K Number
K031673
Device Name
REFOBACIN -PALACOS G
Date Cleared
2004-05-25

(361 days)

Product Code
Regulation Number
888.3027
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
PALACOS G is indicated for use in the second stage of a two stage revision for total joint arthroplasty after the initial infection has been cleared.
Device Description
Palacos® G is an acrylic bone cement for use in orthopedic surgery. It is formed from powder and liquid by exothermic polymerization. It secures the fixation of the grafted artificial joint improving the transfer of forces at the interface implant - bone.
More Information

P810020

Not Found

No
The summary describes a bone cement and does not mention any AI or ML capabilities.

Yes

No
The device, Palacos G, is an acrylic bone cement used to secure artificial joint fixation in orthopedic surgery. Its function is to improve the transfer of forces at the implant-bone interface, not to diagnose a condition or disease.

No

The device description clearly states it is an acrylic bone cement, which is a physical material used in surgery, not a software application.

Based on the provided information, this device is not an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use is for securing the fixation of artificial joints in orthopedic surgery. This is a surgical procedure performed directly on the patient's body.
  • Device Description: The device is an acrylic bone cement used to fix implants to bone. This is a material used in vivo (within the living body).
  • Lack of IVD Characteristics: IVD devices are used to examine specimens (like blood, urine, tissue) in vitro (outside the living body) to provide information about a patient's health status. The description of Palacos G does not involve any such testing of specimens.

Therefore, Palacos G is a medical device used in surgery, not an in vitro diagnostic device.

N/A

Intended Use / Indications for Use

The cement is indicated for use in the second stage of a two stage revision for total joint arthroplasty after the initial infection has been cleared.

Product codes

LOD and MBB

Device Description

Palacos® G is an acrylic bone cement for use in orthopedic surgery. It is formed from powder and liquid by exothermic polymerization. It secures the fixation of the grafted artificial joint improving the transfer of forces at the interface implant - bone.

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

Not Found

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Not Found

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

PALACOS® R BONE CEMENT PMA Number: P810020

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 888.3027 Polymethylmethacrylate (PMMA) bone cement.

(a)
Identification. Polymethylmethacrylate (PMMA) bone cement is a device intended to be implanted that is made from methylmethacrylate, polymethylmethacrylate, esters of methacrylic acid, or copolymers containing polymethylmethacrylate and polystyrene. The device is intended for use in arthroplastic procedures of the hip, knee, and other joints for the fixation of polymer or metallic prosthetic implants to living bone.(b)
Classification. Class II (special controls). The special control for this device is the FDA guidance document entitled “Class II Special Controls Guidance Document: Polymethylmethacrylate (PMMA) Bone Cement.”

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K031673 page: 1/

510(k)

2nd supplement shipment:changes of May 2004

Palacos® G

MAY 2 5 2004

510(k) Summary

| Applicant's name and address | Heraeus Kulzer GmbH & Co. KG
Grüner Weg 11
D-63450 Hanau |
|--------------------------------------------------------------------------|-----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------|
| Contact persons | Dr. K.-D. Kühn
phone: +49 6081 959-264
fax: +49 6081 959-288
klaus-dieter.kuehn@heraeus.com |
| | Dr. C. Tuchscherer
phone: +49 6081 959-278
fax: +49 6081 959-288
christian.tuchscherer@heraeus.com |
| Date of actualized summary | May 11th, 2004 |
| Device trade name | PALACOS® G |
| Classification name | Bone Cement |
| Identification of the marketed device to which
equivalence is claimed | PALACOS® R BONE CEMENT
PMA Number: P810020 |
| Description of the device | Palacos® G is an acrylic bone cement for use in
orthopedic surgery. It is formed from powder and
liquid by exothermic polymerization. It secures the
fixation of the grafted artificial joint improving the
transfer of forces at the interface implant - bone. |
| Intended use | The cement is indicated for use in the second stage
of a two stage revision for total joint arthroplasty
after the initial infection has been cleared. |
| Comparison of technological characteristics | This is the well known Refobacin®-Palacos® R
being marketed for many years in Europe. It
performs most similar to Palacos R. |

Heraeus Kulzer GmbII & Co. KG, KULZER:, Bereich Mcdizin, Dr. Klaus-Dieter Kühn

Image /page/0/Picture/7 description: The image shows a logo with the words "Hercus Krutz" stacked on top of each other. The text is in a bold, sans-serif font. The logo appears to be for a company or organization. The background is a solid color, which contrasts with the text.

1

Image /page/1/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo consists of a circular seal with the text "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" around the perimeter. Inside the circle is a stylized symbol that resembles an abstract human figure with three horizontal lines representing arms or wings.

Public Health Service

MAY 2 5 2004

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

Dr. Klaus-Dieter Kühn Heraeus Kulzer GmbH & Co. KG Grüner Weg 11 D-63450 Hanau Germany

Re: K031673 Trade/Device Name: Palacos G Regulation Number: 21 CFR 888.3027 Regulation Name: Polymethylmethacrylate (PMMA) bone cement Regulatory Class: Class II Product Code: LOD and MBB Dated: February 24, 2004 Received: February 27, 2004

Dear Dr. Kühn:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to such additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be adviscd that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complics with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

2

Page 2 - Dr. Klaus-Dieter Kühn

This letter will allow you to begin marketing your device as described in your Section 510(k) I has letter will and w your to be finding of substantial equivalence of your device to a legally promatics notification. The a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Office of Compliance at (301) 594-4639. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97) you may obtain. Other general information on your responsibilities under the Act may be obtained from the Oiner general Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 443-6597 or at its Internet address http://www.fda.gov/cdrh/dsma/dsmamain.html

Sincerely yours,
Mark N. Milliken

Celia M. Witten, Ph.D., M.D. Director Division of General, Restorative and Neurological Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known): K031673

Device Name: PALACOS G

Indications For Use:

PALACOS G is indicated for use in the second stage of a two stage revision for total joint arthroplasty after the initial infection has been cleared.

Prescription Use yes (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use no (21 CFR 807 Subpart C)

(Please do not write BELOW THIS LINE-CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

Mark N. Milkersen

al. Restorative, and Neurological Devices

10(k) Number KO 31673

510(k) Number.

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