K Number
K130720
Date Cleared
2014-08-14

(514 days)

Product Code
Regulation Number
880.6850
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The Synthes Reusable Sterilization Container System is a device intended to be used to enclose other medical devices to be sterilized by a healthcare provider. It allows sterilization of the enclosed medical devices and maintains sterility of the devices until used for a maximum of 180 days.

Synthes containers are suitable for dynamic air removal (pre-vacuum) steam sterilization when used according to the instructions for use.

Reusable lifting platforms are intended to hold enclosed medical devices above the filter areas of a perforated bottom container during sterilization and storage of the container.

Data cards are used to record information regarding a specific sterilization process load. Filter media allows ingress and egress of sterilant while providing a microbial barrier. Tamper evident arrows provide a visual indication that the container system has not been inadvertently opened prior to use. Each arrow contains a modality-specific (pre-vacuum steam) external process indicator that serves as a visual indication that the system has been exposed to a specific sterilization cycle parameter. Data cards, filters and tamper evident arrows are single use only.

Device Description

The Synthes Reusable Sterilization Container System is a rigid, reusable, container intended to be used to sterilize other Synthes medical devices and maintain sterility of these devices until used. The container system is comprised of a lid with gasket, base, filter, tamper evident arrows, and data cards.
The container system includes a lifting platform to hold Synthes graphic cases containing orthopedic medical devices (instruments and implants) within the container.

AI/ML Overview

The document describes the Synthes Reusable Sterilization Container System and its substantial equivalence to a predicate device (Genesis Reusable Rigid Sterilization Container System K112535). The acceptance criteria and performance are based on non-clinical testing.

1. Table of Acceptance Criteria and Reported Device Performance

Acceptance Criteria / CharacteristicPerformance Requirement (Acceptance Criteria)Reported Device Performance
Sterilization Efficacy (Pre-Vacuum Steam)12 log reduction and a sterility assurance level (SAL) of 10^-6 using biological overkill method and half-cycle validation.Met: Testing demonstrated a 12 log reduction and a sterility assurance level (SAL) of 10^-6 using the biological (BI) overkill method and half-cycle validation.
Dry TimeMinimum dry time of 30 minutes for pre-vacuum steam sterilization modality.Met: Dry time studies established a minimum dry time of 30 minutes for pre-vacuum steam sterilization modality.
180 Day Event Related Shelf LifeSterility maintenance for 180 days.Met: 180 Day Event Related Shelf life studies demonstrated sterility maintenance for the recommended pre-vacuum steam sterilization modality.
Microbial Barrier (Whole Package Integrity)100% negative growth when subjected to an aerosol challenge of 1 x 10^6 Bacillus atrophaeus colony forming units (CFU).Met: Whole package microbial challenge test, exposing a container to a minimum of 1 x 10^6 Bacillus atrophaeus colony forming units (CFU) via an aerosol challenge demonstrating 100% negative growth.

2. Sample Size Used for the Test Set and Data Provenance

The document does not explicitly state the specific sample sizes for each test set, nor does it specify the country of origin or whether the data was retrospective or prospective. It mentions "all test samples" or "a container" without providing numerical details for the sample size. However, the data represents non-clinical testing performed to validate the device's efficacy and integrity.

3. Number of Experts Used to Establish the Ground Truth for the Test Set and Qualifications of Those Experts

Not applicable. The ground truth for this device, a sterilization container, is established through standardized performance testing (e.g., microbial challenge, sterility assurance level determination) rather than expert consensus on interpretive data like medical images. The acceptance criteria are based on established scientific and regulatory standards (ANSI/AAMI ST77:2006, ANSI/AAMI ST79:2010).

4. Adjudication Method for the Test Set

Not applicable. As noted above, the ground truth is established via objective, standardized laboratory testing, not through expert adjudication of subjective assessments.

5. If a Multi Reader Multi Case (MRMC) Comparative Effectiveness Study was done

No, an MRMC comparative effectiveness study was not done. The device is a sterilization container, and its effectiveness is determined through physical and microbiological tests, not through human reader performance with or without AI assistance.

6. If a Standalone (i.e. algorithm only without human-in-the loop performance) was done

Not applicable. This device is a passive sterilization container, not an AI algorithm.

7. The Type of Ground Truth Used

The ground truth used is based on objective, quantifiable results from non-clinical performance tests, specifically:

  • Microbiological assays: Demonstrating a 12 log reduction and a 10^-6 sterility assurance level, and 100% negative growth in microbial challenge tests.
  • Physical measurements/observations: Related to dry time and maintenance of sterility over a specified shelf life.
    These align with established scientific and regulatory standards for sterilization efficacy and package integrity for medical devices.

8. The Sample Size for the Training Set

Not applicable. This device is a physical product, not an AI algorithm, and therefore does not have a "training set" in the context of machine learning.

9. How the Ground Truth for the Training Set was Established

Not applicable, as explained in point 8.

{0}------------------------------------------------

Image /page/0/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo consists of a circular seal with the words "DEPARTMENT OF HEALTH & HUMAN SERVICES • USA" arranged around the perimeter. Inside the circle is a stylized image of three human profiles facing right, layered on top of each other, representing the department's focus on people and health.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-0002

August 14, 2014

Synthes USA Mr. Thomas Shea Senior Regulatory Affairs Specialist 1302 Wrights Lane East West Chester, PA 19380

Re: K130720

Trade/Device Name: Synthes Reusable Sterilization Container Systems Regulation Number: 21 CFR 880.6850 Regulation Name: Sterilization Container Regulatory Class: II Product Code: KCT Dated: July 16, 2014 Received: July 17, 2014

Dear Mr. Shea:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

{1}------------------------------------------------

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Division of Small Manufacturers, International and Consumer Assistance at its tollfree number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/Resourcesfor You/Industry/default.htm. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office

of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours,

Mary S. Runner -S

Erin I. Keith, M.S. Director Division of Anesthesiology, General Hospital, Respiratory, Infection Control and Dental Devices Office of Device Evaluation Center for Devices and Radiological Health

{2}------------------------------------------------

Image /page/2/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a circular symbol with intersecting lines, followed by the company name in bold, dark blue letters. Below the company name, in smaller letters, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red script.

4.0 Indications for Use Statement

510(k): K130720

Device Name: Synthes Reusable Sterilization Container System

Indications for Use:

The Synthes Reusable Sterilization Container System is a device intended to be used to enclose other medical devices to be sterilized by a healthcare provider. It allows sterilization of the enclosed medical devices and maintains sterility of the devices until used for a maximum of 180 days.

Synthes containers are suitable for dynamic air removal (pre-vacuum) steam sterilization when used according to the instructions for use.

Reusable lifting platforms are intended to hold enclosed medical devices above the filter areas of a perforated bottom container during sterilization and storage of the container.

Data cards are used to record information regarding a specific sterilization process load. Filter media allows ingress and egress of sterilant while providing a microbial barrier. Tamper evident arrows provide a visual indication that the container system has not been inadvertently opened prior to use. Each arrow contains a modality-specific (pre-vacuum steam) external process indicator that serves as a visual indication that the system has been exposed to a specific sterilization cycle parameter. Data cards, filters and tamper evident arrows are single use only.

{3}------------------------------------------------

Image /page/3/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol on the left, resembling interconnected circles in a gold color. To the right of the symbol is the company name, "DePuy Synthes," written in a bold, dark blue font. Below the company name, in smaller letters, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red script.

Sterilization MethodCycle ParametersTotal System WeightContainers, Accessories & Validated Contents
Dynamic Air Removal(Pre-Vacuum) SteamExposure Temperature: 270°F(132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesDry Time Cycle: 30 MinutesMinimum Cool Time: 60 minutes (may vary according to load contents)Stacking Not Permitted25 lbs.Solid Bottom Containers;Perforated BottomContainers; Lifting Platforms.Lumen (Cannulated) Devices.Devices or DeviceConfigurations withconjoined surfaces whichmeet, touch or unite. Matedsurfaces.Materials: Intrinsically stablemetals. Composites,thermoplastics andthermosetting polymers withconstant use temperaturesabove 135°C

Examples of device types with conjoined or mated surfaces include: forceps, clamps, bending pliers, and cable or plate cutters. Lumen devices include: cannulated drill bits, guides, screwdrivers and cannulated screws.

Examples of intrinsically stable metals include stainless steel, titanium (CP and alloys) and aluminum. Examples of thermoplastic polymers are PEEK, PEKK, PEI (Ultem), Acetal (Delrin), Radel (PPSU), Nylon, PTFE, Polypropylene, ABS (Acrylonitrile/Butadiene/Styrene) and POM (Polyoxymethylene). Examples of thermosetting polymers are Phenolic and Silicone.

Examples of composites include carbon fiber reinforced epoxy (CFRE).

{4}------------------------------------------------

Image /page/4/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol on the left, resembling interconnected circles in a light brown color. To the right of the symbol is the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, in smaller letters, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red script.

Synthes Reusable Sterilization Container and Accessory Configurations Supported byValidation Data
ModalityType of ContainerDynamic Air Removal (Pre-Vacuum) SteamContents / ConfigurationValidation Details
Perforated BottomContainer and SolidBottom ContainerLifting PlatformYes
Dead end lumen: Ø2.1mm x 330mmYes
Open end lumens: Ø0.9mm x 278mmYes
Open end lumens: Ø1.1mm x 285mmYes
Open end lumens: Ø1.35mm x 278mmYes
Open end lumens: Ø3.65mm x 465mmYes
Open end lumens: Ø4.5mm x 438mmYes
Mated SurfacesYes
Materials: Intrinsically stable metals.Composites, thermoplastics andthermosetting polymers with constant usetemperatures above 135°C.Yes
FilterNST Series
Data CardMD1-1
Tamper Evident ArrowAS2-3
Maximum Total Weight(Container plus Contents)25 lbs.
StackingNot permitted

{5}------------------------------------------------

Image /page/5/Picture/0 description: The image shows the logo for DePuy Synthes, a company that is part of Johnson & Johnson. The logo consists of a geometric symbol on the left, resembling interlocking circles in a gold color. To the right of the symbol is the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, in smaller letters, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red script.

Synthes PartNumberSynthes PartDescriptionVolume to VentRatio (in³/in²)Weight(lbs.)Outer Dimensions(L x W x H), in.Inner Dimensions(L x W x H), in.
Perforated Bottom Containers
62.006.001Full-One Level,Perforated Base268.523.1 x 12.4 x 4.521.0 x 11.4 x 4.2
62.006.002Full-Two Level,Perforated Base318.823.1 x 12.4 x 5.321.0 x 11.4 x 5.1
62.006.003Full-Three Level,Perforated Base429.423.1 x 12.4 x 7.021.0 x 11.4 x 6.8
62.009.004Extended-Four Level,Perforated Base569.725.2 x 12.4 x 8.523.0 x 11.4 x 8.4
62.009.005Extended-Five Level,Perforated Base6310.325.2 x 12.4 x 9.523.0 x 11.4 x 9.4
Solid Bottom Containers
62.016.001Full-One Level, SolidBase527.823.1 x 12.4 x 4.521.0 x 11.4 x 4.2
62.016.002Full-Two Level, SolidBase627.923.1 x 12.4 x 5.321.0 x 11.4 x 5.1
62.016.003Full-Three Level, SolidBase838.523.1 x 12.4 x 7.021.0 x 11.4 x 6.8
62.019.004Extended-Four Level,Solid Base1129.125.2 x 12.4 x 8.523.0 x 11.4 x 8.4
62.019.005Extended-Five Level,Solid Base12610.025.2 x 12.4 x 9.523.0 x 11.4 x 9.4
Lifting Platforms
62.006.010Lifting Platform forFull ContainerNot Applicable2.620.5 x 10.6 x 1.3Not Applicable
62.009.010Lifting Platform forExtended ContainerNot Applicable2.922.5 x 10.6 x 1.3Not Applicable

{6}------------------------------------------------

Image /page/6/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol resembling interlocking circles in a gold color, followed by the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, the text "COMPANIES of Johnson & Johnson" is written, with "Johnson & Johnson" in a red script font.

Additional Items in System
Part NumberDescription
Consumables
DST-3Filters (1,000/Box)
AS2-3Tamper Evident Arrows (1,000/Box)
MD1-1Data Cards (500/Box)
Replacement Parts
Lids
62.006.020Lid for Full Sterilization Container
62.009.021Lid for Extended Sterilization Container
Bases
62.006.031Perforated Base for Full-One Level Container
62.006.032Perforated Base for Full-Two Level Container
62.006.033Perforated Base for Full-Three Level Container
62.009.034Perforated Base for Extended-Four Level Container
62.009.035Perforated Base for Extended-Five Level Container
62.016.031Solid Base for Full-One Level Container
62.016.032Solid Base for Full-Two Level Container
62.016.033Solid Base for Full-Three Level Container
62.019.034Solid Base for Extended-Four Level Container
62.019.035Solid Base for Extended-Five Level Container
Filter Retention Plates
62.010.001Optional Protective Plate
62.010.003Filter Retention Plate, Top
62.010.006Filter Retention Plate, Bottom
Additional Parts
62.010.100Identification Tag

{7}------------------------------------------------

Image /page/7/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The DePuy Synthes logo is in blue and is oriented vertically. Below the logo is a circular design in gold. The Johnson & Johnson logo is in red and is oriented horizontally.

ContainerLidCompatibleGraphic CaseFootprintGraphic CaseDimensions(L x W x H), in.ContentsRequiredAccessoriesMax.Weight(loaded)
ull-One Level,erforated or Solid BaseFull SizeHalf length,1 high10.5 x 9.8 x 2.0Materials: Intrinsically stable metals. Composites,thermoplastics and thermosetting polymers with constant usetemperatures above 135°C.Devices: Graphic Cases, Orthopedic Surgical Instruments,Implants2 Filters (Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
ull-Two Level,erforated or Solid BaseFull Size2/3 length,1 highFull length,1 high13.9 x 9.8 x 2.020.7 x 9.8 x 2.0Device Design Features: Mated Surfaces; Dead end lumen(Ø2.1mm x 330mm); Open end lumens ( $(Ø0.9mm x 278mm)$(Ø1.1mm x 285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)2 Filters (Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
ull-Two Level,erforated or Solid BaseFull SizeHalf length,2 high2/3 length,2 highFull length,2 high10.5 x 9.8 x 3.413.9 x 9.8 x 3.420.7 x 9.8 x 3.4Materials: Intrinsically stable metals. Composites,thermoplastics and thermosetting polymers with constant usetemperatures above 135°C.Devices: Graphic Cases, Orthopedic Surgical Instruments,Implants2 Filters (Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
ull-Three Level,erforated or Solid BaseFull SizeHalf length,3 high2/3 length,3 highFull length,3 high10.5 x 9.8 x 4.913.9 x 9.8 x 4.920.7 x 9.8 x 4.9Device Design Features: Mated Surfaces; Dead end lumen(Ø2.1mm x 330mm); Open end lumens ((Ø0.9mm x 278mm)(Ø1.1mm x 285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)2 Filters (Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
Extended-Four Level,erforated or Solid BaseExtendedHalf length,4 high10.5 x 9.8 x 6.3Materials: Intrinsically stable metals. Composites,thermoplastics and thermosetting polymers with constant use2 Filters (Solid Base)4 Filters (Perf. Base)25 lb.(11.3 kg)
es Reusable Sterilization Container Compatibility, Contents, Accessories and Maximum Allowable Wei
ContainerLidCompatible FootprintGraphic Case Dimensions (L x W x H), inContentsAccessoriesRequiredมอลิก
2/3 length3.9 x 9.8 x 6.3eratures above 135°C. es: Graphic Cases, Orthopedic Surgical Instrmplantsamper EviderArrow
Full length 4 high20.7 x 9.8 x 6.3ce Design Features: Mated Surfaces; Dead end lumen Imm x 330mm); Open end lumens (Ø0.9mm x 278mm Imm x 285mm), (Ø1.35mm x 278mm), (Ø3.65mm x mm), (Ø4.5mm x 438mm)
Half length 5 high10.5 x 9.8 x 7.8terials: Intrinsically stable metals. Composites, rmoplastics and thermosetting polymers with constant speratures above 135°C. wices: Graphic Cases, Orthopedic Surgical Instr
tended-Five Level, rforated or Solid BasExtended2/3 length3 .9 x 9.8 x 7.8mplantslters (Solid Base)25 lb. (11.3 kg)
Full length 5 high20.7 x 9.8 x 7.8ce Design Features: Mated Surfaces; Dead end lumen Imm x 330mm); Open end lumens (Ø0.9mm x 278mm Imm x 285mm); (Ø1.35mm x 278mm), (Ø3.65mm x mm), (Ø4.5mm x 438mm)

{8}------------------------------------------------

Image /page/8/Picture/9 description: The image shows the logo for DePuy Synthes, a company that is part of Johnson & Johnson. The logo consists of the company name, "DePuy Synthes," written vertically in a dark blue sans-serif font. Below the name is a golden-colored abstract symbol. To the right of the name, the text "COMPANIES OF Johnson & Johnson" is written in a smaller, red font.

Prescription Use

(Per 21 CFR 801.109

lver-The-Counter Use AND/OR

X

21 CFR 807 Subpart

LEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDEL

ncurrence of CDRH, Office of Device Evaluation (OD)

720 – Synthes Reusable Sterilization Container Sys

{9}------------------------------------------------

Image /page/9/Picture/0 description: The image is the logo for DePuy Synthes, a Johnson & Johnson company. The logo features a geometric symbol resembling interconnected circles in a tan color on the left. To the right of the symbol is the company name "DePuy Synthes" in a dark blue, sans-serif font. Below the company name, in smaller fonts, it says "COMPANIES of Johnson & Johnson" with "Johnson & Johnson" in a red script font.

5.0 510(k) Summary – K130720

The following is a summary of 510(k) safety and effectiveness information in accordance with 21 CFR 807.92.

Sponsor Information
NameSynthes
Address1302 Wrights Lane East, West Chester, PA 19380
Phone610-719-5679
FAX484-356-9682
Establishment Registration3008812563
Contact PersonThomas N. Shea
Date PreparedAugust 1, 2014
Device Information
Proprietary NameSynthes Reusable Sterilization Container System
Common NameSterilization Container
DeviceSterilization Wrap Containers, Trays, Cassettes & Other Accessories
Regulation DescriptionSterilization Wrap
Classification/Review Panel80 General Hospital
Product CodeKCT
Submission TypeTraditional 510(k)
Regulation880.6850
Device ClassClass II
Predicate DeviceGenesis Reusable Rigid Sterilization Container System (K112535)
Reason for SubmissionIntroduction of a Synthes sterilization container for use with Synthes orthopedic medical devices.
Device DescriptionThe Synthes Reusable Sterilization Container System is a rigid, reusable, container intended to be used to sterilize other Synthes medical devices and maintain sterility of these devices until used. The container system is comprised of a lid with gasket, base, filter, tamper evident arrows, and data cards.The container system includes a lifting platform to hold Synthes graphic cases containing orthopedic medical devices (instruments and implants) within the container.

{10}------------------------------------------------

Image /page/10/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol resembling interconnected circles in a gold color, followed by the company name "DePuy Synthes" in a dark blue sans-serif font. Below the company name, in smaller letters, it says "COMPANIES OF" followed by the Johnson & Johnson logo in red.

Device Models and Accessories:

Container Descriptions and Dimensions
Part NumberDescriptionVolume to Vent Ratio (in³/in²)Weight (lbs.)Outer Dimensions (L x W x H), in.Inner Dimensions (L x W x H), in.
Perforated Bottom Containers
62.006.001Full-One Level, Perforated Base268.523.1 x 12.4 x 4.521.0 x 11.4 x 4.2
62.006.002Full-Two Level, Perforated Base318.823.1 x 12.4 x 5.321.0 x 11.4 x 5.1
62.006.003Full-Three Level, Perforated Base429.423.1 x 12.4 x 7.021.0 x 11.4 x 6.8
62.009.004Extended-Four Level, Perforated Base569.725.2 x 12.4 x 8.523.0 x 11.4 x 8.4
62.009.005Extended-Five Level, Perforated Base6310.325.2 x 12.4 x 9.523.0 x 11.4 x 9.4
Solid Bottom Containers
62.016.001Full-One Level, Solid Base527.823.1 x 12.4 x 4.521.0 x 11.4 x 4.2
62.016.002Full-Two Level, Solid Base627.923.1 x 12.4 x 5.321.0 x 11.4 x 5.1
62.016.003Full-Three Level, Solid Base838.523.1 x 12.4 x 7.021.0 x 11.4 x 6.8
62.019.004Extended-Four Level, Solid Base1129.125.2 x 12.4 x 8.523.0 x 11.4 x 8.4
62.019.005Extended-Five Level, Solid Base12610.025.2 x 12.4 x 9.523.0 x 11.4 x 9.4
Lifting Platforms
62.006.010Lifting Platform for Full ContainerN/A2.620.5 x 10.6 x 1.3N/A
62.009.010Lifting Platform for Extended ContainerN/A2.922.5 x 10.6 x 1.3N/A

{11}------------------------------------------------

Image /page/11/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol on the left, resembling interconnected circles in a gold color. To the right of the symbol is the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, in a smaller font, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red script.

Additional Items in System
Part NumberDescription
Consumables
DST-3Filters (1,000/Box)
AS2-3Tamper Evident Arrows (1,000/Box)
MD1-1Data Cards (500/Box)
Replacement Parts
Lids
62.006.020Lid for Full Sterilization Container
62.009.021Lid for Extended Sterilization Container
Bases
62.006.031Perforated Base for Full-One Level Container
62.006.032Perforated Base for Full-Two Level Container
62.006.033Perforated Base for Full-Three Level Container
62.009.034Perforated Base for Extended-Four Level Container
62.009.035Perforated Base for Extended-Five Level Container
62.016.031Solid Base for Full-One Level Container
62.016.032Solid Base for Full-Two Level Container
62.016.033Solid Base for Full-Three Level Container
62.019.034Solid Base for Extended-Four Level Container
62.019.035Solid Base for Extended-Five Level Container
Filter Retention Plates
62.010.001Optional Protective Plate
62.010.003Filter Retention Plate, Top
62.010.006Filter Retention Plate, Bottom
Additional Parts
62.010.100Identification Tag

{12}------------------------------------------------

Image /page/12/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol on the left, followed by the company name in blue. Below the company name, the text "COMPANIES OF Johnson&Johnson" is written in a smaller font size, with "Johnson&Johnson" in red script.

Comparison with Predicate Device:

ElementK130720 - Subject DeviceK112535 - Predicate
Synthes Reusable Sterilization Container SystemGenesis Reusable Rigid Sterilization Container System
Intended UseThe Synthes Reusable Sterilization Container System is adevice intended to be used to enclose other medical devicesto be sterilized by a healthcare provider. It allowssterilization of the enclosed medical devices and maintainssterility of the devices until used for a maximum of 180days.Synthes containers are suitable for dynamic air removal(pre-vacuum) steam sterilization when used according tothe instructions for use.Reusable lifting platforms are intended to hold enclosedmedical devices above the filter areas of a perforatedbottom container during sterilization and storage of thecontainer.Data cards are used to record information regarding aspecific sterilization process load. Filter media allowsingress and egress of sterilant while providing a microbialbarrier. Tamper evident arrows provide a visual indicationthat the container system has not been inadvertently openedprior to use. Each arrow contains a modality-specific (pre-vacuum steam) external process indicator that serves as avisual indication that the system has been exposed to aspecific sterilization cycle parameter. Data cards, filters andtamper evident arrows are single use only.The Genesis Reusable Rigid Sterilization Container Systemis a device intended to be used to enclose another medicaldevice that is to be sterilized by a healthcare provider. Itallows sterilization of the enclosed medical device andmaintains sterility of the enclosed device until used for amaximum of 180 days.Containers are suitable for dynamic air removal (pre-vacuum) steam sterilization, immediate use pre-vacuumsteam sterilization and 100% ethylene oxide sterilizationwhen used as described in the instructions for use.Reusable baskets and accessory items (pins, dividers, mats,etc.) are intended to organize and secure enclosed medicaldevices during sterilization and storage of the container.Data cards are used to record information regarding aspecific sterilization process load. Filter media allowsingress and egress of sterilant while providing a microbialbarrier. Tamper evident arrows provide a visual indicationthat the container system has not been inadvertently openedprior to use. Each arrow contains a modality-specificexternal process indicator that serves as a visual indicationthat the system has been exposed to a specific sterilizationcycle parameter. Data cards, filters and tamper evidentarrows are single use only.
MaterialCompositionStainless Steel, Aluminum, Silicone (Gasket), SMSPolypropylene (Filter). All components in the subjectsystem are identical in material composition to thepredicate. The subject system does not contain polymericcomponents to hold devices within the container.Stainless Steel, Aluminum, Silicone (Gasket), SiliconeElastomer (Bars, Mats, Instrument Holders), SMSPolypropylene (Filter), Radel/Polyphenysulfone/Aluminum/Silicone Elastomer/Stainless (Laproscopic InstrumentRacks)
ElementK130720 - Subject DeviceSynthes Reusable Sterilization Container SystemK112535 - PredicateGenesis Reusable Rigid Sterilization Container System
Physical PropertiesPhysical properties of the subject container system are identical to the predicated. The sole difference is the color of the lid and branding. The colorization is done according to the same process as the predicate device.The predicate consists of an anodized aluminum container with a secure latching system that seals the lid to the base with a gasket running along the perimeter. Aluminum retention plates secure single use SMS Polypropylene filters in place over ventilation holes in the lid and/or base of the container. The materials of construction have been demonstrated to withstand repeated processing according to reuse and sterilization modality parameters described in the IFU.
ChemicalPropertiesThe material formulation, manufacturing process, chemical composition and steam sterilization modality for the proposed device is identical to the predicate device. The subject system does not include the polymeric components used to organize devices within the predicate container.The predicate system is manufactured from aluminum, stainless steel, closed cell silicone foam, SMS polypropylene, and silicone polymeric components.
Configurations/DimensionsSolid or perforated base with perforated lid. Container sizes range from 23.1 x 12.4 x 4.5 to 25.2 x 12.4 x 9.5, please see the table on the previous page for the dimensions of all subject container models offered.Solid or perforated base with perforated lid. Container sizes cleared under K112535 range from 10.2 x 7.2 x 3.2 (smallest) to 28.1 x 11.2 x 6.4 (max length) 26.5 x 17.0 x 6.9 (max width) 19.2 x 12.5 x 9.4 (max depth).
Air PermeanceThe subject container also has perforated lids and bottoms that feature the same size and amount of vent holes and makes use of the same filter as the predicate device (SMS Polypropylene) and will have the same permeability to allow ingress of sterilant.The predicate container has perforated lids and bottoms and employs an SMS Polypropylene filter to allow ingress of sterilant.
Percent of SurfacePerforationsThe volume to vent ratio (V:V, in3/in2) represents the total container volume divided by the total vent area. The V:V ratios for the proposed Synthes containers range from 26 – 126 in3/in2. All of the proposed containers fall within the range of volume to vent ratios for the predicate device.The volume to vent ratio (V:V, in3/in2) represents the total container volume divided by the total vent area. The V:V ratios for the predicate containers (K120535) range from 24 – 182 in3/in2.
PerformanceSterilantPenetrationLethality testing via over-challenge half-cycle lethality validation demonstrated all test samples were negative for growth following the seven (7) day incubation periodLethality testing via over-challenge half-cycle lethality validation demonstrated all test samples were negative for growth following the seven (7) day incubation period
K130720 - Subject DeviceK112535 - Predicate
ElementSynthes Reusable Sterilization Container SystemGenesis Reusable Rigid Sterilization Container System
identical to the predicate.
Microbial BarrierWhole package integrity/microbial barrier aerosol challengeWhole package integrity/microbial barrier aerosol challenge
Properties (Packagedemonstrated all containers tested passed and were 100%demonstrated all containers tested passed and were 100%
Integrity)negative for growth when subjected to aerosol challengetesting. Identical to the predicate.negative for growth when subjected to aerosol challengetesting.
MaterialThe subject container system is manufactured from theThe materials used in the construction of the containers do
Compatibilitysame materials as the predicate device and it's compatibilitynot degrade and have proven compatibility with the
with the sterilization process is identical to the predicate.sterilization process and sterilants for which the system is
indicated.
ToxicologicalNo patient contact, contact with devices that will haveNo patient contact, contact with devices that will have
Propertiesexternal communicating, tissue/bone/dentin contact (limitedexternal communicating, tissue/bone/dentin contact (limited
(Biocompatibility.exposure). The subject Container System will include aexposure). Primary dermal irritation testing was performed
including Sterilantstainless steel lifting platform that represents the onlyon polymeric components of the container system. All
Residue Limits)internal component to hold devices within the container.samples were subjected to ISO Skin Irritation Testing (2
The lifting platform is manufactured from type 304 stainlessextracts - 0.9% Sodium Chloride and Sesame Oil Extracts)
steel that conforms to ASTM Standard F899 and has anin compliance with the requirements noted in ISO 10993-
established biocompatibility profile. The system will not10. These polymeric components were evaluated for
include the polymeric components, such as silicone bars orbiocompatibility and are considered to be toxicologically
brackets that are included in the predicate system. Theacceptable for their intended use.
proposed system is indicated for prevacuum steam
sterilization only therefore sterilant residues will not pose
any risk to the patient. The material formulation,
manufacturing process, chemical composition, body
contact, and steam sterilization modality of the proposed
device is equivalent to the predicate device.
Shelf Life180 Day shelf life identical to the predicate.180 Day shelf life demonstrated by real time event related
Shelf Life/Package Integrity testing.
Drying Time30 Minute Minimum Dry Time supported by validation30 Minute Minimum Dry Time supported by validation
study utilizing worst case device challenge identical to thestudy utilizing worst case instrument challenge.
predicate.
Aeration TimeN/A - System not indicated for EO Sterilization8 hours at 109.4°F (43°C) supported by 100% Ethylene
Oxide Aeration Residual validation study

{13}------------------------------------------------

Image /page/13/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo features a stylized graphic of interlocking circles in a gold color, followed by the company name "DePuy Synthes" in a dark blue, sans-serif font. Below the company name, the text "COMPANIES of Johnson & Johnson" is displayed, with "COMPANIES of" in gray and "Johnson & Johnson" in a red, script-like font.

{14}------------------------------------------------

Image /page/14/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a circular graphic to the left of the company name, "DePuy Synthes," which is written in a dark blue, sans-serif font. Below the company name, in smaller letters, is the text "COMPANIES OF" in gray, followed by "Johnson & Johnson" in a red, cursive font.

{15}------------------------------------------------

Image /page/15/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a geometric symbol on the left, resembling interconnected circles in a gold color. To the right of the symbol is the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, in smaller letters, it says "COMPANIES OF Johnson & Johnson", with "Johnson & Johnson" in a red script font.

Summary of Technological Characteristics of the Subject Device
CharacteristicProposed DeviceSynthes Reusable Sterilization ContainerPredicateGenesis Reusable RigidSterilization Container System(K112535)
ContainerAnodized AluminumAnodized Aluminum 5000 and1100 Series; Stainless Steel 300Series
GasketClosed Cell Silicone FoamClosed Cell Silicone Foam
Filter MaterialSMS Polypropylene for Pre-Vacuum Steam modalitySMS Polypropylene for allmodalities
LiftingPlatform/BasketLifting Platform 304 StainlessSteel ElectropolishedBasket 304 Stainless SteelElectropolished
Dividers BracketsN/AAluminum 5000 Series
Clips, Posts, PinsN/A300 & 400 Series Stainless
Silicone Bars, MatsN/ASilicone Elastomer
Performance Data
Summary of Non-Clinical Testing Conducted for Determination of Substantial Equivalence
Performance Test Summary - Proposed Device
CharacteristicStandard/Test/FDA GuidanceResults Summary
Sterilization Efficacy:Pre-Vacuum SteamANSI/AAMI ST77:2006Containment Devices forReusable Medical DeviceSterilization.Testing demonstrated a 12 log reductionand a sterility assurance level (SAL) of 10-6using the biological (BI) overkill methodand half-cycle validation.
Dry TimeANSI/AAMI ST77:2006Containment Devices forReusable Medical DeviceSterilization.ANSI/AAMI ST79:2010Comprehensive guide tosteam sterilization andsterility assurance inhealth care facilities.Dry time studies establish minimum drytime of 30 minutes for pre-vacuum steamsterilization modality.
180 Day Event RelatedShelf LifeANSI/AAMI ST77:2006Containment Devices forReusable Medical DeviceSterilization.180 Day Event Related Shelf life studiesdemonstrated sterility maintenance for therecommended pre-vacuum steamsterilization modality.
Microbial ChallengeANSI/AAMI ST77:2006Containment Devices forReusable Medical DeviceSterilization.Whole package microbial challenge test,exposing a container to a minimum of 1 x106 Bacillus atrophaeus colony formingunits (CFU) via an aerosol challengedemonstrating 100% negative growth.

{16}------------------------------------------------

Image /page/16/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo features a geometric symbol resembling interconnected circles in a gold color. To the right of the symbol is the company name "DePuy Synthes" in a bold, dark blue font. Below the company name, in a smaller font, it says "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red.

Summary of Clinical Tests Conducted for Determination of Substantial Equivalence

N/A - No clinical tests were conducted for this submission.

Conclusion

Information presented supports substantial equivalence of the Synthes Reusable Sterilization Container System to the predicate device based on similarities in intended use, design, principles of operation, and performance specifications.

Sterilization Efficacy / Lethality testing was conducted on the proposed sterilization container system to support substantial equivalence to the predicate device and demonstrate effectiveness when used with Synthes orthopedic medical devices.

Filter material properties, package integrity testing and 180 day shelf life validation are exactly the same as the predicate device.

The performance testing data demonstrates that the Synthes Reusable Sterilization Container meet the same criteria as the predicate device is substantial equivalent.

{17}------------------------------------------------

Image /page/17/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a circular graphic on the left, followed by the company name in bold, blue font. Below the company name, in smaller font, is the text "COMPANIES of Johnson & Johnson" with the Johnson & Johnson part in red.

Sterilization Parameters for the Synthes Reusable Sterilization ContainerApplicable to both Solid Bottom and Perforated Bottom Containers with Lifting Platforms
SterilizationMethodCycle ParametersTotalSystemWeightTypes of Medical Devices& Materials Validatedfor Use
Dynamic AirRemoval (Pre-Vacuum) SteamExposure Temperature:270°F (132°C)Pre-Conditioning Pulses: 3Exposure Time: 4 MinutesDry Time Cycle: 30MinutesMinimum Cool Time: 60minutes (may varyaccording to load contents)Stacking Not Permitted25 lbs.(Containerpluscontents)Orthopedic MedicalDevices including Lumen(Cannulated) Devices.Devices or DeviceConfigurations withconjoined surfaces whichmeet, touch or unite.Mated Surfaces.Materials: Intrinsicallystable metals. Composites,thermoplastics andthermosetting polymerswith constant usetemperatures above 135°C.

Examples of device types with conjoined or mated surfaces include: forceps, clamps, bending pliers, and cable or plate cutters. Lumen devices include: cannulated drill bits, guides, screwdrivers and cannulated screws.

Examples of intrinsically stable metals include stainless steel, titanium (CP and alloys) and aluminum. Examples of thermoplastic polymers are PEEK, PEI (Ultem), Acetal (Delrin), Radel (PPSU), Nylon, PTFE, Polypropylene, ABS (Acrylonitrile/Butadiene/Styrene) and POM (Polyoxymethylene).

Examples of thermosetting polymers are Phenolic and Silicone.

Examples of composites include carbon fiber reinforced epoxy (CFRE).

{18}------------------------------------------------

Image /page/18/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a circular graphic on the left, followed by the company name in a bold, sans-serif font. Below the company name, in a smaller font, it says "COMPANIES of Johnson & Johnson".

Synthes Reusable Sterilization Container System & Accessories
Supported by Validation Data
ModalityDynamic Air Removal (Pre-Vacuum) Steam
Type of ContainerContents / ConfigurationValidation Details
Perforated BottomContainer and SolidBottom ContainerLifting PlatformYes
Dead end lumen: Ø2.1mm x 330mmYes
Open end lumens: Ø0.9mm x 278mmYes
Open end lumens: Ø1.1mm x 285mmYes
Open end lumens: Ø1.35mm x 278mmYes
Open end lumens: Ø3.65mm x 465mmYes
Open end lumens: Ø4.5mm x 438mmYes
Mated SurfacesYes
Materials: Intrinsically stable metals.Composites, thermoplastics andthermosetting polymers with constantuse temperatures above 135°C.Yes
FilterNST Series(SMS Polypropylene)
Data CardMD1-1
Tamper Evident ArrowAS2-3
Maximum Total Weight(Container plus Contents)25 lbs.
StackingNot permitted

{19}------------------------------------------------

Container Compatibility, Contents, Accessories, Maximum Allowable Weight
ContainerLidCompatibleGraphic CaseFootprintGraphic CaseDimensions(L x W x H), in.ContentsRequiredAccessoriesMax.Weight(loaded)
Full-One Level.Perforated or Solid BaseFull SizeHalf length,1 high10.5 x 9.8 x 2.0Materials: Intrinsically stable metals.Composites, thermoplastics and thermosettingpolymers with constant use temperaturesabove 135°C.Devices: Graphic Cases, Orthopedic SurgicalInstruments, ImplantsDevice Design Features: Mated Surfaces;Dead end lumen (Ø2.1mm x 330mm); Openend lumens (Ø0.9mm x 2.78mm ) (Ø1.1mm x285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)2 Filters( Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
2/3 length,1 high13.9 x 9.8 x 2.0
Full length,1 high20.7 x 9.8 x 2.0
Full-Two Level,Perforated or Solid BaseFull SizeHalf length,2 high10.5 x 9.8 x 3.4Materials: Intrinsically stable metals.Composites, thermoplastics and thermosettingpolymers with constant use temperaturesabove 135°C.Devices: Graphic Cases, Orthopedic SurgicalInstruments, ImplantsDevice Design Features: Mated Surfaces;Dead end lumen (Ø2.1mm x 330mm); Openend lumens (Ø0.9mm x 2.78mm ) (Ø1.1mm x285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)2 Filters( Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
2/3 length,2 high13.9 x 9.8 x 3.4
Full length.2 high20.7 x 9.8 x 3.4
Full-Three Level,Perforated or Solid BaseFull SizeHalf length,3 high10.5 x 9.8 x 4.9Materials: Intrinsically stable metals.Composites, thermoplastics and thermosettingpolymers with constant use temperatures2 Filters( Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
2/3 length,3 high13.9 x 9.8 x 4.9above 135°C.Devices: Graphic Cases, Orthopedic SurgicalInstruments, Implants
Full length,3 high20.7 x 9.8 x 4.9Device Design Features: Mated Surfaces;Dead end lumen (Ø2.1mm x 330mm); Openend lumens (Ø0.9mm x 2.78mm ) (Ø1.1mm x285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)
Container Compatibility, Contents, Accessories, Maximum Allowable Weight
ContainerLidCompatibleGraphic CaseFootprintGraphic CaseDimensions(L x W x H), in.ContentsRequiredAccessoriesMax.Weight(loaded)
Extended-Four Level,Perforated or Solid BaseExtendedHalf length,4 high10.5 x 9.8 x 6.3Materials: Intrinsically stable metals.Composites, thermoplastics and thermosettingpolymers with constant use temperatures2 Filters( Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
2/3 length,4 high13.9 x 9.8 x 6.3above 135°C.Devices: Graphic Cases, Orthopedic SurgicalInstruments, Implants
Full length,4 high20.7 x 9.8 x 6.3Device Design Features: Mated Surfaces;Dead end lumen (Ø2.1mm x 330mm); Openend lumens (Ø0.9mm x 2.78mm ) (Ø1.1mm x285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)
Extended-Five Level,Perforated or Solid BaseExtendedHalf length,5 high10.5 x 9.8 x 7.8Materials: Intrinsically stable metals.Composites, thermoplastics and thermosettingpolymers with constant use temperatures2 Filters( Solid Base)4 Filters (Perf. Base)Lifting PlatformTamper EvidentArrow25 lb.(11.3 kg)
2/3 length,5 high13.9 x 9.8 x 7.8above 135°C.Devices: Graphic Cases, Orthopedic SurgicalInstruments, ImplantsDevice Design Features: Mated Surfaces;
Full length,5 high20.7 x 9.8 x 7.8Dead end lumen (Ø2.1mm x 330mm); Openend lumens (Ø0.9mm x 2.78mm ) (Ø1.1mm x285mm), (Ø1.35mm x 278mm), (Ø3.65mm x465mm), (Ø4.5mm x 438mm)

{20}------------------------------------------------

Image /page/20/Picture/0 description: The image shows the logo for DePuy Synthes, a company of Johnson & Johnson. The logo consists of a symbol of two overlapping circles in gold, followed by the company name in blue. Below the company name, it says "COMPANIES OF" in gray, followed by "Johnson & Johnson" in red script.

§ 880.6850 Sterilization wrap.

(a)
Identification. A sterilization wrap (pack, sterilization wrapper, bag, or accessories, is a device intended to be used to enclose another medical device that is to be sterilized by a health care provider. It is intended to allow sterilization of the enclosed medical device and also to maintain sterility of the enclosed device until used.(b)
Classification. Class II (performance standards).