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510(k) Data Aggregation

    K Number
    K213848
    Date Cleared
    2022-03-25

    (105 days)

    Product Code
    Regulation Number
    880.6250
    Reference & Predicate Devices
    Predicate For
    N/A
    AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
    Intended Use

    The Medical nitrile examination gloves is intended to be worn on the hands of examiners to prevent contamination between patient and examiner. This is a single-use, powder-free, non-sterile device.

    Device Description

    The subject device is a powder-free nitrile examination glove, provided as a non-sterile and disposable device. The subject device is mainly made from nitrile and there are four sizes, including small (S), medium (M), large (L), X-large (XL) for optional. The gloves are provided with blue color, the colorant is Pigment Blue (CAS No.147-14-8). The examination glove is a smooth surface and has a rolled rim at the cuff edge.

    AI/ML Overview

    Here's a breakdown of the acceptance criteria and the study information for the Medical Nitrile Examination Gloves (Model: JL001), based on the provided text:

    1. Table of Acceptance Criteria and Reported Device Performance

    Test MethodTest PurposeAcceptance CriteriaReported Device PerformanceConclusion
    ASTM D6319-19 (Physical Dimensions)To determine the width, length, and thickness of the glovesWidth:For S: 80±10 mmFor M: 95±10 mmFor L: 110±10 mmFor XL: 120±10 mmLength:For S: ≥220mmFor M/L/XL: ≥230mmFinger Thickness: min. 0.05 mmPalm Thickness: min. 0.05 mmLot Batch 20210716A:Width: S: 7983mm, M: 9397mm, L: 101-105mm, XL: 110mmLength: S: 233237mm, M: 233237mm, L: 240244mm, XL: 240244mmThickness: Finger min: 0.12mm, Palm min: 0.08mmLot Batch 20210719A:Width: S: 7983mm, M: 9497mm, L: 101-104mm, XL: 110mmLength: S: 234236mm, M: 234237mm, L: 240244mm, XL: 240245mmThickness: Finger min: 0.13mm, Palm min: 0.08mmLot Batch 20210721C:Width: S: 8085mm, M: 9498mm, L: 105-109mm, XL: 110mmLength: S: 230235mm, M: 235238mm, L: 239243mm, XL: 240243mmThickness: Finger min: 0.13mm, Palm min: 0.08mmPassed
    ASTM D6319-19 (Physical Properties)To determine the tensile strength and ultimate elongation before and after acceleration agingBefore Aging:Tensile Strength: ≥14MpaUltimate Elongation: ≥500%After Aging:Tensile Strength: ≥14MpaUltimate Elongation: ≥400%For all three lots:Before Aging: Tensile Strength: ≥14Mpa, Ultimate Elongation: ≥500%After Aging: Tensile Strength: ≥14Mpa, Ultimate Elongation: ≥400%Passed
    ASTM D6319-19 (ASTM D5151-11) (Freedom from Holes)To determine the holes in the glovesAQL 2.5For all three lots: Pass at AQL 2.5Passed
    ASTM D6319-19 (ASTM D6124-11) (Residual Powder)To determine the residual powder in the gloves< 2.0 mg/gloveLot Batch 20210716A: 0.12 mg/gloveLot Batch 20210719A: 0.15 mg/gloveLot Batch 20210721C: 0.21 mg/glovePassed
    ISO 10993-10 (Skin Irritation)To evaluate the potential intracutaneous reactivity caused by intracutaneously inject the extract to rabbitsUnder the conditions of study not an irritationUnder the conditions of study not an irritationPassed
    ISO 10993-10 (Skin Sensitization)To determine the skin sensitization potential in guinea pigsUnder the conditions of the study not a sensitizationUnder the conditions of the study not a sensitizationPassed
    ISO 10993-11:2017 (Acute Systemic Toxicity)The test item was evaluated for acute systemic toxicity in ICR mouseUnder the conditions of the study no systemic toxicityUnder the condition of acute systemic toxicity test, the test article did not show acute systemic toxicity in vivo.Passed

    2. Sample Size Used for the Test Set and Data Provenance

    The document provides information on three lot batches used for non-clinical performance testing:

    • Lot Batch: 20210716A
    • Lot Batch: 20210719A
    • Lot Batch: 20210721C

    The specific number of gloves sampled from each lot for each test (e.g., number of gloves for width/length, number of gloves for tensile strength, number of gloves for freedom from holes test to meet AQL 2.5) is not explicitly stated in the provided text. The data provenance is industrial testing of manufacturer's product, consistent with regulatory submissions for medical devices. The country of origin of the data is not explicitly stated, but the manufacturer is Guangdong Jiali Pharmaceutical Co.,Ltd in China.

    3. Number of Experts Used to Establish the Ground Truth for the Test Set and Their Qualifications

    This information is not applicable as the document describes non-clinical performance testing (physical, chemical, and biocompatibility tests) of a medical device (nitrile examination gloves), not a study involving expert interpretation or medical imaging analysis. The "ground truth" for these tests is established by standardized laboratory methods and measurements according to ASTM and ISO standards.

    4. Adjudication Method for the Test Set

    This is not applicable as the study involves standardized physical and biocompatibility testing with objective pass/fail criteria, not subjective interpretations requiring adjudication.

    5. Multi-Reader Multi-Case (MRMC) Comparative Effectiveness Study

    No MRMC comparative effectiveness study was done. This type of study is relevant for diagnostic devices where human readers evaluate cases with and without AI assistance. This document describes the performance of examination gloves, which is not a diagnostic device.

    6. Standalone Performance Study

    Yes, a standalone study was done. The document focuses on the performance of the "Medical nitrile examination gloves" (JL001) itself against established international standards (ASTM and ISO). The device's performance was evaluated independently without human-in-the-loop interaction in a diagnostic sense.

    7. Type of Ground Truth Used

    The ground truth used for the non-clinical performance tests is based on established international standards and objective measurements:

    • For physical properties (width, length, thickness, tensile strength, elongation, residual powder, freedom from holes): Adherence to specific quantitative thresholds defined in ASTM D6319-19 and referenced standards like ASTM D5151-11 and ASTM D6124-11.
    • For biocompatibility: The biological response (irritation, sensitization, systemic toxicity) observed in animal models, evaluated against criteria defined in ISO 10993-10 and ISO 10993-11:2017.

    8. Sample Size for the Training Set

    This information is not applicable. The device described is a physical medical device (examination gloves), not an AI/ML algorithm. Therefore, there is no "training set" in the context of machine learning.

    9. How the Ground Truth for the Training Set Was Established

    This is not applicable for the same reason as point 8.

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