K Number
K142529
Date Cleared
2015-01-08

(121 days)

Product Code
Regulation Number
880.6850
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The Genesis Reusable Rigid Sterilization Container System is a device intended to be used to enclose another medical device that is to be sterilized by a healthcare provider. It allows sterilization of the enclosed medical device and maintains sterility of the enclosed device until used for a maximum of 180 days.

Containers are suitable for dynamic air re-vacuum) steam sterilization, immediate use pre-vacuum steam sterilization and 100% ethylene oxide sterilization when used as described in the instructions for use.

Reusable baskets and accessory items (pins, dividers, mats, etc.) are intended to organize and secure enclosed medical devices during sterilization and storage of the container.

Data cards are used to recording a specific sterilization process load. Filter media allows ingress and egress of sterilant while providing a microbial barrier. Tamper evide a visual indication that the container system has not been inadvertently opened prior to use. Each arrow contains a modality-specific external process indication indication that the system has been exposed to a specific sterilization cycle parameter. Data cards, filters and tamper evident arrows are single use only.

Device Description

The Genesis Reusable Rigid Container System is an assortment of rigid, reusable, stackable containers that are used to sterilize other medical devices and maintain sterility of these devices until used. The container system is comprised of a lid, bottom, filter, tamper evident arrows, and data cards. The container system houses baskets of varying depths and organizing accessory devices that are used to organize and to secure surgical instrumentation and/or other medical devices.

AI/ML Overview

The provided document is a 510(k) premarket notification for a medical device (Genesis™ Reusable Rigid Sterilization Container System). It outlines the device's indications for use, comparison to a predicate device, and a summary of non-clinical performance tests.

Here's an analysis of the acceptance criteria and study information provided, focusing on the available details:


Description of Acceptance Criteria and Device Performance

The device under review is the Genesis™ Reusable Rigid Sterilization Container System. The primary function of this system is to enclose other medical devices for sterilization and maintain their sterility for up to 180 days. The acceptance criteria for this device revolve around demonstrating its efficacy in sterilization and maintaining sterility under various conditions.

The study presented focuses on non-clinical performance testing to validate the sterilization efficacy and dry time of the container system for specific sterilization modalities and contents.

1. Table of Acceptance Criteria and the Reported Device Performance:

Characteristic / Acceptance CriteriaReported Device Performance
Sterilization Efficacy: Pre-vacuum Steam
- Standard/Test/FDA Guidance: ST 77 2013 Containment Devices for Reusable Medical Device SterilizationTesting demonstrated a 12 log reduction and a sterility assurance level (SAL) of 10-6 using biological (BI) overkill method.
Dry Time for Dynamic Air Removal (Pre-vacuum steam modality)
- Standard/Test/FDA Guidance: ST 77 2013 Containment Devices for Reusable Medical Device SterilizationTesting demonstrated validated method of drying by absence of visible moisture.

Additional Performance Parameters and Conditions (from "Sterilization Parameters for the Genesis™ Reusable Rigid Container System by Modality" and "Accessories and Device Challenges by Sterilization Modality and Container Style" tables):

Sterilization MethodCycle Parameters / Contents / ConfigurationsApplicable Containers/Accessories / Performance
Dynamic Air Removal (Pre-Vacuum) Steam (Regular & Immediate Use)- Exposure Temp: 270°F (132°C)- Pre-conditioning Pulses: 3- Exposure Time: 4 Minutes- Dry Time Cycle: 30 minutes (Regular)- Minimum Cool Time: 60 minutes (Regular)- Stack Height: Max 3- Total System Weight: 25 lbs.- Lumen Devices: 2.68 mm x 450 mm (Qty 16), 1.37 mm x 242 mm (Qty 10), 3 mm x 400 mm (Qty 2)Demonstrated efficacy for Solid and Perforated Bottom Containers, Stacking/Non-Stacking Baskets, various Lumen Devices (specified quantities), Devices with conjoined surfaces, Silicone Support Bars/Mats, Laparoscopic Racks, Optional Protective Plates. Materials include Metals, Polymers, Composites. (Performance is "Yes" for all listed components/configurations under these steam methods).
100% Ethylene Oxide- EO Sterilant Conc: 100% EO, 725 mg/L- Pre-Conditioning Time: 30 mins- Temperature: 130°F (55°C)- Exposure Time: 60 mins- Relative Humidity: 50-80%- Aeration: 8 hours @ 109.4°F (43°C)- No stacking- Total System Weight: 15 lbs.- Lumen Devices: 3.0 mm x 400 mm (Qty 5)Demonstrated efficacy for Perforated Bottom Containers (except CD2-10BDL and DINCD2-8B), Non-Stacking Baskets, Lumen Devices (specified quantity), Devices with conjoined surfaces, Silicone Support Bars, Laparoscopic Racks. Materials include Stainless Steel, Aluminum, Silicone, Radel. (Performance is "Yes" for listed components/configurations under EO).

The document explicitly states: "The Genesis Reusable Rigid Container System has been validated to meet the established performance criteria." This indicates that for all the criteria mentioned in the tables, the device successfully demonstrated compliance through the stated non-clinical tests.

2. Sample size(s) used for the test set and the data provenance:

  • The document mentions "Testing" for sterilization efficacy and dry time but does not specify the exact sample sizes (number of containers, number of cycles, number of biological indicators, etc.) for the test sets.
  • Data provenance is not explicitly stated regarding country of origin or whether the tests were retrospective or prospective. Given it's a 510(k) submission for a medical device by a US-based company (CareFusion 2200 Inc, Vernon Hills, IL), and referring to an FDA guidance document (ST 77 2013), it is prospective testing conducted in a controlled laboratory setting, likely within the US.

3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts:

  • This document describes non-clinical performance testing of a sterilization container, not a diagnostic or AI-driven medical imaging device. Therefore, the concept of "experts establishing ground truth for a test set" in the context of clinical interpretation (e.g., radiologists) is not applicable.
  • The "ground truth" for sterilization efficacy is established by scientific principles and validated biological indicators (BI) and sterility assurance levels (SAL) as per recognized standards (ST 77 2013). The validation of dry time is based on the "absence of visible moisture." These are objective measurements rather than subjective expert consensus.

4. Adjudication method (e.g., 2+1, 3+1, none) for the test set:

  • As this is non-clinical performance testing, adjudication methods typically used for subjective clinical assessments are not applicable. The results are based on objective laboratory measurements and adherence to specified performance standards.

5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance:

  • No, this is not applicable. The document is for a physical medical device (sterilization container), not an AI algorithm or a diagnostic tool involving human readers.

6. If a standalone (i.e., algorithm only without human-in-the-loop performance) was done:

  • No, this is not applicable. This document pertains to a physical sterilization container.

7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.):

  • The ground truth for the performance of the sterilization container is based on objective measurements of sterilization efficacy and dryness as defined by recognized industry standards (ST 77 2013).
    • For sterilization efficacy: achieving a 12 log reduction and a Sterility Assurance Level (SAL) of 10^-6 using biological indicators (overkill method).
    • For dry time: absence of visible moisture.

8. The sample size for the training set:

  • Not applicable. This relates to a physical device evaluated through non-clinical performance testing, not an AI model that requires a training set.

9. How the ground truth for the training set was established:

  • Not applicable. As indicated in point 8, there is no training set for this type of device evaluation.

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Image /page/0/Picture/1 description: The image shows the seal of the Department of Health & Human Services - USA. The seal is circular and contains the words "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" around the perimeter. In the center of the seal is a stylized image of a human face in profile, with three overlapping profiles to represent the department's focus on health, human services, and the well-being of the nation. The seal is black and white.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-0002

January 8, 2015

CareFusion 2200 Inc. Ms. Jane Weber Regulatory Affairs Manager 75 N. Fairway Drive Vernon Hills, IL 60061

Re: K142529

Trade/Device Name: Genesis™ Reusable Rigid Sterilization Container System Regulation Number: 21 CFR 880.6850 Regulation Name: Sterilization Wrap, Containers, Trays, Cassettes and Other Accessories Regulatory Class: II Product Code: KCT Dated: December 5, 2014 Received: December 8, 2014

Dear Ms. Weber:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you; however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

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Page 2 - Ms. Weber

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Division of Small Manufacturers, International and Consumer Assistance at its tollfree number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/Resourcesfor You/Industry/default.htm. Also, please note the regulation entitled. "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

of Surveillance and Biometrics/Division of Postmarket Surveillance.

Sincerely yours,

Tejashri Purohit-Sheth, M.D. Tejashri Purohit-Sheth, M.D. Clinical Deputy Director DAGRID/ODE/CDRH FOR

Erin I. Keith, M.S. Director Division of Anesthesiology, General Hospital, Respiratory, Infection Control and Dental Devices Office of Device Evaluation Center for Devices and Radiological Health

{2}------------------------------------------------

Indications for Use

510(k) Number (if known) K142529

Device Name

Genesis Reusable Rigid Sterilization Container System

Indications for Use (Describe)

The Genesis Reusable Rigid Sterilization Container System is a device intended to be used to enclose another medical device that is to be sterilized by a healthcare provider. It allows sterilization of the enclosed medical device and maintains sterility of the enclosed device until used for a maximum of 180 days.

Containers are suitable for dynamic air re-vacuum) steam sterilization, immediate use pre-vacuum steam sterilization and 100% ethylene oxide sterilization when used as described in the instructions for use.

Reusable baskets and accessory items (pins, dividers, mats, etc.) are intended to organize and secure enclosed medical devices during sterilization and storage of the container.

Data cards are used to recording a specific sterilization process load. Filter media allows ingress and egress of sterilant while providing a microbial barrier. Tamper evide a visual indication that the container system has not been inadvertently opened prior to use. Each arrow contains a modality-specific external process indication indication that the system has been exposed to a specific sterilization cycle parameter. Data cards, filters and tamper evident arrows are single use only.

Type of Use (Select one or both, as applicable)

Prescription Use (Part 21 CFR 801 Subpart D)

X Over-The-Counter Use (21 CFR 801 Subpart C)

PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON A SEPARATE PAGE IF NEEDED.

FOR FDA USE ONLY

Concurrence of Center for Devices and Radiological Health (CDRH) (Signature)

Form Approved: OMB No. 0910-0120 Expiration Date: January 31, 2017 See PRA Statement on last page.

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This section applies only to requirements of the Paperwork Reduction Act of 1995.

*DO NOT SEND YOUR COMPLETED FORM TO THE PRA STAFF EMAIL ADDRESS BELOW *

The burden time for this collection of information is estimated to average 79 hours per response, including the time to review instructions, search existing data sources, gather and maintain the data needed and complete and review the collection of information. Send comments regarding this burden estimate or any other aspect of this information collection, including suggestions for reducing this burden, to:

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"An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB number."

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Sterilization Parameters for the Genesis™ Reusable Rigid Container System by Modality

SterilizationMethodCycle ParametersTotalSystemWeightApplicableContainers/Accessories
Dynamic AirRemoval(Pre-Vacuum)SteamExposure Temperature: 270°F(132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesDry Time Cycle: 30 minutesMinimum Cool Time: 60 minutes(may vary according to load contents)Stack Height: Maximum 325 lbs.Solid Bottom Containers;Perforated Bottom Containers;Stacking BasketsNon-Stacking BasketsLumen Devices (2.68 mm x 450 mm) - Qty 16Lumen Devices (1.37 mm x 242 mm) - Qty 10Devices or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support BarsSilicone MatsLaparoscopic RacksOptional Protective PlateMaterials: Metals, Polymers,Composites
Dynamic AirRemoval(Pre-Vacuum)SteamImmediate UseExposure Temperature: 270°F(132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesStack Height: Maximum 3Note: Devices must be usedimmediately and cannot bestored for later use.25 lbs.Solid Bottom Containers;Perforated Bottom Containers;Stacking BasketsNon-Stacking BasketsLumen Devices (2.68 mm x 450 mm) - Qty 16Lumen Devices (1.37 mm x 242 mm) - Qty 10Devices or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support BarsSilicone MatsLaparoscopic RacksOptional Protective Plate*Materials: Metals, Polymers,Composites
100% EthyleneOxideEO Sterilant Concentration:100% EO, 725 mg/LPre-Conditioning Time: 30minutesTemperature: 130°F (55°C)Exposure Time: 60 minutesRelative Humidity: 50-80%Aeration: 8 hours @ 109.4°F(43°C)No stacking15 lbs.Perforated Bottom Containersexcept CD2-10BDL and DINCD2-8B);Non Stacking BasketsLumen Devices (3.0 mm x 400 mm) - Qty 5Device or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support Bars;Laparoscopic Racks;Materials: Stainless Steel,Aluminum, Silicone, Radel

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Examples of instrument types that are conjoined include: scissors, forceps, clamps (including double action), hand held and self retaining retractors, needle holders, osteotomes/chisels, rongeurs, kerrison rongeurs, specula.

Note: Air tight occluded challenges are devices entailing surfaces that are completely obstructed. These types of devices have not been validated for use in the Genesis Reusable Sterilization Container System.

*Materials: Intrinsically stable metals. Composites, thermosetting polymers with constant use temperatures above 135°C.

Examples of intrinsically stable metals include stainless steel, titanium (CP and aluminum. Examples of thermoplastic polymers are PEEK, PEI (Ultem), Acetal (Delrin), Radel (PPSU), Nylon, PTFE, Polypropylene, ABS (Acrylonitrile/Butadiene/ Styrene) and POM (Polyoxymethylene). Examples of thermosetting polymers are Phenolic and Silicone. Examples of composites include carbon fiber reinforced epoxy (CFRE).

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Type of ContainerContents/ConfigurationPre-Vacuum Steam100 % Ethylene Oxide
Solid BottomNon Stacking BasketsYesNo
ContainerStacking BasketsYesNo
Lumen: 1.37 mm (ID) x 242mm(L)Yes, maximum 10No
Lumen: 2.68mm (ID) x 450mm (L)Yes, maximum 16No
Lumen: 3 mm (ID) x 400 mm (L)Yes, maximum 2No
Occluded/Mated ChallengeYesNo
Silicone Support BarYesNo
Silicone MatYesNo
Laparoscopic RackYesNo
Optional Protective PlateYesNo
FilterNST SeriesNo
Data CardMD1-1No
Tamper-Evident ArrowWhite AS SeriesNo
Stack Height3No
MaterialsMaterials: Metals,Polymers, CompositesNo
Maximum Total Container SystemWeight25 lbs.No
Perforated BottomNon Stacking BasketsYesYes
ContainerStacking BasketsYesNo
Lumen: 1.37 mm (ID) x 242mm(L)Yes, maximum 10No
Lumen: 2.68mm (ID) x 450mm (L)Yes, maximum 16No
Lumen: 3 mm (ID) x 400 mm (L)Yes, maximum 2Yes, maximum 5
Occluded/Mated challengeYesYes
Silicone Support BarsYesYes
Silicone MatYesNo
Note: The CD2-Laparoscopic RackYesYes
10BDL andOptional Protective PlateYesNo
DINCD2-8BFilterNST seriesNST series
container modelsData CardsMD1-1MD1-1
are not validatedTamper Evident ArrowWhite AS SeriesYellow AG Series
for use in 100%Stack Height3 maxNo stacking
Ethylene OxidesterilizationMaterialsMaterials: Metals,Polymers, CompositesRadel, Stainless Steel,Aluminum, Silicone
Maximum Total Weight25 lbs.15 lbs.
STERRADNon Stacking BasketsYesYes
CompatibleStacking BasketsYesNo
ContainersLumen: 2.68mm (ID) x 450mm (L)Yes, maximum 2No
Lumen: 3.0mm (ID) x 400mm (L)Yes, maximum 2Yes, maximum 5
Occluded/Mated ChallengeYesYes
Silicone Support BarsYesYes
Silicone MatYesNo
Laparoscopic RackYesYes
Optional Protective PlateYesNo
FilterNST SeriesNST Series
Data CardsMD1-1MD1-1
Tamper-Evident ArrowWhite AS SeriesYellow AG Series
Stack Height3 MaximumNo stacking
MaterialsMaterials: Metals,Polymers, CompositesRadel, Stainless Steel,Aluminum, Silicone
Maximum Total Container SystemWeight25 lbs.15 lbs.

Accessories and Device Challenges by Sterilization Modality and Container Style

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Solid Bottom Containers

Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD0-4CQuarter Length Container9.5 x 12.4 x 3.83.4
CD1-4CHalf Length Container11.8 x 12.4 x 4.54.8
CD1-5CHalf Length Container11.8 x 12.4 x 5.35.0
CD1-6CHalf Length Container11.8 x 12.4 x 6.15.2
CD2-4CMid Length Container19.2 x 12.4 x 4.56.4
CD2-5CMid Length Container19.2 x 12.4 x 5.36.7
CD2-6CMid Length Container19.2 x 12.4 x 6.16.9
CD2-8CMid Length Container19.2 x 12.4 x 7.87.3
CD3-4CFull Length Container23.1 x 12.4 x 4.57.8
CD3-5CFull Length Container23.1 x 12.4 x 5.37.9
CD3-6CFull Length Container23.1 x 12.4 x 6.18.2
CD3-7CFull Length Container23.1 x 12.4 x 7.08.5
CD7-5CExtra Long Container25.2 x 12.4 x 5.98.5
CD7-6CExtra Long Container25.2 x 12.4 x 6.78.8
CD7-9CExtra Long Container25.2 x 12.4 x 8.49.7
CD4-3CSmall Narrow Container20.8 x 7.3 x 3.94.2
CD4-5CSmall Narrow Container20.8 x 7.3 x 5.25.2
CD5-3CLarge Narrow Container28.1 x 11.2 x 5.08.4
CD5-61CLarge Narrow Container28.1 x 11.2 x 6.49.1
CD0-3CMini Container10.2 x 7.2 x 3.22.5
CD6-6CRetractor Container26.5 x 17.0 x 6.912.4
CD1-7CDLHalf Length Container11.9 x 12.5 x 7.55.3
CD1-8CDLHalf Length Container11.9 x 12.5 x 8.35.5
CD2-7CDLHalf Length Container19.2 x 12.5 x 7.07.1
CD2-10CDLMid Length Container19.2 x 12.5 x 9.48.2
CD3-8CDLFull Length Container23.1 x 12.5 x 7.88.8
CD3-9CDLFull Length Container23.1 x 12.5 x 8.88.6
DINCD3-5CFull Length DIN Container23.1 x 11.4 x 5.47.9
DINCD3-6CFull Length DIN Container23.1 x 11.4 x 6.18.2
DINCD3-7CFull Length DIN Container23.1 x 11.4 x 7.18.5
DINCD2-5CMid Length DIN Container19.2 x 11.4 x 5.46.7
DINCD2-6CMid Length DIN Container19.2 x 11.4 x 6.16.9
DINCD2-8CMid Length DIN Container19.2 x 11.4 x 7.87.3
DINCD1-5CHalf Length DIN Container11.6 x 11.4 x 5.45.0
DINCD1-6CHalf Length Container11.6 x 11.4 x 6.15.2

Perforated Bottom Containers

Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD0-4BQuarter Length Container9.5 x 12.4 x 3.83.7
CD1-4BHalf Length Container11.8 x 12.4 x 4.55.2
CD1-5BHalf Length Container11.8 x 12.4 x 5.35.5
CD1-6BHalf Length Container11.8 x 12.4 x 6.15.7
CD2-4BMid Length Container19.2 x 12.4 x 4.56.8
CD2-5BMid Length Container19.2 x 12.4 x 5.37.1
CD2-6BMid Length Container19.2 x 12.4 x 6.17.4
CD2-8BMid Length Container19.2 x 12.4 x 7.87.8
CD3-4BFull Length Container23.1 x 12.4 x 4.58.5
CD3-5BFull Length Container23.1 x 12.4 x 5.38.8
CD3-6BFull Length Container23.1 x 12.4 x 6.19.0
CD3-7BFull Length Container23.1 x 12.4 x 7.09.4
CD7-5BExtra Long Container25.2 x 12.4 x 5.99.0
CD7-6BExtra Long Container25.2 x 12.4 x 6.79.4

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Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD7-9BExtra Long Container25.2 x 12.4 x 8.410.0
CD4-3BSmall Narrow Container20.8 x 7.3 x 3.94.5
CD4-5BSmall Narrow Container20.8 x 7.3 x 5.25.0
CD5-3BLarge Narrow Container28.1 x 11.2 x 5.09.1
CD5-61BLarge Narrow Container28.1 x 11.2 x 6.49.5
CD0-3BMini Container10.2 x 7.2 x 3.22.6
CD6-6BRetractor Container26.5 x 17.0 x 6.913.9
CD1-7BDLHalf Length Container11.9 x 12.5 x 7.55.8
CD1-8BDLHalf Length Container11.9 x 12.5 x 8.36.0
CD2-10BDLMid Length Container19.2 x 12.5 x 9.48.2
CD2-7BDLHalf Length Container19.2 x 12.5 x 7.07.5
CD3-8BDLFull Length Container23.1 x 12.5 x 7.89.6
CD3-9BDLFull Length Container23.1 x 12.5 x 8.89.9
DINCD3-5BFull Length DIN Container23.1 x 11.4 x 5.48.8
DINCD3-6BFull Length DIN Container23.1 x 11.4 x 6.19.0
DINCD3-7BFull Length DIN Container23.1 x 11.4 x 7.19.4
DINCD2-5BMid Length DIN Container19.2 x 11.4 x 5.47.1
DINCD2-6BMid Length DIN Container19.2 x 11.4 x 6.17.4
DINCD2-8BMid Length DIN Container19.2 x 11.4 x 7.87.8
DINCD1-5BHalf Length DIN Container11.6 x 11.4 x 5.45.5
DINCD1-6BHalf Length DIN Container11.6 x 11.4 x 6.15.7

STERRAD Style Containers

Catalog CodeDescriptionContainer Dimension (In)ContainerWeight(lb.)
CD0-4STQuarter Length Container9.5 x 12.4 x 3.83.7
CD1-4STHalf Length Container11.8 x 12.4 x 4.55.2
CD1-5STHalf Length Container11.8 x 12.4 x 5.35.4
CD1-6STHalf Length Container11.8 x 12.4 x 6.15.6
CD2-4STMid Length Container19.2 x 12.4 x 4.56.8
CD2-5STMid Length Container19.2 x 12.4 x 5.37.0
CD2-6STMid Length Container19.2 x 12.4 x 6.17.2
CD2-8STMid Length Container19.2 x 12.4 x 7.87.7
CD3-4STFull Length Container23.1 x 12.4 x 4.58.4
CD3-5STFull Length Containers23.1 x 12.4 x 5.38.6
CD3-6STFull Length Containers23.1 x 12.4 x 6.18.9
CD3-7STFull Length Containers23.1 x 12.4 x 7.09.3
CD4-3STSmall Narrow Shallow Container20.8 x 7.3 x 3.94.2
CD4-5STSmall Narrow Container20.8 x 7.3 x 5.24.8
CD5-3STLarge Narrow Shallow Container28.1 x 11.2 x 5.08.9
CD5-61STLarge Narrow Shallow Container28.1 x 11.2 x 6.49.4
CD0-3STMini Container10.2 x 7.2 x 3.22.6

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eFusion

K142529 510(k) SUMMARY

A summary of 510(k) safety and effectiveness information in accordance with 21 CFR 807.92.

SUBMITTER INFORMATION
NameCareFusion 2200 Inc
Address75 N. Fairway Dr.Vernon Hills, IL 60061
Phone number(847) 362-8094
Fax number(312) 949-0272
EstablishmentRegistration Number1423507
Name of contact personJane Weber, Regulatory Affairs Manager
Date prepared05-JAN-2015
DEVICE INFORMATION
Trade or proprietarynameGenesis™ Reusable Rigid Sterilization Container System
Common or usual nameSterilization Container
Classification nameSterilization Wrap, Containers, Trays, Cassettes and Other Accessories
Classification panel80
RegulationClass II per 21CFR 880.6850, Product code KCT
Product Code(s)KCT
Legally marketeddevice(s) to whichequivalence is claimedGenesis™ Reusable Sterilization Container SystemK140850
Reason for 510(k)submissionExpand indications for use regarding the quantity and types of lumen devicesto be sterilized using the pre-vacuum steam sterilization modality in theGenesis Container System.
Device descriptionThe Genesis Reusable Rigid Container System is an assortment of rigid,reusable, stackable containers that are used to sterilize other medical devicesand maintain sterility of these devices until used. The container system iscomprised of a lid, bottom, filter, tamper evident arrows, and data cards.The container system houses baskets of varying depths and organizingaccessory devices that are used to organize and to secure surgicalinstrumentation and/or other medical devices.

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sion

UMMARY OF THE TECHNOLOGICAL CHARACTERISTICS OF THE DEVICE COMPARED TO THE PREDICATE DEVICE

CharacteristicPredicate Device - K140850New/Modified Device
Intended UseA sterilization container system is a deviceintended to be used to enclose anothermedical device that is to be sterilized by ahealth care provider. It is intended to allowsterilization of the enclosed medical deviceand also to maintain sterility of the enclosedmedical device until used.Same
ContainerAnodized aluminum 5000 and 1100series; stainless steel 300 seriesSame
GasketClosed cell silicone foamSame
FilterSMS polypropylene for all sterilizationmodalitiesSame
Baskets304 Stainless Steel, electropolishedSame
Dividers, bracketsAluminum 5000 seriesSame
Clips, posts, pinsStainless steel 300 and 400 seriesSame
Silicone bars, matsSilicone ElastomerSame
Material Compatibility(materials to be sterilizedwithin container)Intrinsically stable metals, composites,thermoplastics and thermosetting polymerswith constant use temperatures above 135°C.Same
Volume to Vent Ratio$24.0 \text{ to } 182.3 \frac{in^3}{in^2}$Same
Sterilization parametersfor Pre-Vacuum steam forLumen devicesLumens: 2.68 mm (ID) x 450 mm (L) – Qty 2Lumens: 2.68 mm (ID) x 450 mm (L) –Qty 16Lumens 1.37 mm (ID) x 242 mm (L) –Qty 10

PERFORMANCE DATA

SUMMARY OF NON-CLINICAL TESTS CONDUCTED FOR DETERMINATION OF SUBSTANTIAL EQUIVALENCE

Performance Test Summary-New Device

CharacteristicStandard/Test/FDA GuidanceResults Summary
Sterilization Efficacy: Pre-vacuum SteamST 77 2013 Containment Devices for Reusable Medical Device SterilizationTesting demonstrated a 12 log reduction and a sterility assurance level (SAL) of 10-6 using biological (BI) overkill method
Dry Time for Dynamic Air Removal (Pre-vacuum steam modality)ST 77 2013 Containment Devices for Reusable Medical Device SterilizationTesting demonstrated validated method of drying by absence of visible moisture

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EQUIVALENCE AND/OR OF CLINICAL INFORMATION

N/A - No clinical tests were conducted for this submission.

CONCLUSIONS DRAWN FROM NON-CLINICAL AND CLINICAL DATA

The Genesis Reusable Rigid Container System has been validated to meet the established performance criteria. The results of the verification studies demonstrate that the sterilization containers perform as intended and based on the nonclinical tests performed the subject device is as safe, as effective and performs at least as safely and effectively as the legally marketed predicate device, Class II (21 CFR 880.6850), Product code KCT.

INDICATIONS FOR USE

The Genesis Reusable Rigid Sterilization Container System is a device intended to enclose another medical device that is to be sterilized by a health care provider. It allows sterilization of the enclosed medical device and maintains sterility of the enclosed medical device until used for a maximum of 180 days.

Containers are suitable for dynamic air removal (pre-vacuum) steam sterilization, immediate use prevacuum steam sterilization and 100% ethylene oxide sterilization when used as described in the instructions for use.

Reusable baskets and accessory items (pins, dividers, mats, etc.) are intended to organize and secure enclosed medical devices during sterilization and storage of the container.

Data cards are used to record information regarding a specific sterilization process load. Filter media allows ingress and egress of sterilant while providing a microbial barrier. Tamper evident arrows provide a visual indication that the container system has not been inadvertently opened prior to use. Each arrow contains a modality-specific external process indicator that serves as a visual indication that the system has been exposed to a specific sterilization cycle parameter. Data cards, filters and tamper evident arrows are single use only.

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Sterilization Parameters for the Genesis Reusable Rigid Container System by Modality

SterilizationMethodCycle ParametersTotalSystemWeightApplicableContainers/Accessories
Dynamic AirRemoval(Pre-Vacuum)SteamExposure Temperature: 270°F(132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesDry Time Cycle: 30 minutesMinimum Cool Time: 60minutes(may vary according to loadcontents)Stack Height: Maximum 325 lbs.Solid Bottom Containers;Perforated Bottom Containers;Stacking BasketsNon-Stacking BasketsLumen Devices (2.68 mm x 450mm) - Qty 16Lumen Devices (1.37 mm x 242mm) - Qty 10Devices or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support BarsSilicone MatsLaparoscopic RacksOptional Protective PlateMaterials: Metals, Polymers,Composites
Dynamic AirRemoval(Pre-Vacuum)SteamImmediate UseExposure Temperature: 270°F(132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesStack Height: Maximum 3Note: Devices must be usedimmediately and cannot bestored for later use.25 lbs.Solid Bottom Containers;Perforated Bottom Containers;Stacking BasketsNon-Stacking BasketsLumen Devices (2.68 mm x 450mm) - Qty 16Lumen Devices (1.37 mm x 242mm) - Qty 10Devices or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support BarsSilicone MatsLaparoscopic RacksOptional Protective Plate*Materials: Metals, Polymers,Composites
100% EthyleneOxideEO Sterilant Concentration:100% EO, 725 mg/LPre-Conditioning Time: 30minutesTemperature: 130°F (55°C)Exposure Time: 60 minutesRelative Humidity: S0-80%Aeration: 8 hours @ 109.4°F(43°C)No stacking15 lbs.Perforated Bottom Containersexcept CD2-10BDL and DINCD2-8B);Non Stacking BasketsLumen Devices (3.0 mm x 400mm) — Qty 5Device or Device Configurationsentailing conjoined surfaces whichmeet, touch or unite;Silicone Support Bars;Laparoscopic Racks;Materials: Stainless Steel,Aluminum, Silicone, Radel

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Image /page/13/Picture/1 description: The image shows the CareFusion logo. The logo consists of an orange circle with a white shield inside, and the text "CareFusion" in gray. The shield has a yellow accent on the top right.

Examples of instrument types that are conjoined include: scissors, forceps, clamps (including double action), hand held and self retaining retractors, needle holders, osteotomes/chisels, rongeurs, kerrison rongeurs, specula.

Note: Air tight occluded challenges are devices entailing surfaces that are completely obstructed. These types of devices have not been validated for use in the Genesis Reusable Sterilization Container System.

*Materials: Intrinsically stable metals. Composites, and thermosetting polymers with constant use temperatures above 135°C.

Examples of intrinsically stable metals include stainless steel, titanium (CP and aluminum. Examples of thermoplastic polymers are PEEK, PEI (Ultem), Acetal (Delrin), Radel (PPSU), Nylon, PTFE, Polypropylene, ABS (Acrylonitrile/Butadiene/ Styrene) and POM (Polyoxymethylene). Examples of thermosetting polymers are Phenolic and Silicone. Examples of composites include carbon fiber reinforced epoxy (CFRE).

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Accessories and Device Challenges by Sterilization Modality and Container Style
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Type of ContainerContents/ConfigurationPre-Vacuum Steam100 % Ethylene Oxide
Solid BottomContainerNon Stacking BasketsYesNo
Stacking BasketsYesNo
Lumen: 1.37 mm (ID) x 242 mm (L)Yes, maximum 10No
Lumen: 2.68mm (ID) x 450mm (L)Yes, maximum 16No
Lumen: 3 mm (ID) x 400 mm (L)Yes, maximum 2No
Occluded/Mated ChallengeYesNo
Silicone Support BarYesNo
Silicone MatYesNo
Laparoscopic RackYesNo
Optional Protective PlateYesNo
FilterNST SeriesNo
Data CardMD1-1No
Tamper-Evident ArrowWhite AS SeriesNo
Stack Height3No
MaterialsMaterials: Metals,Polymers, CompositesNo
Maximum Total Container SystemWeight25 lbs.No
Perforated BottomContainerNon Stacking BasketsYesYes
Stacking BasketsYesNo
Lumen: 1.37 mm (ID) x 242 mm(L)Yes, maximum 10No
Lumen: 2.68mm (ID) x 450mm (L)Yes, maximum 16No
Lumen: 3 mm (ID) x 400 mm (L)Yes, maximum 2Yes, maximum 5
Occluded/Mated ChallengeYesYes
Silicone Support BarsYesYes
Silicone MatYesNo
Laparoscopic RackYesYes
Optional Protective PlateYesNo
FilterNST seriesNST series
Data CardsMD1-1MD1-1
Tamper Evident ArrowWhite AS SeriesYellow AG Series
Stack Height3 maxNo stacking
MaterialsMaterials: Metals,Polymers, CompositesRadel, Stainless Steel,Aluminum, Silicone
Maximum Total Weight25 lbs.15 lbs.
STERRADCompatibleContainersNon Stacking BasketsYesYes
Stacking BasketsYesNo
Lumen: 2.68mm (ID) x 450mm (L)Yes, maximum 2No
Lumen: 3.0mm (ID) x 400mm (L)Yes, maximum 2Yes, maximum 5
Occluded/Mated ChallengeYesYes
Silicone Support BarsYesYes
Silicone MatYesNo
Laparoscopic RackYesYes
Optional Protective PlateYesNo
FilterNST SeriesNST Series
Data CardsMD1-1MD1-1
Tamper-Evident ArrowWhite AS SeriesYellow AG Series
Stack Height3 MaximumNo stacking
MaterialsMaterials: Metals,Polymers, CompositesRadel, Stainless Steel,Aluminum, Silicone
Maximum Total Container SystemWeight25 lbs.15 lbs.
Note: The CD2-10BDL and DINCD2-8B container models are not validated for use in 100% Ethylene Oxide sterilization

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Image /page/15/Picture/1 description: The image contains the CareFusion logo. The logo consists of an orange circle with a white shield inside, and the text "CareFusion" in gray. The shield has a small orange accent in the upper left corner.

Solid Bottom Containers

Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD0-4CQuarter Length Container9.5 x 12.4 x 3.83.4
CD1-4CHalf Length Container11.8 x 12.4 x 4.54.8
CD1-5CHalf Length Container11.8 x 12.4 x 5.35.0
CD1-6CHalf Length Container11.8 x 12.4 x 6.15.2
CD2-4CMid Length Container19.2 x 12.4 x 4.56.4
CD2-5CMid Length Container19.2 x 12.4 x 5.36.7
CD2-6CMid Length Container19.2 x 12.4 x 6.16.9
CD2-8CMid Length Container19.2 x 12.4 x 7.87.3
CD3-4CFull Length Container23.1 x 12.4 x 4.57.8
CD3-5CFull Length Container23.1 x 12.4 x 5.37.9
CD3-6CFull Length Container23.1 x 12.4 x 6.18.2
CD3-7CFull Length Container23.1 x 12.4 x 7.08.5
CD7-5CExtra Long Container25.2 x 12.4 x 5.98.5
CD7-6CExtra Long Container25.2 x 12.4 x 6.78.8
CD7-9CExtra Long Container25.2 x 12.4 x 8.49.7
CD4-3CSmall Narrow Container20.8 x 7.3 x 3.94.2
CD4-5CSmall Narrow Container20.8 x 7.3 x 5.25.2
CD5-3CLarge Narrow Container28.1 x 11.2 x 5.08.4
CD5-61CLarge Narrow Container28.1 x 11.2 x 6.49.1
CD0-3CMini Container10.2 x 7.2 x 3.22.5
CD6-6CRetractor Container26.5 x 17.0 x 6.912.4
CD1-7CDLHalf Length Container11.9 x 12.5 x 7.55.3
CD1-8CDLHalf Length Container11.9 x 12.5 x 8.35.5
CD2-7CDLHalf Length Container19.2 x 12.5 x 7.07.1
CD2-10CDLMid Length Container19.2 x 12.5 x 9.48.2
CD3-8CDLFull Length Container23.1 x 12.5 x 7.88.8
CD3-9CDLFull Length Container23.1 x 12.5 x 8.88.6
DINCD3-5CFull Length DIN Container23.1 x 11.4 x 5.47.9
DINCD3-6CFull Length DIN Container23.1 x 11.4 x 6.18.2
DINCD3-7CFull Length DIN Container23.1 x 11.4 x 7.18.5
DINCD2-5CMid Length DIN Container19.2 x 11.4 x 5.46.7
DINCD2-6CMid Length DIN Container19.2 x 11.4 x 6.16.9
DINCD2-8CMid Length DIN Container19.2 x 11.4 x 7.87.3
DINCD1-5CHalf Length DIN Container11.6 x 11.4 x 5.45.0
DINCD1-6CHalf Length Container11.6 x 11.4 x 6.15.2

Perforated Bottom Containers

Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD0-4BQuarter Length Container9.5 x 12.4 x 3.83.7
CD1-4BHalf Length Container11.8 x 12.4 x 4.55.2
CD1-5BHalf Length Container11.8 x 12.4 x 5.35.5
CD1-6BHalf Length Container11.8 x 12.4 x 6.15.7
CD2-4BMid Length Container19.2 x 12.4 x 4.56.8
CD2-5BMid Length Container19.2 x 12.4 x 5.37.1
CD2-6BMid Length Container19.2 x 12.4 x 6.17.4
CD2-8BMid Length Container19.2 x 12.4 x 7.87.8
CD3-4BFull Length Container23.1 x 12.4 x 4.58.5
CD3-5BFull Length Container23.1 x 12.4 x 5.38.8
CD3-6BFull Length Container23.1 x 12.4 x 6.19.0
CD3-7BFull Length Container23.1 x 12.4 x 7.09.4

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Catalog CodeDescriptionContainer Dimension (in)ContainerWeight(lb.)
CD7-5BExtra Long Container25.2 x 12.4 x 5.99.0
CD7-6BExtra Long Container25.2 x 12.4 x 6.79.4
CD7-9BExtra Long Container25.2 x 12.4 x 8.410.0
CD4-3BSmall Narrow Container20.8 x 7.3 x 3.94.5
CD4-5BSmall Narrow Container20.8 x 7.3 x 5.25.0
CD5-3BLarge Narrow Container28.1 x 11.2 x 5.09.1
CD5-61BLarge Narrow Container28.1 x 11.2 x 6.49.5
CD0-3BMini Container10.2 x 7.2 x 3.22.6
CD6-6BRetractor Container26.5 x 17.0 x 6.913.9
CD1-7BDLHalf Length Container11.9 x 12.5 x 7.55.8
CD1-8BDLHalf Length Container11.9 x 12.5 x 8.36.0
CD2-10BDLMid Length Container19.2 x 12.5 x 9.48.2
CD2-7BDLHalf Length Container19.2 x 12.5 x 7.07.5
CD3-8BDLFull Length Container23.1 x 12.5 x 7.89.6
CD3-9BDLFull Length Container23.1 x 12.5 x 8.89.9
DINCD3-5BFull Length DIN Container23.1 x 11.4 x 5.48.8
DINCD3-6BFull Length DIN Container23.1 x 11.4 x 6.19.0
DINCD3-7BFull Length DIN Container23.1 x 11.4 x 7.19.4
DINCD2-5BMid Length DIN Container19.2 x 11.4 x 5.47.1
DINCD2-6BMid Length DIN Container19.2 x 11.4 x 6.17.4
DINCD2-8BMid Length DIN Container19.2 x 11.4 x 7.87.8
DINCD1-5BHalf Length DIN Container11.6 x 11.4 x 5.45.5
DINCD1-6BHalf Length DIN Container11.6 x 11.4 x 6.15.7

STERRAD Style Containers

Catalog CodeDescriptionContainer Dimension (In)ContainerWeight(lb.)
CD0-4STQuarter Length Container9.5 x 12.4 x 3.83.7
CD1-4STHalf Length Container11.8 x 12.4 x 4.55.2
CD1-5STHalf Length Container11.8 x 12.4 x 5.35.4
CD1-6STHalf Length Container11.8 x 12.4 x 6.15.6
CD2-4STMid Length Container19.2 x 12.4 x 4.56.8
CD2-5STMid Length Container19.2 x 12.4 x 5.37.0
CD2-6STMid Length Container19.2 x 12.4 x 6.17.2
CD2-8STMid Length Container19.2 x 12.4 x 7.87.7
CD3-4STFull Length Container23.1 x 12.4 x 4.58.4
CD3-5STFull Length Containers23.1 x 12.4 x 5.38.6
CD3-6STFull Length Containers23.1 x 12.4 x 6.18.9
CD3-7STFull Length Containers23.1 x 12.4 x 7.09.3
CD4-3STSmall Narrow Shallow Container20.8 x 7.3 x 3.94.2
CD4-5STSmall Narrow Container20.8 x 7.3 x 5.24.8
CD5-3STLarge Narrow Shallow Container28.1 x 11.2 x 5.08.9
CD5-61STLarge Narrow Shallow Container28.1 x 11.2 x 6.49.4
CD0-3STMini Container10.2 x 7.2 x 3.22.6

§ 880.6850 Sterilization wrap.

(a)
Identification. A sterilization wrap (pack, sterilization wrapper, bag, or accessories, is a device intended to be used to enclose another medical device that is to be sterilized by a health care provider. It is intended to allow sterilization of the enclosed medical device and also to maintain sterility of the enclosed device until used.(b)
Classification. Class II (performance standards).