K Number
K180408
Date Cleared
2018-04-13

(58 days)

Product Code
Regulation Number
892.1550
Reference & Predicate Devices
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The diagnostic ultrasound system (U60) is applicable for adults, pregnant women, pediatric patients' ultrasound evaluation in hospitals and clinics. It is intended for use in abdominal, obstetrics, gynecology, pediatric, small parts, urology, peripheral vascular, musculoskeletal (conventional and superficial), endovaginal and cardiac clinical applications, by or on the order of a physician or similarly qualified health care professional.

Device Description

The U60 is a portable Diagnostic Ultrasound System, which applies advanced technologies. Various image parameter adjustments, 15.0 inch LCD and diverse probes are configured to provide clear and stable images.

AI/ML Overview

The provided text is a 510(k) premarket notification for the Edan Instruments U60 Diagnostic Ultrasound System. This type of FDA submission aims to demonstrate "substantial equivalence" to a predicate device, rather than proving safety and effectiveness from scratch through extensive clinical trials for a new, revolutionary device.

Therefore, the document does not contain detailed information about acceptance criteria and studies demonstrating that the device meets those acceptance criteria in the way one might expect for a novel AI/ML device or a device with new clinical indications. Instead, it focuses on demonstrating that the U60 is substantially equivalent to a predicate device (the U50 Diagnostic Ultrasound System) by showing similar design, intended use, indications for use, fundamental scientific technology, and performance, while complying with relevant safety standards.

Here's a breakdown of what can and cannot be extracted from the document based on your request:

Information Present in the Document:

  • 1. Table of Acceptance Criteria and Reported Device Performance:
    • The document presents a comparison table (within "9. Predicate Device Comparison") between the U60 (subject device) and the U50 (predicate device) across various parameters. This table effectively serves as the "acceptance criteria" for demonstrating substantial equivalence, where the acceptance criteria is generally "same" or "similar" to the predicate.
    • Table of Performance (Comparison to Predicate):
ItemU60 R1.0 Ultrasound System (Edan Instruments) PerformanceU50 R2.2 Ultrasound System (Edan Instruments) PerformanceComparison Result
Intended UseDiagnostic ultrasound imaging or fluid flow analysis of the human bodyDiagnostic ultrasound imaging or fluid flow analysis of the human bodySame
Indications for UseApplicable for adults, pregnant women, pediatric patients' ultrasound evaluation in hospitals and clinics for abdominal, obstetrics, gynecology, pediatric, small parts, urology, peripheral vascular, musculoskeletal (conventional and superficial), endovaginal and cardiac clinical applications.Same as U60Same
Safety StandardsIEC 60601-1, IEC 60601-1-2, IEC 60601-2-37, ISO 10993-1, -5, -10, AIUM, NEMA UD 2, UD3SameSame
Patient Contact MaterialsComplies with ISO 10993Complies with ISO 10993Same
Software life cycle processesComplies with IEC 62304Complies with IEC 62304Same
Mode of OperationsContinuous operationContinuous operationSame
General Imaging modeB-Mode, M-Mode, Color, PDI/DPDI, PW, CWB-Mode, M-Mode, Color, PDI/DPDI, PW, CWSame
Measurements (B-Mode)Distance, Area, Volume, Ratio, Histogram, AngleSameSame
Measurements (M-Mode)Distance, Time, Slope, Heart RateSameSame
Measurements (D-Mode)Time, Heart Rate, Velocity, Acceleration, RI, PI, Auto (auto trace)SameSame
Scanning methodElectronic convex, Electronic linear with slant scanningSameSame
Cine loop1227 frames1227 framesSame
Focus NumberMax=4Max=4Same
Software PackagesAbdomen, obstetric, small parts, gynecology, cardiology, urology, vascular, Pediatrics.SameSame
Principle of OperationApplying high voltage burst to Piezoelectric material in transducer and detect reflected echo to construct diagnostic imageSameSame
Acoustic OutputTrack 3: MI, TIS, TIC, TIB (TI Range 0-6.0), Derated ISPTA: 720 W/cm² max, Mechanic Index ≤1.9 max or Derated ISPPA 190 W/cm² maxSameSame
Transducer TypesConvex Array, Linear Array, Micro Convex Array, Phased ArraySameSame
Transducer Frequency2.0-15.0 MHz2.0-15.0 MHzSame
Primary Display15inch (1024*768)12.1inch (1024*768)Difference
Dimensions/Weight220 mm (W) × 370 mm (L) × 350 mm (H), 8.1kg net weight330 mm (W) × 320 mm (L) × 220 mm (H), 7.8kg net weightDifference
PrinterB/W video thermal printer, Color video thermal printer, Graph/text laser jet printerSameSame
Storage MediaDVD, USB stickDVD, USB stickSame
Temperature (Operating)0°C ~40°C5°C ~40°CDifference
Temperature (Transport/Storage)-20~55°C-20~55°CSame
Relative humidity (Operating)15% ~ 95%RH (no condensation)25% ~ 80%RH (no condensation)Difference
Relative humidity (Transport/Storage)15% ~ 95%RH (no condensation)25% ~ 93%RH (no condensation)Difference
Atmospheric pressure (Operating)860hPa ~1060hPa860hPa ~1060hPaSame
Atmospheric pressure (Transport/Storage)700hPa ~1060hPa700hPa ~1060hPaSame
Power RequirementsAC: 100-240V 50/60HzAC: 100-240V 50/60HzSame
Operation SystemLinuxLinuxSame
Safety ClassificationsClass I (Type BF, main unit: IPX0, probes: IPX7, footswitch: IP68, not suitable for use in flammable gas)SameSame
Displayed depth20-320mm (Probe Dependent)20-320mm (Probe Dependent)Same
Gray Scales256256Same
Dynamic range150dB150dBSame
TGC8 segments8 segmentsSame
ZoomUp to 400%Up to 400%Same
B-Mode Measurement AccuracyDepth/Distance: Max 324mm, Accuracy ≤±5% Area: Max 1126 cm², Accuracy ≤±10% Angle: 0-180°, Accuracy ≤±3% Ratio: Max 1.0, Accuracy <=10% Volume: Max 999 cm³, Accuracy <=15%Same values and accuracies listed for U50Same
M-mode Measurement AccuracyDepth: Max 324mm, Accuracy <=5% Time: Max 13s, Accuracy <=5% Heart rate: Max 999bpm, Accuracy <=5% Slope: Max 999mm/s, Accuracy <=10%Same values and accuracies listed for U50Same
PW mode velocity Measurement AccuracyRange: 0.5-2.5m/s, Accuracy <=10%Same values and accuracies listed for U50Same
CW mode velocity Measurement AccuracyRange: 0.5-2.5m/s, Accuracy <=10%Same values and accuracies listed for U50Same
  • 2. Sample sized used for the test set and the data provenance:

    • The document explicitly states: "Clinical testing is not required." and "Verification and validation testing has been conducted on the U60 Ultrasound Imaging System."
    • This indicates that no patient data (test set) was used in a clinical study to evaluate the device's performance against clinical endpoints. The acceptance criteria and performance data are based on bench testing and engineering verification, which demonstrate that the device performs within established technical specifications comparable to the predicate. Therefore, information about sample size or data provenance (country, retrospective/prospective) for a clinical test set is not applicable here.
  • 6. If a standalone (i.e. algorithm only without human-in-the-loop performance) was done:

    • This is not an AI/ML device. It's a diagnostic ultrasound system. Its "performance" refers to its imaging capabilities and measurement accuracy, which are evaluated intrinsically through non-clinical (bench) testing, not through standalone algorithm performance.
  • 7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.):

    • For the non-clinical tests (e.g., B-Mode Measurement Accuracy, M-mode Measurement Accuracy), the "ground truth" would be established by known physical standards or phantoms with precisely measured characteristics (e.g., a known distance in a test object for distance accuracy). This is standard for ultrasound system performance verification.

Information NOT Present / Not Applicable based on the Document:

  • 3. Number of experts used to establish the ground truth for the test set and the qualifications of those experts (e.g., radiologist with 10 years of experience): Not applicable, as no clinical test set requiring expert ground truth was performed for this 510(k) submission.
  • 4. Adjudication method (e.g., 2+1, 3+1, none) for the test set: Not applicable, for the reason above.
  • 5. If a multi reader multi case (MRMC) comparative effectiveness study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance: Not applicable, as this is a diagnostic ultrasound system, not an AI-assisted device.
  • 8. The sample size for the training set: Not applicable, as this is not an AI/ML device with a training set.
  • 9. How the ground truth for the training set was established: Not applicable, for the reason above.

In summary:

This 510(k) submission for the Edan Instruments U60 Diagnostic Ultrasound System demonstrates substantial equivalence to a predicate (U50) primarily through non-clinical bench testing and adherence to recognized performance and safety standards. It is not an AI/ML device, nor does it present clinical study data with human-in-the-loop performance or expert-established ground truth, as is often seen with AI-based medical devices. The "acceptance criteria" discussed are a comparison of technical specifications and performance metrics to an already cleared device, asserting that the new device is "same" or "similar" and therefore equally safe and effective.

{0}------------------------------------------------

April 13, 2018

Image /page/0/Picture/1 description: The image contains the logo of the U.S. Food and Drug Administration (FDA). On the left is the Department of Health & Human Services logo. To the right of that is the FDA logo, which is a blue square with the letters "FDA" in white. To the right of the blue square is the text "U.S. FOOD & DRUG ADMINISTRATION" in blue.

Edan Instruments, Inc. % Mr. Doug Worth Sr. Dir. US RA/QA Edan Medical 1200 Crossman Avenue, Suite 200 SUNNYVALE CA 94089

Re: K180408

Trade/Device Name: U60 Diagnostic Ultrasound System Regulation Number: 21 CFR 892.1550 Regulation Name: Ultrasonic pulsed doppler imaging system Regulatory Class: II Product Code: IYN, IYO, ITX Dated: March 28, 2018 Received: April 2, 2018

Dear Mr. Worth:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (OS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

{1}------------------------------------------------

Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

For comprehensive regulatory information about mediation-emitting products, including information about labeling regulations, please see Device Advice (https://www.fda.gov/MedicalDevices/DeviceRegulationandGuidance/) and CDRH Learn

(http://www.fda.gov/Training/CDRHLearn). Additionally, you may contact the Division of Industry and Consumer Education (DICE) to ask a question about a specific regulatory topic. See the DICE website (http://www.fda.gov/DICE) for more information or contact DICE by email (DICE@fda.hhs.gov) or phone (1-800-638-2041 or 301-796-7100).

Sincerely,

Michael D. O'Hara For

Robert Ochs. Ph.D. Director Division of Radiological Health Office of In Vitro Diagnostics and Radiological Health Center for Devices and Radiological Health

Enclosure

{2}------------------------------------------------

DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration

Indications for Use

510(k) Number (if known)

K180408

Device Name

U60 Diagnostic Ultrasound System

Indications for Use (Describe)

The diagnostic ultrasound system (U60) is applicable for adults, pregnant women, pediatric patients' ultrasound evaluation in hospitals and clinics. It is intended for use in abdominal, obstetrics, gynecology, pediatric, small parts, urology, peripheral vascular, musculoskeletal (conventional and superficial), endovaginal and cardiac clinical applications, by or on the order of a physician or similarly qualified health care professional.

Prescription Use (Part 21 CFR 801 Subpart D) Over-The-Counter Use (21 CFR 801 Subpart C)
--------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

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EF

Type of Use (Select one or both, as applicable)

{3}------------------------------------------------

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / ObstetricsPPPPPP
AbdominalPPPPPP
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
PediatricPPPPPP
Small Organ (Specify) *PPPPPP
FetalImaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginalPPPPPP
Trans-urethral
Musculo-skeletal(Conventional)PPPPPP
Musculo-skeletal (Superficial)PPPPPP
Intravascular
Other (Specify) **PPPPPP
Adult CardiacPPPPPPP
Pediatric CardiacPPPPPP
CardiacIntravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascularPPPPPP
Other (Specify)

U60 Diagnostic Ultrasound System

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI= Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology
[1]:PDI: Power Doppler Imaging , DPDI: Directional Power Doppler Imaging ,

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{4}------------------------------------------------

Clinical ApplicationMode of OperationBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
GeneralSpecific
OphthalmicOphthalmic
FetalImaging& OtherFetal / ObstetricsPPPPPP
AbdominalPPPPPP
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **PPPPPP
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

U60 with C352UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI= Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW * Small Organ includes Thyroid, Testes, Breast Note

** Other use includes Urology, Gynecology
[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{5}------------------------------------------------

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:
Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
FetalImaging& OtherFetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *PPPPPP
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal (Conventional)PPPPPP
Musculo-skeletal (Superficial)PPPPPP
Intravascular
Other (Specify) **
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascularPPPPPP
Other (Specify)

U60 with L1042UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{6}------------------------------------------------

Clinical ApplicationMode of Operation
SpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *PPPPPP
FetalImaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)PPPPPP
Musculo-skeletal (Superficial)PPPPPP
Intravascular
Other (Specify) **
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralPeripheral vascularPPPPPP
vascularOther (Specify)

U60 with L742UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{7}------------------------------------------------

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / ObstetricsPPPPPP
FetalImaging& OtherAbdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginalPPPPPP
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

U60 with E612UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI= Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW * Small Organ includes Thyroid, Testes, Breast Note

** Other use includes Urology, Gynecology
_______________
[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{8}------------------------------------------------

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
FetalImaging& OtherFetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
PediatricPPPPPP
Small Organ (Specify) *
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **
CardiacAdult Cardiac
Pediatric CardiacPPPPPP
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

U60 with C612UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI= Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW * Small Organ includes Thyroid, Testes, Breast Note

** Other use includes Urology, Gynecology
[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{9}------------------------------------------------

Clinical ApplicationMode of Operation
SpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
GeneralOphthalmic
FetalImaging& OtherFetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
PediatricPPPPPPP
Small Organ (Specify) *
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal (Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **
Adult Cardiac
CardiacPediatric CardiacPPPPPPP
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

U60 with C6152UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{10}------------------------------------------------

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / Obstetrics
AbdominalPPPPPP
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *
FetalImaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **
CardiacAdult CardiacPPPPPPP
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralPeripheral vascular
vascularOther (Specify)

U60 with C422UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{11}------------------------------------------------

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
PediatricPPPPPPP
Small Organ (Specify) *PPPPPPP
FetalImaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)PPPPPPP
Musculo-skeletal (Superficial)PPPPPPP
Intravascular
Other (Specify) **
Adult Cardiac
CardiacPediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralPeripheral vascularPPPPPPP
vascularOther (Specify)

U60 with L552UB Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW * Small Organ includes Thyroid, Testes, Breast Note

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

{12}------------------------------------------------

U60 with C5-2b Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
Fetal / ObstetricsPPPPPP
AbdominalPPPPPP
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *
FetalImaging& OtherNeonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **PPPPPP
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology
[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging
[2]: Biopsy Guidance
CAST THE CONSTITUTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTION CONSULTIO

[3]: Harmonic Imaging, This feature does not use contrast agent.

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Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
FetalImaging& OtherFetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)
Musculo-skeletal (Superficial)
Intravascular
Other (Specify) **
CardiacAdult CardiacPPPPPPP
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascular
Other (Specify)

U60 with P5-1b Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW * Small Organ includes Thyroid, Testes, Breast Note

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

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U60 with L15-7b Transducer

Intended Use: Diagnostic ultrasound imaging or fluid flow analysis of the human body as follows:

Clinical ApplicationMode of Operation
GeneralSpecificBMPWCWColorCombined(Specify) [1]Other(Specify) [2][3]
OphthalmicOphthalmic
FetalImaging& OtherFetal / Obstetrics
Abdominal
Intra-operative (Specify)
Intra-operative (Neuro logical)
Laparoscopic
Pediatric
Small Organ (Specify) *PPPPPPP
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Musculo-skeletal(Conventional)PPPPPP
Musculo-skeletal (Superficial)PPPPPP
Intravascular
Other (Specify) **
CardiacAdult Cardiac
Pediatric Cardiac
Intravascular(Cardiac)
Trans-esoph.(Cardiac)
Intra- cardiac
PeripheralvascularPeripheral vascularPPPPPP
Other (Specify)

N = new indication; P = previously cleared by FDA; E = added under this appendix PDI=Power Doppler Imaging Additional comments: Combined mode: B+M, B+PW, B+Color, B+PDI/DPDI, B+Color+PW, B+PDI/DPDI +PW Note * Small Organ includes Thyroid, Testes, Breast

** Other use includes Urology, Gynecology

[1]: PDI: Power Doppler Imaging ,DPDI: Directional Power Doppler Imaging

[2]: Biopsy Guidance

[3]: Harmonic Imaging, This feature does not use contrast agent.

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510(k) Summary

Prepared in accordance with the requirements of 21 CFR Part 807.92

1. Submitter:Edan Instruments, Inc.
#15 Jinhui Road, Jinsha Community, Kengzi Sub-District, Pingshan District, Shenzhen, 518122 P.R.China.
Tel.: (0755) 26858736
Fax: +1 (408) 418-4059
Contact Person:Crystal Cai
Date prepared:February 12, 2018
2. Device nameand classification:Device Name: U60 Diagnostic Ultrasound System
Model: U60
Classification Name:
892.1550 System, Imaging, Pulsed Doppler, UltrasonicProduct code: IYN
892.1560 Ultrasonic, Pulsed echo, ImagingProduct code: IYO
892.1570 Transducer, Ultrasonic, DiagnosticProduct code: ITX
Regulatory Class: Class II
3.PremarketNotification ClassIII Certificationand SummaryNot applicable, the subject device is Class II.
4. PredicateDevice(s):U50 Diagnostic ultrasound system/ K173003/ Edan Instruments, Inc.
5. Pre-Submission,IDENot applicable, there is no prior submission.

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    1. Device The U60 is a portable Diagnostic Ultrasound System, which applies Description: advanced technologies. Various image parameter adjustments, 15.0 inch LCD and diverse probes are configured to provide clear and stable images.
  • The diagnostic ultrasound system (U60) is applicable for adults, 7. Intended Use: pregnant women, pediatric patients' ultrasound evaluation in hospitals and clinics. It is intended for use in abdominal, obstetrics, gynecology, pediatric, small parts, urology, peripheral vascular, musculoskeletal (conventional and superficial), endovaginal and cardiac clinical applications, by or on the order of a physician or similarly qualified health care professional.

9. Predicate Device Comparison

Comparison to the predicate devices, the subject device has the same intended use, similar product design, same performance effectiveness, performance safety as the predicate device as summarized in the following tables:

ItemU60 R1.0Ultrasound System(Edan Instruments)U50 R2.2Ultrasound System(Edan Instruments)ComparisonResult
510(k)NumberCurrent SubmissionK173003
ManufacturerEDAN InstrumentsEDAN InstrumentsSame
Intended UseDiagnostic ultrasound imaging orfluid flow analysis of the humanbodyDiagnostic ultrasound imaging orfluid flow analysis of the humanbodySame
Indicationsfor UseThe diagnostic ultrasound system(U60) is applicable for adults,pregnant women, pediatricpatients' ultrasound evaluation inhospitals and clinics. It isintended for use in abdominal,obstetrics, gynecology, pediatric,small parts, urology, peripheralvascular, musculoskeletal(conventional and superficial),endovaginal and cardiac clinicalapplications, by or on the orderof a physician or similarlyqualified health careprofessional.The diagnostic ultrasound system(U50) is applicable for adults,pregnant women, pediatricpatients' ultrasound evaluation inhospitals and clinics. It isintended for use in abdominal,obstetrics, gynecology, pediatric,small parts, urology, peripheralvascular, musculoskeletal(conventional and superficial),endovaginal and cardiac clinicalapplications, by or on the orderof a physician or similarlyqualified health careprofessional.Same
Installationand Usea. Portable Equipmentb. Mobile Equipment (when thesystem is installed on the mobiletrolley)a. Portable Equipmentb. Mobile Equipment (when thesystem is installed on the mobiletrolley)Same
SafetyStandardsIEC 60601-1IEC 60601-1-2IEC 60601-2-37ISO 10993-1, -5, -10AIUM, NEMA UD 2, UD3IEC 60601-1IEC 60601-1-2IEC 60601-2-37ISO 10993-1, -5, -10AIUM, NEMA UD 2, UD3Same
PatientContactMaterialsComplies with ISO 10993Complies with ISO 10993Same
Software lifecycleprocessesComplies with the standard: IEC 62304Complies with the standard: IEC 62304Same
Mode ofOperationsContinuous operationContinuous operationSame
GeneralImaging modeB-Mode, M-Mode, Color,PDI/DPDI, PW, CWB-Mode, M-Mode, Color,PDI/DPDI, PW, CWSame
MeasurementsB-Mode: Distance, Area,Volume, Ratio, Histogram andAngleB-Mode: Distance, Area,Volume, Ratio, Histogram andAngleSame
M-Mode: Distance, Time, Slope,and Heart RateM-Mode: Distance, Time, Slope,and Heart Rate
D-Mode: Time, Heart Rate,Velocity, Acceleration, RI, PI andAuto (auto trace)D-Mode: Time, Heart Rate,Velocity, Acceleration, RI, PI andAuto (auto trace)
ScanningmethodElectronic convexElectronic linear with slantscanningElectronic convexElectronic linear with slantscanningSame
Cine loop1227 frames1227 framesSame
FocusNumberMax=4Max=4Same
SoftwarePackagesAbdomen, obstetric, small parts,gynecology, cardiology, urology,vascular and Pediatrics.Abdomen, obstetric, small parts,gynecology, cardiology, urology,vascular and Pediatrics.Same
Principle ofOperationApplying high voltage burst tothe Piezoelectric material in thetransducer and detect reflectedecho to construct diagnosticimageApplying high voltage burst tothe Piezoelectric material in thetransducer and detect reflectedecho to construct diagnosticimageSame
AcousticOutputTrack 3: MI, TIS, TIC, TIB(TIRange 0-6.0)Derated ISPTA: 720 W/cm²maximum, Mechanic Index ≤1.9maximum or Derated ISPPA 190W/cm² maxTrack 3: MI, TIS, TIC, TIB(TIRange 0-6.0)Derated ISPTA: 720 W/cm²maximum, Mechanic Index ≤1.9maximum or Derated ISPPA 190W/cm² maxSame
TransducerTypesConvex ArrayLinear ArrayMicro Convex ArrayPhased ArrayConvex ArrayLinear ArrayMicro Convex ArrayPhased ArraySame
TransducerFrequency2.0-15.0 MHz2.0-15.0 MHzSame
PrimaryDisplayPrimary Screen:15inch(1024*768)Primary Screen:12.1inch(1024*768)Difference
Ports
Dimensions/Weight220 mm (W) × 370 mm (L) ×350mm (H)net weight 8.1kg330 mm (W) × 320 mm (L) ×220 mm (H)net weight 7.8kgDifference
PrinterB/W video thermal printerColor video thermal printerGraph/text laser jet printerB/W video thermal printerColor video thermal printerGraph/text laser jet printerSame
StorageMediaDVD, USB stickDVD, USB stickSame
TemperatureOperating: 0°C 40°CTransport/ Storage: -2055°COperating: 5°C 40°CTransport/ Storage: -2055°CDifference
RelativehumidityOperating: 15% ~ 95%RH (nocondensation)Transport/Storage:15% ~95%RH (no condensation)Operating: 25% ~ 80%RH (nocondensation)Transport/Storage:25% ~93%RH (no condensation)Difference
AtmosphericpressureOperating: 860hPa ~1060hPaTransport/Storage:700hPa~1060hPaOperating: 860hPa ~1060hPaTransport/Storage:700hPa~1060hPaSame
PowerRequirementsAC: 100-240V 50/60HzAC: 100-240V 50/60HzSame
OperationSystemLinuxLinuxSame
Safety Classifications
Typeofprotectionagainstelectric shockClass IClass ISame
The degree ofprotectionagainstelectric shockType BF.Type BF.Same
The degree ofprotectionagainstharmfulingressofliquidThe main unit : IPX0,probes : IPX7Footswitch: IP68The main unit : IPX0,probes : IPX7Footswitch: IP68Same
The degree ofsafetyofapplication inthepresenceofaflammablegasEquipment not suitable for use inthe presence of a flammable gasEquipment not suitable for use inthe presence of a flammable gasSame
The degree ofRFGroup 1, Class AGroup 1, Class ASame
Disinfection
DisinfectionProbe:2.4%Glutaraldehyde,0.55%Ortho-Phthalaldehyde.Needle guide:75% medical alcohol,Probe:2.4%Glutaraldehyde,0.55%Ortho-Phthalaldehyde.Needle guide:75% medical alcohol,Same
2.4%Glutaraldehyde.2.4%Glutaraldehyde.
Performance
Displayeddepth20-320mm (Probe Dependent)20-320mm (Probe Dependent)Same
Gray Scales256256Same
Dynamicrange150dB150dBSame
TGC8 segments8 segmentsSame
ZoomUp to 400%Up to 400%Same
Image Adjustments
Image typeImage type
GainGain
DepthDepth
TGCTGC
Freq(Frequency)Freq(Frequency)
Gray MapGray Map
Dynamic RangeDynamic Range
RejectionRejection
Focus PositionFocus Position
Focus NumberFocus Number
B ModeParameterseSRI(SpackleImaging) RejectioneSRI(SpackleImaging) RejectionSame
Pseudo colorPseudo color
Spatial CompoundSpatial Compound
GAO(Gain Auto Optimization)GAO(Gain Auto Optimization)
Scan AngleScan Angle
Scan ModeScan Mode
Frame PersistFrame Persist
H Reverse(horizontal)H Reverse(horizontal)
V Reverse(vertical)V Reverse(vertical)
90°Rotate90°Rotate
B/W InvertB/W Invert
FreqFreq
Sweep SpeedSweep Speed
Display LayoutDisplay Layout
M ModeParametersGray MapGray MapSame
Focus PositionFocus Position
Dynamic RangeDynamic Range
Pseudo ColorPseudo Color
Line AverageLine Average
Flow typeFlow type
GainGain
Color Mode& PowerFreqFreq
WallfilterWallfilter
DopplerMode &DirectionalPower ModeParametersPRF(PulsedFrequency) RepetitionPRF(PulsedFrequency) RepetitionSame
Base LineBase Line
InvertInvert
Dual LiveDual Live
Angle SteerAngle Steer
Packet sizePacket size
PersistPersist
ThresholdThreshold
Smooth FilterSmooth Filter
ROI box positionand sizeROI box positionand size
adjustmentadjustment
Flow typeFlow type
GainGain
PRFPRFSame
InvertInvert
Angle steerAngle steer
Correction AngleCorrection Angle
Quick AngleQuick Angle
PWModeParametersBase LineBase Line
Sample VolumeSample VolumeSame
WallfilterWallfilter
FreqFreq
Duplex and TriplexDuplex and Triplex
Pseudo ColorPseudo Color
Dyn RngDyn Rng
VolumeVolume
Sweep SpeedSweep Speed
HPRFHPRF
Flow typeFlow typeSame
GainGain
PRFPRF
InvertInvert
Angle steerAngle steer
CWModeParametersCorrection AngleCorrection Angle
Quick AngleQuick Angle
Base LineBase Line
WallfilterWallfilter
Pseudo ColorPseudo Color
Dynamic RangeDynamic Range
VolumeVolume
Sweep SpeedSweep Speed
B-Mode Measurement Accuracy
RangeofDepth/DistanceMaximum 324 mmMaximum 324 mmSame
AccuracyofDepth/Distance≤±5%≤±5%Same
Range of AreaMaximum 1126 cm²Maximum 1126 cm²Same
AccuracyofArea≤±10%≤±10%Same
RangeofAngle0-180°0-180°Same
AccuracyofAngle≤±3%≤±3%Same
RangeofMaximum 1.0Maximum 1.0Same
Ratio
Accuracy of Ratio$<=10%$$<=10%$Same
Range of VolumeMaximum 999 cm³Maximum 999 cm³Same
Accuracy of Volume$<=15%$$<=15%$Same
M-mode Measurement Accuracy
Range of DepthMaximum 324mmMaximum 324mmSame
Accuracy of Depth$<=5%$$<=5%$Same
Range of TimeMaximum 13sMaximum 13sSame
Accuracy of Time$<=5%$$<=5%$Same
Range of Heart rateMaximum 999bpmMaximum 999bpmSame
Accuracy of Heart rate$<=5%$$<=5%$Same
Range of SlopeMaximum 999mm/sMaximum 999mm/sSame
Accuracy of Slope$<=10%$$<=10%$Same
PW mode velocity Measurement Accuracy
Range0.5-2.5m/s0.5-2.5m/sSame
Accuracy$<=10%$$<=10%$Same
CW mode velocity Measurement Accuracy
Range0.5-2.5m/s0.5-2.5m/sSame
Accuracy$<=10%$$<=10%$Same

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The subject device has same intended use, similar product design, and same performance effectiveness, as the predicate device. There are no significant differences between the primary predicate. There are no new questions of safety and/or effectiveness. There are no changes to the intended use, indications for use, nor fundamental scientific technology.

10. Effectiveness and Safety Considerations:

Clinical test:

Clinical testing is not required.

Non-clinical test:

The U60 Diagnostic Ultrasound System complies with:

  • (1) ANSI AAMI ES60601-1:2005/(R)2012 and A1:2012, C1:2009/(R)2012 and A2:2010/(R)2012 (Consolidated Text) Medical electrical equipment - Part 1: General requirements for basic safety and essential performance

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(IEC 60601-1:2005, MOD).

(2) I IEC 60601-1-2:2014: Medical electrical equipment - part 1-2: general requirements for basic safety and essential performance - collateral standard: electromagnetic compatibility - requirements and tests.

(3) IEC 60601-2-37 Edition 2.0 2007, Medical Electrical Equipment - Part 2-37: Particular Requirements for The Basic Safety And Essential Performance Of Ultrasonic Medical Diagnostic And Monitoring Equipment.

(4) NEMA UD 3, Edition 2004 Standard for real-time display of thermal and mechanical acoustic output Indies on diagnostic ultrasound equipment.

(5) Acoustic output testing as per the guideline "Information for Manufacturers Seeking Marketing Clearance of Diagnostic Ultrasound Systems and Transducers" dated September 9, 2008.

(6) NEMA, UD2, Edition 2004 for acoustic output measurement methodology.

The following biocompatibility standards are conducted on the subject device: (1) ISO 10993-1:2009, ISO 10993-5:2009 and ISO 10993-10:2010

The tests were selected to show substantial equivalence between the subject device and the predicate.

11. Substantially Equivalent Determination

Verification and validation testing has been conducted on the U60 Ultrasound Imaging System. This premarket notification submission demonstrates that U60 Ultrasound Imaging System is substantially equivalent to the predicate devices.

§ 892.1550 Ultrasonic pulsed doppler imaging system.

(a)
Identification. An ultrasonic pulsed doppler imaging system is a device that combines the features of continuous wave doppler-effect technology with pulsed-echo effect technology and is intended to determine stationary body tissue characteristics, such as depth or location of tissue interfaces or dynamic tissue characteristics such as velocity of blood or tissue motion. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories.(b)
Classification. Class II.