pass
    ASTM D5250Physical properties (After Aging)Tensile Strength: ≥11MPa Ultimate Elongation: ≥300%Tensile Strength: 1119MPa / Pass Ultimate Elongation: 340529 % / Pass
    ISO 10993-5CytotoxicityNon-Cytotoxicity: device extract is not cytotoxic. / Pass(Reported: "device extract is not cytotoxic. / Pass")
    ISO 10993-10IrritationNon-irritating: not an irritant. / Pass(Reported: "not an irritant. / Pass")
    ISO 10993-10SensitizationNon-sensitizing: not a sensitizer. / Pass(Reported: "not a sensitizer. / Pass")

    2. Sample size used for the test set and the data provenance (e.g. country of origin of the data, retrospective or prospective)

    • Sample Size:
      • Watertightness Test (ASTM D5151): The result 0/125 / Pass indicates that out of 125 units tested, 0 failed, suggesting a sample size of 125 for this specific test.
      • For other tests (Physical Dimensions, Powder Content, Physical Properties, Biocompatibility), the document does not explicitly state the number of samples tested for each criterion. It reports ranges for dimensions and physical properties, which usually implies multiple samples were tested, but the exact count is not given.
    • Data Provenance: The document does not specify the country of origin of the data or whether the tests were retrospective or prospective. The manufacturer is located in Jiujiang City, Jiangxi, China.

    3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts (e.g. radiologist with 10 years of experience)

    This information is not applicable as this device is a physical examination glove, not an AI/ML device requiring expert interpretation for ground truth. The "ground truth" is established by direct measurement and standardized test methods (e.g., ASTM and ISO standards) and their inherent acceptance criteria.

    4. Adjudication method (e.g. 2+1, 3+1, none) for the test set

    This information is not applicable as this device is a physical examination glove. Adjudication methods like 2+1 or 3+1 are used in studies involving human interpretation (e.g., medical imaging) where there might be disagreement among reviewers, needing a tie-breaker. The tests for this device involve objective measurements against established standards.

    5. If a multi reader multi case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

    This information is not applicable as this device is a physical examination glove and not an AI-assisted diagnostic tool.

    6. If a standalone (i.e. algorithm only without human-in-the-loop performance) was done

    This information is not applicable as this device is a physical examination glove and does not involve any algorithms.

    7. The type of ground truth used (expert consensus, pathology, outcomes data, etc)

    The "ground truth" for this device is based on objective measurements against established industry standards, specifically ASTM D5250, ASTM D5151, ASTM D6124, ISO 10993-5, and ISO 10993-10. These standards define acceptable physical properties, freedom from holes, powder content, and biocompatibility, which are directly measured and compared.

    8. The sample size for the training set

    This information is not applicable as this is a physical medical device, not an AI/ML device that requires a "training set."

    9. How the ground truth for the training set was established

    This information is not applicable as this is a physical medical device, not an AI/ML device that requires a "training set" or ground truth for such a set.

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