K Number
K123176
Date Cleared
2013-02-14

(127 days)

Product Code
Regulation Number
868.5430
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The ISO-GARD® ClearAir™ Mask is intended to be used to scavenge waste anesthetic gases from patients during recovery from general anesthesia and to provide supplemental oxygen.

The ISO-GARD® ClearAir™ Mask helps to reduce the amount of anesthetic agents released to the work environment of the healthcare worker.

Device Description

The ISO-GARD® ClearAir™ mask system is an oxygen delivery mask that actively scavenges waste anesthetic gases ("WAGS") exhaled by patients recovering from surgery in the Post-Anesthetic Care Unit ("PACU"). Vacuum/suction for scavenging of WAGS is provided by the institution's regulated vacuum source. The proposed device allows for the delivery of supplemental / therapeutic oxygen to patients to aid in their recovery while reducing the amount of patient expelled waste anesthetic agents released to the work environment of the healthcare workers.

The mask can be used with or without suction / vacuum to function as a standard oxygen mask with an ETCO2 monitoring port.

The ISO-GARD® ClearAir™ mask is offered in several configurations, the differences being some of the components.

AI/ML Overview

The provided document describes a 510(k) premarket notification for the ISO-GARD® ClearAir™ mask. This device is an oxygen delivery mask that actively scavenges waste anesthetic gases (WAGS) and provides supplemental oxygen. The submission is a comparison to legally marketed predicate devices, not a study presenting novel acceptance criteria.

The document explicitly states: "There is no pass / fail criteria for the ISO-GARD® ClearAir™ mask. The testing performed is for disclosure only." This indicates that the study was not designed to meet specific, pre-defined acceptance criteria with pass/fail thresholds. Instead, the testing aimed to characterize the device's performance and demonstrate substantial equivalence to predicate devices.

Therefore, I cannot provide a table of acceptance criteria and reported device performance directly from this document, as such criteria were not defined as "pass/fail" for this submission type. However, I can summarize the performance data disclosed and the nature of the study.

Here's a breakdown of the requested information based on the provided document:

1. A table of acceptance criteria and the reported device performance

As mentioned, no explicit "pass/fail" acceptance criteria were set for this device in the context of this 510(k) submission for the performance testing. The reported performance data is primarily for disclosure and comparison.

Performance CharacteristicReported Device Performance (ISO-GARD® ClearAir™ Mask)Comparison/Context
Delivered Oxygen % (4 lpm O2 flow, 30-50 mm Hg Vacuum)21-23%Equal to or greater than a standard medium concentration oxygen mask while scavenging.
Delivered Oxygen % (6 lpm O2 flow, 30-50 mm Hg Vacuum)31-32%Equal to or greater than a standard medium concentration oxygen mask while scavenging.
Delivered Oxygen % (8 lpm O2 flow, 30-50 mm Hg Vacuum)38%Equal to or greater than a standard medium concentration oxygen mask while scavenging.
Delivered Oxygen % (10 lpm O2 flow, 30-50 mm Hg Vacuum)43-44%Equal to or greater than a standard medium concentration oxygen mask while scavenging.
No₂O detection in chamberNo measurable N₂O detectedSupports effective scavenging at the patient.
Delivered Oxygen % (with no N₂O, compared to standard mask with no N₂O)Higher than a standard oxygen mask at all flow rates and vacuum settings.Performance superior to a standard oxygen mask in these conditions.
End-tidal CO₂ tracing and waveformMore consistent than the predicate Bi-Flo nasal sampling cannula.Indicates improved or equivalent ETCO2 monitoring capabilities.
BiocompatibilityMeets the requirements of ISO 10993 (cytotoxicity, sensitization, irritation).Demonstrates material safety.

2. Sample size used for the test set and the data provenance (e.g. country of origin of the data, retrospective or prospective)

  • Test Set Sample Size: The document does not specify a numerical sample size for the "test set" in terms of how many devices were tested or how many test conditions were numerically replicated. It describes performance testing in a "simulation bench set-up."
  • Data Provenance: The studies are described as "Non-clinical Performance Testing" and "simulation bench set-up." This indicates a prospective, controlled laboratory setting. The country of origin of the data is not explicitly stated, but the submission is to the U.S. FDA by Teleflex Medical, Inc., located in Research Triangle Park, NC, USA.

3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts (e.g. radiologist with 10 years of experience)

This type of information is not applicable to this submission. The "ground truth" for this device's performance (e.g., oxygen percentage, scavenging effectiveness) would be established through a validated physical measurement system in the benchtop simulation, not through expert consensus or clinical interpretation of data.

4. Adjudication method (e.g. 2+1, 3+1, none) for the test set

This information is not applicable. As the testing involved objective physical measurements on a benchtop, there was no need for expert adjudication of results.

5. If a multi reader multi case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

This information is not applicable. This is a medical device, not an AI-driven diagnostic or image analysis tool. Therefore, MRMC studies and "human reader improvement with AI" are not relevant to this submission.

6. If a standalone (i.e. algorithm only without human-in-the-loop performance) was done

This information is not applicable. This is a physical medical device. "Standalone (algorithm only)" is a concept for AI or software devices, not relevant here.

7. The type of ground truth used (expert concensus, pathology, outcomes data, etc)

The "ground truth" for the performance claims in this submission is based on objective physical measurements from a validated simulation bench set-up. For example, oxygen percentage was measured, and the absence of N₂O was detected. Biocompatibility was assessed against ISO 10993 standards.

8. The sample size for the training set

This information is not applicable. There is no "training set" in the context of this traditional medical device submission. Training sets are typically associated with machine learning or AI algorithm development.

9. How the ground truth for the training set was established

This information is not applicable as there is no training set for this device.

{0}------------------------------------------------

K123176

510(k) Summary Page 1 of 11

FEB 1 4 2013

Date prepared:29-Oct-12
Sponsor:Teleflex Medical, Inc.2917 Weck DriveP.O. Box 12600Research Triangle Park, NC 27709
Official Contact:Angela BouseSenior Regulatory Affairs SpecialistTel: 919-433-4904Fax: 919-433-4996
Proprietary or Trade Name:ISO- GARD® ClearAir™ mask
Common/Usual Name:Apparatus, gas-scavenging
Classification:Product code - CBNCFR 868.5430 - apparatus, gas-scavengingClass 2
Predicate Devices:K953269 - Advanced Warming Systems (Apotheus)SafeCircuit ManifoldK950771 - Advanced Warming Systems (Apotheus)Adhesive Face MaskK961150 - Teleflex Bi-Flo ETCO2 nasal cannula
Device Description:

The ISO-GARD® ClearAir™ mask system is an oxygen delivery mask that actively scavenges waste anesthetic gases ("WAGS") exhaled by patients recovering from surgery in the Post-Anesthetic Care Unit ("PACU"). Vacuum/suction for scavenging of WAGS is provided by the institution's regulated vacuum source. The proposed device allows for the delivery of supplemental / therapeutic oxygen to patients to aid in their recovery while reducing the amount of patient expelled waste anesthetic agents released to the work environment of the healthcare workers.

The mask can be used with or without suction / vacuum to function as a standard oxygen mask with an ETCO2 monitoring port.

The ISO-GARD® ClearAir™ mask is offered in several configurations, the differences being some of the components. Table 1. lists the configurations.

Technology / Mode of Operation:

The ISO-GARD® ClearAir™ mask is a simple modified oxygen mask which is placed on the patient's face and connected to a standard oxygen source to deliver supplemental oxygen as needed and a separate hose which is connected to a vacuum / suction source to scavenge the patient's exhaled air. The user may adjust the oxygen flow rate and the vacuum rate as needed to deliver the required oxygen and effectively scavenge the WAGS.

{1}------------------------------------------------

510(k) Summary Page 2 of 11 29-Oct-12

Table 1: ISO-GARD® ClearAir™ Mask Product Codes

Product CodeProduct Description
8011ISO-GARD ClearAir Mask, with Tubing
8012ISO-GARD ClearAir Mask, 8011 with Filter
8013ISO-GARD ClearAir Mask, Wye and Clamps
8014ISO-GARD ClearAir Mask, 8013 with Filter

Indications for Use:

The ISO-GARD® ClearAir™ Mask is intended to be used to scavenge waste anesthetic gases from patients during recovery from general anesthesia and to provide supplemental oxygen.

The ISO-GARD® ClearAir™ Mask helps to reduce the amount of anesthetic agents released to the work environment of the healthcare worker.

Patient Population:

Patients recovering from general anesthesia in the PACU.

Environments of use:

The environment of use is - Post-operative Care Units (PACU) in hospital, sub-acute facilities.

Predicate Device Comparison:

The ISO-GARD® ClearAir™ mask is viewed as substantially equivalent to the predicate devices because:

Indications -

Scavenging waste anesthetic gases and providing supplemental oxygen

The intended uses are identical and the indications for use of scavenging of waste anesthetic gases from patients recovery from general anesthesia and provide supplement oxygen are identical to the predicate, Advanced Warming Systems (Apotheus) SafeCircuit (K953269) when used with the Advanced Warming Systems (Apotheus) Adhesive face mask (K950771).

Discussion -

There are no differences in the intended use and indications for use for the ISO-GARD® ClearAir™ mask and the predicate, Advanced Warming Systems (Apotheus) SafeCircuit (K953269) when used with the Advanced Warming Systems (Apotheus) Adhesive face mask (K950771).

Measuring end-tidal CO2

The indications for use of measuring end-tidal CO2 near the patient's mouth are identical to the predicate Hudson (Teleflex) Bi-Flo ETCO2 Nasal Cannula (K961150).

{2}------------------------------------------------

510(k) Summary Page 3 of 11 29-Oct-12

Discussion -

There are no differences in the indications for use for the ISO-GARD® ClearAir™ mask and the predicate, Hudson (Teleflex) Bi-Flo ETCO2 Nasal Cannula (K961150) for delivering supplemental oxygen and gas sampling.

Technology -

The use of a face mask which provides a seal to improve gas scavenging while delivering supplemental oxygen and providing a gas sampling port is identical to the predicates, Advanced Warming Systems (Apotheus) SafeCircuit (K953269) when used with the Advanced Warming Systems (Apotheus) Adhesive face mask (K950771) and Hudson (Teleflex) Bi-Flo ETCO2 Nasal Cannula (K961150).

Providing excess positive and negative pressure relief for safety is equivalent to the predicate Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

The source of oxygen and vacuum are identical to the predicate Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

Discussion -

All the technological characteristics of the proposed device are substantially equivalent to the predicates Advanced Warming Systems (Apotheus) SafeCircuit (K953269) when used with the Advanced Warming Systems (Apotheus) Adhesive face mask (K950771) and Hudson (Teleflex) Bi-Flo ETCO2 Nasal Cannula (K961150) and any difference do not raise any new safety concerns.

Materials -

The materials are either identified predicates or have been tested per ISO 10993.

Discussion -

The materials have been determined to be safe for the intended use based upon being identical to existing devices or having been tested per ISO 10993.

Environment of Use -

The proposed environment of use in the Post-Operative Care Unit ("PACU") is identical to the predicate, Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

Discussion -

There are no differences in the environments of use for the ISO-GARD® ClearAir™ mask and the predicate, Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

Patient Population -

Patients recovering from general anesthesia and may need supplemental oxygen is identical to the predicate Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

{3}------------------------------------------------

510(k) Summary Page 4 of 11 29-Oct-12

Discussion -

There are no differences in the intended patient population for use for the ISO-GARD® ClearAir™ mask and the predicate, Advanced Warming Systems (Apotheus) SafeCircuit (K953269).

Table 2 is a comparison of the predicates Advanced Warming Systems (Apotheus) SafeCircuit (K953269) and Advanced Warming Systems (Apotheus) Adhesive face mask (K950771), while Table 3 is a comparison of the proposed device to the predicate Hudson (Teleflex) Bi-Flo ETCO2 Nasal Cannula (K961150).

{4}------------------------------------------------

510(k) Summary
Page 5 of 11
29-Oct-12

FeaturesProposedISO-GARD® ClearAir™ MaskPredicateK953269Advanced Warming Systems(Apotheus) SafeCircuitPredicateK950771Advanced Warming Systems(Apotheus) Adhesive Mask
Classification nameProduct Code / CFRApparatus, gas scavengingCBN868.5430SecondaryCCK - Gaseous-Phase Carbon Dioxide GasAnalyzer868.1400Apparatus, gas scavengingCBN868.5430Mask, gas, anestheticBSJ868.5550
Intended UseTo scavenge waste anesthetic gases andprovide supplemental oxygenTo scavenge waste anesthetic gases andprovide supplemental oxygenTo provide a patient seal whenconnected to a breathing circuit andallow for gases to be delivered to thepatient
Indications for useThe ISO-GARD® ClearAir™ Mask isintended to be used to scavenge wasteanesthetic gases from patients during recoveryfrom general anesthesia and to providesupplemental oxygen.To be used to scavenging of wastesanesthetic gases from patients recoveryfrom general anesthesia and providesupplement oxygenTo be used in conjunction with theSafeCircuit (K953269) manifold toprovide the seal for scavenging ofwaste anesthetic gases and delivery ofsupplemental oxygen
The ISO-GARD® ClearAir™ Mask helps toreduce the amount of anesthetic agentsreleased to the work environment of thehealthcare worker.When used with the SafeCircuit Adhesivemask and a standard breathing circuit, theunit helps to reduce the amount ofanesthetic agents and airbornecontaminants released to the workenvironment of the healthcare worker.
FeaturesProposedISO-GARD® ClearAir™ MaskPredicateK953269Advanced Warming Systems(Apotheus) SafeCircuitPredicateK950771Advanced Warming Systems(Apotheus) Adhesive Mask
Environment of UseHospital, sub-acute facilities PACUHospital, sub-acute facilities PACUHospital, sub-acute facilities PACU
Patient PopulationPatients recovering from general anesthesiaand may need supplemental oxygenPatients recovering from general anesthesiaand may need supplemental oxygenUsed with the SafeCircuit manifold
Basic componentsAdultsMaskOxygen delivery tubingVacuum (scavenging) tubingMask Manifold controlling oxygen deliveryand scavengingPediatrics and AdultsUsed with Adhesive maskBreathing circuit for oxygen deliveryConnects to vacuum for scavengingManifold with directional valves forcontrolling oxygen delivery and scavengingPediatric and AdultsAdhesive mask used with SafeCircuitmanifold
Design, Features, and SpecificationsMaskFlexible oxygen mask with sealing foamUses Adhesive mask to seal around thepatient's faceAdhesive mask used with SafeCircuitmanifold with an adhesive seal
Method to hold mask onpatient for sealElastic band / strapHead strap plus adhesive seal of maskHead strap plus adhesive seal of mask
Tubing to deliveroxygenStandard oxygen tubingBreathing circuit tubing 22 mmStandard oxygen tubing
Excess negativepressureContains entrainment valves if the negativepressure from vacuum is too greatValves are one-way flapper/diaphragmvalves that open with minimal negativepressure or flow.Incorporates excess negative pressure reliefvalves in case of excess vacuumN/A
Excess positive pressureContains entrainment valves if patient'sinhalation is greater than the supply of theoxygenIncorporates excess positive pressure reliefvalves if patient inhalation exceeds theavailable supply of gasN/A
FeaturesProposedISO-GARD® ClearAir™ MaskPredicateK953269Advanced Warming Systems(Apotheus) SafeCircuitPredicateK950771Advanced Warming Systems(Apotheus) Adhesive Mask
Method to assist in sealingFoam pad around bridge of nose to assist in sealing of the maskAdhesive along the edges of the mask to permit a tight seal between the patient's face and the maskN/A
Method to separate oxygen delivery from scavengingMask manifold body is a divided adapter which has an oxygen inlet and a scavenging outletDirectional valves in the SafeCircuit manifold direct oxygen to the patient which a scavenging from the manifoldN/A
Oxygen sourceWall oxygenWall oxygenWall oxygen
Vacuum sourceWall vacuumWall vacuumN/A
For sampling end-tidal CO2Port connector on exhalation side of MaskManifold adapterNot offered at the timeSee BiFlo nasal cannula (K961150)
Typical oxygen delivered flow ratesUp to 10 lpmNot specified by could be up to 10 lpmUp to 10 lpm
Specifications delivered oxygen at various Oxygen flow and Vacuum rate4 lpm O2 @ 30 mm Hg = 23% O210 lpm O2 @ 30 mm Hg = 44% O24 lpm O2 @ 50 mm Hg = 22% O210 lpm O2 @ 50 mm Hg = 43% O2Not specified but equivalentN/A
Sizes133
MaterialsMaterials are identical to already cleared devices or have been tested per ISO 10993Biocompatible materialsBiocompatible materials
Performance StandardsNoneNoneNone

'

·

{5}------------------------------------------------

510(k) Summary

:

:

:

. .

:

.

.

·

.

incorporates excess pos
valves if patient inhalati
available supply of gas

{6}------------------------------------------------

'510(k) Summary

:

:

.

.

1

:

{7}------------------------------------------------

. 510(k) Summary

29-Oct-12

Table 3 - Predicate Device Comparison Table – Teleflex Bi-Flo ETCO2 Nasal cannula (K961150)

FeaturesProposedISO-GARD® ClearAir™ MaskPredicateK961150Teleflex
Classification nameApparatus, gas scavengingBi-Flo ETCO₂ Nasal CannulaGaseous-Phase Carbon Dioxide Gas Analyzer
Product Code / CFRCBN868.5430
SecondaryCCK - Gaseous-Phase Carbon Dioxide GasAnalyzer868.1400CCK - Gaseous-Phase Carbon Dioxide GasAnalyzer868.1400
Intended UseTo scavenge waste anesthetic gases andprovide supplemental oxygen and be able tosample for ET CO2To provide supplemental oxygen and beable to sample for ET CO2
Indications for useThe ISO-GARD® ClearAir™ Mask isintended to be used to scavenge wasteanesthetic gases from patients during recoveryfrom general anesthesia and to providesupplemental oxygen. [To providesupplemental oxygen and be able to sample forET CO2]The Hudson RCI Gas Sampling OxygenNasal Cannula is an adjunct to oxygentherapy with its primary function being thatof delivering low flow oxygen to a patientwhile providing a means to sample expiredgas. It is intended for use in patientsrequiring oxygen therapy to improve bloodoxygen levels while monitoring expired gas
The ISO-GARD® ClearAir™ Mask helps toreduce the amount of anesthetic agentsreleased to the work environment of thehealthcare worker.to determine ventilator rate.
Environment of UseHospital, sub-acute facilities PACUHospital, sub-acute facilities no limitationof specific locations of use
Patient PopulationPatients recovering from general anesthesiaand may need supplemental oxygenAdultsPatient requiring supplemental oxygen andthe ability to sample for ET CO2
Design, Features and SpecificationsPediatrics and Adults
Connects to ETCO2monitorYesYes
Connector to samplinglineStandard female luer lockStandard female luer lock
Method of separatinggas flowsDivided manifold for separating vacuum andoxygen delivery and then a separatesampling portDivided cannula for oxygen and gassampling
Performance standardNoneNone
MaterialsISO 10993 tested or identical to predicatesBiocompatible materials

·

{8}------------------------------------------------

510(k) Summary Page 9 of 11 29-Oct-12

Non-clinical Performance Testing Summary:

Materials - Biocompatibility:

The materials were tested per ISO 10993 - cytotoxicity, sensitization, and irritation as surface contact, skin, limited duration or external communicating, tissue contact, limited duration.

Discussion -

The biocompatibility testing demonstrated that the materials meet the requirements of ISO 10993.

Performance Testing:

A simulation bench set-up was developed and validated to perform design and final product validation testing. The simulated bench testing is designed to evaluate measure and confirm the design performance of the ISO-GARD® ClearAir™ mask.

Pass / Fail criteria:

There is no pass / fail criteria for the ISO-GARD® ClearAir™ mask. The testing performed is for disclosure only.

The tests performed are summarized in Table 4 below.

Table 4 - Validation / Performance Testing Summary

General Description
Scavenging and Oxygen Delivery performance at variable oxygen flow rates and Vacuum levels at standard Tidal Volumes of 500 ml
Scavenging and Oxygen Delivery performance at variable oxygen flow rates and Vacuum levels at Tidal Volumes outside 500 ml
Intentional leak - Scavenging and Oxygen Delivery performance at variable oxygen flow rates and Vacuum levels at standard Tidal Volumes of 500 ml
Performance when the vacuum source is a suction canister vs. wall vacuum
Performance of oxygen delivery without the use of N₂O
Evaluate simulation set-up to see the build-up of WAGS when no vacuum is applied
Characterize the oxygen delivery performance of medium concentration oxygen masks without N2O present
ET CO2 performance in simulated conditions
Comparative ET CO₂ performance of the predicate nasal cannula

{9}------------------------------------------------

510(k) Summary Page 10 of 11 29-Oct-12

Summary of Non-clinical Test Results

Table 5 - Delivered Oxygen % at various O2 Flow and Vacuum rates (Tidal Volume of 500 ml) - Part 1

Vacuum
Oxygen Flowrate30 mm Hg40 mm Hg50 mm Hg
4 lpm23%21%22%
6 lpm32%31%31%
8 lpm38%38%38%
10 lpm44%44%43%

Discussion:

The delivered oxygen % for the ISO-GARD® ClearAir™ mask was equal to or greater than a standard medium concentration oxygen mask for all vacuum settings, see Table 7.

Therefore the proposed device can deliver oxygen % equivalent to other oxygen mask while scavenging.

There was no measurable No o detected in the chamber, supporting effective scavenging at the patient.

Vacuum
Oxygen Flowrate30 mm Hg40 mm Hg50 mm Hg
4 lpm34%27%28%
6 lpm37%31%30%
8 lpm37%35%33%
10 lpm40%36%35%

Table 6 - Delivered Oxygen % with no N2O - Part 5

Discussion:

The delivered oxygen % for the ISO-GARD® ClearAir™ mask without N20 was greater than a standard oxygen mask at all flow rates and vacuum, see Table 8.

Table 7 - Standard Oxygen Mask Delivered Oxygen % with N20 - Part 6
% Delivered OxygenOxygen Flow rate
4 lpmરેજે
6 lpm7%
8 lpm11%
10 lpm17%

{10}------------------------------------------------

510(k) Summary Page 11 of 11 29-Oct-12

Discussion:

The delivered oxygen % for the standard oxygen mask at all flow rates can be compared with Table 8 while N2O built up in the test chamber.

Oxygen Flow rateDelivered Oxygen %
4 lpm25%
6 lpm26%
8 lpm29%
10 lpm32%
Table 8 - Delivered Oxygen % with no N2O with Standard Oxygen Mask - Part 7
-----------------------------------------------------------------------------------

Discussion:

The delivered oxygen % for the standard oxygen mask at all flow rates without N2O is less than the performance of the ISO-GARD® ClearAir™ mask under the same conditions, see Table 5.

End-tidal CO2 tracing and waveform with ISO-GARD™ ClearAir™ mask - Part 8

Discussion:

The tracings and waveform were more consistent that compared to the predicate Bi-Flo nasal sampling cannula.

Substantial Equivalence Conclusion -

The sponsor has demonstrated through performance testing, design features, and non-clinical testing that the proposed device and predicates have been found to substantially equivalent.

{11}------------------------------------------------

Image /page/11/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo consists of a stylized eagle with three stripes forming its wing and tail. The text "DEPARTMENT OF HEALTH & HUMAN SERVICES • USA" is arranged in a circular fashion around the eagle.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-0002

February 14, 2013

Ms. Angela Bouse Senior Regulatory Affairs Specialist Teleflex Medical, Incorporated 2917 Weck Drive PO Box 12600 RESEARCH TRIANGLE PARK NC 27709

Re: K123176

Trade/Device Name: ISO-GARD® ClearAir™ Mask Regulation Number: 21 CFR 868.5430 Regulation Name: Gas-Scavenging Apparatus Regulatory Class: II Product Code: CBN Dated: January 16, 2013 Received: January 17, 2013

Dear Ms Bouse: .

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you; however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

{12}------------------------------------------------

Page 2 - Ms. Bouse

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please go to http://www.fda.gov/AboutFDA/CentersOffices/CDRH/CDRHOffices/ucm115809.htm for the Center for Devices and Radiological Health's (CDRH's) Office of Compliance. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDeyices/Safety/ReportaProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours,

Image /page/12/Picture/6 description: The image shows the name "Kwame O. Ulmer" in a bold, sans-serif font. The letters are black, and the name is centered in the image. There is a design behind the name that looks like a stylized logo or emblem. The design is made up of horizontal lines and geometric shapes.

Anthony D. Watson, B.S., M.S., M.B.A. Director Division of Anesthesiology, General Hospital, Respiratory, Infection Control and Dental Devices

Office of Device Evaluation

Center for Devices and Radiological Health

Enclosure

{13}------------------------------------------------

Indications for Use Statement

510(k) Number:

p123176 (To be assigned)

Device Name:

ISO-GARD® ClearAir™ Mask

Indications for Use:

The ISO-GARD® ClearAir™ Mask is intended to be used to scavenge waste anesthetic gases from patients during recovery from general anesthesia and to provide supplemental oxygen.

The ISO-GARD® ClearAir™ Mask helps to reduce the amount of anesthetic agents released to the work environment of the healthcare worker.

Prescription Use XX (Part 21 CFR 801 Subpart D)

Over-the-counter use (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

or

Concurrence of CDRH, Office of Device Evaluation (ODE)

Lester W. Schult 2013.02.15 15 15:07 00"

(Division Sign-Off) Division of Anesthestology, General Hospital Infaction Control, Dental Devices

K123176 510(k) Number:

Teleflex Medical, Inc

PDF Page 17 of 311

Page 4.2

§ 868.5430 Gas-scavenging apparatus.

(a)
Identification. A gas-scavenging apparatus is a device intended to collect excess anesthetic, analgesic, or trace gases or vapors from a patient's breathing system, ventilator, or extracorporeal pump-oxygenator, and to conduct these gases out of the area by means of an exhaust system.(b)
Classification. Class II (performance standards).