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510(k) Data Aggregation

    K Number
    K221648
    Date Cleared
    2022-08-25

    (79 days)

    Product Code
    Regulation Number
    880.6250
    Reference & Predicate Devices
    Predicate For
    N/A
    AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
    Intended Use

    This non-powdered patient examination glove is a disposable device intended for medical purposes that is worn on the examiner's hand to prevent contamination between patient and examiner.

    Device Description

    The subject device in this 510(k) Notification is Iconic Latex Glove - Powder Free Latex Examination Glove. The subject device is a patient examination glove made from Latex compound, Natural White color, powder free and non-sterile (Per 21 CFR 880.6250 - class I). The device meets the specifications in ASTM D3578-19 Standard specification for Rubber Examination Gloves. The available sizes of the subject devices are Small, Medium, Large, X-Larqe.

    AI/ML Overview

    The information provided describes the acceptance criteria and the study conducted for the Iconic Latex Glove, a non-powdered patient examination glove.

    Here's a breakdown of the requested information:

    1. A table of acceptance criteria and the reported device performance

    Characteristics / Test MethodologyAcceptance Criteria (from Section 4.0 and 7.0)Reported Device Performance (Average Results from Section 8.0)Final Results (from Section 8.0)
    Product CodeLYYLYYsame
    Intended UseA powder-free patient examination glove, disposable, for medical purposes, worn on examiner's hand to prevent contamination between patient and examiner. For over-the-counter use.This powder-free patient examination glove is a disposable device intended for medical purposes that is worn on the examiner's hand to prevent contamination between patient and examiner. The device is for over-the-counter use.same
    Material UsedLatex - Natural RubberLatex - Natural Rubbersame
    ColorN/A (Predicate: Natural White)Natural Whitesame
    SterilitySterile/Non-sterileNon sterile- (Not explicitly "same", but matches expectation)
    Single UseSingle useSingle usesame
    Freedom from pinholes (ASTM D5151-19)AQL 2.5 Inspection Level G-1Pass (across all sizes)Pass
    Overall Length (ASTM D3578-19)Min 230mmSmall: 230.8mm, Medium: 240.5mm, Large: 237.5mm, X-Large: 236.8mmPass
    Width (ASTM D3578-19)Small - 80mm (±10mm); Medium - 95mm (±10mm); Large - 110mm (±10mm); X-Large - 120mm (±10mm) (Note: Table in 4.0 has typo for Large - 110 vs table in 7.0/8.0 as 111)Small: 83mm, Medium: 96mm, Large: 108.4mm, X-Large: 118.7mmPass
    Thickness at Palm (ASTM D3578-19)Min 0.05 mm (from Section 4.0) Min: 0.08 mm (from Section 7.0/8.0)0.14mm (Small), 0.13mm (Medium), 0.12mm (Large), 0.14mm (X-Large)Pass
    Thickness at Fingertip (ASTM D3578-19)Min 0.05 mm (from Section 4.0) Min: 0.08 mm (from Section 7.0/8.0)0.10mm (Small), 0.10mm (Medium), 0.09mm (Large), 0.14mm (X-Large)Pass
    Physical Properties Before Aging (ASTM D3578-19)Tensile Strength = 18 MPa, min.; Ultimate Elongation = 650 % minTensile Strength: 20.8 (S), 23.4 (M), 21.4 (L), 20.7 (XL); Ultimate Elongation: 1018.7 (S), 878.9 (M), 1127.9 (L), 1097.6 (XL)Pass
    Stress at 500% Elongation (Before Aging)N/A (Standard specifies min tensile and ultimate elongation)3.3 (S), 3.9 (M), 3.7 (L), 3.3 (XL)Pass
    Physical Properties After Accelerated Aging (ASTM D3578-19)Tensile Strength = 14 MPa, min.; Ultimate Elongation = 500 % minTensile Strength: 15.3 (S), 17.3 (M), 16.9 (L), 17.4 (XL); Ultimate Elongation: 856.4 (S), 890.8 (M), 1077.3 (L), 956.8 (XL)Pass
    Residual Powder (ASTM D6124-06)< 2.0 mg/pc0.12 (S), 0.26 (M), 0.38 (L), 0.18 (XL)Pass
    Extractable Protein (ASTM D5712-15)Maximum 50 µg/dm²Small = 10.3 µg/dm², Medium = 8.7 µg/dm², Large = 9.6 µg/dm², X-Large = 8.8 µg/dm²Pass
    In vitro cytotoxicity (ISO 10993-5)Complies with the requirement of this standardComplies with the requirement of this standardPass
    Skin sensitization (ISO 10993-10)Non-SensitizerUnder the conditions of this study, the test article was a non-sensitizer (also stated as "Non - Skin Sensitized")Pass
    Systemic toxicity (ISO 10993-11)Not induce systemic toxicityNot induce systemic toxicityPass
    Irritation (ISO 10993-23)Non-irritantUnder the conditions of this study, the test article was a non-irritant (also stated as "Non-Irritant")Pass

    2. Sample size used for the test set and the data provenance

    The document does not specify the exact sample sizes used for each individual test (e.g., number of gloves tested for pinholes, physical properties, etc.). It only provides the average results for different glove sizes (Small, Medium, Large, X-Large). The data provenance is not explicitly stated beyond the fact that the tests were conducted by a company in Malaysia (Iconic Medicare Sdn Bhd is in Malaysia, and the general testing information implies this is where their reports originated). These appear to be retrospective tests conducted on manufactured batches of the device.

    3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts

    This is not applicable as the device is a medical glove, and the "ground truth" is established through standardized laboratory testing against international and national standards (ASTM, ISO). There are no "experts" in the sense of clinicians or radiologists establishing ground truth.

    4. Adjudication method (e.g. 2+1, 3+1, none) for the test set

    This is not applicable. Adjudication methods like "2+1" or "3+1" are typically used for interpreting results (e.g., medical images) where human judgment is involved in establishing a diagnosis or reading. The tests performed for this device are objective measurements against defined acceptance criteria in laboratory settings.

    5. If a multi-reader multi-case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance

    This is not applicable. The device is a medical glove, not an AI-powered diagnostic or assistive tool. MRMC studies are used to evaluate diagnostic performance with and without AI assistance.

    6. If a standalone (i.e. algorithm only without human-in-the loop performance) was done

    This is not applicable. The device is a medical glove, not an algorithm.

    7. The type of ground truth used (expert consensus, pathology, outcomes data, etc)

    The "ground truth" for this device's performance is established by objective measurements and results from standardized laboratory tests according to recognized national and international standards (ASTM D3578-19, ASTM D5151-19, ASTM D6124-06, ASTM D5712 -15, ISO 10993-5:2009, ISO 10993-10:2021, ISO 10993-11:2017, ISO 10993-23:2021).

    8. The sample size for the training set

    This is not applicable. The device is a physical product (a glove), not a machine learning model that requires a training set.

    9. How the ground truth for the training set was established

    This is not applicable (see point 8).

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