K Number
K210388
Date Cleared
2021-12-13

(307 days)

Product Code
Regulation Number
880.6250
Reference & Predicate Devices
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

A powder-free patient examination glove is a disposable device intended for medical purposes that is wom on the examiner's hand or finger to prevent contamination between patient and examiner.

Device Description

The Powder Free Nitrile Examination Gloves are non sterile, single use, and disposable. These gloves are available in Blue, Green, and Black colors. This device is to protect the examiner and prevent contamination between patient and the examiner when properly worn. The sizes of the gloves are Small, Medium, Large and X-Large. Non Sterile Nitrile Powder Free Examination Gloves meet all current specifications listed under ASTM Specifications D6319.

AI/ML Overview

This document describes the acceptance criteria and performance data for Mexpo International Inc.'s Non Sterile Nitrile Powder Free Examination Gloves.

1. Table of Acceptance Criteria and Reported Device Performance:

The primary acceptance criteria are based on the ASTM D6319 and ASTM D6124 standards for nitrile examination gloves.

CharacteristicASTM D6319/D6124 RequirementReported Device Performance (Table 3, for Blue, Green, and Black Gloves)
DIMENSIONS
Overall LengthSmall: Pass (237-253 mm) Medium: Pass (240-251 mm) Large: Pass (240-255 mm) X-Large: Pass (241-277 mm)
- Small220 mm minimumPass
- Medium230 mm minimumPass
- Large230 mm minimumPass
- X-large230 mm minimumPass
WidthSmall: Pass (85-88 mm) Medium: Pass (95-98 mm) Large: Pass (105-109 mm) X-Large: Pass (113-116 mm)
- Small$80 \pm 10$ mmPass
- Medium$95 \pm 10$ mmPass
- Large$110 \pm 10$ mmPass
- X-large$120 \pm 10$ mmPass
Palm Thickness0.05 mm minimumSmall: Pass (0.06-0.14 mm) Medium: Pass (0.06-0.13 mm) Large: Pass (0.05-0.13 mm) X-Large: Pass (0.06-0.13 mm)
Finger Thickness0.05 mm minimumSmall: Pass (0.09-0.17 mm) Medium: Pass (0.09-0.18 mm) Large: Pass (0.10-0.16 mm) X-Large: Pass (0.10-0.16 mm)
PHYSICAL PROPERTIES
Tensile Strength (Before Aging)14 MPa minimumSmall: Pass (24.1-41.2 MPa) Medium: Pass (25.9-46.5 MPa) Large: Pass (21.2-42.2 MPa) X-Large: Pass (19.6-43.5 MPa)
Tensile Strength (After Aging)14 MPa minimumSmall: Pass (24.4-43.5 MPa) Medium: Pass (24.8-45.8 MPa) Large: Pass (20.7-43.0 MPa) X-Large: Pass (21.6-44.8 MPa)
Ultimate Elongation (Before Aging)500% minimumSmall: Pass (500-600%) Medium: Pass (500-600%) Large: Pass (500-600%) X-Large: Pass (460-560%) Note: X-Large Black glove reports 460-540%, which includes values below 500% (e.g., 460%). This is a slight discrepancy against the "500% minimum" requirement, though generally reported as "Pass".
Ultimate Elongation (After Aging)400% minimumSmall: Pass (460-580%) Medium: Pass (460-600%) Large: Pass (480-560%) X-Large: Pass (440-560%)
FREEDOM FROM HOLES (Pinhole Inspection)AQL=2.5Small: Pass (Found=0-2) Medium: Pass (Found=0) Large: Pass (Found=0-1) X-Large: Pass (Found=1-6)
Inspection LevelG-1Pass
POWDER FREE/Powder ContentDoes not exceed 2 mg/gloveSmall: Pass (Average: 0.04-0.36 mg/glove) Medium: Pass (Average: 0.06-0.70 mg/glove) Large: Pass (Average: 0.04-0.30 mg/glove) X-Large: Pass (Average: 0.10-1.02 mg/glove)
BIOCOMPATIBILITYISO 10993-10, ISO 10993-11Non-irritant, non-sensitizer, no acute systemic toxic effects.

2. Sample Size Used for the Test Set and Data Provenance:

  • Sample Size: The document does not explicitly state the total sample size across all tests for the subject device. However, for the "Freedom from Holes (Pinhole Inspection)" test, the sample size per size/color variation is reported as n=200 gloves (as indicated by "Accept on 10 (n=200)" or "Accept on 7 (n=200)"). The specific number of gloves tested for other physical and dimensional properties is not detailed, but it is implied that sufficient samples were tested to demonstrate compliance with ASTM standards.
  • Data Provenance: The document does not specify the country of origin of the data or whether the studies were retrospective or prospective. It presents the results as "Summary of Device Specifications and Performance Results" and "Performance Test Results Comparison," implying the data was generated from testing of the subject gloves.

3. Number of Experts Used to Establish the Ground Truth for the Test Set and Their Qualifications:

This information is not applicable to this type of device (nitrile examination gloves). The "ground truth" for glove performance is established by objective, standardized laboratory tests according to recognized industry standards (ASTM D6319, ASTM D6124, ISO 10993 series for biocompatibility), not by expert consensus in the way medical imaging or diagnostic devices might require.

4. Adjudication Method for the Test Set:

This information is not applicable. As standard laboratory tests are used, there is no subjective interpretation requiring an adjudication method. The results are quantitative measurements or pass/fail criteria against established standards.

5. If a Multi-Reader Multi-Case (MRMC) Comparative Effectiveness Study Was Done:

No, an MRMC comparative effectiveness study was not done. This type of study assesses the impact of a device on human expert performance, which is not relevant for examination gloves.

6. If a Standalone Performance Study Was Done:

Yes, a standalone (algorithm only, without human-in-the-loop performance) study was done. The document presents the performance of the device itself against recognized objective standards without requiring human interaction or interpretation beyond performing the tests. The results in Table 3 directly reflect the intrinsic properties of the gloves.

7. The Type of Ground Truth Used:

The ground truth used is based on established industry standards and objective physical/chemical measurements. Specifically:

  • ASTM D6319: Standard Specification for Nitrile Examination Gloves for Medical Application
  • ASTM D6124: Standard Test Method for Residual Powder on Medical Gloves
  • ASTM D5151-06 (2011): Standard Test Method for Detection of Holes in Medical Gloves
  • ISO 10993-10: Biological evaluation of medical devices -- Part 10: Tests for irritation and skin sensitization
  • ISO 10993-11: Biological evaluation of medical devices -- Part 11: Tests for systemic toxicity

These standards define the acceptable ranges and methodologies for determining the "truth" of a glove's dimensions, physical properties, freedom from holes, and biocompatibility.

8. The Sample Size for the Training Set:

This information is not applicable. Examination gloves do not typically involve a "training set" in the context of machine learning or AI. The manufacturing process is controlled to consistently produce gloves meeting specifications.

9. How the Ground Truth for the Training Set Was Established:

This information is not applicable for the same reason as point 8. The "ground truth" for quality control and manufacturing is the continuous adherence to the established product specifications and the ASTM/ISO standards.

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Image /page/0/Picture/0 description: The image contains the logos of the Department of Health and Human Services and the Food and Drug Administration (FDA). The Department of Health and Human Services logo is on the left, and the FDA logo is on the right. The FDA logo includes the letters "FDA" in a blue square, followed by the words "U.S. FOOD & DRUG ADMINISTRATION" in blue text.

December 13, 2021

Mexpo International Inc. Tim Thai Official Correspondent 2828 Faber Street Union City, California 94587

Re: K210388

Trade/Device Name: Non Sterile Nitrile Powder Free Examination Gloves - Blue, Green and Black color Regulation Number: 21 CFR 880.6250 Regulation Name: Non-Powdered Patient Examination Glove Regulatory Class: Class I, reserved Product Code: LZA Dated: November 10, 2021 Received: November 12, 2021

Dear Tim Thai:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. Although this letter refers to your product as a device, please be aware that some cleared products may instead be combination products. The 510(k) Premarket Notification Database located at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm identifies combination product submissions. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal

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statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting of medical device-related adverse events) (21 CFR 803) for devices or postmarketing safety reporting (21 CFR 4, Subpart B) for combination products (see https://www.fda.gov/combination-products/guidance-regulatory-information/postmarketing-safety-reportingcombination-products); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820) for devices or current good manufacturing practices (21 CFR 4, Subpart A) for combination products; and, if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to https://www.fda.gov/medical-device-safety/medical-device-reportingmdr-how-report-medical-device-problems.

For comprehensive regulatory information about mediation-emitting products, including information about labeling regulations, please see Device Advice (https://www.fda.gov/medicaldevices/device-advice-comprehensive-regulatory-assistance) and CDRH Learn (https://www.fda.gov/training-and-continuing-education/cdrh-learn). Additionally, you may contact the Division of Industry and Consumer Education (DICE) to ask a question about a specific regulatory topic. See the DICE website (https://www.fda.gov/medical-device-advice-comprehensive-regulatoryassistance/contact-us-division-industry-and-consumer-education-dice) for more information or contact DICE by email (DICE@fda.hhs.gov) or phone (1-800-638-2041 or 301-796-7100).

Sincerely,

For Clarence W. Murray III, PhD Assistant Director DHT4B: Division of Infection Control and Plastic Surgery Devices OHT4: Office of Surgical and Infection Control Devices Office of Product Evaluation and Quality Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known) K210388

Device Name

NON STERILE NITRILE POWDER FREE EXAMINATION GLOVES - BLUE, GREEN AND BLACK COLOR

Indications for Use (Describe)

A powder-free patient examination glove is a disposable device intended for medical purposes that is wom on the examiner's hand or finger to prevent contamination between patient and examiner.

Type of Use (Select one or both, as applicable)

Prescription Use (Part 21 CFR 801 Subpart D)

11

|X] Over-The-Counter Use (21 CFR 801 Subpart C)

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510K SUMMARY

Date of Summary Prepared: November 9, 2021

510K Number: K210388

  1. Applicant : MEXPO INTERNATIONAL INC. Address : 2828 Faber Street, Union City, CA 94587, U.S.A. Tel : 510 — 489 6800 Fax : 510-489 3111 E-mails : : mexpoglove@aol.com and acct@mexpo-glove.com

Official Correspondence: Tim Thai (President)

    1. Device Name: Non Sterile Nitrile Powder Free Examination Gloves Blue, Green And Black color.

3. Regulatory Information

Classification Name: Nitrile Powder Free Examination Gloves
Classification: Class I
Product Code: LZA
Regulation Number: 21 CFR 880.6250

4. Predicate Device

510K Number: K143289- YTY Industry (Manjung) Sdn. Bhd.
Device Name: Non Sterile, Powder Free Nitrile Examination Gloves -Orange, Green, Blue and Violet Color.

5. Intended Use

A powder-free patient examination glove is a disposable device intended for medical purposes that is worn on the examiner's hand or finger to prevent contamination between patient and examiner.

6. Description

The Powder Free Nitrile Examination Gloves are non sterile, single use, and disposable. These gloves are available in Blue, Green, and Black colors. This device is to protect the examiner and prevent contamination between patient and the examiner when properly worn. The sizes of the gloves are Small, Medium, Large and X-Large. Non Sterile Nitrile Powder Free Examination Gloves meet all current specifications listed under ASTM Specifications D6319.

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Summary of Comparison and Technological Characteristic
Table 1 - General Comparison
SUBJECT DEVICE:K210388PREDICATE DEVICE:K143289Comparison
Company NameMexpo International Inc.YTY INDUSTRY(MANJUNG) SDN. BHD
Product NameNon Sterile, Powder FreeNitrile ExaminationGloves-BLUE, GREEN ANDBLACKNon Sterile, Powder FreeNitrile ExaminationGloves-Orange, Green,Blue and Violet Color
Available ColorsBlue, Green and BlackBlue, Green and OthersSimilar
Available SizesSmall, Medium, Large andX-LargeNot specified but dataprovided on MediumSimilar
Indications for UseA powder free patientexamination glove is adisposable deviceintended for medicalpurposes that is worn onthe examiner's hand orfinger to preventcontamination betweenpatient and examiner.A patient examinationgloves is a disposabledevice intended formedical purpose that isworn on the examiner'shand or finger to preventcontamination betweenpatient and examiner.Similar. The subjectdevice includes languageto clarify that it ispowder free asrecommended in theFDA's Glove GuidanceDocument
MATERIALSCarboxylated ButadieneAcrylonitrile as basematerialCarboxylated ButadieneAcrylonitrile as basematerialSame
DIMENSIONSMeets ASTM D6319CriteriaMeets ASTM D6319CriteriaSame
PHYSICALPROPERTIESMeets ASTM D6319CriteriaMeets ASTM D6319CriteriaSame
FREEDOM FROMHOLES/WatertightMeets ASTMD6319/ASTM D5151CriteriaMeets ASTM D5151CriteriaSame
POWDERFREE/Residual PowderMeets ASTM D6124CriteriaMeets ASTM D6124CriteriaSame
BIOCOMPATABILITYPer ISO 10993-10: Non-irritant (ResponseCategory is Negligible)and Non-sensitizer (Nosensitization)Per ISO 10993-11: AcuteSystemic Toxicity; Notoxic effectsPer ISO 10993-10: Non-irritant andNon-sensitizerSame
Product CommonNameNon sterile Nitrile PowderFree Examination GlovesNon sterile Nitrile PowderFree Examination GlovesSame
Product Code/ClassLZAClass I(21 CFR 880.6250)LZAClass I(21 CFR 880.6250)Same
Sterility/UseNon-Sterile/Single UseNon-Sterile/Single UseSame
OTC UseYesYesSame
SUBJECT DEVICE:K210388PREDICATE DEVICE:K143289Comparison
MexpoInternational IncYTY INDUSTRY(MANJUNG) SDN.BHD
Glove Color/SizeBLUE/MediumBLUE/Medium
DIMENSIONASTM D6319Accept Criteria
Overall Length230 mmMinimum240-246 mm240-250 mmSame. Both meetASTM D6319Acceptance Criteria
Width95 +/-10 mm95-98 mm95-99 mmSame. Both meetASTM D6319Acceptance Criteria
Palm Thickness0.05 mmMinimum0.06-0.06 mm0.05-0.06 mmSame. Both meetASTM D6319Acceptance Criteria
Finger thickness0.05 mmMinimum0.09-0.10 mm0.09-0.10 mmSame. Both meetASTM D6319Acceptance Criteria
PHYSICAL PROPERTIES
Tensile Strength(before aging)14 MPa,Minimum25.9-32.0 MPa28.46-33.44 MPaSame. Both meetASTM D6319Acceptance Criteria
Tensile Strength(after aging)14 MPa,Minimum25.4-34.0 MPa29.76-34.18 MPaSame. Both meetASTM D6319Acceptance Criteria
Ultimate Elongation(before aging)500 %Minimum500-540 %520-580 %Same. Both meetASTM D6319Acceptance Criteria
Ultimate Elongation(after aging)400 %Minimum480-520 %440-520 %Same. Both meetASTM D6319Acceptance Criteria
FREEDOM FROMHOLES/WatertightPer ASTMD5151-06(2011)Holes Found: 0Holes Found: 0(Accept 1, Reject 7)Same. Both meetASTM D6319Acceptance Criteria
Pinhole AQLInspectionLevel G-1;AQL=2.5Inspection Level G-1; AQL=2.5Inspection Level G-1; AQL=2.5Same. Both meetASTM D6319Acceptance Criteria
POWDERFREE/ResidualPowderResidue limitof 2.0mg/glove0.70 mg/glove0.20 mg/gloveSame. Both meetASTM D6124Acceptance Criteria

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Table 2 Specifications and Performance Test Results Comparison

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Table 3 Summary of Device Specifications and Performance Results

ASTM D6319RequirementBLUE GlovesGREEN GlovesBLACK Gloves
DIMENSIONS
Overall Length
-Small220 mm minimumPass (242-253 mm)Pass (237-243 mm)Pass (239-248 mm)
-Medium230 mm minimumPass (240-246 mm)Pass (240-247 mm)Pass (244-251 mm)
-Large230 mm minimumPass (245-255 mm)Pass (240-247 mm)Pass (243-251 mm)
-X large230 mm minimumPass (243-253 mm)Pass (240-250 mm)Pass (241-277 mm)
Width
-Small$80 \pm 10$ mmPass (85-87 mm)Pass (86-88 mm)Pass (85-86 mm)
-Medium$95 \pm 10$ mmPass (95-98 mm)Pass (95-96 mm)Pass (95-97 mm)
-Large$110 \pm 10$ mmPass (106-109 mm)Pass (106-106 mm)Pass (105-106 mm)
-X large$120 \pm 10$ mmPass (113-115 mm)Pass (114-116 mm)Pass (115-115 mm)
Palm Thickness
-Small0.05 mmminimumPass (0.06-0.07 mm)Pass (0.12-0.14 mm)Pass (0.07-0.08 mm)
-Medium0.05 mmminimumPass (0.06-0.06 mm)Pass (0.13-0.13 mm)Pass (0.07-0.07 mm)
-Large0.05 mmminimumPass (0.05-0.07 mm)Pass (0.11-0.13 mm)Pass (0.07-0.07 mm)
-X large0.05 mmminimumPass (0.06-0.06 mm)Pass (0.12-0.13 mm)Pass (0.06-0.07 mm)
Finger thickness
-Small0.05 mmminimumPass (0.09-0.11 mm)Pass (0.15-0.17 mm)Pass (0.11-0.13 mm)
-Medium0.05 mmminimumPass (0.09-0.10 mm)Pass (0.15-0.18 mm)Pass (0.11-0.13 mm)
-Large0.05 mmminimumPass (0.10-0.11 mm)Pass (0.15-0.16 mm)Pass (0.11-0.13 mm)
-X large0.05 mmminimumPass (0.10-0.11 mm)Pass (0.15-0.16 mm)Pass (0.11-0.14 mm)

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ASTM D6319RequirementBLUE GlovesGREEN GlovesBLACK Gloves
PHYSICAL PROPERTIES
Tensile Strength (Before Aging)
-Small14 MPa minimumPass (25.2-31.9 MPa)Pass (24.1-34.1 MPa)Pass (33.5-41.2 MPa)
-Medium14 MPa minimumPass (25.9-32.0 MPa)Pass (25.9-32.0 MPa)Pass (34.3-46.5 MPa)
-Large14 MPa minimumPass (23.9-34.3 MPa)Pass (21.2-28.8 MPa)Pass (31.6-42.2 MPa)
-X large14 MPa minimumPass (28.2-39.2 MPa)Pass (19.6-29.9 MPa)Pass (25.2-43.5 MPa)
Tensile Strength (After Aging)
-Small14 MPa minimumPass (25.6-34.9 MPa)Pass (24.4-38.1 MPa)Pass (25.7-43.5 MPa)
-Medium14 MPa minimumPass (25.4-34.0 MPa)Pass (24.8-32.3 MPa)Pass (34.7-45.8 MPa)
-Large14 MPa minimumPass (24.0-37.4 MPa)Pass (20.7-33.9 MPa)Pass (35.1-43.0 MPa)
-X large14 MPa minimumPass (33.2-40.2 MPa)Pass (21.6-32.1 MPa)Pass (24.7-44.8 MPa)
Ultimate Elongation (Before Aging)
-Small500% minimumPass (500-540%)Pass (500-580%)Pass (540-600%)
-Medium500% minimumPass (500-540%)Pass (500-560%)Pass (520-600%)
-Large500% minimumPass (500-560%)Pass (500-580%)Pass (520-600%)
-X large500% minimumPass (500-560%)Pass (540-580%)Pass (460-540%)
Ultimate Elongation (After Aging)
-Small400% minimumPass (480-520%)Pass (460-540%)Pass (540-580%)
-Medium400% minimumPass (480-520%)Pass (460-540%)Pass (520-600%)
-Large400% minimumPass (480-520%)Pass (480-560%)Pass (520-560%)
-X large400% minimumPass (480-520%)Pass (500-560%)Pass (440-520%)
ASTM D6319 RequirementBLUE GlovesGREEN GlovesBLACK Gloves
FREEDOM FROM HOLES (Pinhole Inspection)
-SmallAQL=2.5; Accept on 10 (n=200)Pass (Found=1)Pass (Found=0)Pass (Found=2)
-MediumAQL=2.5; Accept on 7 (n=200)Pass (Found=0)Pass (Found=0)Pass (Found=0)
-LargeAQL=2.5; Accept on 10 (n=200)Pass (Found=1)Pass (Found=1)Pass (Found=0)
-X LargeAQL=2.5; Accept on 10 (n=200)Pass (Found=0)Pass (Found=6)Pass (Found=1)
ASTM D6124RequirementBLUE GlovesGREEN GlovesBLACK Gloves
POWDER FREE/Powder Content
-Smalldoes not exceed 2mg per glovePass (Average: 0.36mg per glove)Pass (Average: 0.18mg per glove)Pass (Average: 0.04mg per glove)
-MediumDoes not exceed2 mg per glovePass (Average: 0.70mg per glove)Pass (Average: 0.10mg per glove)Pass (Average: 0.06mg per glove)
-LargeDoes not exceed2 mg per glovePass (Average: 0.30mg per glove)Pass (Average: 0.16mg per glove)Pass (Average: 0.04mg per glove)
-X LargeDoes not exceed2 mg per glovePass (Average: 1.02mg per glove)Pass (Average: 0.24mg per glove)Pass (Average: 0.10mg per glove)

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7. Conclusion

The conclusion drawn from the nonclinical tests demonstrates that the subject device in 510(K) submission K210388, MEXPO NON STERILE NITRILE POWDER FREE EXAMINATION GLOVES – BLUE, GREEN AND BLACK, is as safe, as effective, and performs as well as or better than the legally marketed predicate device Non Sterile, Powder Free Nitrile Examination Gloves-Orange, Green, Blue and Violet Color in K143289.

§ 880.6250 Non-powdered patient examination glove.

(a)
Identification. A non-powdered patient examination glove is a disposable device intended for medical purposes that is worn on the examiner's hand or finger to prevent contamination between patient and examiner. A non-powdered patient examination glove does not incorporate powder for purposes other than manufacturing. The final finished glove includes only residual powder from manufacturing.(b)
Classification. Class I (general controls). The device, when it is a finger cot, is exempt from the premarket notification procedures in subpart E of part 807 of this chapter subject to the limitations in § 880.9.