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SyMRI is a post-processing software medical device intended for use in visualization of soft tissue. SyMRI analyzes input data from MR imaging systems. SyMRI utilizes data from supported MR sequences to generate parametric maps of R1, R2 relaxation rates, and proton density (PD). SyMRI is intended for automatic labeling, visualization and volumetric quantification of segmentable brain tissues from a set of MR images. Brain tissue volumes are determined based on modeling of parametric maps from SyMRI. SyMRI can also generate multiple image contrasts from the parametric maps. SyMRI enables post-acquisition image contrast adjustment. SyMRI is indicated for head imaging. When interpreted by a trained physician, output from SyMRI can provide information useful in determining diagnosis. SyMRI 2D is intended to be used in combination with at least one other, conventional MR acquisition (e.g. T2-FLAIR). T1W and T2W images from SyMRI 3D may replace conventional MR images in a clinical setting when interpreting together with a conventional 3D T2W FLAIR image.

SyMRI works by post-processing a multi-delay, multi-echo acquisition into parametric maps. The acquisition is either a multi-slice 2D approach (M2D-MDME), consisting of 4 delays with a short and a long echo time each (8 images per slice), or a 3D approach (3D-QALAS) consisting of 4 delays with a short echo and 1 delay with a long echo time (5 images per slice). The parametric maps are R1, R2 relaxation rates, and proton density (PD). The inverse relaxation parameters, T1 relaxation time (1/R1), and T2 relaxation time (1/R2) are also provided as parametric maps. SyMRI also enables the users to obtain volumetric information in the head, including white matter (WM), gray matter (GM), cerebrospinal fluid (CSF), Myelin correlated (MyC) partial volume, brain parenchyma (BP) and intracranial cavity (IC). This is accomplished by using tissue definitions based on the parametric maps. The tissue definitions provide tissue partial volume, or tissue fraction, per voxel. SyMRI also provides image processing tools to extract the values of the parametric maps, and tissue partial volume, per individual voxel, per region of interest, or the entire imaging volume. The parametric maps can be visualized as contrast weighted MR images, such as T1, T2, PD, and Inversion Recovery (IR) weighted images (including T1-FLAIR, STIR, Double IR, and PSIR weighted images). The parametric maps can be visualized as contrast weighted MR images from SyMRI 3D may replace conventional MR images in a clinical setting when interpreting together with a conventional 3D T2W FLAIR image. SyMRI calculates the pixel signal intensity as a function of R1, R2, PD, and desired MR scanner settings, such as echo time (TE), repetition time (TR), and inversion delay time (TI). A number of default settings for TE, TR, and TI are provided, but the user has the ability to change the contrast of the images. SyMRI generates all the different image contrasts from the same parametric maps, derived from the same acquisition. This leads to enhanced image slice registration, owing to the absence of inter-acquisition patient movement. SyMRI provides the user the ability to change the contrast of the images after the acquisition. This is performed by adjusting the TE, TR, and/or TI parameters post-acquisition, to generate the specific contrast desired. SyMRI is intended to be used on data produced by any of the following acquisition sequences: - . MDME sequence data from GE MAGiC - MDME sequence data from Philips SyntAc - . MDME sequence data from Siemens TSE_MDME - 3D-QALAS sequence data from Philips 3DsyntAc