K Number
K210903
Date Cleared
2021-07-23

(119 days)

Product Code
Regulation Number
872.3630
Panel
Dental
Reference & Predicate Devices
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

IS Multi Unit Abutment System is intended for use with a dental implant to provide support for prosthetic restorations such as bridges.

Device Description

IS Multi Unit Abutments are premanufactured dental implant abutments directly connected to the endosseous dental implant with internal hex connections (multiple tooth). IS Multi Unit Abutment System is made of Titanium ELI according to ASTM F136.

IS Multi Unit Abutment System is composed of IS Multi Unit Abutment, IS Multi Unit Angled Abutment, Multi Unit Abutment Cylinder, Multi Unit Healing Cap, Multi Unit Temporary Cylinder, IS Multi Unit Angled Abutment Screw and Cylinder Screw.

All Multi-Unit Abutments (Straight/Angled) are intended only for multi-unit loaded restoration.

AI/ML Overview

I am sorry, but the provided text does not contain information about the acceptance criteria and the study that proves a device meets them in the context of an AI/ML medical device.

The document is a 510(k) premarket notification for a dental implant abutment system (IS Multi Unit Abutment System) and focuses on demonstrating substantial equivalence to predicate devices, which is a regulatory pathway for traditional medical devices, not typically AI/ML-driven ones.

Therefore, I cannot provide the requested information, including:

  1. A table of acceptance criteria and reported device performance.
  2. Sample size used for the test set and data provenance.
  3. Number and qualifications of experts for ground truth.
  4. Adjudication method.
  5. MRMC comparative effectiveness study results.
  6. Standalone performance.
  7. Type of ground truth used.
  8. Sample size for the training set.
  9. How ground truth for the training set was established.

The document primarily details device descriptions, indications for use, material specifications, and comparisons to predicate devices in terms of physical characteristics and intended use. It also mentions non-clinical testing data related to sterilization and fatigue testing for the physical dental device components.

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Image /page/0/Picture/0 description: The image contains the logos of the Department of Health & Human Services and the Food and Drug Administration (FDA). The Department of Health & Human Services logo is on the left, and the FDA logo is on the right. The FDA logo includes the text "U.S. Food & Drug Administration" in blue.

Neobiotech Co., Ltd. % April Lee Consultant Withus Group Inc 106 Superior Irvine, California 92620

Re: K210903

Trade/Device Name: IS Multi Unit Abutment System Regulation Number: 21 CFR 872.3630 Regulation Name: Endosseous Dental Implant Abutment Regulatory Class: Class II Product Code: NHA Dated: April 21, 2021 Received: April 26, 2021

Dear April Lee:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. Although this letter refers to your product as a device, please be aware that some cleared products may instead be combination products. The 510(k) Premarket Notification Database located at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm identifies combination product submissions. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

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Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting of medical device-related adverse events) (21 CFR 803) for devices or postmarketing safety reporting (21 CFR 4, Subpart B) for combination products (see https://www.fda.gov/combination-products/guidance-regulatory-information/postmarketing-safety-reportingcombination-products); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820) for devices or current good manufacturing practices (21 CFR 4, Subpart A) for combination products; and, if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to https://www.fda.gov/medical-device-safety/medical-device-reportingmdr-how-report-medical-device-problems.

For comprehensive regulatory information about medical devices and radiation-emitting products, including information about labeling regulations, please see Device Advice (https://www.fda.gov/medicaldevices/device-advice-comprehensive-regulatory-assistance) and CDRH Learn (https://www.fda.gov/training-and-continuing-education/cdrh-learn). Additionally, you may contact the Division of Industry and Consumer Education (DICE) to ask a question about a specific regulatory topic. See the DICE website (https://www.fda.gov/medical-device-advice-comprehensive-regulatoryassistance/contact-us-division-industry-and-consumer-education-dice) for more information or contact DICE by email (DICE@fda.hhs.gov) or phone (1-800-638-2041 or 301-796-7100).

Sincerely,

Andrew I. Steen Assistant Director DHT1B: Division of Dental and ENT Devices OHT1: Office of Ophthalmic, Anesthesia, Respiratory, ENT and Dental Devices Office of Product Evaluation and Quality Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known) K210903

Device Name IS Multi Unit Abutment System

Indications for Use (Describe)

IS Multi Unit Abutment System is intended for use with a dental implant to provide support for prosthetic restorations such as bridges.

Type of Use (Select one or both, as applicable)
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Prescription Use (Part 21 CFR 801 Subpart D)

Over-The-Counter Use (21 CFR 801 Subpart C)

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510(k) Summary

Submitter

Neobiotech Co., Ltd. Young-Ku, Heo #204, 36, Digital-ro 27 gil Guro-gu, Seoul, 08381, South Korea Email: sypark@neobiotech.com Tel. +82-2-582-2885 Fax. +82-2-582-2883

Official Correspondent

Withus Group Inc April Lee 106 Superior, Irvine, CA 92620 USA Email: withus6664@gmail.com Phone: 1-909-274-9971 Fax: 1-909-460-8122

Device Information

  • Trade Name: IS Multi Unit Abutment System
  • Common Name: Endosseous Dental Implant Abutment
  • Classification Name: Abutment, Implant, Dental, Endosseous
  • . Product Code: NHA
  • Panel: Dental
  • Regulation Number: 21 CFR 872.3630
  • Device Class: Class II
  • Date Prepared: 07/22/2021

Predicate Devices:

Primary Predicate

  • K161689, OSSTEM Implant System-Abutment by Osstem Implant Co.,Ltd. .

Reference Devices

  • . K120530, DENTIN Dental Implant System by Dentin Implant Technologies Ltd.
  • K180282, MIS Internal Hex Dental Implant System by MIS Implant Technologies Ltd.
  • K181138, IS-III active System by Neobiotech Co., Ltd.
  • K182091, Osstem Abutment System by Osstem Implant Co.,Ltd. ●
  • K182194, UV Active Implant System by DIO Corporation ●

Indications for Use:

IS Multi Unit Abutment System is intended for use with a dental implant to provide support for prosthetic restorations such as bridges.

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Device Description

IS Multi Unit Abutments are premanufactured dental implant abutments directly connected to the endosseous dental implant with internal hex connections (multiple tooth). IS Multi Unit Abutment System is made of Titanium ELI according to ASTM F136.

IS Multi Unit Abutment System is composed of IS Multi Unit Abutment, IS Multi Unit Angled Abutment, Multi Unit Abutment Cylinder, Multi Unit Healing Cap, Multi Unit Temporary Cylinder, IS Multi Unit Angled Abutment Screw and Cylinder Screw.

All Multi-Unit Abutments (Straight/Angled) are intended only for multi-unit loaded restoration.

NameDiameter(Ø)Cuff(mm)Length(mm)Angulation
IS Multi Unit AbutmentØ 4.81.0/2.0/3.0/4.0/5.0/6.0-
IS Multi Unit Angled AbutmentØ 4.81.0/2.0/3.0/4.0-17°,30°
Multi Unit Abutment CylinderØ 4.8-5.0
Multi Unit Healing CapØ 4.8-4.1
Multi Unit Temporary CylinderØ 4.8/6.0-11.0
IS Multi Unit Angled Abutment ScrewØ2.3-8.3
Cylinder ScrewØ2.3-4.1

The dimensions of abutments are as following:

The tolerance of dimension shall be within ± 1% range.

K numberSystem NameDiameter (Ø)Length(mm)
K181138IS-III active SystemØ 4.0/4.5/5.0/5.57.3/8.5/10.0/11.5/13.0/15.0
Ø 6.0/7.07.3/8.5/10.0/11.5/13.0
K120503CMI Implant IS II activeØ 4.0/4.5/5.0/5.5/6.0/7.0/8.07.3/8.5/10.0/11.5/13.0/15.0

The IS Multi Unit Abutment System is compatible with following implant system:

The features of each abutment are as following:

NameUsesSurfaceTreatmentConnection
IS Multi Unit AbutmentIt is connected with Fixture and it supportsN/AScrewRetained
IS Multi Unit AngledAbutmentprosthesis which restores tooth function.N/AHex,Non-Hex,
Multi Unit Abutment CylinderIt is connected with Multi Unit Abutment(Straight/Angled) in order to cement finalprosthesis.N/ANon-Hex
Multi Unit Healing CapIt is connected with Multi Unit Abutment (Straight/Angled type) in order to protect Multi UnitAbutment (Straight/Angled) and inner hole duringthe healing period.N/AScrewRetained
Multi Unit TemporaryCylinderIt is connected with Multi Unit Abutment (Straight/Angled) and it supports prosthesis which restorestooth function as a temporary dental prosthesis.N/ANon-Hex
IS Multi Unit AngledAbutment ScrewIt is used to fix Multi Unit Angled Abutment at thetop of Fixture.N/AScrewRetained

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Cylinder ScrewIt is used to fix Multi Unit Abutment Cylinder orMulti Unit Temporary Cylinder at the top of MultiUnit Abutment (Straight/ Angled).N/AScrewRetained
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Multi Unit Healing Cap is supplied sterile, and intended for singled use. Other Multi Unit components are supplied non sterile, to be steam sterilized by the user according to the labeling, and intended for single use.

IS Multi Unit Angled Abutment, Multi Unit Temporary Cylinder, Multi Unit Abutment Cylinder are provided with IS Multi Unit Abutment Screw or Cylinder Screw in packing.

And IS Multi Unit Abutment and Multi Unit Healing Cap have built in screw as an integral system. All of above products including enclosed product are packed separately for convenience.

Materials:

All subject devices are made of Titanium ELI of ASTM F136.

Summaries of Technological Characteristics: 1) IS Multi Unit Abutment

Subject DevicePrimary Predicate DeviceReference Device
CompanyNeobiotech Co., LtdOsstem Implant Co., Ltd.Dentin Implants TechnologiesLtd.
Device NameIS Multi Unit Abutment SystemOSSTEM Implant System-AbutmentDENTIN Dental Implant System
510(k) NumberK210903K161689K120530
ClassificationNameAbutment, Implant, Dental,EndosseousAbutment, Implant, Dental,EndosseousAbutment, Implant, Dental,Endosseous
Product CodeNHANHANHA
RegulationNumber872.3630872.3630872.3630
Intended UseIS Multi Unit Abutment Systemis intended for use with a dentalimplant to provide support forprosthetic restorations such asbridges.The OSSTEM Implant System –Abutment is intended for usewith a dental implant to providesupport for prostheticrestorations such as crowns,bridges, or overdentureDENTIN® Dental ImplantsSystem is indicated for use insurgical and restorativeapplications for placement in thebone of the upper or lower jawto provide supportfor prosthetic devices, such asartificial teeth, in order to restorethe patient'schewing function. DENTIN®Dental Implants System isindicated also forimmediate loading when goodprimary stability is achieved andwith appropriateocclusal loading.Two Stage Implants: CLASSIC,RAPID, PRESTIGE.One Stage Implants: ONEPIECEDENTIN® ONEPIECE Implants3.0 mmd are intended forplacement at the mandibularcentral and lateral incisors andmaxillary and lateral incisors.

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Indicated also for denturestabilization using multipleimplants.
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Design 1Image: Design 2Image: Design 3
Abutment/Implant InterfaceConnectionTypeInternal Non-HexInternal Non-HexInternal Non-Hex
Diameters (Ø)4.84.85.0
Cuff(mm)1.0/2.0/3.0/4.0/5.0/6.01.0/2.0/3.0/4.0/5.06.0
Post Height(mm)2.2--
SurfaceTreatmentN/ATiN-CoatingTiN-Coating
SterilizationEnd-User Moist HeatSterilization--
Principle ofOperationIt is indicated for cementretained bridge restorations.It is indicated for screw-retainedsingle tooth or cement retainedsingle tooth and bridgerestorations.It is indicated for screw-retainedsingle tooth or cement retainedsingle tooth and bridgerestorations.
Shelf LifeN/AN/AN/A
SimilaritiesThe subject and primary predicate have same functions, materials, principle of operation and similarindications for use, design and dimensions.
DifferencesThere are differences in Indications for Use, design, cuff length and surface treatment between thesubject device and primary predicate.- Indications for Use: The subject device doesn't include the "O-ring" as the component; therefore, it isnot intended to use for overdenture. Also, since the subject devices are only indicated for multi-unitrestorations, it is not intended to use for crowns. As the indications for use of the subject device are inrange of the predicate's, it doesn't affect the substantial equivalence.- Design, Cuff length, and Surface treatment: To support Ø4.8X6.0mm of subject abutment and surfacetreatment, K120530 was added as the reference device. These differences don't affect product'sfundamental functions and substantial equivalence.

2) IS Multi Unit Angled Abutment

Subject DeviceReference Device
CompanyNeobiotech Co., LtdDio Corporation
Device NameIS Multi Unit Angled AbutmentUV Active Implant System-Angled Multi-Unit Abutment
510(k) NumberK210903K182194
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136

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Design
Abutment/ImplantInterfaceConnection TypeInternal HexInternal Non-HexInternal Hex
Diameters (Ø)4.84.8
Cuff(mm)1.0/2.0/3.0/4.01.5/2.5/3.5/4.5/5.5
Post Height(mm)2.2-
Angle(°)17/3020/30
Surface TreatmentN/AN/A
SterilizationEnd-User Moist Heat Sterilization-
Principle ofOperationIt is indicated for cement retained bridgerestorations.It is indicated for screw-retained single toothor cement retained single tooth and bridgerestorations.
Shelf LifeN/AN/A
SimilaritiesThe subject and reference devices have same intended use, functions, materials, surfacetreatment, general shape (design) and dimensions.
DifferencesThere are slightly different designs and dimensions between subject and reference devices.These differences don't affect product's fundamental functions and substantial equivalence.

3) Multi Unit Abutment Cylinder

Subject DeviceReference Device
CompanyNeobiotech Co., LtdMIS Implants Technologies Ltd.
Device NameMulti Unit Abutment CylinderCementing cap for Multi-Unit
510(k) NumberK210903K180282
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Multi Unit Abutment Cylinder designImage: Cementing cap for Multi-Unit design
Diameters (Ø)4.84.8
Lengths(mm)5.03.3
Post Height(mm)5.03.3
Surface TreatmentN/ATiN-Coating
SterilizationEnd-User Moist Heat SterilizationGamma irradiation
Principle ofOperationIt is used to support the prosthesis, and it isconnected with Multi Unit Abutment withCylinder Screw.It is used to support the prosthesis, and it isconnected with Multi Unit Abutment withCylinder Screw.
Shelf LifeN/A5 years
SimilaritiesThe subject and reference devices have same intended use, functions, materials, surfacetreatment, general shape (design) and dimensions.
DifferencesThere are slightly different design and length. These differences don't affect product'sfundamental functions and substantial equivalence.

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4) Multi Unit Healing Cap

Subject DeviceReference Device
CompanyNeobiotech Co., LtdMIS Implants Technologies Ltd.
Device NameMulti Unit Healing CapHealing Cap
510(k)NumberK210903K180282
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Subject Device DesignImage: Reference Device Design
Diameters(Ø)4.84.8
Length (mm)4.14.3
Post Height(mm)4.14.3
SurfaceTreatmentN/ATiN-Coating
SterilizationGamma irradiation-
Principle ofOperationIt is connected to the dental Abutment duringsoft tissue healing period combined withImplant. It should be removed when thesuperstructure is set up.It is connected to the dental Abutment duringsoft tissue healing period combined withImplant. It should be removed when thesuperstructure is set up.
Shelf Life5 years5 years
SimilaritiesThe subject and reference devices have same intended use, functions, materials, general shape(design) and dimensions.
DifferencesThere are slightly different design and length. These differences don't affect product's fundamentalfunctions and substantial equivalence.

5) Multi Unit Temporary Cylinder

Subject DeviceReference Device
CompanyNeobiotech Co., LtdDIO Corporation
DeviceNameMulti Unit Temporary CylinderTemporary Cylinder
510(k)NumberK210903K182194
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Subject Device DesignImage: Reference Device Design
Diameters(Ø)4.8/6.05.4
Length(mm)11.012.0
Post Height(mm)11.012.0
SurfaceTreatmentN/AN/A
SterilizationEnd-User Moist Heat Sterilization-
Principle ofOperationIt is designed to serve as a temporary dentalprosthesis during the healing process until apermanent bridges are made.It is designed to serve as a temporary dentalprosthesis during the healing process until apermanent crown is made.
Shelf LifeN/AN/A

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SimilaritiesThe subject and reference devices have same intended use, functions, materials, and general shape(design).
DifferencesThere are slightly different design and dimensions. These differences don't affect device'sfundamental functions and substantial equivalence.

6) IS Multi Unit Angled Abutment Screw

6) IS Multi Unit Angled Abutment Screw
Subject DeviceReference Device
CompanyNeobiotech Co., LtdDio Coporation
Device NameIS Multi Unit Angled Abutment ScrewMulti Angled Abutment Screw
510(k)NumberK210903K182194
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Subject Device DesignImage: Reference Device Design
Diameters(Ø)2.32.2
Length (mm)8.36.0
SurfaceTreatmentN/AN/A
SterilizationEnd-User Moist Heat Sterilization
Principle ofOperationThis product is a screw for connected withAbutment and fixture.This product is a screw for connected withAbutment and fixture.
Shelf LifeN/AN/A
SimilaritiesThe subject and reference devices have same intended use, functions, materials, and general shape(design).
DifferencesThere are slightly different design and dimensions. These differences don't affect device'sfundamental functions and substantial equivalence.

7) Cylinder Screw

Subject DeviceReference Device
CompanyNeobiotech Co., LtdDio Coporation
Device NameCylinder ScrewCylinder Screw
510(k) NumberK210903K182194
MaterialTi-6Al-4V ELI of ASTM F136Ti-6Al-4V ELI of ASTM F136
DesignImage: Cylinder ScrewImage: Cylinder Screw
Diameters(Ø)2.32.15
Length (mm)4.14.0
Surface TreatmentN/AN/A
SterilizationEnd-User Moist Heat Sterilization-
Principle of OperationThis product is a screw for connected with Multi Unit Abutment (Straight/Angled) and Cylinder.This product is a screw for connected with Multi Unit Abutment (Straight/Angled) and Cylinder.
Shelf LifeN/AN/A
SimilaritiesThe subject and reference devices have same intended use, functions, materials, and general shape (design).
DifferencesThere are slightly different design and dimensions. These differences don't affect device's fundamental functions and substantial equivalence.

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Similarities:

IS Multi Unit Abutment System has same device characteristics with the Primary predicate devices, OSSTEM Implant System-Abutment (K161689) and commercially available products based on the indications for use, the technology used, the material composition employed and performance characteristics as predicate devices. The subject device has been supposed to performance and product validations prior to release. Testing including performance and fatigue test has been finished to ensure the devices comply with the applicable International standards and US FDA Guidance.

Differences:

There are differences in Indications for Use, design, cuff length and surface treatment between the subject device and primary predicate.

  • Indications for Use: The subject device doesn't include the "O-ring" as the component; therefore, it is not intended to use for overdenture. As the indications for use of the subject device are in range of the predicate's, it doesn't affect the substantial equivalence.
  • Design, Cuff length, and Surface treatment: To support Ø4.8X6.0mm of subject abutment and surface treatment, K182194 and K120530 were added as the reference device. These differences don't affect product's fundamental functions and substantial equivalence.

Non-clinical testing data:

The subject device was tested to evaluate its substantial equivalence according to the following standards.

  • End User Sterilization Validation Test Report on IS Multi Unit Abutment Angled Abutment ● (Hex type) according to ANSI/AAMI ST79, ISO 17665-1, ISO 17665-2, ISO 11737-1, ISO 11737-2, and ISO 11138-1
  • . Fatigue Test Report according to ISO 14801:2016

Below tests were performed for predicate devices and leveraged for the subject device:

  • Sterilization Validation Test on Healing Abutments according to ISO 11137-1,2,3 referenced in K181138
  • Shelf-Life Test on Healing Abutments according to ASTM F1980 referenced in K181138
  • Biocompatibility Test according to ISO 10993-1 referenced in K181138
  • Bacterial Endotoxin Testing on Healing Abutments according to ANSI/AAMI ST72:2011, USP ● <161>, and USP <85>, referenced in K181138

The results of the above tests have met the criteria of the standards, and demonstrated the substantial equivalence with the predicate device.

The non-clinical testing results demonstrate that the subject device is substantially equivalent to the predicate device.

Conclusion

IS Multi Unit Abutment System constitutes a substantially equivalent medical device, meeting all the declared requirements of its intended use. This system has the same intended use and fundamental scientific technology as its predicate devices. Therefore, IS Multi Unit Abutment System and its predicates are substantially equivalent.

§ 872.3630 Endosseous dental implant abutment.

(a)
Identification. An endosseous dental implant abutment is a premanufactured prosthetic component directly connected to the endosseous dental implant and is intended for use as an aid in prosthetic rehabilitation.(b)
Classification. Class II (special controls). The guidance document entitled “Class II Special Controls Guidance Document: Root-Form Endosseous Dental Implants and Endosseous Dental Implant Abutments” will serve as the special control. (See § 872.1(e) for the availability of this guidance document.)