K Number
K022858
Manufacturer
Date Cleared
2002-09-06

(9 days)

Product Code
Regulation Number
892.1550
Reference & Predicate Devices
Predicate For
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The device is intended for use by a qualified physician for ultrasound evaluation of Fetal: Abdominal: Intra-operative (abdominal, thoracic, and vascular); Intra-operative Neuro; Pediatric; Small Organ (Thyroid, Breast, Testes, etc.); Neonatal Cephalic; Adult Cephalic; Trans-rectal; Trans vaginal; Trans-esoph. (non-cardiac); Cardiac Adult; Cardiac Pediatric; Trans-esoph (Cardiac), Peripheral Vessel.

Device Description

The SuperNova is a general purpose diagnostic ultrasound system. It consists of a Personal Display Unit approximately 4 inches wide and 3 inches high that can be held by the user in one hand and includes buttons for controlling the system and a screen that display ultrasound mages and user interface . The Imaging Unit can be held by the user in one hand accommodates a removable transducer module. Signals received from the transducer module are digitized and preprocessed. The transducer module comes into contact with the patient and both transmits and receives ultrasound energy. The docking station provides holders for the Personal Display Unit, the Imaging Unit, and transducer modules, as well as battery chargers.

AI/ML Overview

The provided text is a 510(k) Summary of Safety and Effectiveness for the Novasonics SuperNova Ultrasound System and its associated transducers. This document primarily focuses on establishing substantial equivalence to predicate devices for regulatory clearance, rather than presenting a performance study with detailed acceptance criteria and results.

Therefore, many of the requested details about acceptance criteria, study design, and performance metrics are not explicitly available in the provided text. The document is a regulatory submission demonstrating equivalency for market clearance, not typically a detailed report of a clinical efficacy trial.

Here's a breakdown of what can be extracted and what is not present:


1. Table of Acceptance Criteria and Reported Device Performance

The document does not provide a table of acceptance criteria with specific performance metrics (e.g., sensitivity, specificity, accuracy) or quantitative reported device performance in the way a clinical study report would.

Instead, the acceptance criteria are implicitly met by demonstrating substantial equivalence to predicate devices. The "performance" mentioned is in terms of the range of clinical applications and operating modes the device supports, which are stated to be a "subset of these approved devices."

The tables in the "Indications For Use" sections (pages 5-9) list the modes of operation for various clinical applications for each transducer type (Union of all, Curvilinear, Phased Array, Endo-Vaginal, Linear). The "N" in these tables indicates a "new indication" for the SuperNova system in those specific modes for those applications. This implies that the device is capable of performing these functions, and its performance for these functions is considered substantially equivalent to the predicate devices.

Acceptance Criteria (Implicit - Substantial Equivalence):
The device must be substantially equivalent to legally marketed predicate devices (Phillips ATL HDT® 5000 or GE Logiq 9™ systems) in terms of:

  • Intended Uses
  • Functional Modes
  • Technological Characteristics (design, construction, materials)

Reported Device Performance (Implicit - Functional Equivalence):
The SuperNova system, with its various transducers, is functionally capable of various modes (B-Mode, M-Mode, PWD-Mode, CWD, Color Doppler, Combined Modes, Color M-Mode) across a wide range of clinical applications (Fetal, Abdominal, Intra-operative, Pediatric, Small Organ, Neonatal Cephalic, Adult Cephalic, Trans-rectal, Trans-vaginal, Cardiac Adult, Cardiac Pediatric, Peripheral Vessel). The "N" indicates that these are "new indications" for this specific device, implying that its performance for these indications is deemed equivalent to the predicates.


2. Sample size used for the test set and the data provenance

The document does not specify a sample size for a test set or data provenance (e.g., country of origin, retrospective/prospective). This is a 510(k) submission, which relies on demonstrating substantial equivalence to existing devices, often through engineering analysis and comparison of technical specifications, rather than a new clinical study with a test set of patient data.


3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts

This information is not provided. Since there's no mention of a clinical test set with patient data, there's no mention of experts establishing ground truth for such a set.


4. Adjudication method (e.g. 2+1, 3+1, none) for the test set

This information is not provided. Without a test set and ground truth establishment, adjudication methods are not applicable here.


5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

An MRMC comparative effectiveness study was not done. The device described is a general-purpose diagnostic ultrasound system, not an AI-powered image analysis tool. Therefore, the concept of human readers improving with AI assistance is not relevant to this submission.


6. If a standalone (i.e. algorithm only without human-in-the-loop performance) was done

A standalone performance study was not done in the context of an algorithm or AI. This is a hardware diagnostic imaging device. Its "performance" refers to its ability to generate images and Doppler signals, which are then interpreted by a human operator (physician).


7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.)

Ground truth, in the context of a clinical study, is not explicitly mentioned as being used for performance evaluation in this 510(k) submission. The basis for clearance is substantial equivalence to predicate devices, which implies that the device can produce images/data comparable to those accepted as diagnostically valid from the predicate devices.


8. The sample size for the training set

The concept of a "training set" is not applicable to this type of device (a diagnostic ultrasound system without AI/machine learning components).


9. How the ground truth for the training set was established

Not applicable, as there is no training set for an AI/ML algorithm.


Summary of the K022858 510(k) Clearance:

The K022858 application for the Novasonics SuperNova Ultrasound System (with Doppler and Harmonic Imaging modes) was cleared by the FDA based on substantial equivalence to existing predicate devices (Phillips ATL HDT® 5000 and GE Logiq 9™ systems). The device is a general-purpose diagnostic ultrasound system, and its "performance" for regulatory purposes in this context is demonstrated by its technological equivalence and ability to perform the same (or a subset of) clinical functions as the cleared predicate devices. The FDA letter requests a postclearance special report that should contain "complete information, including acoustic output measurements based on production line devices," as an additional control for this Class II device, but this is a condition of clearance, not part of the initial performance study for substantial equivalence.

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Kozls5g

Attachment E: Summary of Safety and Effectiveness Prepared in accordance with 21 CFR Part 807.92(c). 510(k) Summary of Safety and effectiveness

This summary of 510(k) safety and effectiveness information is being submitted in accordance with the requirements of SMD 1990 and 21 CFR 807.92.

The assigned 510(k) number is:

Applicant Information:
Date Prepared:March 18, 2002
Name:Novasonics, Inc.1061 Terra Bella Ave.Mountain View, CA 94043
Contact Persons:Cheryl A. BlakeDirector, Quality AssuranceRegulatory Affairs
Telephone Numbers:650-230-2715
Fax Number:650-230-2818
Device Information:
Classification:Class II
Trade Name:Novasonics SuperNova Ultrasound System
Common Name:Diagnostic Ultrasound System

Nova Plus Diagnostic Ultrasound System Device Name:

FR NumberProduct Code
Ultrasonic Pulsed Doppler Imaging System892.155090-IYN
Ultrasonic Pulsed Echo Imaging System892.156090-IYO
Diagnostic Ultrasound Transducer892.157090-ITX

The HDI 5000: K002003 and the GE LOGIC 9: K011188 Marketed Device(s):

Device Description: The SuperNova is a general purpose diagnostic ultrasound system. It consists of a Personal Display Unit approximately 4 inches wide and 3 inches high that can be held by the user in one hand and includes buttons for controlling the system and a screen that display ultrasound mages and user interface . The Imaging Unit can be held by the user in one hand accommodates a removable transducer module. Signals received from the transducer module are digitized and preprocessed. The transducer module comes into contact with the patient and both transmits and receives ultrasound energy

The docking station provides holders for the Personal Display Unit, the Imaging Unit, and transducer modules, as well as battery chargers.

Indications For Use: The device is intended for use by a qualified physician for ultrasound evaluation of Fetal: Abdominal: Intra-operative (abdominal, thoracic, and vascular); Intra-operative Neuro; Pediatric; Small Organ (Thyroid, Breast, Testes, etc.); Neonatal Cephalic; Adult Cephalic; Trans-rectal; Trans

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vaginal; Trans-esoph. (non-cardiac); Cardiac Adult; Cardiac Pediatric; Trans-esoph (Cardiac), Peripheral Vessel.

Comparison with Predicate Device: The SuperNova ultrasound system equipped with Doppler and Harmonic imaging modes is substantially equivalent from both a transducer and user point of view to the Phillips ATL HDT® 5000 or the GE Logiq 9™ systems, that are currently in commercial distribution in the United States. Since the SuperNova unit has intended uses and functional modes that are a subset of these approved devices it is felt that the SuperNova unit meets the criteria for substantial equivalence as required for 510(k) filling.

The technological characteristics utilized in design, construction, and materials are similar, and have the same intended uses and basic operating modes as the predicate devices.

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DEPARTMENT OF HEALTH & HUMAN SERVICES

Image /page/2/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo is circular and contains the words "DEPARTMENT OF HEALTH & HUMAN SERVICES • USA" around the perimeter. Inside the circle is a stylized image of an eagle with three lines representing its wings.

Food and Druq Administrat 9200 Corporate Boulevaro Rockville MD 20850

Novasonics, Inc. % Mr. Mark Job Program Manager TÜV Product Service, Inc. 1775 Old Highway 8 NW, Suite 104 NEW BRIGHTON MN 55112-1891

Re: K022858

Trade Name: SuperNova Diagnostic Ultrasound Scanning System Regulation Number: 21 CFR 892.1550 Regulation Name: Ultrasonic pulsed doppler imaging system Regulation Number: 21 CFR 892.1560 Regulation Name: Ultrasonic pulsed echo imaging system Regulation Number: 21 CFR 892.1570 Regulation Name: Diagnostic ultrasonic transducer Regulatory Class: II Product Code: 90 IYN, IYO, and ITX Dated: August 23, 2002 Received: August 28, 2002

Dear Mr. Job:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and we have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

This determination of substantial equivalence applies to the following transducers intended for use with the SuperNova Diagnostic Ultrasound Scanning System, as described in your premarket notification:

Transducer Model Number

$\frac{C2^4}{S2^4}$

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If vour device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to such additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register. Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

This determination of substantial equivalence is granted on the condition that prior to shipping the first device, you submit a postclearance special report. This report should contain complete information, including acoustic output measurements based on production line devices, requested in Appendix G. (enclosed) of the Center's September 30, 1997 "Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers." If the special report is incomplete or contains unacceptable values (e.g., acoustic output greater than approved levels), then the 510(k) clearance may not apply to the production units which as a result may be considered adulterated or misbranded.

The special report should reference the manufacturer's 510(k) number. It should be clearly and prominently marked "ADD-TO-FILE" and should be submitted in duplicate to:

Food and Drug Administration Center for Devices and Radiological Health Document Mail Center (HFZ-401) 9200 Corporate Boulevard Rockville, Maryland 20850

This letter will allow you to begin marketing your device as described in your premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus permits your device to proceed to market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801, please contact the Office of Compliance at (301) 594-4591. Additionally, for questions on the promotion and advertising of your device, please contact the Office of Compliance at (301) 594-4639. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Part 807.97). Other general information on your responsibilities under the Act may be obtained from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or at (301) 443-6597 or at its Internet address "http://www.fda.gov/cdrh/dsmamain.html".

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If you have any questions regarding the content of this letter, please contact Rodrigo C. Perez at (301) 594-1212. · . ..

Sincerely yours,

David A. Lyon

for

Nancy C. Brogdon Director, Division of Reproductive, Abdominal and Radiological Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure(s)

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K 0.22858

Draft

SuperNova System with Doppler and Harmonic Imaging Modes

Transducer: SuperNova System (Union of all Transducer Types)

I ransucct. Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
General(Track I Only)Specific(Track I & III)B1MPWD2CWDColorDoppler3CombinedModes4Other5
OphthalmicOphthalmic
FetalNNNNNNN
AbdominalNNNNNNN
Intra-operative(Specify)6NNNNNN
Intra-operative(Neuro)NNNNN
Laparoscopic
PediatricNNNNNNN
Small Organ(Thyroid, Breast,Testes, etc.)NNNNNN
Fetal ImagingNeonatal CephalicNNNNNNN
& OtherAdult CephalicNNNNNNN
Trans-rectalNNNNNN
Trans-vaginalNNNNNN
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel.
(Conventional)
Musculo-skel.
(Superficial)
Intra-luminal
Other (Specify)
Cardiac AdultNNNNNNN
Cardiac PediatricNNNNNNN
CardiacTrans-esoph.
(Cardiac)
Other (Specify)
PeripheralPeripheral VesselNNNNNN
VesselOther (Specify)

N = new indication; P = previously cleared by FDA; E = added under Appendix E

1 Includes B-Mode and Harmonic imaging (HI)

2 Includes PWD-Mode imaging and High Pulse Repetition Rate PWD-Mode (HPRF)

3 Includes Color Doppler (CD), Directional Power Doppler (DPD), and Power Doppler (PD)

4 Includes B+M, B+M+CM, B+CD+M+CM, B+CD+PWD where CD could represent (CD, DPD, PD, or BD)

5 Color M-Mode (CM)

Color M-Mode (CM)
Intraoperative includes abdominal, thoracic (cardiac) and vascular (PV (Division Sign-Off)

David C. Hyam
(Division Sign-Off)

Prescription Use

Division of Reproductive, Abdomina and Radiological D 510(k) Number

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Draft

. SuperNova System with Curvilinear Transducer PN 84001

System: SuperNova System with Doppler and Harmonic Imaging modes

Transducer: C2

.

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
General(Track I Only)Specific(Track I & III)B1MPWD2CWDColorDoppler3CombinedModes4Other5
OphthalmicOphthalmic
FetalNNNNNN
Abdominal6NNNNNN
Intra-operative(Specify)
Intra-operative(Neuro)
Laparoscopic
PediatricNNNNNN
Small Organ(Thyroid, Breast,Testes, etc.)
Fetal Imaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel.(Conventional)
Musculo-skel.(Superficial)
Intra-luminal
Other (Specify)
Cardiac Adult
Cardiac Pediatric
CardiacTrans-esoph.(Cardiac)
Other (Specify)
PeripheralVesselPeripheral VesselNNNNNN
Other (Specify)

N = new indication; P = previously cleared by FDA; E = added under Appendix E

1 Includes B-Mode and Harmonic imaging (HI)

2 Includes PWD-Mode imaging and High Pulse Repetition Rate PWD-Mode (HPRF)

3 Includes Color Doppler (CD), Directional Power Doppler (DPD), and Power Doppler (PD)

4 Includes B+M, B+M+CM, B+CD+M+CM, B+CD+PWD where CD could represent (CD, DPD, PD, or BD)

5 Color M-Mode (CM)

6 Abdominal includes renal, GYN/Pelvic

Prescription Use

Daniel A. Segner

(Division Sign-Off) Division of Reproductive, Abdon and Radiological Dev 510(k) Number _

Revision 3 SuperNova

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Draft · .

SuperNova System with Phased (Sector) Array Transducer PN 84004

System: SuperNova System with Doppler and Harmonic Imaging modes

Transducer: S2

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
General(Track I Only)Specific(Track I & III)B1MPWD2CWDColorDoppler3CombinedModes4Other5
OphthalmicOphthalmic
FetalNNNNNNN
Abdominal6NNNNNNN
Intra-operative(Specify)7
Intra-operative(Neuro)
Laparoscopic
PediatricNNNNNNN
Small Organ(Thyroid, Breast,Testes, etc.)
Fetal Imaging& OtherNeonatal CephalicNNNNNNN
Adult CephalicNNNNNNN
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel.(Conventional)
Musculo-skel.(Superficial)
Intra-luminal
Other (Specify)
CardiacCardiac AdultNNNNNNN
Cardiac PediatricNNNNNNN
Trans-esoph.(Cardiac)
Other (Specify)
PeripheralVesselPeripheral Vessel
Other (Specify)

N = new indication; P = previously cleared by FDA; E = added under Appendix E

I Includes B-Mode and Harmonic imaging (HI)

2 Includes PWD-Mode imaging and High Pulse Repetition Rate PWD-Mode (HPRF)

3 Includes Color Doppler (CD), Directional Power Doppler (DPD), and Power Doppler (PD)

4 Includes B+M, B+M+CM, B+CD+M+CM, B+CD+PWD where CD could represent (CD, DPD, PD, or BD)

5 Color M-Mode (CM)

6 Abdominal includes renal, GYN/Pelvic

Prescription Use

Daniel A. Lyons

(Division Sign-Off) Division of Reproductive, Abdominal, Division of Reproductive and Radiological Devigo
510k) Number 510(k) Number _

Revision 3 SuperNova

12

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Draft

SuperNova System with Endo-Vaginal Transducer PN 84002

System: SuperNova System with Doppler and Harmonic Imaging modes

Transducer: EV

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
General(Track I Only)Specific(Track I & III)B1MPWD2CWDColorDoppler3CombinedModes4Other5
OphthalmicOphthalmic
FetalNNNNNN
Abdominal
Intra-operative(Specify)7
Intra-operative(Neuro)
Laparoscopic
Pediatric
Small Organ(Thyroid, Breast,Testes, etc.)
Fetal Imaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectalNNNNNN
Trans-vaginalNNNNNN
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel.(Conventional)
Musculo-skel.(Superficial)
Intra-luminal
Other (Specify)
Cardiac Adult
Cardiac Pediatric
CardiacTrans-esoph.(Cardiac)
Other (Specify)
PeripheralVesselPeripheral VesselOther (Specify)

N = new indication; P = previously cleared by FDA; E = added under Appendix E

1 Includes B-Mode and Harmonic imaging (HI)

2 Includes PWD-Mode imaging and High Pulse Repetition Rate PWD-Mode (HPRF)

3 Includes Color Doppler (CD), Directional Power Doppler (DPD), and Power Doppler (PD)

4 Includes B+M, B+M+CM, B+CD+M+CM, B+CD+PWD where CD could represent (CD, DPD, PD, or BD)

5 Color M-Mode (CM)

Prescription Use

David A. Segner

(Division Sign-Off) Division of Reproductive, Abdomina and Radiological Devices 510(k) Number _

Revision 3 SuperNova

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Draft -

SuperNova System with Linear Transducer PN 84003

System: SuperNova System with Doppler and Harmonic Imaging modes Transducer: L's

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows

Clinical ApplicationMode of Operation
General(Track I Only)Specific(Track I & III)B1MPWD2CWDColorDoppler3CombinedModes4Other5
OphthalmicOphthalmic
Fetal Imaging& OtherFetalNNNNNNN
Abdominal6NNNNNNN
Intra-operative(Specify)7NNNNNNN
Intra-operative(Neuro)NNNNN
Laparoscopic
PediatricNNNNNNN
Small Organ(Thyroid, Breast,Testes, etc.)NNNNNNN
Neonatal CephalicNNNNNNN
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel.(Conventional)
Musculo-skel.(Superficial)
Intra-luminal
Other (Specify)8
CardiacCardiac Adult
Cardiac Pediatric
Trans-esoph.(Cardiac)
Other (Specify)
PeripheralVesselPeripheral VesselNNNNNNN
Other (Specify)

N = new indication; P = previously cleared by FDA; E = added under Appendix E

1 Includes B-Mode and Harmonic imaging (HI)

2 Includes PWD-Mode imaging and High Pulse Repetition Rate PWD-Mode (HPRF)

3 Includes Color Doppler (CD), Directional Power Doppler (DPD), and Power Doppler (PD)

4 Includes B+M, B+M+CM, B+CD+M+CM, B+CD+PWD where CD could represent (CD, DPD, PD, or BD)

5 Color M-Mode (CM)

6 Abdominal includes renal, GYN/Pelvic

7 Intra operative includes abdominal, thoracic (cardiac) and vascular (PV)

Prescription Use

David A. Symm

(Division Sign-Off) Division of Reproductive, Abdo and Radiological Devices 510(k) Number

Revision 3 SuperNova

§ 892.1550 Ultrasonic pulsed doppler imaging system.

(a)
Identification. An ultrasonic pulsed doppler imaging system is a device that combines the features of continuous wave doppler-effect technology with pulsed-echo effect technology and is intended to determine stationary body tissue characteristics, such as depth or location of tissue interfaces or dynamic tissue characteristics such as velocity of blood or tissue motion. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories.(b)
Classification. Class II.