K Number
K060762
Device Name
AESCULAP PEEK VERTEBRAL BODY REPLACEMENT SYSTEM
Manufacturer
Date Cleared
2006-09-14

(177 days)

Product Code
Regulation Number
888.3060
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
The Aesculap PEEK Vertebral Body Replacement (VBR) System is indicated for use in the thoracolumbar spine (T1 to L5) for partial or total replacement of a collapsed, damaged, or unstable vertebral body due to tumor or trauma (i.e. fracture) to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body. The Aesculap PEEK VBR System is intended for use with supplemental spinal fixation systems such as the Aesculap S4 System. The Aesculap PEEK VBR System implants can be used individually or in pairs. The Aesculap PEEK VBR System is also intended for use with bone graft.
Device Description
The Aesculap PEEK VBR System is a vertebral body replacement device that is implanted into the vertebral body space to improve stability of the spine. Components are offered in a variety of shapes and sizes to meet he requirements of the individual patient anatomy. Components are manufactured from PEEK – Optima (per ASTM F2026).
More Information

Not Found

No
The summary describes a passive implantable device made of PEEK for vertebral body replacement and does not mention any computational or analytical functions, let alone AI/ML.

Yes.
The device is used to replace a collapsed, damaged, or unstable vertebral body in the spine due to tumor or trauma, aiming to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body. These actions directly address a medical condition and restore function, aligning with the definition of a therapeutic device.

No
The device is a vertebral body replacement system, an implant used in surgery, not a tool for diagnosis.

No

The device description clearly states it is a vertebral body replacement device manufactured from PEEK, indicating it is a physical implant, not software.

No, this device is not an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use clearly describes a device that is surgically implanted into the spine to replace damaged vertebral bodies. This is a therapeutic and structural device, not a diagnostic one.
  • Device Description: The description details the material (PEEK) and the purpose of the device as a vertebral body replacement for spinal stability. This aligns with a surgical implant, not a diagnostic test.
  • Lack of Diagnostic Elements: There is no mention of analyzing samples (blood, tissue, etc.), detecting biomarkers, or providing information for diagnosis.
  • Performance Studies: The performance studies mentioned are related to the mechanical strength and stability of the implant (ASTM F 2077 and F1717), which are relevant for surgical devices, not IVDs.

IVD devices are used to examine specimens derived from the human body to provide information for the diagnosis, prevention, monitoring, treatment, or alleviation of disease. This device does not fit that description.

N/A

Intended Use / Indications for Use

The Aesculap PEEK Vertebral Body Replacement (VBR) System is indicated for use in the thoracolumbar spine (T1 to L5) for partial or total replacement of a collapsed, damaged, or unstable vertebral body due to tumor or trauma (i.e. fracture) to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body. The Aesculap PEEK VBR System is intended for use with supplemental spinal fixation systems such as the Aesculap S4 System. The Aesculap PEEK VBR System implants can be used individually or in pairs. The Aesculap PEEK VBR System is also intended for use with bone graft.

Product codes (comma separated list FDA assigned to the subject device)

MOP, MQP

Device Description

The Aesculap PEEK VBR System is a vertebral body replacement device that is implanted into the vertebral body space to improve stability of the spine. Components are offered in a variety of shapes and sizes to meet he requirements of the individual patient anatomy. Components are manufactured from PEEK – Optima (per ASTM F2026).

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

thoracolumbar spine (T1 to L5)

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Static and dynamic testing of the Aesculap VBR System was performed in accordance with ASTM F 2077 and/or F1717 as recommended by the FDA Guidance for Spinal System 510(k)'s.

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s): If the device was cleared using the 510(k) pathway, identify the Predicate Device(s) K/DEN number used to claim substantial equivalence and list them here in a comma separated list exactly as they appear in the text. List the primary predicate first in the list.

K031757, K041888, K043316, K051659, K052096, K042201, K042571, K051205

Reference Device(s): Identify the Reference Device(s) K/DEN number and list them here in a comma separated list exactly as they appear in the text.

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information for the subject device only (e.g. presence / absence, what scope was granted / cleared under the PCCP, any restrictions, etc).

Not Found

§ 888.3060 Spinal intervertebral body fixation orthosis.

(a)
Identification. A spinal intervertebral body fixation orthosis is a device intended to be implanted made of titanium. It consists of various vertebral plates that are punched into each of a series of vertebral bodies. An eye-type screw is inserted in a hole in the center of each of the plates. A braided cable is threaded through each eye-type screw. The cable is tightened with a tension device and it is fastened or crimped at each eye-type screw. The device is used to apply force to a series of vertebrae to correct “sway back,” scoliosis (lateral curvature of the spine), or other conditions.(b)
Classification. Class II.

0

SEP ] 4 2006

060762 Page 1 of 2

510(k) SUMMARY (as required by 21 CFR 807.92) B.

Aesculap PEEK VBR System 20 March 2006

| COMPANY: | Aesculap ®, Inc.
3773 Corporate Parkway
Center Valley, PA 18034
Establishment Registration Number: 2916714 |
|----------------------|---------------------------------------------------------------------------------------------------------------------|
| CONTACT: | Matthew M. Hull
800-258-1946 (phone)
610-791-6882 (fax) |
| TRADE NAME: | Aesculap PEEK VBR System |
| COMMON NAME: | Vertebral Body Replacement Device |
| CLASSIFICATION NAME: | Spinal Vertebral Body Replacement Device |
| REGULATION NUMBER: | 868.3060 |
| PRODUCT CODE: | MOP |

SUBSTANTIAL EQUIVALENCE

Aesculap®, Inc. believes that the Aesculap PEEK VBR System is substantially equivalent to:

  • PEEK Tetris Spinal Implant by Signus Medical LLC (K031757) 1)
    1. Curved PEEK Tetris Spinal Implant by Signus Medizintechnik (K041888)
    1. Rabea Spinal Implant by Signus Medizintechnik (K043316)
    1. Semial Spinal Implant by Signus Medical (K051659)
    1. Nubic Spinal Implant by Signus Medical ((K052096)
  • Novel VBR Spinal System by Alphatec/ Nexmed (K042201) 6)
  • Stryker Spine AVS PEEK Spacers (K042571) and (K051205) 7)

DEVICE DESCRIPTION

The Aesculap PEEK VBR System is a vertebral body replacement device that is implanted into the vertebral body space to improve stability of the spine. Components are offered in a variety of shapes and sizes to meet he requirements of the individual patient anatomy. Components are manufactured from PEEK – Optima (per ASTM F2026).

1

KO60762 Page 2 of 2

INDICATIONS FOR USE

The Aesculap PEEK VBR System is indicated for use in the thoracolumbar spine (T1 to L5) for partial or total replacement of a collapsed, damaged, or unstable vertebral body due to tumor or trauma (i.e. fracture) to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body. The Aesculap PEEK VBR System is intended for use with supplemental spinal fixation systems such as the Aesculap S4 System. The Aesculap PEEK VBR System implants can be used individually or in pairs. The Aesculap PEEK VBR System is also intended for use with bone graft.

TECHNOLIGICAL CHARACTERISTICS(compared to Predicate(s)}

The components of the Aesculap VBR System are offered in a similar range of shapes and sizes as the predicate devices. The material used for the Aesculap device is the same as that used to manufacture the predicate devices.

PERFORMANCE DATA

Static and dynamic testing of the Aesculap VBR System was performed in accordance with ASTM F 2077 and/or F1717 as recommended by the FDA Guidance for Spinal System 510(k)'s.

2

Image /page/2/Picture/1 description: The image shows the logo for the Department of Health and Human Services (HHS). The logo consists of a stylized eagle with three lines representing its wings, and the text "DEPARTMENT OF HEALTH AND HUMAN SERVICES . USA" arranged in a circular fashion around the eagle. The eagle is facing to the right.

Public Health Service

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

SEP 1 4 2006

Aesculap, Inc. % Mr. Matthew M. Hull Regulatory Affairs Manager 3773 Corporate Parkway Center Valley, Pennsylvania 18034

Re: K060762

Trade/Device Name: Aesculap PEEK Vertebral Body Replacement (VBR) System Regulation Number: 21 CFR 888.3060 Regulation Name: Spinal intervertebral body fixation orthosis Regulatory Class: Class II Product Code: MQP Dated: August 10, 2006 Received: August 11, 2006

Dear Mr. Hull:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to such additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA 's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

3

Page 2 - Mr. Matthew M. Hull

This letter will allow you to begin marketing your device as described in your Section 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Office of Compliance at (240) 276-0120. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Part 807.97). You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (240) 276-3150 or at its Internet address http://www.fda.gov/cdrh/industry/support/index.html.

Sincerely vours,

Cbavare Buetht
to

Mark N. Melkerson Director Division of General, Restorative and Neurological Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

4

Page 1 of 1

A. INDICATIONS FOR USE STATEMENT

510(k) Number: K060762

Device Name: Aesculap PEEK Vertebral Body Replacement (VBR) System

Indications for Use:

The Aesculap PEEK Vertebral Body Replacement (VBR) System is indicated for use in the thoracolumbar spine (T1 to L5) for partial or total replacement of a collapsed, damaged, or unstable vertebral body due to tumor or trauma (i.e. fracture) to achieve anterior decompression of the spinal cord and neural tissues, and to restore the height of a collapsed vertebral body. The Aesculap PEEK VBR System is intended for use with supplemental spinal fixation systems such as the Aesculap S4 System. The Aesculap PEEK VBR System implants can be used individually or in pairs. The Aesculap PEEK VBR System is also intended for use with bone graft.

X Prescription Use (per 21 CFR 801.109)

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED) Concurrence of CDRH, Office of Device Evaluation (ODE)

Sarbarc Budum

Division of General, Restorative, and Neurological Devices

510(k) Number K060762