K Number
K111908
Device Name
BIOMET MICROFIXATION STERNAL CLOSURE SYSTEM
Date Cleared
2011-11-29

(147 days)

Product Code
Regulation Number
888.3040
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
The Biomet Microfixation Sternal Closure System is intended for use in the stabilization and fixation of fractures of the anterior chest wall including sternal fixation following sternotomy and sternal reconstructive surgical procedures, to promote fusion. The Biomet Microfixation Sternal Closure System is intended for use in patients with normal and poor bone quality.
Device Description
Biomet Microfixation Sternal Closure System contains a variety of plates and 2.4mm and 2.7mm diameter self-drilling screws with maximum length of 20mm. The tip of the screw is designed so that a predrilled hole is not required, but may be used. Material: Titanium. Sterility Information: The Biomet Microfixation Sternal Closure System will be marketed as non-sterile, single use devices. Validated steam sterilization recommendations are included in the package insert.
More Information

Not Found

No
The summary describes a mechanical sternal closure system with plates and screws, and the performance studies focus on mechanical testing. There is no mention of AI or ML in the intended use, device description, or performance studies.

No
A therapeutic device is one that treats or cures a disease or condition. This device is a surgical fixation system that stabilizes fractures and promotes fusion, which is a supportive and facilitative role in healing rather than an active treatment or cure.

No

The Biomet Microfixation Sternal Closure System is a surgical implant designed for the stabilization and fixation of chest wall fractures. It is used in treatment and repair, not for diagnosing medical conditions.

No

The device description clearly states it contains physical components (plates and screws made of titanium) and is marketed as non-sterile, single-use devices. It is a hardware-based medical device.

Based on the provided information, this device is not an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use is for the stabilization and fixation of fractures of the anterior chest wall, specifically sternal fixation following surgery. This is a surgical procedure performed directly on the patient's body.
  • Device Description: The device consists of plates and screws made of titanium, designed for surgical implantation.
  • Lack of IVD Characteristics: There is no mention of the device being used to examine specimens derived from the human body (like blood, urine, tissue, etc.) to provide information for diagnosis, monitoring, or compatibility testing.

IVD devices are used in vitro (outside the body) to analyze biological samples. This device is used in vivo (inside the body) for structural support.

N/A

Intended Use / Indications for Use

The Biomet Microfixation Sternal Closure System is intended for use in the stabilization and fixation of fractures of the anterior chest wall including sternal fixation following sternotomy and sternal reconstructive surgical procedures, to promote fusion. The Biomet Microfixation Sternal Closure System is intended for use in patients with normal and poor bone quality.

Product codes (comma separated list FDA assigned to the subject device)

87HRS, HWC

Device Description

Biomet Microfixation Sternal Closure System contains a variety of plates and 2.4mm and 2.7mm diameter self-drilling screws with maximum length of 20mm. The tip of the screw is designed so that a predrilled hole is not required, but may be used.
Material: Titanium

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

anterior chest wall, sternum

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Mechanical testing was performed to compare the Sternalock Blu Plating System to Stainless Steel surgical wire, for sternal closure. The testing was conducted using a polyurethane foam substrate which simulates Osteoporotic bone (see Patel Article, "Compressive properties of commercially available polyurethane foams as mechanical models for osteoporotic human cancellous bone") The mechanical testing showed that the Sternalock Blu Plating System had better performance compared to stainless steel surgical wire with respect to fatigue testing, shear force testing and lateral pull apart testing.

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s): If the device was cleared using the 510(k) pathway, identify the Predicate Device(s) K/DEN number used to claim substantial equivalence and list them here in a comma separated list exactly as they appear in the text. List the primary predicate first in the list.

K011076, K033740, K063506, K110574, K093772, K110789, K931271, K946173

Reference Device(s): Identify the Reference Device(s) K/DEN number and list them here in a comma separated list exactly as they appear in the text.

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information for the subject device only (e.g. presence / absence, what scope was granted / cleared under the PCCP, any restrictions, etc).

Not Found

§ 888.3040 Smooth or threaded metallic bone fixation fastener.

(a)
Identification. A smooth or threaded metallic bone fixation fastener is a device intended to be implanted that consists of a stiff wire segment or rod made of alloys, such as cobalt-chromium-molybdenum and stainless steel, and that may be smooth on the outside, fully or partially threaded, straight or U-shaped; and may be either blunt pointed, sharp pointed, or have a formed, slotted head on the end. It may be used for fixation of bone fractures, for bone reconstructions, as a guide pin for insertion of other implants, or it may be implanted through the skin so that a pulling force (traction) may be applied to the skeletal system.(b)
Classification. Class II.

0

NOV 2 9 2011

510(k) Summarv

September 27, 2011

Contact: Biomet Microfixation 1520 Tradeport Drive : Jacksonville, FL 32218-2480

Kim Reed, Regulatory Affairs Manager kim.reed@biomet.com 904-741-9443 fax 904-741-9425

Device Name: Biomet Microfixation Sternal Closure System Common Name: Plates and Screws

Classification Name: Single/multiple component metallic bone fixation appliances and accessories

Device Product Code: 87HRS (21 CFR 888.3030) Device Classification: Class II

Intended Use: The Biomet Microfixation Sternal Closure System is intended for use in the stabilization and fixation of fractures of the anterior chest wall including sternal fixation following sternotomy and sternal reconstructive surgical procedures, to promote fusion. The Biomet Microfixation Sternal Closure System is intended for use in patients with normal and poor bone quality.

Description: Biomet Microfixation Sternal Closure System contains a variety of plates and 2.4mm and 2.7mm diameter self-drilling screws with maximum length of 20mm. The tip of the screw is designed so that a predrilled hole is not required, but may be used.

Material: Titanium

Sterility Information: The Biomet Microfixation Sternal Closure System will be marketed as non-sterile, single use devices. Validated steam sterilization recommendations are included in the package insert.

Possible risks:

  • Poor bone formation, Osteoporosis, Osteomyelitis, inhibited revascularization, or 1. infection can cause loosening, bending, cracking or fracture of the device.
  • Nonunion or delayed union, which may lead to breakage of the implant. 2.
    1. Migration, bending, fracture or loosening of the implant.
    1. Metal sensitivity, or allergic reaction to a foreign body.
    1. Decrease in bone density due to stress shielding.
  • Pain, discomfort, abnormal sensation, or palpability due to the presence of the device. 6.
  • Increased fibrous tissue response around the fracture site and/or the implant. 7.
    1. Necrosis of bone.
  • Inadequate healing. g.
    1. Selection of screws which are longer than the depth of the sternum may cause possible impingement on structures internal to the chest wall including vessels, pleura and other structures.

Apart from these adverse effects there are always possible complications of any surgical procedure such as, but not limited to, infection, nerve damage, and pain which may not be related to the implant.

1

Image /page/1/Picture/1 description: The image shows the logo for Biomet Microfixation. The logo consists of the word "BIOMET" in a stylized font, with the word "MICROFIXATION" underneath in a smaller, sans-serif font. The logo is black and white and appears to be a vector graphic.

Substantial Equivalence: Biomet Microfixation considers the Biomet Microfixation Sternal Closure System to be equivalent to the Lorenz Sternal Closure System with Modular Screw (K011076), the Lorenz Sternal Closure System (K033740), the Lorenz Sternal Closure System (K063506) and the Biomet Microfixation Sternal Closure System (K110574) as well as Synthes Sternal Closure System (K093772), Synthes Zipfix (K110789), and Ethicon K931271 and K946173 Stainless Steel Suture Wire.

| Characteristic | Device In this submission | Predicates:
K011076,
K033740,
K063506,
K110574 | Predicates: Synthes K093772
and K110789 | Ethicon Stainless steel suture
wire K931271 and K946173 |
|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|-------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Design | The Sternal Closure System
includes the same plate and screw
configurations contained in the predicate
510k's listed to the right. | Identical | K093772 Titanium plates and
screws plates and screws
K110789 (PEEK Optima LT-3)
cable ties with detachable,
stainless steel needle. | Stainless steel wire |
| Material | Plates: Titanium
Screws: Titanium | Plates: Titanium
Screws: Titanium | Plates: Titanium
Screws: Titanium
Zipfix: PEEK LT-3 | 316L Stainless steel |
| Size Range | Plates: various configurations
Screws: 8mm to 20mm length | Plates: various
configurations
Screws:
8mm to 20mm length | unknown | Unknown |
| Indication | The Biomet Microfixation
Sternal Closure System is
intended for use in the
stabilization and fixation of
fractures of the anterior chest
wall including sternal fixation
following sternotomy and
sternal reconstructive surgical
procedures, to promote
fusion. The Biomet
Microfixation Sternal Closure
System is intended for use in
patients with normal and poor
bone quality. | The Biomet Microfixation
Sternal Closure System is
intended for use in the
stabilization and fixation of
fractures of the anterior chest
wall including sternal fixation
following sternotomy and
sternal reconstructive surgical
procedures. | Intended for use in the
primary or secondary
closure/repair of the sternum
following sternotomy or
fracture of the sternum to
stabilize the sternum and
promote fusion. | Current standard of care for
sternal closure applications – all
bone types

A nonabsorbable, sterile surgical
suture composed of 316L
stainless steel. Surgical stainless
steel suture is available as a
monofilament. Indicated for use
in abdominal wound closure,
hernia repair, sternal closure and
orthopaedic procedures including
cerclage and tendon repair. |
| Non-Clinical Testing | | | | |
| Mechanical testing was performed to compare the Sternalock Blu Plating System to Stainless Steel surgical wire, for sternal closure. The testing was
conducted using a polyurethane foam substrate which simulates Osteoporotic bone (see Patel Article, "Compressive properties of commercially
available polyurethane foams as mechanical models for osteoporotic human cancellous bone") The mechanical testing showed that the Sternalock
Blu Plating System had better performance compared to stainless steel surgical wire with respect to fatigue testing, shear force testing and lateral | | | | |

: .

. .

pull apart testing.

2

Image /page/2/Picture/1 description: The image shows the logo for the Department of Health & Human Services - USA. The logo features a stylized image of an eagle with its wings spread, and the text "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" is arranged around the eagle in a circular fashion. The logo is black and white.

Food and Drug Administration 10903 New Hampshire Avenue Document Control Room -WO66-G609 Silver Spring, MD 20993-0002

Biomet Microfixation % Ms. Kim Reed Regulatory Affairs Manager 1520 Tradeport Drive Jacksonville, Florida 32218

NOV 2 9 2011

Re: K111908

Trade/Device Name: Biomet Microfixation Sternal Closure System Regulation Number: 21 CFR 888.3030 Regulation Name: Single/multiple component metallic bone fixation appliance and accessories Regulatory Class: Class II Product Code: HRS. HWC Dated: September 27, 2011 Received: October 3, 2011

Dear Ms. Reed:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food. Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21

3

Page 2 - Ms. Kim Reed

CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please go to http://www.fda.gov/AboutFDA/CentersOffices/CDRH/CDRHOffices/ucm115809.htm for the Center for Devices and Radiological Health's (CDRH's) Office of Compliance. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDevices/Safety/ReportalProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/Resourcesfor You/Industry/default.htm.

http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours,

Mark N. Melkers Director Division of Surgical, Orthopedic and Restorative Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

4

Indications for Use

510(k) Number (if known): K111908

Device Name: Biomet Microfixation Sternal Closure System

Indications For Use:

The Biomet Microfixation Sternal Closure System is intended for use in the stabilization and fixation of fractures of the anterior chest wall including sternal fixation following sternotomy and sternal reconstructive surgical procedures, to promote fusion. The Biomet Microfixation Sternal Closure System is intended for use in patients with normal and poor bone quality.

Prescription Use XX (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use __ (21 CFR 801 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of GDRH, Office of Device Evaluation (ODE)

Mitchel Dues for MXM
(Division Sign-Off)

(Division Sign-Off) Division of Surgical, Orthopedic, and Restorative Devices

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510(k) Number 111508