K Number
K042108
Device Name
VISTA PLUS
Manufacturer
Date Cleared
2005-01-19

(168 days)

Product Code
Regulation Number
870.2800
Reference & Predicate Devices
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

Recorder :

Vista Plus is intended to record one, two or three channels surface ECG data from ambulatory patients (Holter) for period up to 11 days on one channel, 6 days on two channels, 4 days on three channels. Recorded data are intended to be analysed by holterSoft Ultima analysis on the ECG data.

Software :

HolterSoft Ultima is intended to read data acquired by the Vista Plus, analyze, edit, review, report and store these data. The system is intended to be used by trained operators under the direct supervision of a licensed Health Care practitioner in a hospital or a clinic environment.

Device Description

The VISTA PLUS holter recorder is a miniature ambulatory ECG recorder (ECG holter) which can continuously record one, two or three channels for a period up to several days ( 1 1 days on 1 channel, 6 days on 2 channels, 4 days on 3 channels).

The entire ECG is stored on a removable memory (compact falsh card) and can be read directly by HolterSoft Ultima software installed in a computer.

The VISTA PLUS has a microphone allowing the recording of voice messages from the physician or the patient (patient diary) during monitoring.

This ECG holter recorder does not perform any analysis on the ECG data.

The VISTA PLUS recorder weighs about 100gr. including flash card and batteries and is connected to the patient with a single multilead cable connected to the ECG electrodes.

The VISTA PLUS is supplied in a case containing a 128 MB compact flash memory card, one standard ECG cable 180cm, two neck protective pouches, one protective pouch for belt, one shoulder strap, two 1,5V AAA batterics, and a CD-Rom which contains multilingual user's manual.

AI/ML Overview

The provided text is a 510(k) summary for the NOVACOR VISTA PLUS Holter Recorder and HolterSoft Ultima software. It primarily focuses on demonstrating substantial equivalence to predicate devices rather than proving the device meets specific acceptance criteria through a dedicated study.

Therefore, many of the requested elements (acceptance criteria table, study details, sample sizes, expert qualifications, adjudication methods, MRMC studies, standalone performance, and ground truth establishment for training) are not available in the provided document. The document describes the device's technical specifications and intended use, and then compares these to predicate devices to establish equivalence.

However, I can extract the following information:

1. A table of (implied) acceptance criteria and the reported device performance

The document does not explicitly state "acceptance criteria" but instead provides a comparative table of specifications between the Vista Plus and its predicate devices. The implicit acceptance criterion is that the Vista Plus's specifications should be comparable to or better than the predicate devices to demonstrate substantial equivalence.

SpecificationVista Plus Performance (Novacor)Implied "Acceptance Criterion" (Based on Predicate Devices)
Recorder:
TypeDigitalDigital (matched)
Number of channels1, 2, 3Comparable (Predicate: 2,3,5,9; 2,3,12; 2,3)
Recording durationUp to: 264 hComparable or better (Predicate: Up to 96 h; Up to 48 h; Up to 120 h)
Sampling rate200 HzComparable (Predicate: 200 Hz; 1024 Hz; 175 Hz)
Resolution10 bitsComparable (Predicate: 15 bits; 12 bits; 10 bits)
Dynamic range+/- 6 mVComparable (Predicate: +/- 16 mV; +/- 6, +/-3 or +/- 1,5 mV; +/- 6 mV)
Bit resolution12 μVComparable (Predicate: 10 μV; 1,465 μV) - Note: Direct comparison difficult without more context.
CompressionNoFlexible (Predicate: Yes; No; No)
Analogue Bandwidth(Not specified directly, implied comparable)Comparable (Predicate: 0,05-25 Hz/0,05-80 Hz; 0,05-75 Hz; 0,05-60Hz)
Pacemaker spike detect. & reportYesYes (matched)
Open lead detectionYesYes (matched)
Impedance testYesYes (matched)
Storage capacityUp to 512 MBComparable or better (Predicate: Up to 64 MB; Up to 512 MB)
Memory typeCF cardComparable (Predicate: MMC or SD flash card; CF card; Internal Flash memory)
LCDYesYes (matched)
KeyboardYesYes (matched)
Size86x54x19Comparable (Predicate: 97x54x23 mm; 108x79x22 mm; 85x65x20 mm)
Weight100gComparable (Predicate: 110g; 145g; 100g)
Cables5 wiresComparable (Predicate: 3,5,7 wires; 5,7 wires; 5 wires)
AccessoriesBelt, shoulder strap, pouch, neck pouchComparable (Predicate: Belt + pouch)
Batteries2 AAA (1,5 V)Comparable (Predicate: 1 AA (1,5V), 1 or 2 AA (1,5V), 1 AA (1,5 V)º)
Rechargeable batteriesAcceptedAccepted (matched)
Patient ID recordVocal messageComparable (Predicate: With the display + keyboard)
ECG displayAt any time (programmable)Comparable (Predicate: Preview only)
Real-time built-in analysisYes, for real-time HR calculationComparable (Predicate: No; No; No) - Distinguishing feature, but not a mismatch for equivalence
Event markerYes (event key + vocal message)Yes (matched)
Display during recordingTime programmable, HR programmable, HR curve programmableComparable (Predicate: Yes (during hook up only); Yes (during hook up inly); Yes)
ECG analysisAnalysis software on PCAnalysis software on PC (matched)
Replay and analysis systemHolterSoft UltimaSyneview/Synescope; Holter for Windows; Philips 1810 series or 2010 software
Software:
TypeSoftwareSoftware/Workstation (matched)
PC basedYesYes (matched)
OS compatibilityWindows 98,NT,2000, XPComparable (Predicate: Windows 98/NT/2000/XP)
Input dataDigital (CF card from Vista series recorders)Comparable
Graphic User InterfaceYesYes (matched)
Templates (shapes) editionYesYes (matched)
Events list displayYesYes (matched)
Arrhythmia detectionYesYes (matched)
Conduction abnormalities detect.YesYes (matched)
ST segmentmultichannelmultichannel (matched)
SuperimpositionYesYes (matched)
PM patient analysisYesYes (matched)
Report customisationYesYes (matched)
Report editionYesYes (matched)
ECG strip edition and printingYesYes (matched)
ArchivingYesYes (matched)
Report ExportYesComparable (Predicate: No; No; No) - Advantage, but not a mismatch
AFibYesComparable (Predicate: No; No; No) - Advantage, but not a mismatch
EventsYesYes (matched)
Histograms/trends (RR histrogram)YesYes (matched)
Editing/Printing full disclosureYesYes (matched)
Editing tools for QRS ins./supp.YesYes (matched)
Time domain HRVYesYes (matched)
Frequency Domain HRVYesYes (matched)
QTYesComparable (Predicate: Yes (but not commercially available in the US); Yes; Yes)
OSASYesComparable (Predicate: No; No; No) - Advantage, but not a mismatch
NetworkingYesYes (matched)
Patient DiaryVoice MessagesComparable (Predicate: No; No; Text Input)

AFib Module: The document also compares the HolterSoft Ultima AF module to a predicate device for Atrial Fibrillation.

SpecificationHolterSoft Ultima AF module PerformanceImplied "Acceptance Criterion" (Based on Predicate)
Type of data recordedContinuous ECGECG strips (Comparable, different approach)
Sampling rate200 Hz218 Hz (Comparable)
Bit resolution10 μV15,6 μV (Comparable, higher resolution often beneficial)
Monitoring duration264 hours7 days (Comparable, 264 hours = 11 days, so better)
Recording duration264 hours10 minutes (Comparable, much longer duration so better)
Maximum number of eventsNo limit60 (Comparable, "No limit" is better)
Maximum event length264 hours10 minutes (Comparable, much longer duration so better)
Number of channels used for analys1 to 31 (Comparable, more channels for Novacor)

2. Sample sized used for the test set and the data provenance: Not available in the provided text. The submission is a 510(k) summary focusing on substantial equivalence to predicate devices based on technical specifications rather than a new clinical study with a test set.

3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts: Not available in the provided text. No specific test set or ground truth establishment process is described beyond the device's functional specifications.

4. Adjudication method (e.g. 2+1, 3+1, none) for the test set: Not available in the provided text.

5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance: Not available in the provided text. The device is an ECG recorder and analysis software without explicit AI assistance described, and no MRMC study is mentioned.

6. If a standalone (i.e. algorithm only without human-in-the-loop performance) was done: Not available in the provided text. The software performs analysis, but the submission doesn't detail standalone performance metrics in a study. The "Intended Use" states the system is "intended to be used by trained operators under the direct supervision of a licensed Health Care practitioner."

7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.): Not available in the provided text. The submission focuses on comparing technical specifications with predicate devices to establish substantial equivalence, not on validating performance against a "ground truth" derived from patient data.

8. The sample size for the training set: Not available in the provided text. The document does not describe the development of an algorithm that would typically require a training set.

9. How the ground truth for the training set was established: Not available in the provided text.

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Image /page/0/Picture/0 description: The image shows the word "NOVACOR" in a bold, sans-serif font. Above the word is a barcode. The barcode is made up of a series of vertical black lines of varying widths. The word "NOVACOR" is in all caps.

JAN | 9 2005

Image /page/0/Picture/2 description: The image shows a document with the address "4, passage Saint Antoine, 92508 Rueil Malmaison Cedex 08 France". It also includes the telephone number "Tel: +33 1 41 39 01 61" and fax number "Fax: +33 1 41 39 01 99". There is also some handwritten text at the top of the image that says "K042/08/ P1/5".

510(k) SUMMARY of SAFETY & EFFECTIVENESS

Submitter : NOVACOR France 4, Passage Saint Antoinc 92508 Rueil Malmaison cedex - France

Phone : 00 33 1 41 39 05 78 Fax : 00 33 1 41 39 01 99 E-mail : dgrenier(@novacor.fr

Contact person : Mrs. Dominique GRENIER - Regulatory Affairs Director

Device trade name : VISTA PLUS HOLTER RECORDER

Common/Usual name: Ambulatory ECG Holter Recorder

Classification name : Electrocardiograph, Ambulatory with analysis algorithm.

Predicate devices :

Spiderview - ELA MEDICAL Inc. - K032466 Cardio ID+(RZ153+) - ROZINN ELECTRONICS Inc. - K022540 Digitrak Plus -- BRAEMER CORP -- K993617

Device description :

The VISTA PLUS holter recorder is a miniature ambulatory ECG recorder (ECG holter) which can continuously record one, two or three channels for a period up to several days ( 1 1 days on 1 channel, 6 days on 2 channels, 4 days on 3 channels).

The entire ECG is stored on a removable memory (compact falsh card) and can be read directly by HolterSoft Ultima software installed in a computer.

The VISTA PLUS has a microphone allowing the recording of voice messages from the physician or the patient (patient diary) during monitoring.

This ECG holter recorder does not perform any analysis on the ECG data.

The VISTA PLUS recorder weighs about 100gr. including flash card and batteries and is connected to the patient with a single multilead cable connected to the ECG electrodes.

The VISTA PLUS is supplied in a case containing a 128 MB compact flash memory card, one standard ECG cable 180cm, two neck protective pouches, one protective pouch for belt, one shoulder strap, two 1,5V AAA batterics, and a CD-Rom which contains multilingual user's manual.

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Image /page/1/Picture/0 description: The image shows the word "NOVACOR" in a bold, serif font. Above the word is a barcode-like graphic consisting of vertical black lines of varying widths. The word is in all caps and is centered below the graphic.

92508 Rueil Malmaison ! Fax . +33 | 41 39 01 99

042108/52
43/5

Intended use :

VISTA PLUS and HOLTERSOFT ULTIMA INTENDED USE

Recorder :

Vista Plus is intended to record one, two or three channels surface ECG data from ambulatory patients (Holter) for period up to 11 days on one channels, 4 days on two channels. Recorded data are intended to be analysed by holterSoft Ultima analysis on the ECG data.

Software :

HolterSoft Ultima is intended to read data acquired by the Vista Plus, analyze, edit, review, report and store these data. The system is intended to be used by trained operators under the direct supervision of a licensed Health Carc practitioner in a hospital or a clinic environment.

The Heart Rate Variability (HRV) Option of HolterSoft Ultima is intended to be used for the analysis of the variability in RR intervals (heart rate) and to report measurements of the variability of Heart Rate data. HRV option is intended to provide only HRV measurements and is not intended to produce any interpretation of these measurements or any kind of diagnosis

The HRV measurements produces by HRV option are intended to be used by qualified personnel in evaluating the patient in conjunction with patient's clinical history, symptoms, other diagnostic tests, as well as the professional's clinical judgement.

The HRV feature of this device has not been shown to be safe and effective for a specific clinical diagnosis.

The Obstructive Sleep Apnoea Syndrome option is intended to be used for a specific analysis of the Variability of the Increment of the RR Intervals and to report the resulting measurements.

OSAS option is intended to provide only measurements and is not intended to produce any interpretation of these measurements or any kind of diagnosis

The OSAS measurements produces by HRV option are intended to be used by qualified personnel in evaluating the patient in conjunction with patient's clinical history, symptoms, other diagnostic tests, as well as the professional's clinical judgement.

The QT option of HolterSoft Ultima is intended to be used for analysis each ECG channel separately for obtaining the measurements of the QT Interval and the T wave.

QT option is intended to provide only QT Interval and T wave measurements and is not intended to produce any interpretation of these measurements or any kind of diagnosis

The measurements produces by QT option are intended to be used by qualified personnel in evaluating the patient in conjunction with patient's clinical history, symptoms, other diagnostic tests, as well as the professional's clinical judgement.

The QT option is intended to be used for adult patients only

Comparison of technology characteristics to predicate devices :

RECORDERS :

Predicate devices :

  • Spiderview ELA Medical K032466 -
  • Cardio Id+ (RZ153+) ROZINN ELECTRONICS K022540 -
  • Digitrak Plus BRAEMAR (commercialisé par ZYMED/PHILIPS) K993617 -
SpecificationVista PlusSpiderviewCardio Id+(RZ153+)Digitrak Plus
NovacorELA MedicalRozinnBraemar
TypeDigitalDigitalDigitalDigital
Number of channels1, 2, 32, 3, 5, 92, 3, 12 (option)2, 3
Recording durationUp to :264 hUp to 96 hUp to 48 hUp to 120 h
Sampling rate200 Hz200 Hz1024 Hz175 Hz
Resolution10 bits15 bits12 bits10 bits
Dynamic range+/- 6 mV+/- 16 mV+/- 6, +/-3 or+/- 6 mV
+/- 1,5 mV
Bit resolution12 μV10 μV1,465 μV
CompressionNoYesNoNo
AnalogueBandwidth0,05-25 Hz in standardmode; 0,05-80 Hz inno compression mode0,05-75 Hz0,05-60Hz
Pacemaker spikedetection andreportingYesYesYesYes
Open lead detectionYesYesYesYes
Impedance testYesYesYesYes
Storage capacityUp to 512 MBUp to 64 MBUp to 512 MB
Memory typeCF cardMMC or SD flash cardCF cardInternal Flashmemory (nonremovable)
LCDYesYesYesYes
KeyboardYesYesYesYes
Size86x54x1997x54x23 mm108x79x22 mm85x65x20 mm
Weight100g110g145 g100 g
Cables5 wires3, 5, 7 wires5, 7 wires5 wires
AccessoriesBelt, shoulderstrap, pouch, neckpouchBelt + pouchBelt + pouchBelt + pouch
Batteries2 AAA (1,5 V)1 AA (1,5 V)1 or 2 AA (1,5 V)1 AA (1,5 V)º
RechargcablebatteriesAcceptedAcceptedAcceptedAccepted
Patient ID recordVocal messageWith the display +keyboardWith the display +keyboardWith the display+ keyboard
ECG displayAt any time(programmable)Preview onlyPreview onlyPreview only
Real-type built inanalysisYes, for real-timeHR calculationNoNoNo
Event markerYes (event key +vocal message)YesYesYes
Display duringrecording
Time programmableYes (during hook upinly)YesYes
HR programmableNoNoNo
HR curve programmableNoNoNo
ECG analysisAnalysis softwareon PCAnalysis software onPCAnalysis softwareon PCAnalysissoftware on PC
Replay and analysissystemHolterSoft UltimaSyneview/SynescopeHolter for WindowsPhilips 1810series or 2010software

{2}------------------------------------------------

NOVACOR

<042108;
toine 92508 Rueil Malmaison Codex 08 Codex 08
92508 Rueil Malmaison Codex 08 Codex 08

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Image /page/3/Picture/0 description: The image shows the word "NOVACOR" in a bold, serif font. Above the word is a graphic that resembles a barcode. The barcode is made up of a series of vertical lines of varying widths. The word "NOVACOR" is in all caps.

142168152 4, passage Saint Antoine 92508 Rueil Malmaison Cedcx 08 France Tel : +33 1 41 39 (1 61
Fax : +33 1 41 39 (1 99

SOFTWARE :

Predicate devices for HolterSoft Ultima:

  • Synetec, ELA Medical K002817 -
  • Bylietoo, ELF Modical Tredical Tredition K010949 -
  • MARS Unity, MARQUETTE/GE K991786 -
SpecificationsHolterSoft UltimaSynetec2010 plus HolterMars Unity
NovacorELA MedicalAgilentMarquette
TypeSoftwareSoftwareSoftwareWorkstation
PC basedYesYesYesYes
OS compatibilityWindows98,NT,2000, XPWindows98/NT/2000/XPWindows 98,NT,2000,XPNA
Input dataDigital (CF cardfrom Vista seriesrecorders)Digital (PCMCIAflashcards fromSyneflad/MMC orSM cards fromSpiderview) andtapeDigital (USBtransfer fromZymed DigitrakPlus recorder)Digital (USBtransfer from the"Seer Light"interface) andtape
Graphic User InterfaceYesYesYesYes
Templates (shapes)editionYesYesYesYes
Events list displayYesYesYesNo
Arrhythmia detectionYesYesYesYes
ConductionabnormalitiesdetectionYesYesYesYes
ST segmentmultichannelmultichannelmultichannelmultichannel
SuperimpositionYesYesYesYes
PM patient analysisYesYesYesYes
Report customisationYesYesYesYes
Report editionYesYesYesYes
ECG strip edition andprintingYesYesYesYes
ArchivingYesYesYesYes
Report ExportYesNoNoNo
AFibYesNoNoNo
EventsYesYes?Yes
Histograms/trends
RR histrogramYesYesYesYes
Editing/Printing fulldisclosureYesYesYesYes
Editing tools for QRSinsertion/suppressionYesYes?Yes
Time domain HRVYesYesYesYes
Frequency DomainHRVYesYesYesYes
QTYesYes (but notcommerciallyavailable in theUS)YesYes
OSASYesNoNoNo
NetworkingYesYesYesYes
Patient DiaryVoice MessagesNoNoText Input

{4}------------------------------------------------

4, passage Saint An oine 92508 Rueil Malmaison Cedex 08 France Tel : +33 1 41 39 (11 61 Fax : +33 1 41 39 (11 99

Predicate devices for HolterSoft Ultima Atrial Fibrillation Module :

King of Heart Express + AF K, CARD GUARD/INSTROMEDIX, K020825
DeviceHolterSoft Ultima AF moduleKing of Heart Express + AF
Type of data recordedContinuous ECGECG strips
Sampling rate200 Hz218 Hz
Bit resolution10 μV15,6 μV
Monitoring duration264 hours7 days
Recording duration264 hours10 minutes
Maximum number of eventsNo limit60
Maximum event length264 hours10 minutes
Number of channels used for the analysis1 to 31

Conclusion :

The information presented in this submission provides reasonable assurance that the VISTA PLUS Holter ECG recorder will perform in a safe and effective manner.

{5}------------------------------------------------

DEPARTMENT OF HEALTH & HUMAN SERVICES

DEPARTMENT OF HEALTH & HUMAN SERVICES • USA

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

JAN 1 9 2005

Novacor c/o Mr. Dominique Grenier Regulatory Affairs Officer 4 Passage Saint Antoine 92508 Rueil Malmaison Cedex FRANCE

Re: K042108 Trade Name: Vista Plus Regulation Number: 21 CFR 870.2800 Regulation Name: Medical Magnetic Tape Recorder Regulatory Class: II (two) Product Code: MLO Dated: December 23, 2004 Received: December 29, 2004

Dear Mr. Grenier:

We have reviewed your Section 510(k) premarket notification of intent to market the device w oneve rowled your betermined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate for ass surfal to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The r ou may) mereleve, mains of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it n your device is elaborition (600 as coprols. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

{6}------------------------------------------------

Page 2 - Mr. Dominique Grenier

Please be advised that FDA's issuance of a substantial equivalence determination does not mean Please be advised that FDA s issuated of a backers. In other requirements of the Act
that FDA has made a determination that your device complies with other requirements of th that FDA has made a decormination and Jointinered by other Federal agencies. You must of any recetal statutes and regulations and using, but not limited to: registration and listing (21 comply with an the Act 3 requirements, metally, good manufacturing practice requirements as set CrK Fatt 807), adomig (21 CFR Part 820); and if applicable, the electronic forth in the quality systems (Sections 531-542 of the Act); 21 CFR 1000-1050. product radiation control provisions (beeting your device as described in your Section 510(k) This letter will anow you to ocgin maxicoing of substantial equivalence of your device to a legally prematicated predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please If you desire specific advice ior Joan as 1040) 276-0120. Also, please note the regulation entitled, Colliact the Office of Complaner as (21) = 17 = 1 = 1 807.97). You may obtain other general information on your responsibilities under the Act from the Division of Small other general informational and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 443-6597 or at its Internet address http://www.fda.gov/cdrh/dsma/dsmamain.html

Sincerely yours,

Blymmuma for

Bram D. Zuckerman, M.D. Director Division of Cardiovascular Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

{7}------------------------------------------------

K042108/52

Indications for Use

510(k) Number (if known): K041008

Device Name: VISTA PLUS

Indications For Use:

Recorder :

Vista Plus is intended to record one, two or three channels surface ECG data from ambulatory patients (Holter) for period up to 11 days on one channel, 6 days on two channels, 4 days on three channels. Recorded data are intended to be analysed by holterSoft Ultima analysis on the ECG data.

Software :

HolterSoft Ultima is intended to read data acquired by the Vista Plus, analyze, edit, review, report and store these data. The system is intended to be used by trained operators under the direct supervision of a licensed Health Care practitioner in a hospital or a clinic environment.

Blumuma

ovision Sign-Off vision of Cardiovascular Devices 42/00 5 | O(k) Number

Prescription Use × (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use _________________________________________________________________________________________________________________________________________________________ (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE) Page 1 of

§ 870.2800 Medical magnetic tape recorder.

(a)
Identification. A medical magnetic tape recorder is a device used to record and play back signals from, for example, physiological amplifiers, signal conditioners, or computers.(b)
Classification. Class II (performance standards).