K Number
K990800
Device Name
INTERGARD KNITTED ULTRA THIN AND INTERGARD KNITTED COLLAGEN COATED AND HEPARIN BONDED VASCULAR PROTHESIS
Date Cleared
2001-01-08

(670 days)

Product Code
Regulation Number
870.3450
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
InterGard Collagen Coated and Heparin Bonded vascular prostheses are indicated for surgical repair, bypass, or replacement of arteries in the treatment of aneurysmal and occlusive disease of the abdominal aorta, visceral arteries, and peripheral arteries. Due to the low porosity of the grafts, these products are recommended for use in patients requiring heparinization prior to or during surgery.
Device Description
The InterGard Knitted Collagen Coated & Heparin Bonded Vascular Prostheses including The InterGard Knitted Ultra-Thin, are Vascular Grafts made of Dacron fabric and coated with bovine collagen. These products are offered in numerous lengths and diameters exceeding 6 mm.
More Information

Not Found

Not Found

No
The summary describes a physical vascular prosthesis made of Dacron fabric and coated with collagen, with no mention of software, algorithms, or any computational processing that would suggest AI/ML.

Yes
The device is a vascular prosthesis designed for surgical repair, bypass, or replacement of arteries to treat diseases, which aligns with the definition of a therapeutic device.

No
Explanation: The device is a vascular prosthesis intended for surgical repair, bypass, or replacement of arteries, which is a therapeutic function, not a diagnostic one.

No

The device description clearly states it is a vascular prosthesis made of Dacron fabric and coated with bovine collagen, which are physical materials, not software.

No, this device is not an IVD (In Vitro Diagnostic).

Here's why:

  • IVD Definition: In Vitro Diagnostics are medical devices used to perform tests on samples taken from the human body (like blood, urine, or tissue) to provide information about a person's health.
  • Device Description and Intended Use: The description clearly states that this device is a "Vascular Graft made of Dacron fabric and coated with bovine collagen" intended for "surgical repair, bypass, or replacement of arteries." This is a surgically implanted device used directly within the body to replace or repair blood vessels.
  • Lack of Diagnostic Function: The device does not perform any tests on samples to diagnose a condition or provide information about a patient's health status based on analysis of those samples.

Therefore, based on the provided information, this device falls under the category of a surgically implanted medical device, not an In Vitro Diagnostic.

N/A

Intended Use / Indications for Use

The InterGard Knitted Collagen Coated & Heparin Bonded Vascular Prosthesis is indicated for surgical repair, bypass or replacement of arteries in the treatment of aneurysmal and occlusive disease of the abdominal aotta, visceral arteries and pexipheral arteries. Due to the low porosity of the InterGard vascular grafts, these products are recommended for use in patients requiring heparinization prior to or during surgery. The Indications for these products are the same as the predicate devices.

Product codes

DSY

Device Description

The InterGard Knitted Collagen Coated & Heparin Bonded Vascular Prostheses including The Interesati Khinee Conagen Grafts made of Dacron fabric and coated with bovine Natied Onla-Xhin, are Visousan Shares are offered in numerous lengths and diameters exceeding 6 mm.

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

abdominal aotta, visceral arteries, pexipheral arteries

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Bench and animal studies were conducted and further supported by published clinical data.
Based on the conclusions drawn from the safety analysis conducted on this device, the Based on the conclusions wawn from the sace, and you conded grafts are safe and perform in a manner equivalent to the predicate devices mentioned above.

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

InterGard Knitted Collagen Coated Vascular Prostheses, InterGard Knitted Ultra-Thin Collagen Coated Vascular Prostheses

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 870.3450 Vascular graft prosthesis.

(a)
Identification. A vascular graft prosthesis is an implanted device intended to repair, replace, or bypass sections of native or artificial vessels, excluding coronary or cerebral vasculature, and to provide vascular access. It is commonly constructed of materials such as polyethylene terephthalate and polytetrafluoroethylene, and it may be coated with a biological coating, such as albumin or collagen, or a synthetic coating, such as silicone. The graft structure itself is not made of materials of animal origin, including human umbilical cords.(b)
Classification. Class II (special controls). The special control for this device is the FDA guidance document entitled “Guidance Document for Vascular Prostheses 510(k) Submissions.”

0

510(K) SUMMARY

This summary of safety and effectiveness information is being submitted in accordance with
This summer 1917 A 4980 - d 21 CFR . Part 807.92. I his suffifiary of safety and executive and 21 CFR, Part 807.92.

4990800

Robert Hill, Director Regulatory Affairs & Quality Assurance Name: InterVascular, La Ciotat, France Address: 33-442087786 Telephone: 33-442081349 Fax: InterGard Knitted Collagen Coated & Heparin Bonded Trade Names: Vascular Prostheses. Vascural Prosulesos.
InterGard Knitted Ultra-Thin Collagen Coated & Heparin Bonded Vascular Prostheses. Vascular Prostheses or Grafts Common Names: 21 CFR 870.3460, Vascular graft prostheses of 6 mm and Classification Name: greater diameter InterGard Knitted Collagen Coated Vascular Prostheses Predicate Names: InterGard Knitted Ultra-Thin Collagen Coated Vascular Prostheses

The InterGard Knitted Collagen Coated & Heparin Bonded Vascular Prostheses including The Interesati Khinee Conagen Grafts made of Dacron fabric and coated with bovine Natied Onla-Xhin, are Visousan Shares are offered in numerous lengths and diameters exceeding 6 mm.

The InterGard Knitted Collagen Coated & Heparin Bonded Vascular Prosthesis is indicated for surgical repair, bypass or replacement of arteries in the treatment of aneurysmal and occlusive disease of the abdominal aotta, visceral arteries and pexipheral arteries. Due to the low porosity of the InterGard vascular grafts, these products are recommended for use in patients requiring heparinization prior to or during surgery. The Indications for these products are the same as the predicate devices.

The InterGard Knitted Collagen Coated and Heparin Bonded Vascular Prostheses have similar technological characteristics as their predicate devices, including the use of the same underlying fabric and collagen coating material. These products also meet the same strength (circumferential probe burst and radial strength), collagen adherence, and water permeability

1

specifications as the predicate devices. Testing was conducted consistent with AAMI
n benefit and specifications as the predicate cevits: "These results were validated by bench and animal studies and further supported by published clinical data.

Based on the conclusions drawn from the safety analysis conducted on this device, the Based on the conclusions wawn from the sace, and you conded grafts are safe and perform in a manner equivalent to the predicate devices mentioned above. .

.

2

Image /page/2/Picture/1 description: The image shows the logo for the U.S. Department of Health & Human Services. The logo consists of a circular seal with the text "DEPARTMENT OF HEALTH & HUMAN SERVICES - USA" arranged around the perimeter. Inside the circle is a stylized emblem featuring three overlapping, curved shapes that resemble an abstract representation of the human form.

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

JAN - 8 2001

Mr. Vincent Bucci President President
Health Policy Associates, Inc. c/o InterVascular, Inc. C70 Walnut Street, Suite 12 Wellesley, MA 02181

K990800/S3
Trade Name: InterGard Knitted Ultra Thin Collagen Coated and Re : InterGard Knifted Urcra Thin Corpos and InterGard Heparin Bonded Vascular Proschebro and Grafts Regulatory Class: II Product Code: DSY Froddo. November 21, 2000 Baccived: December 11, 2000

Dear Mr. Bucci:

We have reviewed your Section .510 (k) notification of intent to market
is a more and show and shows and we have determined the device is We have reviewed your wection we have determined the device is the device referenced above and we indications for use stated in the
substantially equivalent (for the indications for use ted in substantially equivalent (for the increase devices marketed in enclosure) to legally marketed predicate activent date of the interstate commerce prior to May 20, 1970, che bare been reclassified
Medical Device Amendment, or to devices that have been Food, Drug, and Medical Device Amendments, of the Federal Food, Drug, and in accordance with the provisions of the rederal room, season of the productions of the productions Cosmetic Act (Act). You may, the Act. The general controls the general controls provisions of the neers for annual registration,
provisions of the Act include requirements for annual registration, and provisions of the Act Include requirements rise and the listing of devices, good mandidor.
prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special If your device is classified (see above) incoles may be subject to such (Premiarket Approval)) is major regulations affecting your device additional controls. additional controls. Existing mayor roylations, Title 21, Parts 800
can be found in the Code of Federal Regioninations, assumes compliance can be found in the Code of regulvation assumes compliance
to 895. A substantially equivalent determination assumes as set to 895. A substantially equivating assessments, as set
with the Current Good Manufacturing Practice requirements, Devices: with the Current Good nameraccaring (QS) for Medical Devices:
forth in the Quality System Regulation (QS) for Medical periodic forth in the Quality System Regulation (20) - , through periodic QS
General regulation (21 CFR Part 820) and that, FDD) will verify Su General regulation (2) Crk rate book (FDA) will verify such the rood and brug Administration may result in assumptions. assumptions. Frailure to Compry with the end asy and any our ements
regulatory action. In addition, FDA may publish further announcements

3

Page 2- Mr. Vincent Bucci

concerning your device in the Federal Register. Please note: this concerning your actroon submission submission does not affect any response to your premains under sections 531 through 542 of the Act obligation you might have ander broduct Radiation Control provisions, or other Federal laws or regulations.

This letter will allow you to begin marketing your device as described inis recei will arrow you co icention. The FDA finding of substantial in your 510(x) premainte noto a legally marketed predicate device equivalence or your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801 and additionally 809.10 for in vitro regulation (21 crk rare over and the promotion and advertising of your device, please contact the Office of Compliance at Also, please note the regulation entitled, (301) 594-4639. "Misbranding by reference to premarket notification" (21CFR 807.97). MESDIanding by Formation on your responsibilities under the Act may other general information on your as a manufacturers Assistance at its be obtained rrom the broad-2041 or (301) 443-6597 or at its Internet address "http://www.fda.gov/cdrh/dsma/dsmamain.html".

Sincerely yours,

Stacey Anthony Lee

or James E. Dillard III Director Division of Cardiovascular and Respiratory Devices Office of Device Evaluation Center for Devices and Radiological Health

4

PRODUCT INDICATIONS FOR USE (Page 1 of 1)

1990800

510(k) Number:

Device Names:

Indications for Use:

InterGard Knitted Collagen Coated and Heparin Bonded Vascular Prosthesis

: . .

InterGard Knitted Ultra Thin Collagen Coated and Heparin
Coated College Presthasis Bonded Vascular Prosthesis

InterGard Collagen Coated and Heparin Bonded vascular
Collagen Collage Collection ourgical repair, hypass, of InterGard Collagen Coated for surgical repair, bypass, or
prostheses are indicated for surgical repair, of aneurysmal prostheses are indicated in the treatment of aneurysmal replacement of arenes in the abdominal and and wisceral and occusive disease of the unceries. Due to the low porceity arteries, and penpheral arteries. Fecommended for use in of the grans, these products are resomment.
patients requiring heparinization prior to or during surgery.

Concurrence of CDRH, Office of Device Evaluation (ODE)

Prescription Use (Per 21 CFR 801.109)

Over-The-Counter Use

Aram Patrus. 1-5-

OR

Division of Cardiovascular & Respiratory Devices
510(k) Number K990800