K Number
K123898
Device Name
VOLCANO S5/S5I INTRAVASCULAR ULTRASOUND IMAGING AND PRESSURE SYSTEM
Date Cleared
2013-01-14

(27 days)

Product Code
Regulation Number
892.1560
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
The Volcano s5™/s5i® Series Intravascular Imaging and Pressure System is used for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vessels of the peripheral vasculature. It is also indicated as an adjunct to conventional angiographic procedures to provide an image of vessel lumen and wall structures. ChromaFlo® is indicated for qualitative blood flow information from peripheral and coronary vasculature; flow information can be an adjunct to other methods of estimating blood flow and blood perfusion. VH® IVUS is intended to be used in conjunction with imaging catheters during diagnostic ultrasound imaging of the peripheral and coronary vasculature. The Volcano VH IVUS System is intended to semiautomatically visualize boundary features and perform spectral analysis of RF ultrasound signals of vascular features that the user may wish to examine more closely during routine diagnostic ultrasound imaging examinations. The pressure feature is intended for use in all blood vessels, including coronary and peripheral arteries, to measure intravascular blood pressure during diagnostic angiography and/or interventional procedures. Rotational 45MHz feature is intended for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vasculature. As an adjunct to conventional angiographic procedures to provide an image of the vessel lumen and wall structures. The pullback feature of the PMr withdraws the imaging core within the protective sheath for a maximum of 15 cm.
Device Description
The Volcano s5™/s5i@ Intravascular Ultrasound Imaging and Pressure Systems are currently available in 2 configurations: (1) a tower or a portable model where the device can be moved from one room to another, and (2) an integrated model, where the system is integrated into the catheterization (cath) lab. Both tower and integrated configurations of the Volcano s5/s5i Imaging and Pressure system offer: (1) the Intravascular Ultrasound (IVUS) imaging mode and (2) the pressure mode. When operating the IVUS mode, the system console gathers and displays high-resolution intraluminal images that can be analyzed both quantitatively and qualitatively. When operating in pressure mode, the system acquires intraluminal data from a pressure guidewire while simultaneously taking aortic pressure data from the established ECG/EKG catheterization lab equipment. Catheters and guidewires are connected to the system via the Patient Interface Modules (PIMs).
More Information

K11706, K113486

Not Found

No
The document describes image processing and semi-automatic analysis features (VH IVUS), but does not mention AI, ML, or related terms. The performance studies focus on software verification and validation, image assessment, and use validation, without indicating the use of AI/ML training or testing.

No
Explanation: The device is described as an imaging and pressure system used for diagnostic purposes such as evaluating vascular morphology and measuring intravascular pressure. It is not indicated for treating or curing any medical condition.

Yes

Explanation: The "Intended Use / Indications for Use" section explicitly states that the device is used for "qualitative and quantitative evaluation of vascular morphology" and provides an "image of vessel lumen and wall structures," which are diagnostic purposes. It also mentions "H® IVUS is intended to be used in conjunction with imaging catheters during diagnostic ultrasound imaging" and "the pressure feature is intended for use...to measure intravascular blood pressure during diagnostic angiography".

No

The device description explicitly states it is a "System" with "configurations" including a "tower or a portable model" and an "integrated model," indicating the presence of hardware components beyond just software. It also mentions "system console" and "Patient Interface Modules (PIMs)" which are hardware.

Based on the provided information, this device is not an In Vitro Diagnostic (IVD).

Here's why:

  • IVDs are used to examine specimens derived from the human body. The description of the Volcano s5™/s5i® System clearly states that it is used for "intravascular imaging and pressure system" and "intraluminal images" and "intraluminal data". This means it is used within the body to image and measure directly, not to analyze samples taken from the body.
  • The intended use and device description focus on imaging and pressure measurement within blood vessels. This is a direct diagnostic procedure performed on the patient, not an analysis of a biological sample in a lab setting.

Therefore, the Volcano s5™/s5i® System falls under the category of an in vivo diagnostic device, not an in vitro diagnostic device.

N/A

Intended Use / Indications for Use

The Volcano s5™/s5i® Series Intravascular Imaging and Pressure System is used for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vessels of the peripheral vasculature. It is also indicated as an adjunct to conventional angiographic procedures to provide an image of vessel lumen and wall structures.

ChromaFlo® is indicated for qualitative blood flow information from peripheral and coronary vasculature; flow information can be an adjunct to other methods of estimating blood flow and blood perfusion.

VH® IVUS is intended to be used in conjunction with imaging catheters during diagnostic ultrasound imaging of the peripheral and coronary vasculature. The Volcano VH IVUS System is intended to semi-automatically visualize boundary features and perform spectral analysis of RF ultrasound signals of vascular features that the user may wish to examine more closely during routine diagnostic ultrasound imaging examinations.

The pressure feature is intended for use in all blood vessels, including coronary and peripheral arteries, to measure intravascular blood pressure during diagnostic angiography and/or interventional procedures.

Rotational 45MHz feature is intended for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vasculature. As an adjunct to conventional angiographic procedures to provide an image of the vessel lumen and wall structures. The pullback feature of the PIMr withdraws the imaging core within the protective sheath for a maximum of 15 cm.

Product codes

IYO, DSK, DSA

Device Description

The Volcano s5™/s5i@ Intravascular Ultrasound Imaging and Pressure Systems are currently available in 2 configurations: (1) a tower or a portable model where the device can be moved from one room to another, and (2) an integrated model, where the system is integrated into the catheterization (cath) lab. Both tower and integrated configurations of the Volcano s5/s5i Imaging and Pressure system offer: (1) the Intravascular Ultrasound (IVUS) imaging mode and (2) the pressure mode.

When operating the IVUS mode, the system console gathers and displays high-resolution intraluminal images that can be analyzed both quantitatively and qualitatively. When operating in pressure mode, the system acquires intraluminal data from a pressure guidewire while simultaneously taking aortic pressure data from the established ECG/EKG catheterization lab equipment. Catheters and guidewires are connected to the system via the Patient Interface Modules (PIMs).

Mentions image processing

Yes

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Intravascular Ultrasound (IVUS)

Anatomical Site

coronary arteries and vessels of the peripheral vasculature, all blood vessels, including coronary and peripheral arteries

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Applicable testing was performed as required by the Quality System to evaluate the software modification to the Volcano s5/s5i Intravascular Imaging and Pressure System. The following tests were conducted:

  • . Software Verification and Validation
  • . Image Assessment
  • . Use Validation

The test results were found to be acceptable by the respective test plans and protocols. The changes to the device involve modifications to the Rotational IVUS software feature. Biocompatibility and sterilization testing was not required for the device modification.

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

K11706 and K113486

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 892.1560 Ultrasonic pulsed echo imaging system.

(a)
Identification. An ultrasonic pulsed echo imaging system is a device intended to project a pulsed sound beam into body tissue to determine the depth or location of the tissue interfaces and to measure the duration of an acoustic pulse from the transmitter to the tissue interface and back to the receiver. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories.(b)
Classification. Class II (special controls). A biopsy needle guide kit intended for use with an ultrasonic pulsed echo imaging system only is exempt from the premarket notification procedures in subpart E of part 807 of this chapter subject to the limitations in § 892.9.

0

K123898

510(k) SUMMARY

JAN 1 4 2013

The 510(k) Summary is submitted as required by section 807.92(a)

SPONSOR: Volcano Corporation 2870 Kilgore Road Rancho Cordova, CA 95670 CONTACT/SUBMITTER: Jwala Jawharkar Regulatory Affairs Specialist 2870 Kilgore Road Rancho Cordova. CA 95670 Tel. (916) 281-2925 Fax: (916) 638-8112 DATE OF SUBMISSION: December 17, 2012 Volcano s5™/s5i® Intravascular Ultrasound Imaging System DEVICE: Trade Name: Volcano s5™/s5i® Intravascular Ultrasound Imaging System Common Name: Ultrasonic pulsed echo imaging system Classification: 892.1560 Ultrasonic pulsed echo imaging system. II, IYO 870.1110 Blood Pressure Computer, II, DSK 870.2900 Patient Transducer and Electrical Cable, II, DSA PREDICATE DEVICE: Volcano s57M/s5i® Intravascular Ultrasound Imaging System (K11706 and K113486)

DEVICE DESCRIPTON:

The Volcano s5™/s5i@ Intravascular Ultrasound Imaging and Pressure Systems are currently available in 2 configurations: (1) a tower or a portable model where the device can be moved from one room to another, and (2) an integrated model, where the system is integrated into the catheterization (cath) lab. Both tower and integrated configurations of the Volcano s5/s5i Imaging and Pressure system offer: (1) the Intravascular Ultrasound (IVUS) imaging mode and (2) the pressure mode.

When operating the IVUS mode, the system console gathers and displays high-resolution intraluminal images that can be analyzed both quantitatively and qualitatively. When operating in pressure mode, the system acquires intraluminal data from a pressure guidewire while simultaneously taking aortic pressure data from the established ECG/EKG catheterization lab equipment. Catheters and guidewires are connected to the system via the Patient Interface Modules (PIMs).

1

INDICATIONS FOR USE:

The Volcano s5™/s5i@ Series Intravascular Imaging and Pressure System is used for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vessels of the peripheral vasculature. It is also indicated as an adjunct to conventional angiographic procedures to provide an image of vessel lumen and wall structures.

ChromaFlo® is indicated for qualitative blood flow information from peripheral and coronary vasculature; flow information can be an adjunct to other methods of estimating blood flow and blood perfusion.

VH® IVUS is intended to be used in conjunction with imaging catheters during diagnostic ultrasound imaging of the peripheral and coronary vasculature. The Volcano VH IVUS System is intended to semiautomatically visualize boundary features and perform spectral analysis of RF ultrasound signals of vascular features that the user may wish to examine more closely during routine diagnostic ultrasound imaging examinations.

The pressure feature is intended for use in all blood vessels, including coronary and peripheral arteries, to measure intravascular blood pressure during diagnostic angiography and/or interventional procedures.

Rotational 45MHz feature is intended for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vasculature. As an adjunct to conventional angiographic procedures to provide an image of the vessel lumen and wall structures. The pullback feature of the PMr withdraws the imaging core within the protective sheath for a maximum of 15 cm.

COMPARISON OF CHARACTERISTICS:

The proposed device is identical to the currently marketed device except for the Rotational IVUS software feature designed to offer users the option to select from multiple imaging options with the same Revolution® catheter. This allows the user to select the imaging option preference that he/she prefers to visualize blood speckle and tissue along the lumen border. The proposed device shares the same intended use, same design characteristics, and the same fundamental scientific technology as that of the predicate device.

PERFORMANCE DATA:

Applicable testing was performed as required by the Quality System to evaluate the software modification to the Volcano s5/s5i Intravascular Imaging and Pressure System. The following tests were conducted:

  • . Software Verification and Validation
  • . Image Assessment
  • . Use Validation

The test results were found to be acceptable by the respective test plans and protocols. The changes to the device involve modifications to the Rotational IVUS software feature. Biocompatibility and sterilization testing was not required for the device modification.

2

Image /page/2/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo consists of a circular seal with the text "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" arranged around the perimeter. Inside the circle is an abstract symbol featuring three stylized lines or stripes, resembling an eagle or bird in flight.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-002

January 14, 2013

Mr. Jwala Jawharkar Regulatory Affairs Specialist Volcano Corporation 2870 Kilgore Road RANCHO CORDOVA, CA 95670

Re: K123898

Trade/Device Name: Volcano s5™/s5i® Intravascular Ultrasound Imaging and Pressure System Regulation Number: 21 CFR 892.1560 Regulation Name: Ultrasonic pulsed echo imaging system Regulatory Class: II Product Code: IYO, DSK, and DSA Dated: December 17, 2012 Received: December 18, 2012

Dear Mr. Jawharkar:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA): You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices. good manufacturing practice. labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set

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forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please go to http://www.fda.gov/AboutFDA/CentersOffices/CDRH/CDRHOffices/ucm115809.htm for the Center for Devices and Radiological Health's (CDRH's) Office of Compliance. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638 2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours,

Sean M. Boyd -S for

Janine M. Morris Director, Division of Radiological Health Office of In Vitro Diagnostics and Radiological Health Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known): K123898

Device Name: Volcano s5™/s5i® Intravascular Ultrasound Imaging and Pressure System

Indications for Use:

The Volcano s5™/s5i® Series Intravascular Imaging and Pressure System is used for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vessels of the peripheral vasculature. It is also indicated as an adjunct to conventional angiographic procedures to provide an image of vessel lumen and wall structures.

ChromaFlo® is indicated for qualitative blood flow information from peripheral and coronary vasculature; flow information can be an adjunct to other methods of estimating blood flow and blood perfusion.

VH® IVUS is intended to be used in conjunction with imaging catheters during diagnostic ultrasound imaging of the peripheral and coronary vasculature. The Volcano VH IVUS System is intended to semi-automatically visualize boundary features and perform spectral analysis of RF ultrasound signals of vascular features that the user may wish to examine more closely during routine diagnostic ultrasound imaging examinations.

The pressure feature is intended for use in all blood vessels, including coronary and peripheral arteries, to measure intravascular blood pressure during diagnostic angiography and/or interventional procedures.

Rotational 45MHz feature is intended for the qualitative and quantitative evaluation of vascular morphology in the coronary arteries and vasculature. As an adjunct to conventional angiographic procedures to provide an image of the vessel lumen and wall structures. The pullback feature of the PIMr withdraws the imaging core within the protective sheath for a maximum of 15 cm.

Prescription Use (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH. Office of In Vitro Diagnostics and Radiological Health (OIR)

Sean M. Boyd -S

(Division Sign Off) Division of Radiological Health Office of In Vitro Diagnostic and Radiological Health

K123898 510(K) =

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