K Number
K152111
Date Cleared
2016-04-14

(260 days)

Product Code
Regulation Number
880.6850
Reference & Predicate Devices
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The Symmetry Surgical Quad-Lock® Container System is indicated for use by hospitals and by health care facilities to: · organize and protect stainless steel, aluminum, plastic* and silicone surgical instruments that will be sterilized · allow sterilization of the contained instruments by prevacuum steam, ethylene oxide, and low temperature hydrogen peroxide sterilization cycles (validated modalities and parameters are shown in Table 1) · When sterilized by prevacuum steam sterilization, the Quad-Lock® Containers maintain the sterility of the contents for up to 180 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised · When sterilized by ethylene oxide or low temperature hydrogen peroxide cycle types the Quad-Lock® Containers maintain the sterility of the contents when sterilized by any of the above for up to 30 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised The system has not been tested for maintenance of sterility after transportation outside the health care facility. The system is intended for use with stainless steel, aluminum, plastic and silicone surgical instruments. *The use of plastic instruments has only been confirmed for steam sterilization. For effective sterilization and drying of any size Symmetry Surgical Quad-Lock® Sterilization Container, the recommended maximum combined weight of the single container, lid. basket/tray contents is defined in Table 1. For each cvcle type the qualified lumen size is the minimum length that has been qualified for use are shown in Table 1. Container System Compatibility by Cycle Type details are shown in Table 2.

Device Description

The Symmetry Surgical Quad-Lock® Container System provides a means to organize and protect stainless steel, aluminum, titanium, plastic and silicone surgical instruments during sterilization and storage. The filter lids, security lids, and container bottoms are made from anodized aluminum. The security lids help ensure sterility during storage and protect the container lid when the containers are stacked. The Container System includes the container base, filter lid, security lid, filters and other accessories.

AI/ML Overview

The provided text describes the acceptance criteria and a study to demonstrate the performance of the Symmetry Surgical Quad-Lock™ Container System.

Here's an organized breakdown of the requested information:

1. Table of Acceptance Criteria and Reported Device Performance:

Acceptance Criteria CategorySpecific CriteriaReported Device Performance
Sterilization EfficacyAchieve a sterilization assurance level (SAL) of 10-6 for prevacuum steam, ethylene oxide (EtO), and low-temperature hydrogen peroxide (H2O2) sterilization cycles.Prevacuum Steam: - Temperature: 132°C - Exposure Time: 4 minutes - Drying Time: 30 minutes - Stackable: Yes, up to three containers - Qualified Lumen Size (Full/Three Quarter): 3mm x 400mm - Qualified Lumen Size (Half Size): 3mm x 250mm - Maximum Quantity: 4 lumen per container - Load Requirements: 25 lbs (all sizes) Ethylene Oxide: - Concentration: 725mg/L - Temperature: 55°C - Exposure Time: 60 minutes - Humidity: 50-70% - Aeration Time: 8 hours at 110°F (43°C) - Stackable: No - Qualified Lumen Size (Full/Three Quarter): 3mm x 400mm - Qualified Lumen Size (Half Size): 2mm x 250mm - Maximum Quantity: 4 Lumen per container - Load Requirements: 25 lbs (all sizes) Low Temperature H2O2 Sterilizers: (Parameters are set by sterilizer manufacturer) - STERRAD 100NX Standard/DUO: Fixed Cycle Type, Stackable: No - Qualified Lumen Size (Full Size): 2mm x 400mm - Qualified Lumen Size (Three Quarter/Half Sizes): 2mm x 250mm - Maximum Quantity: 5 Lumen per container - Load Requirements (Full): 21.4 lbs - Load Requirements (Three Quarter/Half): 13.85 lbs (DUO: 13.2 lbs) - STERRAD 100NX FLEX: Fixed Cycle Type, Stackable: No - Qualified Lumen Size (All Sizes): One 1mm x 850mm Flexible Endoscope per container - Load Requirements (Full): 16.65 lbs - Load Requirements (Three Quarter): 12.40 lbs - Load Requirements (Half): 10.75 lbs - STERRAD NX Standard/Advanced: Fixed Cycle Type, Stackable: No - Qualified Lumen Size (Full Size): 1mm x 400mm (Standard) / 2mm x 250mm (Advanced) - Qualified Lumen Size (Three Quarter/Half Sizes): 2mm x 250mm - Maximum Quantity: 5 Lumen per container - Load Requirements (Full): 21.4 lbs - Load Requirements (Three Quarter/Half): 13.85 lbs - STERRAD 100S Standard: Fixed Cycle Type, Stackable: No - Qualified Lumen Size (Full Size): 3mm x 400mm - Qualified Lumen Size (Three Quarter/Half Sizes): 2mm x 250mm - Maximum Quantity: 5 Lumen per container - Load Requirements (All Sizes): 18.2 lbs - STERIS V-PRO™ 1 PLUS Lumen/No Lumen: Cycle time = 55 minutes, Stackable: No - Qualified Lumen Size (Full Size): 3mm x 400mm - Qualified Lumen Size (Three Quarter/Half Sizes): 2mm x 250mm - Maximum Quantity: 10 lumen per container - Load Requirements (All Sizes): 19.65 lbs All sterilization efficacy and simulated use testing to achieve SAL of 10-6 passed.
Maintenance of Sterility (Shelf Life)Maintain sterility for up to 180 days with prevacuum steam sterilization. Maintain sterility for up to 30 days with ethylene oxide and low-temperature hydrogen peroxide sterilization cycles.Prevacuum Steam: Sterility maintained for up to 180 days during storage and transport within the healthcare facility, as long as container integrity is not compromised. Ethylene Oxide & Low Temperature H2O2: Sterility maintained for up to 30 days during storage and transport within the healthcare facility, as long as container integrity is not compromised. The shelf life testing for 30 days of storage passed.
Reuse TestingDemonstrate microbial challenge following multiple sterilization cycles for up to 100 sterilization cycles.Microbial Challenge following multiple sterilization cycles verified for up to 100 sterilization cycles passed.
BiocompatibilityIn vitro evaluations for biocompatibility, extractables, and leachables must have acceptable results.In vitro evaluations for these tests had acceptable results.
Functional Strength of HandlesTesting performed in accordance with ST77 (presumably ANSI/AAMI ST77, a standard for sterile packaging).Testing performed in accordance with ST77 had acceptable results.

2. Sample size used for the test set and the data provenance:
The document does not specify numerical sample sizes for the test set for its performance studies (sterilization efficacy, shelf life, reuse testing, biocompatibility, or functional strength).
The data provenance is not explicitly mentioned as a country of origin or whether it's retrospective or prospective; however, the submission is from "Symmetry Surgical, Inc." which is based in Antioch, TN, USA, suggesting the studies likely occurred in the US. The studies are described as "performance testing" and "non-clinical tests," implying they were conducted specifically for this submission, making them prospective in nature for this application.

3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts:
This information is not provided in the document. The studies are described as laboratory-based performance testing rather than studies requiring expert interpretation of results for ground truth establishment (e.g., medical image analysis).

4. Adjudication method (e.g., 2+1, 3+1, none) for the test set:
This information is not applicable and therefore not provided in the document. The studies described are objective performance tests (e.g., sterilization assurance levels, material properties) that do not typically involve human adjudication in the way medical diagnostic studies do.

5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance:
This information is not applicable and therefore not provided in the document. The device is a sterilization container system, not an AI-powered diagnostic or assistive tool for human readers.

6. If a standalone (i.e. algorithm only without human-in-the loop performance) was done:
This information is not applicable and therefore not provided in the document. The device is a physical medical device (sterilization container), not an algorithm or software.

7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.):
The ground truth for the performance studies appears to be based on objective, measurable criteria derived from scientific and engineering principles for sterilization, material integrity, and functionality. For instance, "sterilization efficacy" ground truth is defined by achieving a specified Sterilization Assurance Level (SAL of 10-6), which is typically confirmed through validated microbiological testing (e.g., biological indicators). Shelf life is determined by maintaining sterility over time, also verified through microbiological methods. Biocompatibility relies on established in vitro evaluation standards.

8. The sample size for the training set:
This information is not applicable and therefore not provided in the document. The product is a physical device, not a machine learning model, so there is no "training set."

9. How the ground truth for the training set was established:
This information is not applicable as there is no training set for this type of device.

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Image /page/0/Picture/1 description: The image shows the seal of the Department of Health & Human Services - USA. The seal is circular and contains the words "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" around the perimeter. In the center of the seal is an image of an eagle with three human profiles incorporated into its design. The eagle is facing to the right.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-0002

April 14, 2016

Symmetry Surgical, Inc. c/o Ms. Michele Lucey Regulatory Affairs Consultant Lakeshore Medical Device Consulting LLC 128 Blye Hill Landing Newbury, NH 03255

Re: K152111

Trade/Device Name: Symmetry Surgical Quad-Lock™ Container System Regulation Number: 21 CFR 880.6850 Regulation Name: Sterilization wrap Regulatory Class: Class II Product Code: KCT Dated: March 11, 2016 Received: March 15, 2016

Dear Ms. Michele Lucey:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act

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or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Division of Industry and Consumer Education at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address

http://www.fda.gov/MedicalDevices/Resourcesfor You/Industry/default.htm. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Industry and Consumer Education at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address

http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely vours.

Tejashri Purohit-Sheth, M.D.

Tejashri Purohit-Sheth, M.D. Clinical Deputy Director DAGRID/ODE/CDRH FOR

Erin I. Keith, M.S. Director Division of Anesthesiology, General Hospital, Respiratory, Infection Control and Dental Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known) K152111

Device Name

Symmetry Surgical Quad-Lock® Container System

Indications for Use (Describe) Indications for Use:

The Symmetry Surgical Quad-Lock® Container System is indicated for use by hospitals and by health care facilities to: · organize and protect stainless steel, aluminum, plastic* and silicone surgical instruments that will be sterilized · allow sterilization of the contained instruments by prevacuum steam, ethylene oxide, and low temperature hydrogen peroxide sterilization cycles (validated modalities and parameters are shown in Table 1)

· When sterilized by prevacuum steam sterilization, the Quad-Lock® Containers maintain the sterility of the contents for up to 180 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised

· When sterilized by ethylene oxide or low temperature hydrogen peroxide cycle types the Quad-Lock® Containers maintain the sterility of the contents when sterilized by any of the above for up to 30 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised

The system has not been tested for maintenance of sterility after transportation outside the health care facility.

The system is intended for use with stainless steel, aluminum, plastic and silicone surgical instruments.

*The use of plastic instruments has only been confirmed for steam sterilization.

For effective sterilization and drying of any size Symmetry Surgical Quad-Lock® Sterilization Container, the recommended maximum combined weight of the single container, lid. basket/tray contents is defined in Table 1. For each cvcle type the qualified lumen size is the minimum length that has been qualified for use are shown in Table 1. Container System Compatibility by Cycle Type details are shown in Table 2.

Type of Use (Select one or both, as applicable)
[ ] Prescription Use (Part 21 CFR 801 Subpart D)[X] Over-The-Counter Use (21 CFR 801 Subpart C)

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Table 1Sterilization Parameters
SterilizationModalityCycle TypeCycleParametersInstrumentTypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
SteamPrevacuumTemperature:132°CExposureTime: 4minutesDrying Time:30 minutesStackable –Yes, up tothreecontainersstainless steel,aluminum,titanium,plastic* andsilicone surgicalinstrumentsFull and ThreeQuarter Sizes:3 mm x 400mmHalf Size:3mm x 250mmsize4 lumen percontainerFull, ThreeQuarter and HalfSizes:25 lbs
Ethylene Oxide100% ETOConcentration:725mg/LTemperature:55°CExposureTime: 60minutesHumidity: 50-70%Aeration time8 hours at110°F (43°C)Stackable – Nostainless steel,aluminum,titanium, andsilicone surgicalinstrumentsFull and ThreeQuarter Sizes:3 mm x 400mmHalf Size:2mm x 250mm4 Lumen percontainerFull, ThreeQuarter and HalfSizes:25 lbs
Low Temperature H2O2 Sterilizers by Model Name/Cycle TypeSterilization Parameters for each cycle type are set by the manufacturer
STERRAD 100NXStandardFixed CycleType**Stackable – Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:2mm x 400mmThree Quarter andHalf Sizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarter andHalf Sizes:13.85 lbs
Table 1Sterilization Parameters
SterilizationModalityCycle TypeCycleParametersInstrumentTypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
DUOFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:2mm x 400mmThree Quarter andHalf Sizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarter andHalf Sizes:13.2 lbs
FLEXFixed CycleType**Stackable - NoPorous LumensFull, Three Quarterand Half Sizes:One 1mm x 850mmFlexible Endoscopeper containerFull Size:16.65 lbsThree QuarterSize:12.40 lbsHalf Size:10.75 lbs
STERRAD NXStandardFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:1mm x 400mmThree Quarter andHalf Size:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarter andHalf Sizes:13.85 lbs
AdvancedFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull, Three Quarter,and Half Sizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarter andHalf Sizes:13.85 lbs
Table 1Sterilization Parameters
SterilizationModalityCycle TypeCycle ParametersInstrument TypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
STERRAD 100SStandardFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:3mm x 400mmThree Quarter andHalf Size: 2mm x250mm5 Lumen percontainerFull, ThreeQuarter, and HalfSizes:18.2 lbs
STERISV-PRO™ 1 PLUSLumen orNo LumenCycle time = 55minutesStackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:3mm x 400mmThree Quarter andHalf Sizes: 2mm x250mm10 lumen percontainerFull, ThreeQuarter, and HalfSizes:19.65 lbs

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*The use of plastic instruments has only been confirmed for steam sterilization.

**For all STERRAD manufactured sterilizers all cycle parameters are preset by the manufacturer and cannot be reset by the user.

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Table 2Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
Filter Bottom Container Base
Full LengthHeight
508726100mm (4 inch)YESYESYESYES
508727135mm (5 inch)YESYESYESYES
508728150mm (6 inch)YESYESYESYES
508729200mm (8 inch)YESYESYESYES
508730260mm (10 inch)YESYESYESYES
Three-QuarterLength
508736100mm (4 inch)YESYESYESYES
508737135mm (5 inch)YESYESYESYES
508738150mm (6 inch)YESYESYESYES
Half Length
508731100mm (4 inch)YESYESYESYES
508732135mm (5 inch)YESYESYESYES
508733150mm (6 inch)YESYESYESYES
508734200mm (8 inch)YESYESYESYES
508735260mm (10 inch)YESYESYESYES
Solid Bottom Container Base
Full Length
508739100mm (4 inch)YESYESNONO
508740135mm (5 inch)YESYESNONO
508741150mm (6 inch)YESYESNONO
Table 2Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
508742200mm (8 inch)YESYESNONO
508743260mm (10 inch)YESYESNONO
Three-QuarterLength
508749100mm (4 inch)YESYESNONO
508750135mm (5 inch)YESYESNONO
508751150mm (6 inch)YESYESNONO
Half Length
508744100mm (4 inch)YESYESNONO
508745135mm (5 inch)YESYESNONO
508746150mm (6 inch)YESYESNONO
508747200 (8 inch)YESYESNONO
508748260 (10 inch)YESYESNONO
Filter Lids
Product CodeColor
Full Length
508944GreyYESYESYESYES
508945YellowYESNONONO
508946GreenYESNONONO
508947BlueYESNONONO
508948RedYESNONONO
508949BlackYESNONONO
Three-QuarterLength
508956GreyYESYESYESYES
508957YellowYESNONONO
Table 2Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
508958GreenYESNONONO
508959BlueYESNONONO
508960RedYESNONONO
508961BlackYESNONONO
Half Length
508950GreyYESYESYESYES
508951YellowYESNONONO
508952GreenYESNONONO
508953BlueYESNONONO
508954RedYESNONONO
508955BlackYESNONONO
Security Lids
Product CodeColor
Full Length
508869GreyYESYESYESYES
508870YellowYESYESYESYES
508871GreenYESYESYESYES
508872BlueYESYESYESYES
508873RedYESYESYESYES
508874BlackYESYESYESYES
Three-QuarterLength
508881GreyYESYESYESYES
508882YellowYESYESYESYES
508883GreenYESYESYESYES
508884BlueYESYESYESYES
Table 2Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
508885RedYESYESYESYES
508886BlackYESYESYESYES
Half Length
508875GreyYESYESYESYES
508876YellowYESYESYESYES
508877GreenYESYESYESYES
508878BlueYESYESYESYES
508879RedYESYESYESYES
508880BlackYESYESYESYES
Basket Configurations
Product CodeHeight
Full Length
50850030mm (1 inch)YESYESYESYES
50850150mm (2 inch)YESYESYESYES
50850270mm (3 inch)YESYESYESYES
508503100mm (4 inch)YESYESYESYES
Three-QuarterLength
50850830mm (1 inch)YESYESYESYES
50850950mm (2 inch)YESYESYESYES
50851070mm (3 inch)YESYESYESYES
508511100mm (4 inch)YESYESYESYES
Half Length
50850430mm (1 inch)YESYESYESYES
50850550mm (2 inch)YESYESYESYES

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Table 2
Product CodeSizePre-VacuumSteam100%EthyleneOxideContainer System Compatibility by Cycle Type
STERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
50850670mm (3 inch)YESYESYESYES
508507100mm (4 inch)YESYESYESYES
Wire Base Configurations
Product CodeLengthHeight
508512Half26mm (1inch)YESYESYESYES
508513Three-Quarter26mm (1inch)YESYESYESYES
508514Full26mm (1inch)YESYESYESYES
Protective Mat
Product CodeLength
508550HalfYESNOYES
508551Three-QuarterYESNOYES
508552FullYESNOYES

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K152111

510(k) Summary As required by 21 CFR 807.92

Date Prepared:April 8, 2016
Company Name:Symmetry Surgical, Inc.3034 Owen Drive, Antioch TN 370131-800-251-30001-615-964-5567 (fax)
Contact PersonMichele LuceyLakeshore Medical Device Consulting LLC128 Blye Hill LandingNewbury NH603-763-3455Lucey_m@msn.com
Device Proprietary Name:Container System Device Common Name:Symmetry Surgical Quad-Lock® Container SystemContainer Sterilization System
Classification Name:Container Sterilization System
Device Classification:Class II (21 CFR 880.6850) (KCT)
Type of 510(k) Submission:Traditional 510(k)
Basis for Submission:Expand Indications for Use
Predicate Device(s):K092437, K120117 Codman™ Sterilization Container

Device Description:

The Symmetry Surgical Quad-Lock® Container System provides a means to organize and protect stainless steel, aluminum, titanium, plastic and silicone surgical instruments during sterilization and storage. The filter lids, security lids, and container bottoms are made from anodized aluminum. The security lids help ensure sterility during storage and protect the container lid when the containers are stacked. The Container System includes the container base, filter lid, security lid, filters and other accessories.

Indications for Use:

Intended Use:

The Symmetry Surgical Quad-Lock® Container System is indicated for use by hospitals and by health care facilities to:

  • . organize and protect stainless steel, aluminum, titanium, plastic* and silicone surgical instruments that will be sterilized

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  • allow sterilization of the contained instruments by prevacuum steam, ethylene oxide, and low temperature hydrogen peroxide sterilization cycles (validated modalities and parameters are shown in Table 1)
  • When sterilized by prevacuum steam sterilization, the Quad-Lock® Containers maintain the sterility ● of the contents for up to 180 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised
  • . When sterilized by ethylene oxide or low temperature hydrogen peroxide cycle types the Quad-Lock® Containers maintain the sterility of the contents when sterilized by any of the above for up to 30 days during storage and transport within the healthcare facility, as long as the integrity of the container has not been compromised

The system has not been tested for maintenance of sterility after transportation outside the health care facility.

The system is intended for use with stainless steel, aluminum, plastic* and silicone surgical instruments.

*The use of plastic instruments has only been confirmed for steam sterilization.

For effective sterilization and drying of any size Symmetry Surgical Quad-Lock® Sterilization Container. the recommended maximum combined weight of the single container, lid, basket/tray contents is defined in Table 1. For each cycle type the qualified lumen size is the minimum diameter and maximum length that has been qualified for use are shown in Table 1. Container System Compatibility by Cycle Type details are shown in Table 2.

Table 1Sterilization Parameters
SterilizationModalityCycle TypeCycleParameters*InstrumentTypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
SteamPrevacuumTemperature:132°CExposureTime: 4minutesDrying Time:30 minutesStackable –Yes, up to threecontainersstainless steel,aluminum,titanium, plastic*and siliconesurgicalinstrumentsFull and ThreeQuarter Sizes :3 mm x 400mmHalf Size:3mm x 250mmsize4 lumen percontainerFull, ThreeQuarter and HalfSizes:25 lbs
Ethylene Oxide100% ETOConcentration:725mg/LTemperature:55°CExposureTime: 60minutesHumidity: 50-70%Aeration time 8stainless steel,aluminum,titanium, andsilicone surgicalinstrumentsFull and ThreeQuarter Sizes:3 mm x 400mmHalf Size:2mm x 250mm4 Lumen percontainerFull, ThreeQuarter and HalfSizes:25 lbs
SterilizationModalityCycle TypeCycleParameters*InstrumentTypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
Table 1Sterilization Parameters
hours at 110°F(43°C)Stackable - No
Low Temperature H2O2 Sterilizers by Model Name/Cycle TypeSterilization Parameters for each cycle type are set by the manufacturer
STERRAD100NXStandardFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:2mm x 400mmThree Quarter andHalf Sizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbThree Quarterand Half Sizes:13.85 lbs
DUOFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:2mm x 400mmThree Quarter andHalf Sizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarterand Half Sizes:13.2 lbs
STERRAD100NXFLEXFixed CycleType**Stackable - NoPorous LumensFull, ThreeQuarter and HalfSizes:One 1mm x 850mmFlexible Endoscopeper containerFull Size:16.65 lbsThree QuarterSize : 12.40 lbsHalf Size:10.75 lbs
STERRAD NXStandardFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:1mm x 400mmThree Quarter andHalf Size:2mm x 250mmFull Size:21.4 lbsThree Quarterand Half Sizes:13.85 lbs
Table 1Sterilization Parameters
SterilizationModalityCycle TypeCycleParameters*InstrumentTypeQualifiedLumenSize/MaximumQuantityLoadRequirements(MaximumWeight)
5 Lumen percontainer
AdvancedFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull, ThreeQuarter, and HalfSizes:2mm x 250mm5 Lumen percontainerFull Size:21.4 lbsThree Quarterand Half Sizes:13.85 lbs
STERRAD 100SStandardFixed CycleType**Stackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:3mm x 400mmThree Quarter andHalf Size: 2mm x250mm5 Lumen percontainerFull, ThreeQuarter, and HalfSizes:18.2 lbs
STERISV-PRO™ 1 PLUSLumen or NoLumenCycle time =55 minutesStackable - Nostainless steel,aluminum,titanium, and,silicone surgicalinstrumentsFull Size:3mm x 400mmThree Quarter andHalf Sizes: 2mm x250mm10 lumen percontainerFull, ThreeQuarter, and HalfSizes:19.65 lbs

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*The use of plastic instruments has only been confirmed for steam sterilization

**For all STERRAD manufactured sterilizers all cycle parameters are preset by the manufacturer and cannot be reset by the user.

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Table 2
Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
Filter Bottom Container Base
Full LengthHeight
508726100mm (4 inch)YESYESYESYES
508727135mm (5 inch)YESYESYESYES
508728150mm (6 inch)YESYESYESYES
508729200mm (8 inch)YESYESYESYES
508730260mm (10 inch)YESYESYESYES
Three-QuarterLength
508736100mm (4 inch)YESYESYESYES
508737135mm (5 inch)YESYESYESYES
508738150mm (6 inch)YESYESYESYES
Half Length
508731100mm (4 inch)YESYESYESYES
508732135mm (5 inch)YESYESYESYES
508733150mm (6 inch)YESYESYESYES
508734200mm (8 inch)YESYESYESYES
508735260mm (10 inch)YESYESYESYES
Solid Bottom Container Base
Full Length
508739100mm (4 inch)YESYESNONO
508740135mm (5 inch)YESYESNONO
508741150mm (6 inch)YESYESNONO
508742200mm (8 inch)YESYESNONO
508743260mm (10 inch)YESYESNONO
Three-QuarterLength
508749100mm (4 inch)YESYESNONO
508750135mm (5 inch)YESYESNONO
508751150mm (6 inch)YESYESNONO
Half Length
508744100mm (4 inch)YESYESNONO
508745135mm (5 inch)YESYESNONO
508746150mm (6 inch)YESYESNONO
508747200 (8 inch)YESYESNONO
508748260 (10 inch)YESYESNONO
Table 2
Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
Filter Lids
Product CodeColor
Full Length
508944GreyYESYESYESYES
508945YellowYESNONONO
508946GreenYESNONONO
508947BlueYESNONONO
508948RedYESNONONO
508949BlackYESNONONO
Three-QuarterLength
508956GreyYESYESYESYES
508957YellowYESNONONO
508958GreenYESNONONO
508959BlueYESNONONO
508960RedYESNONONO
508961BlackYESNONONO
Half Length
508950GreyYESYESYESYES
508951YellowYESNONONO
508952GreenYESNONONO
508953BlueYESNONONO
508954RedYESNONONO
508955BlackYESNONONO
Security Lids
Product CodeColor
Full Length
508869GreyYESYESYESYES
508870YellowYESYESYESYES
508871GreenYESYESYESYES
508872BlueYESYESYESYES
508873RedYESYESYESYES
508874BlackYESYESYESYES
Three-QuarterLength
508881GreyYESYESYESYES
508882YellowYESYESYESYES
508883GreenYESYESYESYES
508884BlueYESYESYESYES
Table 2Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
508885RedYESYESYESYES
508886BlackYESYESYESYES
Half Length
508875GreyYESYESYESYES
508876YellowYESYESYESYES
508877GreenYESYESYESYES
508878BlueYESYESYESYES
508879RedYESYESYESYES
508880BlackYESYESYESYES
Basket Configurations
Product CodeHeight
Full Length
50850030mm (1 inch)YESYESYESYES
50850150mm (2 inch)YESYESYESYES
50850270mm (3 inch)YESYESYESYES
508503100mm (4 inch)YESYESYESYES
Three-QuarterLength
50850830mm (1 inch)YESYESYESYES
50850950mm (2 inch)YESYESYESYES
50851070mm (3 inch)YESYESYESYES
508511100mm (4 inch)YESYESYESYES
Half Length
50850430mm (1 inch)YESYESYESYES
50850550mm (2 inch)YESYESYESYES
50850670mm (3 inch)YESYESYESYES
508507100mm (4 inch)YESYESYESYES
Wire Base Configurations
Product CodeLengthHeight
508512Half26mm (1 inch)YESYESYESYES
508513Three-Quarter26mm (1 inch)YESYESYESYES
508514Full26mm (1 inch)YESYESYESYES
Table 2
Container System Compatibility by Cycle Type
Product CodeSizePre-VacuumSteam100%EthyleneOxideSTERRAD100SNX StandardNX Advanced100NX Standard100NX FLEX100NX DUOSTERISV-Pro 1PlusLumen
Container Component Compatibility
Protective Mat
Product CodeLength
508550HalfYESYESNOYES
508551Three-QuarterYESYESNOYES
508552FullYESYESNOYES

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Technological Characteristics:

The technological characteristics of this device, including design and materials, are similar to the predicate device, Codman" Sterilization Container (K092437, K120117). Table 3 provides a summary of the device characteristics compared to the predicate device:

Similarities andDifferencesPredicateSymmetry Surgical Quad-Lock® Container Systems(Previously Codman)PredicateSymmetry SurgicalQuad-Lock® ContainerSystems(Previously Codman)ProposedSymmetry Surgical Quad-Lock® Container Systems
Table 3
Substantial Equivalence Comparison
510(k) NumberK092437K120117This Submission
Trade NameCodman SterilizationContainersCodman® SterilizationContainersSymmetry Surgical Quad-Lock® Container Systems
510(k) DecisionDateMarch 25, 2010April 16, 2012NA
FDA ProductCodeKCTSameSame
ClassificationSection21CFR880.6850SameSame
ClassificationNameSterilization wrap containers,trays, cassettes & otheraccessoriesSameSame
Use DescriptionMeans to organize and protectinstruments during sterilizationand storageSameSame
MaterialsAluminum alloy, StainlessSteel & SiliconeSameSame
Indications forUseThe Symmetry Surgical Quad-Lock® Sterilization ContainerSystem is indicated for use byhospitals and by health carefacilities to:organize and protectstainless steel,aluminum, and titaniumgeneral surgicalinstruments that will besterilized allow sterilization of thecontained instruments byprevacuum steamsterilization maintain the sterility of thecontents for up to 180 daysduring storage and transportwithin the health care facility,as long as the integrity of thecontainer has not beencompromisedThe Symmetry SurgicalQuad-Lock® SterilizationContainer System isindicated for use byhospitals and by healthcare facilities to:organize and protectstainless steel,aluminum, titanium,plastic and siliconesurgical instrumentsthat will besterilized allow sterilizationof the containedinstruments byprevacuum steamsterilization maintain the sterility ofthe contents for up to 180days during storage andtransport within the healthcare facility, as long asthe integrity of thecontainer has not beencompromisedThe Symmetry Surgical Quad-Lock® is indicated for useby hospitals and by health care facilities to:organize and protect stainless steel, aluminum,titanium, plastic* and silicone surgical instrumentsthat will be sterilized allow sterilization of the contained instruments byprevacuum steam, ethylene oxide, and lowtemperature hydrogen peroxide sterilization cycles(validated parameters shown in Table 1) When sterilized by prevacuum steam sterilization,the Quad-Lock® Containers maintain the sterilityof the contents for up to 180 days during storageand transport within the healthcare facility, as longas the integrity of the container has not beencompromised When sterilized by ethylene oxide or lowtemperature hydrogen peroxide cycle types theQuad-Lock® Containers maintain the sterility ofthe contents when sterilized by any of the abovefor up to 30 days during storage and transportwithin the healthcare facility, as long as theintegrity of the container has not beencompromised New modalities have been validated to demonstrate

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Table 3
Substantial Equivalence Comparison
Similarities andDifferencesPredicateSymmetry Surgical Quad-Lock® Container Systems(Previously Codman)PredicateSymmetry SurgicalQuad-Lock® ContainerSystems(Previously Codman)ProposedSymmetry Surgical Quad-Lock® Container Systems
compromiseddifferences.*The inclusion of plastic instruments applies only tosteam sterilization.
MaterialsAluminum, stainless steel,polycarbonate, silicone, nylonSameSame
StackingCaution: Do not stack thecontainers in the sterilizerThe Symmetry SurgicalQuad-Lock® ContainerSystems can be stackedduring sterilization withup to three containers.Same as K120117
Volume to VentRatiomm³/mm²1004-5316SameSame
Energy modalityNoneSameSame
Maximum Weightof ContainerFor effective sterilization anddrying of any size SymmetrySurgical Quad-Lock®Container Systems, therecommended maximumcombined weight of the singlecontainer, lid, basket andbasket contents is 25 lb. (11.3kg).SameFor effective sterilization and drying of any sizeSymmetry Surgical Quad-Lock® Container Systems, therecommended maximum combined weight of the singlecontainer, lid, basket and basket contents is defined foreach container type. The weights are similar to thepredicate.Container weights are specified in the labeling. No newissues are raised due to these differences.
Sterilization Parameters
SterilizationParametersCycle Type - Pre-vacuumTemperature - 132°CExposure Time – 4 minutesDrying Time - 30 minutesSameSterilizationModality Cycle Type CycleParameters Steam Prevacuum Temperature:132°CExposure Time: 4minutesDrying Time: 30minutesStackable - Yes,up to threecontainers EthyleneOxide 100% ETO Concentration:725mg/LTemperature:55°CExposure Time:60 minutesHumidity: 50-70%Stackable - No

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Table 3Substantial Equivalence Comparison
Similarities andDifferencesPredicateSymmetry Surgical Quad-Lock® Container Systems(Previously Codman)PredicateProposedSymmetry Surgical Quad-Lock® Container Systems
Low Temperature H2O2 Sterilizers by ModelName/Cycle TypeSterilization Parameters for each cycle typeare set by the manufacturerStackable - NoSilicone Mat - Not compatible with LowTemperature H2O2 sterilization cyclesSTERRAD 100NX StandardDUOFLEX STERRAD NX StandardAdvanced STERRAD 100S Standard V-PRO™ 1 PLUS LumenNo Lumen New modalities have been validated to demonstrateefficacy. No new issues are raised due to thesedifferences.
StorageThe contents of the unopenedcontainers will maintainsterility for 180 days.When sterilized by prevacuum steam sterilization,the Quad-Lock® Containers maintain the sterilityof the contents for up to 180 days during storageand transport within the healthcare facility, as longas the integrity of the container has not beencompromised When sterilized by ethylene oxide or lowtemperature hydrogen peroxide cycle types theQuad-Lock® Containers maintain the sterility ofthe contents when sterilized by any of the abovefor up to 30 days during storage and transportwithin the healthcare facility, as long as theintegrity of the container has not beencompromised New modalities have been validated to demonstrateefficacy. No new issues are raised due to thesedifferences.
ReuseThe container may be used upto 100 sterilization cyclesSame
SterilizationModalitySteamSteam, Ethylene Oxide, and Low TemperatureHydrogen Peroxide.New modalities have been validated to demonstrateefficacy. No new issues are raised due to these

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Table 3
Substantial Equivalence Comparison
Similarities andDifferencesPredicateSymmetry Surgical Quad-Lock® Container Systems(Previously Codman)PredicateSymmetry SurgicalQuad-Lock® ContainerSystems(Previously Codman)ProposedSymmetry Surgical Quad-Lock® Container Systems
differences.

Non-Clinical Performance Testing

The intention of this Traditional 510(k) is to expand the cleared Indications for Use for the Symmetry Surgical Quad-Lock® Container. The device has been previously cleared for steam sterilization. Testing has been completed and supports the safety and effectiveness of the Quad-Lock® Container to support the system for expanded indications using EtO and low temperature H-O2 sterilization modalities. The following table summarizes the performance testing that has been completed for each sterilization modality that has been added:

Summary of Performance Testing
Tests PerformedDescriptionResults
Sterilization efficacy andsimulated use testingValidated sterility assurance level of $10^{-6}$Pass
Shelf life of sterile containerMaintenance of sterility after 30 days ofstoragePass
Reuse TestingMicrobial Challenge following multiplesterilization cycles verified for up to100sterilization cyclesPass
Biocompatibility, extractables,and leachablesIn vitro evaluations for these tests hadacceptable resultsPass
Functional strength of handlesTesting performed in accordance with ST77had acceptable resultsPass

Clinical Performance Testing

The intention of this Traditional 510(k) is to expand the cleared Indications for Use for the Symmetry Surgical Quad-Lock® Container Systems. The Codman Quad-Lock Sterilization Container Systems were originally cleared by the FDA under 510(k) K092437 and K120117. There were no Clinical Tests performed.

Statement of Substantial Equivalence

Based on the intended use, indications for use, technological characteristics, performance data and nonclinical tests performed the Symmetry Surgical Quad-Lock® Container Systems are substantially equivalent to the predicate devices, Codman™ Sterilization Containers (K092437 and K120117).

§ 880.6850 Sterilization wrap.

(a)
Identification. A sterilization wrap (pack, sterilization wrapper, bag, or accessories, is a device intended to be used to enclose another medical device that is to be sterilized by a health care provider. It is intended to allow sterilization of the enclosed medical device and also to maintain sterility of the enclosed device until used.(b)
Classification. Class II (performance standards).