K Number
K964036
Manufacturer
Date Cleared
1997-07-18

(283 days)

Product Code
Regulation Number
870.2920
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

Transtelephonic monitoring of arrhythmia and/or pacemaker implant patients that do not require emergency medical intervention.

In-office acquisition and display of single and/or multi-lead ECG. Collection, storing, reporting, transfer, and management of patient(s) health information.

Device Description

CardioMagic® 2000 Cardiac Monitoring System Software (CMS) is a productivity enhancing, office automation product. The intended users of CMS are physicians, clinics, and hospitals with cardiac patient follow-up and monitoring practices. CMS is a database software product, intended to involve competent intervention before any impact on health occurs. The software does not analyze the information. Clinical judgment and experience are required to check and interpret the printed reports, as part of the process of evaluating pacemaker performance, or patient ECG rhythms. There are no known contraindications for use of this device.

CardioMagic software is installed on an IBM compatible personal computer, which may also be networked to other PC's. An Instromedix LifeSigns Receiving Center™ (LRC) may be attached to the PC, to acquire transmitted data and waveforms from transtelephonic pacemaker monitors and ECG event recorders.

CardioMagic provides remote control of the LRC, presents the received waveforms and data on the computer screen, assists in editing, viewing, and organizing the received data, and provides database support for patient and device information, and provide reports.

AI/ML Overview

The CardioMagic® 2000 Software is not a device that performs any analysis or provides diagnostic output. It is described as a "productivity enhancing, office automation product" that assists in editing, viewing, and organizing received data, and provides database support. The document explicitly states: "The software does not analyze the information. Clinical judgment and experience are required to check and interpret the printed reports, as part of the process of evaluating pacemaker performance, or patient ECG rhythms."

Therefore, the typical acceptance criteria related to diagnostic performance (e.g., sensitivity, specificity, accuracy) are not applicable to this software. The "study" described in the document is a substantial equivalence comparison to predicate devices rather than a performance study in the traditional sense for AI/ML devices.

Here's an analysis based on the provided text, focusing on the available information:

1. Table of Acceptance Criteria and Reported Device Performance

Given that the device is a data management and display tool and not a diagnostic AI/ML algorithm, there are no specific performance metrics like sensitivity, specificity, or AUC mentioned. The acceptance criteria relate to its functionality and equivalence to existing systems. The table below summarizes the comparison features, which serve as the "acceptance criteria" for functionality, and the device's reported capabilities.

Acceptance Feature/Spec (Criteria)CardioMagic® 2000 Performance
Emphasis
MINUETT™ ArrhythmiaYES
CONCERTO™ Pacer Follow-upYES
SYMPHONY™ BothYES
Compatibility
Single UserYES
Network CompatibleYES
IBM Compatible ComputersYES
Operating SystemWIN 95
Transtelephonic ReceptionYES
In-Office ECG ReceptionYES
Screen Tools
ECG Strips ViewingYES
Screen CalipersYES
Edit TransmissionsYES
Context Sensitive Help SupportYES
Receiver ControlYES
Software ECG FiltersYES
Pacer F/U
Display/Record ECG and Pacemaker Pulse EventsYES
Magnet Mode MarkersYES
Non-Magnet and Magnet Mode ECG CollectionYES
Manual Entry of Magnet RateYES
Automatically Measures Pacer PulsewidthNO (stated as NO for Symphony)
Manual Pacer Pulse Data EntryYES
Records Pacer Pulse Data from TransmitterYES
Measures Pacer Pulse WidthYES
ECG F/U
Support of IMX 3X FormatsYES
Support of M, IMX 1X FormatsYES
Automatically Determines Heart RateYES (stated as YES for Symphony)
On-Screen Editing of ECGYES
Interfaces
Interfaces to External ECG Transtelephonic ReceiverYES
Receives Digitized ECG Signals via Serial PortYES
Implant Interrogator Connection InterfaceYES
Printer InterfaceYES
Remote User SupportYES
AutodialerYES
Outputs
Hardcopy Report GenerationYES
File TransferYES
Fax ReportsYES
Mailing List/Data MergeYES
Electronic Data Transfer/MergeYES
Database
Database Storage and RetrievalYES
Database Search & FiltersYES
Relational Database of Patient Demographics, Lead/Electrode, Insurance, Referring Physician InfoYES
Relational Database of Implant Info, Programming Parameters, ThresholdsYES
Device DictionaryYES
Scheduler
Telephone Calling ScheduleYES
Office Call SchedulingYES
Security
Security KeyYES
Security CodeYES
Net Security (via network)YES

2. Sample Size Used for the Test Set and Data Provenance

This is not applicable as there was no "test set" in the context of proving diagnostic performance. The submission is a substantial equivalence claim based on comparing functionalities of the CardioMagic® 2000 Software to legally marketed predicate devices (previous CardioMagic products, PaceArt CPTS, and PaceBase). The data provenance would refer to the features of these predicate devices and the new device.

3. Number of Experts Used to Establish Ground Truth for the Test Set and Qualifications

This is not applicable. There was no ground truth establishment for a diagnostic test set. The review focused on functional equivalence.

4. Adjudication Method for the Test Set

This is not applicable. No test set requiring adjudication was used.

5. Multi-Reader Multi-Case (MRMC) Comparative Effectiveness Study

No MRMC study was conducted or mentioned. The device does not involve human readers interpreting AI output to improve performance. It is a data management tool.

6. Standalone Performance Study

No standalone performance study (i.e., algorithm only without human-in-the-loop performance) was conducted or mentioned. The software's purpose is to manage and display data, not to perform automated analysis or provide diagnostic outputs independently. The document explicitly states: "The software does not analyze the information."

7. Type of Ground Truth Used

This is not applicable as there was no ground truth for diagnostic or analytical performance. The basis for acceptance was the functional equivalence of the software's features to those of predicate devices.

8. Sample Size for the Training Set

This is not applicable. The CardioMagic® 2000 Software is not an AI/ML model that requires a training set. It's a software application with predefined functionalities.

9. How the Ground Truth for the Training Set Was Established

This is not applicable.

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JUL 18 1997

Image /page/0/Picture/1 description: The image shows the logo for "Instromedix". The logo features a stylized "X" symbol to the left of the company name, which is written in a bold, sans-serif font. Below the company name is the tagline "Tools for medicine to help humankind".

SUMMARY STATEMENT OF SAFETY AND EFFECTIVENESS CARDIOMAGIC® 2000 SOFTWARE INSTROMEDIX, INC. 510(k) NUMBER K964036

CardioMagic® 2000 Cardiac Monitoring System Software (CMS) is a productivity enhancing, office automation product. The intended users of CMS are physicians, clinics, and hospitals with cardiac patient follow-up and monitoring practices. CMS is a database software product, intended to involve competent intervention before any impact on health occurs. The software does not analyze the information. Clinical judgment and experience are required to check and interpret the printed reports, as part of the process of evaluating pacemaker performance, or patient ECG rhythms. There are no known contraindications for use of this device.

CardioMagic software is installed on an IBM compatible personal computer, which may also be networked to other PC's. An Instromedix LifeSigns Receiving Center™ (LRC) may be attached to the PC, to acquire transmitted data and waveforms from transtelephonic pacemaker monitors and ECG event recorders.

CardioMagic provides remote control of the LRC, presents the received waveforms and data on the computer screen, assists in editing, viewing, and organizing the received data, and provides database support for patient and device information, and provide reports.

The CardioMagic® 2000 CMS is substantially equivalent to previous CardioMagic products, PaceArt CPTS, and PaceBase.

One Technology Center
7431 Ν.Ε. Evergreen Parkway
Hillsboro, Oregon 97124-5898 USA
Phone: (503) 681-9000
(800) 633-3361
FAX: (503) 681-8230

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Tools for medicine to help humankind

SUMMARY STATEMENT OF SAFETY AND EFFECTIVENESS CARDIOMAGIC® 2000 SOFTWARE Page 2 of 3

COMPARISONFEATURE/SPECCARDIOMAGIC® 2000CARDIOMAGIC® S/WPACEART®PACEBASE®
EMPHASISMINUETT™ARRHYTHMIACONCERTO™PACER FOLLOWUPSYMPHONY™BOTHAMARRHYTHMIAENHANCEDBOTHBOTHBOTH
COMPATIBILITY
SINGLE USERYESYESYESYESYESYESYES
NETWORK COMPATIBLENONOYESYESYESYESYES
IBM COMPATIBLE COMPUTERSYESYESYESYESYESYESYES
OPERATING SYSTEMWIN 95WIN 95WIN 95DOS, WIN 95DOS, WIN,WIN 95DOS,WIN WIN 95DOS
TRANSTELEPHONIC RECEPTIONYESYESYESYESYESYESYES
IN-OFFICE ECG RECEPTIONYESYESYESYESYESYESYES
SCREEN TOOLS
ECG STRIPS VIEWINGYESYESYESYESYESYESYES
SCREEN CALIPERSYESYESYESYESYESYESNO
EDIT TRANSMISSIONSYESYESYESYESYESYESYES
CONTEXT SENSITIVE HELP SUPPORTYESYESYESNONOUNKNO
RECEIVER CONTROLYESYESYESYESYESYESYES
SOFTWARE ECG FILTERSYESYESYESNONOYESNO
PACER F/U
DISPLAY/RECORD ECG ANDPACEMAKER PULSE EVENTSNANOYESNAYESYESYES
MAGNET MODE MARKERSNAYESYESNAYESYESNO
NON-MAGNET AND MAGNET MODE ECGCOLLECTIONNAYESYESNAYESYESNO
MANUAL ENTRY OF MAGNET RATENAYESYESNAYESYESYES
AUTOMATICALLY MEASURES PACERPULSEWIDTHNANONONANOYESYES
MANUAL PACER PULSE DATA ENTRYNAYESYESNAYESYESYES
RECORDS PACER PULSE DATA FROMTRANSMITTERNAYESYESNAYESYESYES
MEASURES PACER PULSE WIDTHNANOYESNAYESYESYES
ECG F/U
SUPPORT OF IMX 3X FORMATSYESYESYESYESYESNONO
SUPPORT OF M, IMX 1X FORMATSYESYESYESYESYESYESYES
AUTOMATICALLY DETERMINES HEARTRATEYESYESYESNONOYESNO
ON-SCREEN EDITING OF ECGYESYESYESYESYESYESNO
INTERFACES
INTERFACES TO EXTERNAL ECGTRANSTELEPHONIC RECEIVERYESYESYESYESYESYESYES
RECEIVES DIGITIZED ECG SIGNALS VIASERIAL PORTYESYESYESYESYESYESYES
IMPLANT INTERROGATOR CONNECTIONINTERFACENONOYESNONOYESYES
PRINTER INTERFACEYESYESYESYESYESYESYES
REMOTE USER SUPPORTYESYESYESNOYESYESNO
AUTODIALERNONOYESNONOYESNO
OUTPUTS
HARDCOPY REPORT GENERATIONYESYESYESYESYESYESYES
FILE TRANSFERYESYESYESYESYESYESYES
FAX REPORTSYESYESYESNOYESYESNO
MAILING LIST/DATA MERGEYESYESYESYESYESYESNO
ELECTRONIC DATA TRANSFER/MERGEYESYESYESNOYESYESNO
DATABASE
DATA BASE STORAGE AND RETRIEVALYESYESYESYESYESYESYES
DATABASE SEARCH & FILTERSYESYESYESYESYESYESYES
RELATIONAL DATA BASE OF PATIENTDEMOGRAPHIC INFORMATION; LEADAND ELECTRODE INFORMATION;INSURANCE INFORMATION; REFERRINGPHYSICIAN INFORMATIONYESYESYESYESYESYESYES
RELATIONAL DATA BASE OF IMPLANTINFORMATION; PROGRAMMINGPARAMETERS; THRESHOLDS;NOYESYESYESYESYESYES
DEVICE DICTIONARYNOYESYESNOYESYESYES
SCHEDULER
TELEPHONE CALLING SCHEDULENOYESYESYESYESYESYES
OFFICE CALL SCHEDULINGNOYESYESYESYESYESYES
SECURITY
SECURITY KEYYESYESYESYESYESUNKUNK
SECURITY CODENONOYESYESYESUNKYES
NET SECURITY (VIA NETWORK)YESYESYESYESYESUNKUNK

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ls for medicine to help humankind

SUMMARY STATEMENT OF SAFETY AND EFFECTIVENESS CARDIOMAGIC® 2000 SOFTWARE Page 3 of 3

The primary purpose of CardioMagic, PaceArt and PaceBase software products is to provide to cardiac clinicians and automated computer system for tracking cardiac patients. These systems utilize a commercial relational database system. The database provides fields for storing device information such as: threshold, elective replacement intervals, device parameters and measurements, and telemetry data; and patient information inch includes contacts and scheduled appointments. These systems store ECG signals and related data. The CardioMagic, PaceArt and PaceBase systems are application programs which operate on IBM compatible personal computers. Unlike the PaceArt CPTS product, CMS does not perform any waveform analysis on a patient's ECG. Thus, CardioMagic 2000 is substantially equivalent to previous CardioMagic products, PaceArt CPTS, and PaceBase.

© Copyright 1997, Instromedix, Inc. All rights reserved.

The device does not sound any real-time

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Image /page/3/Picture/1 description: The image shows the logo for the U.S. Department of Health and Human Services. The logo consists of a circular seal with the text "DEPARTMENT OF HEALTH & HUMAN SERVICES • USA" arranged around the perimeter. Inside the circle is a stylized image of three human figures, possibly representing a family, with their arms raised in a gesture of support or unity.

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

JUL 1 8 1997

Herbert H. Semler, M.D. Instromedix, Inc. One. Technology Center 7431 N.E. Evergreen Parkway Hillsboro, Oregon 97124-5898

Re: K964036 CardioMagic® 2000 Software Requlatory Class: II (two) Product Code: 74 DXH Dated: April 15, 1997 Received: April 21, 1997

Dear Dr. Semler:

We have reviewed your Section 510(k) notification of intent to market the device referenced above and we have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Druq, and Cosmetic Act (Act). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (Premarket Approval), it may be subject to such additional controls. Existing major regulations affecting your device can be found in the Code of Federal Requlations, Title 21, Parts 800 A substantially equivalent determination assumes compliance to 895. with the current Good Manufacturing Practice requirements, as set forth in the Quality System Regulation (QS) for Medical Devices: General requlation (21 CFR Part 820) and that, through periodic (QS) inspections, the Food and Drug Administration (FDA) will verify such assumptions. Failure to comply with the GMP regulation may result in regulatory action. In addition, FDA may publish further announcements concerning your device in the Federal Register. Please note: this response to your premarket notification submission does not affect any obligation you might have under sections 531 through 542 of the Act for devices under the Electronic Product Radiation Control provisions, or other Federal laws or requlations.

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Page 2 - Herbert H. Semler, M.D.

This letter will allow you to begin marketing your device as described in your 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801 and additionally 809.10 for in vitro diagnostic devices), please contact the Office of Compliance at (301) 594-4648. Additionally, for questions on the promotion and advertising of your device, please contact the Office of Compliance at (301) 594-4639. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR 807.97). Other general information on your responsibilities under the Act may be obtained from the Division of Small Manufacturers Assistance at its toll-free number (800) 638-2041 or (301) 443-6597 or at its internet address "http://www.fda.gov/cdrh/dsmamain.html".

Sincerely yours,

Thomas J. Callahan

Thomas J. Callahan, Ph.D. Director Division of Cardiovascular, Respiratory, and Neurological Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

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INSTROMED I X

@003

Page 1 of 1

510(k) Number (if known): K964036

Device Name: _CardioMagic® 2000 Software

Indications For Use:

Transtelephonic monitoring of arthythmia and/or pacemaker implant patients that do not require emergency medical intervention.

In-office acquisition and display of single and/or multi-lead ECG. Collection, storing, reporting, transfer, and management of patient(s) health information.

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

D.J. Don A. Carloco

(Division Sign-Off) (Division Sign-Oit)
Division of Cardiovascular, Respiratory, Division ological Devices

510(k) Number J

Prescription Use_ X (Per 21 CFR 801.109)

§ 870.2920 Telephone electrocardiograph transmitter and receiver.

(a)
Identification. A telephone electrocardiograph transmitter and receiver is a device used to condition an electrocardiograph signal so that it can be transmitted via a telephone line to another location. This device also includes a receiver that reconditions the received signal into its original format so that it can be displayed. The device includes devices used to transmit and receive pacemaker signals.(b)
Classification. Class II (performance standards).