K Number
K992311
Device Name
K-ASSAY CRP(1), K-ASSAY CRP MULTI-CALIBRATOR A, K-ASSAY CRP MULTI-CALIBRATORC
Date Cleared
1999-09-13

(66 days)

Product Code
Regulation Number
866.5270
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
The K-ASSAY CRP (I) Assay is intended to be used for the quantitative determination of C-Reactive Protein (CRP) in serum by a latex enhanced immunoturbidimetric method. Measurement of CRP is useful as an aid in the detection and evaluation of inflammatory conditions and tissue injury. CRP is an acute phase reactant protein that is elevated in the presence of inflammatory processes, infection, and tissue injury. Measurement of CRP is useful as an aid in the detection and evaluation of inflammatory conditions and tissue injury. The K-ASSAY CRP Multi-Calibrator A is intended to be used for the calibration of the K-ASSAY CRP (I) Assay. The K-ASSAY CRP Multi-Calibrator C is intended to be used for the calibration of the K-ASSAY CRP (I) Assay.
Device Description
Not Found
More Information

Not Found

No Reference Device(s) K/DEN number are present in the text.

No
The summary describes a laboratory assay based on a standard immunoturbidimetric method, with no mention of AI, ML, image processing, or any computational analysis beyond standard assay calculations.

No.
The device is described as an assay for the quantitative determination of C-Reactive Protein (CRP) to aid in the detection and evaluation of inflammatory conditions, which is a diagnostic purpose, not a therapeutic one.

Yes

The device, K-ASSAY CRP (I) Assay, is intended for the "quantitative determination of C-Reactive Protein (CRP) in serum" and its "measurement of CRP is useful as an aid in the detection and evaluation of inflammatory conditions and tissue injury." This indicates its use in diagnosing or aiding in the diagnosis of medical conditions.

No

The device description is not found, but the intended use describes a "latex enhanced immunoturbidimetric method" for determining C-Reactive Protein in serum, which is a laboratory assay method involving physical reagents and equipment, not solely software.

Yes, based on the provided information, this device is an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use clearly states that the assay is for the "quantitative determination of C-Reactive Protein (CRP) in serum". Serum is a biological sample taken from the body.
  • Method: It uses a "latex enhanced immunoturbidimetric method," which is a laboratory technique performed in vitro (outside the living body).
  • Purpose: The measurement of CRP is described as "useful as an aid in the detection and evaluation of inflammatory conditions and tissue injury." This indicates a diagnostic purpose.
  • Calibrators: The mention of calibrators (K-ASSAY CRP Multi-Calibrator A and C) further supports its use in a laboratory setting for quantitative measurement, a hallmark of IVDs.

The definition of an IVD generally includes reagents, instruments, and systems intended for use in the diagnosis of disease or other conditions, including a determination of the state of health, in order to cure, mitigate, treat, or prevent disease or its sequelae. This device fits that description.

N/A

Intended Use / Indications for Use

The K-ASSAY CRP (I) Assay is intended to be used for the quantitative determination of enhanced immunoturbidimetric C-Reactive i forem (ORT) in obrain by faten participant of the amount of injury to body tissues.

The K-ASSAY CRP Multi-Calibrator A is intended to be used for the calibration of the K-ASSAY CRP (I) Assay.

The K-ASSAY CRP Multi-Calibrator C is intended to be used for the calibration of the K-ASSAY CRP (I) Assay.

Product codes

DCK

Device Description

Not Found

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

Not Found

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Not Found

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

Not Found

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 866.5270 C-reactive protein immunological test system.

(a)
Identification. A C-reactive protein immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the C-reactive protein in serum and other body fluids. Measurement of C-reactive protein aids in evaluation of the amount of injury to body tissues.(b)
Classification. Class II (performance standards).

0

Image /page/0/Picture/0 description: The image shows the text "DEPARTMENT OF HEALTH & HUMAN SERVICES". The text is in all caps and is in a bold, serif font. The text is slightly tilted.

SEP 1 3 1999

Food and Drug Administration 2098 Gaither Road Rockville MD 20850

Mr. Colin Getty Official Correspondent Kamiya Biomedical Company 910 Industry Drive Seattle, Washington 98188

Re: K992311

Trade Name: K-ASSAY CRP (1), K-ASSAY CRP Multi-Calibrator A, K-ASSAY CRP Multi-Calibrator C

Regulatory Class: II Product Code: DCK Dated: July 7, 1999 Received: July 9, 1999

Dear Mr. Getty:

We have reviewed your Section 510(k) notification of intent to market the device referenced above and we have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (Premarket Approval), it may be subject to such additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 895. A substantially equivalent determination assumes compliance with the Current Good Manufacturing Practice requirements, as set forth in the Quality System Regulation (QS) for Medical Devices: General regulation (21 CFR Part 820) and that, through periodic QS inspections, the Food and Drug Administration (FDA) will verify such assumptions. Failure to comply with the GMP regulation may result in regulatory action. In addition, FDA may publish further announcements concerning your device in the Federal Register. Please note: this response to your premarket notification submission does not affect any obligation you might have under sections 531 through 542 of the Act for devices under the Electronic Product Radiation Control provisions, or other Federal laws or regulations.

1

Page 2

Under the Clinical Laboratory Improvement Amendments of 1988 (CLIA-88), this device may require a CLIA complexity categorization. To determine if it does, you should contact the Centers for Disease Control and Prevention (CDC) at (770) 488-7655.

This letter will allow you to begin marketing your device as described in your 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801 and additionally 809.10 for in vitro diagnostic devices), please contact the Office of Compliance at (301) 594-4588. Additionally, for questions on the promotion and advertising of your device, please contact the Office of Compliance at (301) 594-4639. Also, please note the regulation entitled, "Misbranding by reference to premarket notification"(21 CFR 807.97). Other general information on your responsibilities under the Act may be obtained from the Division of Small Manufacturers Assistance at its toll-free number (800) 638-2041 or (301) 443-6597, or at its internet address "http://www.fda.gov/cdrh/dsma/dsmamain.html".

Sincerely vours.

Steven Putman

Steven I. Gutman, M.D. M.B.A. Director Division of Clinical Laboratory Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

2

INDICATIONS FOR USE STATEMENT

510(k) Number (if known): K992311/A²/1

K-ASSAY CRP (I) Device Name:

Indications For Use:

The K-ASSAY CRP (I) Assay is intended to be used for the quantitative determination of The N-ASSAT ONL (1) 7 (1) 1.66ay to intel enhanced immunoturbidimetric C-Reactive i forem (ORT) in obrain by faten participant of the amount of injury to body tissues.

The K-ASSAY CRP Multi-Calibrator A is intended to be used for the calibration of the K-ASSAY CRP (I) Assay.

The K-ASSAY CRP Multi-Calibrator C is intended to be used for the calibration of the K-ASSAY CRP (I) Assay.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Devise Evaluation (ODE)

Peter Malone

(Division Sign-Off)
Division of Clinical Laboratory Devices K992311
510(k) Number

Division of Clinical Laboratory Devices
510(k) Number K99

OR

Over-The-Counter Use _

Optional Format 1-2-96)

Prescription Use / (Per 21 CFR 801.109)