K Number
K250063
Date Cleared
2025-07-10

(181 days)

Product Code
Regulation Number
872.6660
Panel
Dental
Reference & Predicate Devices
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

Non-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) are indicated for the production of artificial teeth in fixed or removable dentures, or for jacket crowns, facings, and veneers. All zirconia block are processed through dental laboratories or by dental professionals.

Device Description

Non-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) used to produce dental restoration to support designing computer for dental use and to process cutting as a manufacture unit, on which CAD/CAM system is applied for processing and sintering. After application, this material cannot to be reused for fabrication.

AI/ML Overview

The provided FDA 510(k) clearance letter pertains to a Non-Sterile Zirconia Block used for dental restorations. This document focuses on demonstrating the substantial equivalence of the new device (ARENA Star, Galaxy Star) to a predicate device (Non-Sterile Zirconia Block, K223253) based on its material properties and chemical composition, not on an AI or software-driven diagnostic or assistive system.

Therefore, the requested information about acceptance criteria, study design for AI performance, expert ground truth, adjudication methods, MRMC studies, or standalone algorithm performance does not apply to this submission. This is a material science and manufacturing equivalency clearance, not a performance study for AI.

However, I can extract the acceptance criteria related to the material properties and the type of non-clinical testing performed.

Updated Information based on the provided document:

Acceptance Criteria and Device Performance for ARENA Star, Galaxy Star (Non-Sterile Zirconia Block)

The acceptance criteria for this device are based on demonstrating mechanical and biological equivalence to a predicate device and adherence to international standards for dental ceramic materials.

  1. Table of Acceptance Criteria and Reported Device Performance:
CriteriaAcceptance Standard (Predicate Device)Reported Device Performance (Subject Device)
Density (post sintering)6.00 g/cm³6.00 g/cm³
Flexural Strength>800 MPa per ISO 6872:2015 Type II Class 5>800 MPa per ISO 6872:2015 Type II Class 5
Sintering temperature1500 ± 50 ℃1500 ± 50 ℃
BiocompatibilityMeets ISO 10993 requirementsMeets ISO 10993 requirements
Chemical CompositionZrO2 with others (Specific raw materials listed)ZrO2 with others (Specific raw materials listed)
Non-Clinical Performance TestsConformance to specified tests including Visual, Dimensions, Packaging, Uniformity, Extraneous materials, Chemical Solubility, Linear Thermal Expansion (all per ISO 6872)Conforms to all specified tests per ISO 6872
CytotoxicityConformance to ISO 10993-5:2009Conforms to ISO 10993-5:2009
Intracutaneous Reactivity TestConformance to ISO 10993-10:2010Conforms to ISO 10993-10:2010
Sensitization TestConformance to ISO 10993-10:2010Conforms to ISO 10993-10:2010
Acute Systematic ToxicityConformance to ISO 10993-11:2017Conforms to ISO 10993-11:2017

The remaining information requested is typically relevant for AI/ML-based medical devices, which operate on analyzing data (e.g., images, signals) and often involve performance metrics like sensitivity, specificity, accuracy, and comparisons to human expert performance. This 510(k) submission is for a physical medical device (zirconia block), where the "study" demonstrating criteria fulfillment is primarily non-clinical bench testing and chemical analysis to confirm material properties and biocompatibility.

Therefore, for aspects like "Sample size for the test set," "Experts used to establish ground truth," "Adjudication method," "MRMC study," "Standalone performance," "Type of ground truth," "Training set sample size," and "Ground truth for the training set" – these points are not applicable to this specific device and the information provided in the 510(k) clearance letter. The "ground truth" here is established through standardized material testing methods and chemical analysis, not through expert interpretation of data.

FDA 510(k) Clearance Letter - K250063

Page 1

U.S. Food & Drug Administration
10903 New Hampshire Avenue
Silver Spring, MD 20993
www.fda.gov

Doc ID # 04017.07.05

July 10, 2025

ARUM Dentistry Co., Ltd.
Choi Won-Yi
Official Applicant
23, Gukjegwahak 11-ro, Yuseong-gu
Daejeon, 34002
SOUTH KOREA

Re: K250063
Trade/Device Name: ARENA Star, Galaxy Star
Regulation Number: 21 CFR 872.6660
Regulation Name: Porcelain Powder For Clinical Use
Regulatory Class: Class II
Product Code: EIH
Dated: July 1, 2025
Received: July 1, 2025

Dear Choi Won-Yi:

We have reviewed your section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (the Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. Although this letter refers to your product as a device, please be aware that some cleared products may instead be combination products. The 510(k) Premarket Notification Database available at https://www.accessdata.fda.gov/scripts/cdrh/cfdocs/cfpmn/pmn.cfm identifies combination product submissions. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

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K250063 - Choi Won-Yi Page 2

Additional information about changes that may require a new premarket notification are provided in the FDA guidance documents entitled "Deciding When to Submit a 510(k) for a Change to an Existing Device" (https://www.fda.gov/media/99812/download) and "Deciding When to Submit a 510(k) for a Software Change to an Existing Device" (https://www.fda.gov/media/99785/download).

Your device is also subject to, among other requirements, the Quality System (QS) regulation (21 CFR Part 820), which includes, but is not limited to, 21 CFR 820.30, Design controls; 21 CFR 820.90, Nonconforming product; and 21 CFR 820.100, Corrective and preventive action. Please note that regardless of whether a change requires premarket review, the QS regulation requires device manufacturers to review and approve changes to device design and production (21 CFR 820.30 and 21 CFR 820.70) and document changes and approvals in the device master record (21 CFR 820.181).

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR Part 803) for devices or postmarketing safety reporting (21 CFR Part 4, Subpart B) for combination products (see https://www.fda.gov/combination-products/guidance-regulatory-information/postmarketing-safety-reporting-combination-products); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820) for devices or current good manufacturing practices (21 CFR Part 4, Subpart A) for combination products; and, if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR Parts 1000-1050.

All medical devices, including Class I and unclassified devices and combination product device constituent parts are required to be in compliance with the final Unique Device Identification System rule ("UDI Rule"). The UDI Rule requires, among other things, that a device bear a unique device identifier (UDI) on its label and package (21 CFR 801.20(a)) unless an exception or alternative applies (21 CFR 801.20(b)) and that the dates on the device label be formatted in accordance with 21 CFR 801.18. The UDI Rule (21 CFR 830.300(a) and 830.320(b)) also requires that certain information be submitted to the Global Unique Device Identification Database (GUDID) (21 CFR Part 830 Subpart E). For additional information on these requirements, please see the UDI System webpage at https://www.fda.gov/medical-devices/device-advice-comprehensive-regulatory-assistance/unique-device-identification-system-udi-system.

Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to https://www.fda.gov/medical-devices/medical-device-safety/medical-device-reporting-mdr-how-report-medical-device-problems.

For comprehensive regulatory information about medical devices and radiation-emitting products, including information about labeling regulations, please see Device Advice (https://www.fda.gov/medical-devices/device-advice-comprehensive-regulatory-assistance) and CDRH Learn (https://www.fda.gov/training-and-continuing-education/cdrh-learn). Additionally, you may contact the Division of Industry and Consumer Education (DICE) to ask a question about a specific regulatory topic. See the DICE website (https://www.fda.gov/medical-devices/device-advice-comprehensive-regulatory-

Page 3

K250063 - Choi Won-Yi Page 3

assistance/contact-us-division-industry-and-consumer-education-dice) for more information or contact DICE by email (DICE@fda.hhs.gov) or phone (1-800-638-2041 or 301-796-7100).

Sincerely,

MICHAEL E. ADJODHA -S

Michael E. Adjodha, MChE, RAC, CQIA
Assistant Director
DHT1B: Division of Dental and ENT Devices
OHT1: Office of Ophthalmic, Anesthesia, Respiratory, ENT, and Dental Devices
Office of Product Evaluation and Quality
Center for Devices and Radiological Health

Enclosure

Page 4

FORM FDA 3881 (6/20) Page 1 of 1

DEPARTMENT OF HEALTH AND HUMAN SERVICES
Food and Drug Administration

Indications for Use

Form Approved: OMB No. 0910-0120
Expiration Date: 06/30/2023
See PRA Statement below.

510(k) Number (if known): K250063

Device Name: ARENA Star, Galaxy Star

Indications for Use (Describe):

Non-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) are indicated for the production of artificial teeth in fixed or removable dentures, or for jacket crowns, facings, and veneers. All zirconia block are processed through dental laboratories or by dental professionals.

Type of Use (Select one or both, as applicable):
☒ Prescription Use (Part 21 CFR 801 Subpart D)
☐ Over-The-Counter Use (21 CFR 801 Subpart C)

CONTINUE ON A SEPARATE PAGE IF NEEDED.

This section applies only to requirements of the Paperwork Reduction Act of 1995.

DO NOT SEND YOUR COMPLETED FORM TO THE PRA STAFF EMAIL ADDRESS BELOW.

The burden time for this collection of information is estimated to average 79 hours per response, including the time to review instructions, search existing data sources, gather and maintain the data needed and complete and review the collection of information. Send comments regarding this burden estimate or any other aspect of this information collection, including suggestions for reducing this burden, to:

Department of Health and Human Services
Food and Drug Administration
Office of Chief Information Officer
Paperwork Reduction Act (PRA) Staff
PRAStaff@fda.hhs.gov

"An agency may not conduct or sponsor, and a person is not required to respond to, a collection of information unless it displays a currently valid OMB number."

Page 5

7. 510(K) Summary

Submitter

ARUM DENTISTRY Co., Ltd.
Won-Yi Choi
23, Gukjegwahak 11-ro, Yuseong-gu
Daejeon, 34002
Republic of Korea
Email: arum_ra@arumdentistry.com
Tel. +82-42-935-3644
Fax. +82-42-935-3633

Device Information

  • Trade Name: ARENA Star, Galaxy Star
  • Common Name: Powder, Porcelain
  • Classification Name: Porcelain Powder For Clinical Use
  • Primary Product Code: EIH
  • Panel: Dental
  • Regulation Number: 21 CFR 872.6660
  • Device Class: Class II
  • Date Prepared: 1/10/2025

Predicate Devices

The subject device is substantially equivalent to the following predicate devices:

Primary Predicate

  • K223253 Non-Sterile Zirconia Block (ARENA Star, MontBlanc) by Arumdentistry Co., Ltd.

K250063

Page 6

7.1. Device Description

7.1.1. General Description

Non-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) used to produce dental restoration to support designing computer for dental use and to process cutting as a manufacture unit, on which CAD/CAM system is applied for processing and sintering. After application, this material cannot to be reused for fabrication.

Definition of Brand name & Series name

Model nameShapeSeries nameDiameter
Arena StarUML5-WR SeriesAML5-WR SeriesGUML5-WR SeriesGAML5-WR Series98.5 mm
UML5-ZR Series98.5 mm
Galaxy StarGalaxyStar-WR-10GalaxyStar-WR-10 A1~D498.5 mm
GalaxyStar- WR SeriesGalaxyStar HT series98.5 mm

Indication for Use

Non-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) are indicated for the production of artificial teeth in fixed or removable dentures, or for jacket crowns, facings, and veneers. All zirconia block are processed through dental laboratories or by dental professionals.

Page 7

Principle of Operation

This product is a zirconia block, a ceramic material used to manufacture dental restorations such as artificial teeth, crowns and veneers. It is a ceramic material that is cut by a dental computer-aided design and manufacturing unit. It is processed using a CAD/CAM system and sintered go through.

Materials

List of Raw materials of the Device
NoRaw material nameComponentsCAS NoExposure or exposure limited(wt%)
1Zirconium oxide A (T4Y-010OP)Zirconium Oxide (ZrO2)1314-23-484.0-94.0wt%
2Yttrium oxide (Y2O3)1314-36-96.0-9.0wt%
3Poly (vinyl alcohol)9002-89-5≤6.0wt%
4Zirconium oxide B (T4Y-010DP)Zirconium Oxide (ZrO2)1314-23-484.0-94.0wt%
5Yttrium oxide (Y2O3)1314-36-96.0-9.0wt%
6Ferric oxide1332-37-1≤0.5wt%
7Poly (vinyl alcohol)9002-89-5≤6.0wt%
8Zirconium oxide C (T4E-010OP)Zirconium Oxide (ZrO2)1314-23-479.0-89.0wt%
9Erbium Oxide12061-16-410.0-14.0wt%
10Poly (vinyl alcohol)9002-89-5≤6.0wt%
11Zirconium oxide D (T4Y-010EP)Zirconium Oxide (ZrO2)1314-23-484.0-94.0wt%
12Yttrium oxide (Y2O3)1314-36-96.0-9.0wt%
13Manganese oxide1344-43-0≤0.03wt%
14Poly (vinyl alcohol)9002-89-5≤6.0wt%

The MSDS of the raw materials can be found in the eCopy #006, 007, 008, and 009.

Page 8

Combination ratio of Raw materials of the Device

Single-Layer Block
NoColorRaw MaterialCombination ratio(%)
1A0(White)Zirconium oxide A100%
2A1Zirconium oxide A68.39%
Zirconium oxide B30.00%
Zirconium oxide C1.61%
3A2Zirconium oxide A57.85%
Zirconium oxide B40.00%
Zirconium oxide C2.15%
4A3Zirconium oxide A53.44%
Zirconium oxide B43.33%
Zirconium oxide C3.23%
5A3.5Zirconium oxide A29.03%
Zirconium oxide B66.67%
Zirconium oxide C4.30%
6A4Zirconium oxide A7.96%
Zirconium oxide B80.00%
Zirconium oxide C5.38%
Zirconium oxide D6.67%
7B1Zirconium oxide A68.92%
Zirconium oxide B30.00%
Zirconium oxide C1.08%
8B2Zirconium oxide A65.06%
Zirconium oxide B33.33%
Zirconium oxide C1.61%
9B3Zirconium oxide A53.18%
Zirconium oxide B43.33%
Zirconium oxide C2.15%
Zirconium oxide D1.33%
10B4Zirconium oxide A32.80%
Zirconium oxide B66.67%
Zirconium oxide C0.53%
11C1Zirconium oxide A62.26%
Zirconium oxide B30.00%
Zirconium oxide C1.08%
Zirconium oxide D6.66%
12C2Zirconium oxide A45.05%
Zirconium oxide B46.67%
Zirconium oxide C1.61%
Zirconium oxide D6.67%
13C3Zirconium oxide A30.00%

Page 9

| | | Zirconium oxide B | 60.00% |
| | | Zirconium oxide D | 10.00% |
| 14 | C4 | Zirconium oxide A | 5.59% |
| | | Zirconium oxide B | 80.00% |
| | | Zirconium oxide C | 1.08% |
| | | Zirconium oxide D | 13.33% |
| 15 | D2 | Zirconium oxide A | 31.18% |
| | | Zirconium oxide B | 60.00% |
| | | Zirconium oxide C | 2.15% |
| | | Zirconium oxide D | 6.67% |
| 16 | D3 | Zirconium oxide A | 28.65% |
| | | Zirconium oxide B | 66.67% |
| | | Zirconium oxide C | 2.68% |
| | | Zirconium oxide D | 2.00% |
| 17 | D4 | Zirconium oxide A | 40.00% |
| | | Zirconium oxide B | 56.67% |
| | | Zirconium oxide D | 3.33% |

Multi-Layer Block
NoColorRaw MaterialCombination ratio (%)
137 models besides UML512A1-WRZirconium oxide A61.8%
Zirconium oxide B36.0%
Zirconium oxide C2.2%
272 models besides UML512A2-WRZirconium oxide A49.7%
Zirconium oxide B46.0%
Zirconium oxide C3.0%
Zirconium oxide D1.3%
372 models besides UML512A3-WRZirconium oxide A43.4%
Zirconium oxide B52.0%
Zirconium oxide C3.3%
Zirconium oxide D1.3%
427 models besides AML512M1-WRZirconium oxide A87.4%
Zirconium oxide B12.0%
Zirconium oxide C0.6%
527 models besides AML512M2-WRZirconium oxide A81.0%
Zirconium oxide B18.0%
Zirconium oxide C1.0%
627 models besides AML512M3-WRZirconium oxide A78.9%
Zirconium oxide B20.0%
Zirconium oxide C1.1%
727 models besides UML512B1-WRZirconium oxide A80.6%
Zirconium oxide B18.7%

Page 10

| | | Zirconium oxide C | 0.7% |
| 8 | 27 models besides UML512B2-WR | Zirconium oxide A | 71.2% |
| | | Zirconium oxide B | 27.3% |
| | | Zirconium oxide C | 1.2% |
| | | Zirconium oxide D | 0.3% |
| 9 | 27 models besides UML512B3-WR | Zirconium oxide A | 68.1% |
| | | Zirconium oxide B | 30.0% |
| | | Zirconium oxide C | 1.4% |
| | | Zirconium oxide D | 0.5% |
| 10 | 27 models besides UML512B4-WR | Zirconium oxide A | 64.0% |
| | | Zirconium oxide B | 34.7% |
| | | Zirconium oxide C | 1.0% |
| | | Zirconium oxide D | 0.3% |
| 11 | 27 models besides UML512C1-WR | Zirconium oxide A | 62.9% |
| | | Zirconium oxide B | 30.7% |
| | | Zirconium oxide C | 1.1% |
| | | Zirconium oxide D | 5.3% |
| 12 | 27 models besides UML512C2-WR | Zirconium oxide A | 56.5% |
| | | Zirconium oxide B | 36.6% |
| | | Zirconium oxide C | 0.9% |
| | | Zirconium oxide D | 6.0% |
| 13 | 27 models besides UML512C3-WR | Zirconium oxide A | 61.0% |
| | | Zirconium oxide B | 33.4% |
| | | Zirconium oxide C | 0.3% |
| | | Zirconium oxide D | 5.3% |
| 14 | 27 models besides UML512C4-WR | Zirconium oxide A | 48.6% |
| | | Zirconium oxide B | 43.3% |
| | | Zirconium oxide C | 0.8% |
| | | Zirconium oxide D | 7.3% |
| 15 | 27 models besides UML512D2-WR | Zirconium oxide A | 44.5% |
| | | Zirconium oxide B | 49.3% |
| | | Zirconium oxide C | 1.8% |
| | | Zirconium oxide D | 4.4% |
| 16 | 27 models besides UML512D3-WR | Zirconium oxide A | 43.9% |
| | | Zirconium oxide B | 50.7% |
| | | Zirconium oxide C | 1.9% |
| | | Zirconium oxide D | 3.5% |
| 17 | 27 models besides UML512D4-WR | Zirconium oxide A | 45.7% |
| | | Zirconium oxide B | 50.0% |
| | | Zirconium oxide C | 1.5% |
| | | Zirconium oxide D | 2.8% |

※ The color used in the layer composition is calculated by the ratio of each layer and the

Page 11

content of the summed up raw materials is shown.

Multi-Layer Block Structure and Color
Nomodel nameNumber of Layerlayer compositionCombination ratioNote (Concept diagram)
137 models besides UML512A1-WR5A0A1A2A3A3520%20%20%20%20%5-layer4-layer3-layer2-layer1-layer
272 models besides UML512A2-WR5A0A2A3A35A420%20%20%20%20%
372 models besides UML512A3-WR5A1A2A3A35A420%20%20%20%20%
427 models besides AML512M1-WR5A0A0A0A1A120%20%20%20%20%
527 models besides AML512M2-WR5A0A0A1A1A120%20%20%20%20%
627 models besides AML512M3-WR5A0A0A1A1A220%20%20%20%20%
727 models besides UML512B1-WR5A0A0B1B1B220%20%20%20%20%
827 models besides UML512B2-WR5A0B120%20%

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| | | | B1B2B3 | 20%20%20% |
| 9 | 27 models besides UML512B3-WR | 5 | A0B1B2B3B3 | 20%20%20%20%20% |
| 10 | 27 models besides UML512B4-WR | 5 | A0B1B2B3B4 | 20%20%20%20%20% |
| 11 | 27 models besides UML512C1-WR | 5 | A0C1C1C2C2 | 20%20%20%20%20% |
| 12 | 27 models besides UML512C2-WR | 5 | A0C1C2C2C3 | 20%20%20%20%20% |
| 13 | 27 models besides UML512C3-WR | 5 | A0C1C2C3C3 | 20%20%20%20%20% |
| 14 | 27 models besides UML512C4-WR | 5 | A0C1C2C3C4 | 20%20%20%20%20% |
| 15 | 27 models besides UML512D2-WR | 5 | A0D2D2D2D3 | 20%20%20%20%20% |
| 16 | 27 models besides UML512D3-WR | 5 | A0D2D2D3 | 20%20%20%20% |

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| | | | D3 | 20% |
| 17 | 27 models besides UML512D4-WR | 5 | A0D2D3D3D4 | 20%20%20%20%20% |

※ The colors used for the layer composition are the same as the 17 colors indicated on the raw material solid block.

Page 14

Summaries of Technological Characteristics & Substantial Equivalence Discussion

Subject DevicePrimary Predicate
CompanyARUMDENTISTRY Co., Ltd.ARUMDENTISTRY Co., Ltd.
Device NameARENA Star, Galaxy StarNon-Sterile Zirconia Block
510(k) NumberNAK223253
Model NameARENA Star, Galaxy StarARENA Star, MontBlanc
Device ClassificationPOWDER, PORCELAIN/ Porcelain Powder For Clinical UsePOWDER, PORCELAIN/ Porcelain Powder For Clinical Use
Product CodeEIHEIH
Regulation Number21 CFR 872.666021 CFR 872.6660
Indications for UseNon-Sterile Zirconia Block (Model name: ARENA Star, Galaxy Star) are indicated for the production of artificial teeth in fixed or removable dentures, or for jacket crowns, facings, and veneers.Non-Sterile Zirconia Block (Model name: ARENA Star, MontBlanc) are indicated for the production of artificial teeth in fixed or removable dentures, or for jacket crowns, facings, and veneers.
Principle of OperationsThis partial sintered zirconia block is milled and finally sintered to make dental prosthesisThis partial sintered zirconia block is milled and finally sintered to make dental prosthesis
FeatureColoredColored
ShapeDiscsDiscs
Thickness10, 12, 14, 16, 18, 20, 22, 25, 28, 3010, 12, 14, 16, 18, 20, 22, 25, 28, 30
SterilityNon-sterileNon-sterile
Chemical CompositionZrO2 with othersZrO2 with others
Density (post sintering)6.00g/cm³6.00g/cm³
Flexural Strength>800 MPa per ISO 6872:2015 Type II Class 5>800 MPa per ISO 6872:2015 Type II Class 5
Sintering temperature1500 ± 50 ℃1500 ± 50 ℃
Shade(s)A0, A1, A2, A3, A3.5, A4, B1, B2, B3, B4, C1, C2, C3, C4, D2, D3, D4A0, A1, A2, A3, A3.5, A4, B1, B2, B3, B4, C1, C2, C3, C4, D2, D3, D4
Contact LevelSurface device with permanent contactSurface device with permanent contact
BiocompatibilityMeets ISO 10993 requirementsMeets ISO 10993 requirements

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Similarities

The subject device and the primary predicate have similar indications, principle of operation, technological characteristics, and materials. They encompass the same range of physical and chemical properties. Therefore, both devices are substantial equivalent.

Differences

The differences between the subject device and predicate are addition of shades. The chemical composition of both devices is same. In addition, shade colors of the subject device are added. However, it doesn't affect the product's fundamental scientific functionality. Therefore, both devices are substantial equivalent.

Page 16

Non-Clinical Performance Data

Non-clinical testing data submitted, referenced or relied on in this submission support demonstrating substantial equivalence.

Performance Bench Testing

The proposed device was tested and conforms to:

  • Performance tests including Visual, Dimensions, Packaging, Uniformity, Extraneous materials, Chemical Solubility, Flexural Strength, Linear Thermal Expansion, Flexural Strength in accordance with ISO 6872
  • Cytotoxicity per ISO 10993-5:2009;
  • Intracutaneous Reactivity Test per ISO 10993-10:2010;
  • Sensitization Test per ISO 10993-10:2010;
  • Acute Systematic Toxicity per ISO 10993-11:2017.

Biocompatibility

Biocompatibility evaluation of proposed Non-Sterile Zirconia Block was considered followed the FDA Guidance Document Use of International Standard ISO 10993-1, "Biological evaluation of medical devices – Part 1: Evaluation and testing within a risk management process," the ISO 10993 suite of standards. The biocompatibility for the proposed device was found to be substantially equivalent to the predicate devices as a result.

Sterilization Validation and Shelf-life

Proposed Non-Sterile Zirconia Block is delivered in non-sterile status and this device is unnecessary of sterilization prior to use. Therefore, sterilization validation was not considered.

Conclusion

Overall, the technological characteristics of the subject device are highly similar to the predicate device. Proposed Non-Sterile Zirconia Block has been designed and tested in accordance with ISO 6872 Dentistry - Ceramic Materials. All tests have passed the evaluation criteria and met the requirement of product-specific ISO 6872 specifies for Class 5 dental ceramics. The data included in this premarket notification demonstrate substantial equivalence to the Predicate device listed above. The mechanical properties were found to be substantially equivalent to the predicate devices as a result.

§ 872.6660 Porcelain powder for clinical use.

(a)
Identification. Porcelain powder for clinical use is a device consisting of a mixture of kaolin, felspar, quartz, or other substances intended for use in the production of artificial teeth in fixed or removable dentures, of jacket crowns, facings, and veneers. The device is used in prosthetic dentistry by heating the powder mixture to a high temperature in an oven to produce a hard prosthesis with a glass-like finish.(b)
Classification. Class II.