K Number
K051405
Device Name
REGENSIS PERICARDIAL PATCH
Date Cleared
2005-08-31

(92 days)

Product Code
Regulation Number
870.3470
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
The CorMatrix Pericardial Patch is intended for the reconstruction and repair of the pericardium.
Device Description
The CorMatrix Pericardial Patch is manufactured from porcine small intestinal i he Conviatiix refleardial is manufactures are a seets with varying dimensions.
More Information

Not Found

No
The summary describes a biological patch for surgical repair and does not mention any software, algorithms, or AI/ML components.

Yes
The device is described as "intended for the reconstruction and repair of the pericardium," which are actions aimed at treating or alleviating a condition, thus making it a therapeutic device.

No
The device description states its intended use is for "reconstruction and repair of the pericardium," which indicates a therapeutic or restorative purpose rather than a diagnostic one.

No

The device description clearly states it is a "Pericardial Patch manufactured from porcine small intestinal submucosa," indicating it is a physical implantable device, not software.

Based on the provided information, this device is not an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use is "reconstruction and repair of the pericardium." This is a surgical procedure performed directly on a patient's tissue, not a test performed on a sample taken from the body to diagnose a condition.
  • Device Description: The device is a "Pericardial Patch" made from porcine tissue. This is a physical implant used for repair, not a reagent, instrument, or system used for in vitro testing.
  • Lack of IVD Characteristics: The description does not mention any of the typical characteristics of an IVD, such as:
    • Analyzing biological samples (blood, urine, tissue, etc.)
    • Detecting or measuring substances in samples
    • Providing diagnostic information about a patient's health status

Therefore, the CorMatrix Pericardial Patch is a surgical implant, not an in vitro diagnostic device.

N/A

Intended Use / Indications for Use

The CorMatrix Pericardial Patch is intended for the reconstruction and repair of the pericardium.

Product codes

DXZ

Device Description

The CorMatrix Pericardial Patch is manufactured from porcine small intestinal submucosa. The CorMatrix Pericardial Patch will be provided sterile in sheets with varying dimensions.

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

pericardium

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

The performance and safety of the CorMatrix Pericardial Patch was evaluated through extensive bench top and animal testing.

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

K980431, K020455, K012098, K031948

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 870.3470 Intracardiac patch or pledget made of polypropylene, polyethylene terephthalate, or polytetrafluoroethylene.

(a)
Identification. An intracardiac patch or pledget made of polypropylene, polyethylene terephthalate, or polytetrafluoroethylene is a fabric device placed in the heart that is used to repair septal defects, for patch grafting, to repair tissue, and to buttress sutures.(b)
Classification. Class II (performance standards).

0

AUG 3 1 2005

510(k) SUMMARY

510(k) Notification K051405

GENERAL INFORMATION

Applicant:

CorMatrix Cardiovascular, Inc. 919 Waverly Road Tallahassee, FL 32312 Phone: 850-508-0100 850-383-1699 FAX:

Contact Person:

Ms. Punam Gollamudi Regulatory Project Manager Experien Group, LLC 155 Moffett Park Drive, Suite A-101 Sunnyvale, CA 94089 Phone: 408-400-0856 FAX: 408-400-0865 Email: punam@experiengroup.com

Date Prepared:

July 18, 2005

DEVICE INFORMATION

Trade/Proprietary Name:

CorMatrix Pericardial Patch

Common/Classification Name/Product Code:

Product Code: DXZ Device Classification Name: Patch, Pericardial

Device Classification:

Class II

PREDICATE DEVICES

  • Cook Biotech, Inc., SurgiSIS (K980431) .
  • TEI Biosciences, Inc., TISSUEMEND (K020455) .
  • W.L. Gore & Associates, Inc., Preclude Pericardial Membrane (K012098) ◆
  • PM Devices, Inc., Peripatch Sheet (K031948) .

1

KOSI40S 0.222

INTENDED USE

INTENDED USE
The CorMatrix Pericardial Patch is intended for the reconstruction and repair of the pericardium.

PRODUCT DESCRIPTION

PRODUCT DESCRIPTION
The CorMatrix Pericardial Patch is manufactured from porcine small intestinal i he Conviatiix refleardial is manufactures are a seets with varying dimensions.

SUBSTANTIAL EQUIVALENCE

SUBSTANTIAL EQUIPALENCE
The proposed indications for the CorMatrix Pericardial Patch are substantially The proposed indications for use of the predicate devices. Any differences in the equivalent to the midications for ass or ass of the prices do not raise any new issues of safety or technological characterishes between the actives substantially equivalent to the predicate devices.

TESTING IN SUPPORT OF SUBSTANTIAL EQUIVALENCE DETERMINATION

I ESTING IN SUITORY OF DOBS INFERRActeristics between the CorMatrix Pericardial Patch and the predicate devices do not raise any new issues of safety or efficacy. The and the predicate devices do not raise any hased in the CorMatrix Pericardial Patch was performance and satery of the bro material as onimal testing. The collective evaluated infough oxlonstre block.ppMatrix Pericardial Patch is substantially equivalent to the respective predicate devices with regard to safety and efficacy.

SUMMARY

SUMMANT
The CorMatrix Pericardial Patch is substantially equivalent to the predicate devices.

2

DEPARTMENT OF HEALTH & HUMAN SERVICES

Public Health Service

Image /page/2/Picture/2 description: The image is a black and white seal for the U.S. Department of Health & Human Services. The seal is circular and contains the words "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" around the perimeter. Inside the circle is a stylized image of an eagle.

FEB 23 2009

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

CorMatrix Cardiovascular, Inc. c/o Ms. Punam Gollamudi Regulatory Consultant 919 Waverly Road Tallahassee, FL 32312

Re: K051405

CorMatrix Pericardial Patch Regulation Number: 21 CFR 870.3470 Regulation Name: Intracardiac patch or pledget Regulatory Class: II (two) Product Code: 74 DXZ Dated: July 18, 2005 Received: July 19, 2005

Dear Ms. Gollamudi:

This letter corrects our substantially equivalent letter of August 31, 2005.

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments or to devices that have been reclassified in accordance with the provisions of the Federal Food. Drug. and Cosmetic Act (Act) that do not require approval of a premarket approval (PMA). You may. therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices. good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21

3

Page 2 - Ms. Punam Gollamudi

CFR Part 807); labeling (21 CFR Part 801); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (sections 531-542 of the Act); 21 CFR 1000-1050.

This letter will allow you to continue marketing your device as described in your Section 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Office of Compliance at (240) 276-0120. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (240) 276-3150 or at its Internet address http://www.fda.gov/cdrh/dsma/dsmamain.html

Sincerely yours,

Duna D. Vachner

Bram D. Zuckerman, M.D. Director Division of Cardiovascular Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

4

Indications for Use

510(k) Number (if known): K051405

Device Name:_CorMatrix Pericardial Patch

Indications For Use: The CorMatrix Pericardial Patch is intended for the reconstruction and repair of the pericardium.

V Prescription Use (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use _ (21 CFR 801 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

Duna R. Jackson

(Division Sign-Off) Casion of Cardiovascular Devices

510(k) Number_1605 1405

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