K Number
K133454
Date Cleared
2013-12-16

(34 days)

Product Code
Regulation Number
892.1550
Reference & Predicate Devices
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The SonoSite Edge Ultrasound System is a general purpose ultrasound system intended for use by a qualified physician for evaluation by ultrasound imaging or fluid flow analysis of the human body. Specific clinical applications and exam types include:

Ophthalmic Fetal - OB/GYN Abdominal Intra-operative (abdominal organs and vascular) Intra-operative (Neuro.) Pediatric Small Organ (breast, thyroid, testicle, prostate) Neonatal Cephalic Adult Cephalic Trans-rectal Trans-vaginal Musculo-skeletal (Conventional) Musculo-skeletal (Superficial) Cardiac Adult Cardiac Pediatric Trans-esophageal (cardiac) Peripheral Vessel

Device Description

The SonoSite Edge Ultrasound System is a portable laptop style, full featured, general purpose, diagnostic ultrasound system used to acquire and display high-resolution, real-time ultrasound data through multiple imaging modes. Edge is a custom fabricated digital electronic design that readliy lends itself to be configured for specific ultrasound imaging applications through different system feature selections. Edge can operate on either battery or AC power.

AI/ML Overview

The provided 510(k) summary for the SonoSite Edge Ultrasound System (K133454) states that clinical studies were not required to support the determination of substantial equivalence. The submission relies on non-clinical tests and a comparison of technological characteristics to predicate devices.

Therefore, many of the requested details about acceptance criteria, study design, ground truth, and expert involvement are not explicitly mentioned in the provided text as they would typically stem from a clinical study.

Here's a breakdown of the available information:

1. Table of Acceptance Criteria and Reported Device Performance:

Since no clinical study was performed for this 510(k) submission, there are no specific performance criteria or reported performance results in the context of a clinical evaluation. The document focuses on compliance with established safety standards and equivalence to predicate devices.

The "acceptance criteria" here are implicitly the existing standards and the characteristics of the predicate devices. The "reported device performance" is that it conforms to these standards and shares similar features, functionality, and performance parameters with its predicates.

Acceptance Criteria (Implicit)Reported Device Performance (Summary of Non-Clinical Tests)
Electrical safety complianceDevice evaluated for electrical safety and found to conform to applicable mandatory medical device safety standards (e.g., IEC 60601-1, AAMI / ANSI ES60601-1).
Thermal safety complianceDevice evaluated for thermal safety and found to conform to applicable mandatory medical device safety standards.
Mechanical safety complianceDevice evaluated for mechanical safety and found to conform to applicable mandatory medical device safety standards.
EMC safety complianceDevice evaluated for EMC safety and found to conform to applicable mandatory medical device safety standards (e.g., IEC 60601-1-2, CISPR 11, IEC 61000-4 pt 2-5).
Cleaning/DisinfectionDevice evaluated for cleaning/disinfection procedures.
BiocompatibilityAll patient contact materials are biocompatible (evaluated per ISO 10993-1).
Acoustic output complianceAcoustic output evaluated and found to conform to applicable mandatory medical device safety standards (e.g., IEC 60601-2-37, NEMA UD 2-2004, NEMA UD 3-2004).
Quality assuranceAssurance of quality established by employing Design Phase Reviews, Risk Assessment, Requirements Development, System and Software Verification, Hardware Verification, Safety Compliance Verification, Clinical Validation, Human Factors Validation.
Overall EquivalenceIntended uses and other key features are consistent with traditional clinical practice and FDA guidance. Device conforms to applicable electromedical device safety standards, shares indications for use, has biosafety equivalence, and is manufactured using the same ISO 13485 quality system as predicate devices.

2. Sample Size Used for the Test Set and Data Provenance:

Not applicable, as no clinical study was performed. The evaluation relied on non-clinical testing and comparison to predicate devices, which implies leveraging existing data and regulatory clearances from those predicate devices.

3. Number of Experts Used to Establish the Ground Truth for the Test Set and Qualifications of those Experts:

Not applicable, as no clinical study and associated ground truth establishment for a test set were conducted.

4. Adjudication Method for the Test Set:

Not applicable, as no clinical study was performed.

5. If a Multi-Reader Multi-Case (MRMC) Comparative Effectiveness Study was done, If so, what was the effect size of how much human readers improve with AI vs without AI assistance:

Not applicable, as no clinical study, particularly an MRMC study, comparing AI assistance to human readers was performed. The device described is a general-purpose ultrasound system, not an AI-powered diagnostic tool.

6. If a Standalone (i.e., algorithm only without human-in-the-loop performance) was done:

Not applicable, as the device is a diagnostic ultrasound system, which inherently involves a human operator (qualified physician) for its intended use. It is not an AI algorithm operating autonomously.

7. The type of ground truth used (expert consensus, pathology, outcomes data, etc.):

Not applicable, as no clinical study was performed requiring the establishment of ground truth for diagnostic accuracy. For non-clinical aspects like safety and performance, the "ground truth" is adherence to recognized standards and engineering specifications.

8. The sample size for the training set:

Not applicable, as no clinical study was performed, and the device is not described as utilizing a machine learning algorithm that would require a training set of patient data.

9. How the ground truth for the training set was established:

Not applicable, as no clinical study was performed and no machine learning training set is mentioned for the device.

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K133454
Page 1 of 6

510(K) Summary

This summary of safety and effectiveness is provided as part of this Premarket Notification in compliance with 21 CFR, Part 807, Subpart E, Section 807.92.

1) Submitter's name, address, telephone number, contact person:

FUJIFILM SonoSite, Inc. 21919 30" Drive SE Bothell, WA 98021-3904

Corresponding Official:

E-mail: Telephone: . Facsimile: Date prepared: Patricia Liau Regulatory Affairs Specialist Patricia.Liau@sonosite.com (425) 951-6870 (425) 951-6713 October 17, 2013

2) Name of the device, including the trade or proprietary name if applicable, the common or usual name, and the classification name, if known:

Common/ Usual Name

Diagnostic Ultrasound System with Accessories

Proprietary Name

SonoSite Edge® Ultrasound System (subject to change)

Classification Names

NameFR NumberProduct Code
Ultrasonic Pulsed Doppler Imaging System892.155090-IYN
Ultrasonic Pulsed Echo Imaging System892.156090-IYO
Diagnostic Ultrasound Transducer892.157090-ITX
Picture Archiving and Communications System892.2050LLZ

3) Identification of the predicate or legally marketed device:

SonoSite Edge Ultrasound SystemK113156
SonoSite Maxx Series Ultrasound SystemK130173

4) Device Description:

The SonoSite Edge Ultrasound System is a portable laptop style, full featured, general purpose, diagnostic ultrasound system used to acquire and display high-resolution, real-time ultrasound data through multiple imaging modes. Edge is a custom fabricated digital electronic design that readliy lends itself to be configured for specific ultrasound imaging applications through different system feature selections. Edge can operate on either battery or AC power.

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5) Intended Use:

The SonoSite Edge Ultrasound System is a general purpose ultrasound system intended for use by a qualified physician for evaluation by ultrasound imaging or fluid flow analysis of the human body. Specific clinical applications and exam types include:

  • Ophthalmic Fetal - OB/GYN Abdominal Intra-operative (abdominal organs and vascular) Intra-operative (Neuro.) Pediatric Small Organ (breast, thyroid, testicle, prostate) Neonatal Cephalic Adult Cephalic Trans-rectal Trans-vaginal Musculo-skeletal (Conventional) Musculo-skeletal (Superficial) Cardiac Adult Cardiac Pediatric Trans-esophageal (cardiac) Peripheral Vessel

6) Technological Characteristics:

SonoSite Edge and Maxx Series Ultrasound Systems are both Track 3 devices that employ the same fundamental scientific technology. A comparison table is provided below.

FeatureSonoSite EdgeUltrasound System(This Submission)SonoSite EdgeUltrasound System(K113156)SonoSite M-Turbo (Maxx Series) UltrasoundSystem(K130173)
Intended UseDiagnostic ultrasound imaging orfluid flow analysis of the humanbodyDiagnostic ultrasound imaging orfluid flow analysis of the humanbodyDiagnostic ultrasound imaging orfluid flow analysis of the humanbody
Indications forUseOpthalmicFetal - OB/GYNAbdominalIntra-operative (abdominal organsand vascular)Intra-operative (Neuro.)PediatricSmall Organ (breast, thyroid,testicle. prostate)Neonatal CephalicAdult CephalicTrans-RectalTrans-VaginalMusculo-skeletal (Conventional)Musculo-skeletal (Superficial)Cardiac AdultCardiac PediatricTrans-esophageal (cardiac)Peripheral VesselNeedle guidanceOpthalmicFetal - OB/GYNAbdominalIntra-operative (abdominal organsand vascular)Intra-operative (Neuro.)PediatricSmall Organ (breast, thyroid,testicle, prostate)Neonatal CephalicAdult CephalicTrans-RectalTrans-VaginalMusculo-skeletal (Conventional)Musculo-skeletal (Superficial)Cardiac AdultCardiac PediatricTrans-esophageal (cardiac)Peripheral VesselNeedle guidanceOpthalmicFetal - OB/GYNAbdominalIntra-operative (abdominal organsand vascular)Intra-operative (Neuro.)PediatricSmall Organ (breast, thyroid,testicle, prostate)Neonatal CephalicAdult CephalicTrans-RectalTrans-VaginalMusculo-skeletal (Conventional)Musculo-skeletal (Superficial)Cardiac AdultCardiac PediatricTrans-esophageal (cardiac)Peripheral VesselNeedle guidance
TransducerTypesLinear ArrayCurved Linear ArrayIntracavitaryPhased ArrayLinear ArrayCurved Linear ArrayIntracavitaryPhased ArrayLinear ArrayCurved Linear ArrayIntracavitaryPhased Array
FeatureSonoSite EdgeUltrasound System(This Submission)SonoSite EdgeUltrasound System(K113156)SonoSite M-Turbo (MaxxSeries) UltrasoundSystem(K130173)
Static ProbesStatic ProbesStatic Probes
Trans-esophagealTrans-esophagealTrans-esophageal
TransducerFrequency1.0 - 15.0 MHz1.0 - 15.0 MHz1.0 - 15.0 MHz
GlobalI spta 3: .709 (TEEX)I spta 3: .709 (TEEX)I spta 3: .709 (TEEx)
MaximumTI Type: TIB(P21x)TI Value: 3.7 (P21x)TI Type: TIB(P21x)TI Value: 3.7 (P21x)TI Type: TIB(P21x)TI Value: 3.9 (P21x)
Outputs/WorstMI: 1.5 (P21x & L38xi)MI: 1.5 (P21x & L38xi)MI: 1.51 (P21x)
Case SettingI pa 3@MI Max: 776 (L38xi)I pa 3@MI Max: 776 (L38xi)I pa 3@MI Max: 439.9 (L38x)
AcousticDisplay Feature for HigherDisplay Feature for HigherDisplay Feature for Higher
Output DisplayOutputsMI Output DisplayOutputsMI Output DisplayOutputsMI Output Display
& FDA LimitsTI Output DisplayTI Output DisplayTI Output Display
Modes ofB-mode Grayscale ImagingB-mode Grayscale ImagingB-mode Grayscale Imaging
Operation3D/4D Grayscale Imaging
Tissue Harmonic ImagingTissue Harmonic ImagingTissue Harmonic Imaging
M-modeM-modeM-modeAnatomical M-Mode
Color M-ModeColor M-ModeColor M-Mode
Color Power DopplerColor Power DopplerColor Power Doppler
ZoomZoomZoom
Combination ModesCombination ModesCombination Modes
Pulsed Wave (PW) DopplerPulsed Wave (PW) DopplerPulsed Wave (PW) Doppler
Continuous Wave (CW) DopplerSonoHD2 Noise ReductionContinuous Wave (CW) DopplerSonoHD2 Noise ReductionContinuous Wave (CW) DopplerSonoRes/SonoHD Noise
SonoMB/MBe ImageSonoMB/MBe ImageReduction
CompoundingCompoundingSonoMB Image Compounding
Steered CW DopplerSteered CW DopplerSteered CW Doppler
Velocity Color DopplerVelocity Color DopplerVelocity Color Doppler
Color TDIColor TDIColor TDI
PW DopplerAvailable on all imagingtransducers except D2x/2 MHz.Available on all imagingtransducers except D2x/2 MHz.Available on all imagingtransducers except D2x/2 MHz
Adjustable sample volume size:1.0 - 25 mmAdjustable sample volume size:1.0 – 25 mmAdjustable sample volume size:1.0 - 25 mm
Simultaneous or duplex mode ofoperationSimultaneous or duplex mode ofoperationSimultaneous or duplex mode ofoperation
Simultaneous B-mode and PWDopplerSimultaneous B-mode and PWDopplerSimultaneous B-mode and PWDoppler
High PRF capabilityHigh PRF capabilityHigh PRF capability
CW DopplerAvailable on C11x, D2x/2, P10x,P21x, TEExAvailable on C11x, D2x/2, P10x,P21x, TEExAvailable on C11x, D2x/2, P10x,P17x, P21x, TEEx
Simultaneous or duplex mode ofoperationSimultaneous or duplex mode ofoperationSimultaneous or duplex mode ofoperation
Simultaneous B-mode and CWDopplerSimultaneous B-mode and CWDopplerSimultaneous B-mode and CWDoppler
Velocity ColorAvailable on all transducersexcept D2x/2Available on all transducersexcept D2x/2Available on all transducersexcept D2x/2
Doppler
Elastography(Strain), andAvailable on all transducersexcept D2x/2Available on all transducersexcept D2x/2Available on all transducersexcept D2x/2
Strain Rate
Imaging
ECG FeatureOne 3-lead ECG input, orOne external ECG input, orOne 3-lead ECG input, orOne external ECG input, orOne 3-lead ECG input, orOne external ECG input, or
One other physio inputOne other physio inputOne other physio input
DICOMDICOM 3.0 CStore, Print, andModality Worklist service classDICOM 3.0 CStore, Print, andModality Worklist service classDICOM 3.0 CStore, Print, andModality Worklist service class
user featuresuser features.user features.

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FeatureSonoSite EdgeUltrasound System(This Submission)SonoSite EdgeUltrasound System(K113156)SonoSite M-Turbo (MaxxSeries) UltrasoundSystem(K130173)
IMTSonoCalc IMT provides theSonoCalc IMT provides theSonoCalc IMT provides the
capability for automatedcapability for automatedcapability for automated
Measurementmeasurement of intima-mediameasurement of intima-mediameasurement of intima-media
thickness (IMT) of the carotidthickness (IMT) of the carotidthickness (IMT) of the carotid
artery. IMT functionality isartery. IMT functionality isartery. IMT functionality is
available both on the ultrasoundavailable both on the ultrasoundavailable both on the ultrasound
system and in a stand alonesystem and in a stand alonesystem and in a stand alone
software program that runs on asoftware program that runs on asoftware program that runs on a
personal computer.personal computer.personal computer.
128 digital channels128 digital channels128 digital channels
#TransmitChannels
#Receive128 digital channels (using SA)128 digital channels (using SA)128 digital channels (using SA)
Channels
PatientTransducers:Transducers:Transducers:
ContactAcrylonitrile-butadien-styreneAcrylonitrile-butadien-styreneAcrylonitrile-butadien-styrene
Materials(ABS)(ABS)(ABS)
CycoloyCycoloyCycoloy
Dow Medical Adhesive, Type ADow Medical Adhesive, Type ADow Medical Adhesive, Type A
Epoxy paste adhesive,Epoxy paste adhesive.Epoxy paste adhesive.
Polysulfone UDEL P1700Polysulfone UDEL P1700Polysulfone UDEL P1700
PolyurethanePolyurethanePolyurethane
Poly-Vinyl-Chloride (PVC)Poly-Vinyl-Chloride (PVC)Poly-Vinyl-Chloride (PVC)
Silicone RubberSilicone RubberSilicone Rubber
UrethaneUrethaneUrethane
Needle Guides:Needle Guides:Needle Guides:
Acetal copolymerAcetal copolymerAcetal copolymer
Acrylonitrile-butadien-styreneAcrylonitrile-butadien-styreneAcrylonitrile-butadien-styrene
(ABS)(ABS)(ABS)
CAN/CSA C22.2 No. 601.1CAN/CSA C22.2 No. 601.1CAN/CSA C22.2 No. 601.1
Product SafetyEN 60601-1EN 60601-1EN 60601-1
CertificationEN 60601-1-1EN 60601-1-1EN 60601-1-1
UL 60601-1UL 60601-1UL 60601-1
JIS T 0601-1, JIS T 1507JIS T 0601-1, JIS T 1507JIS T 0601-1, JIS T 1507
CEI/IEC 61157CEI/IEC 61157CEI/IEC 61157
ANSI/AAMI EC53ANSI/AAMI EC53ANSI/AAMI EC53
EMCEN 60601-1-2:2007EN 60601-1-2:2007EN 60601-1-2:2007
ComplianceCISPR 11CISPR 11CISPR 11
IEC 61000-4 pt 2-5IEC 61000-4 pt 2-5IEC 61000-4 pt 2-5
DICOMNEMA PS3.15 2003NEMA PS3.15 2003NEMA PS3.15 2003
AirborneRTCA/DO160D (section 21)RTCA/DO160D (section 21)RTCA/DO160D (section 21)
Equipment
Standards
SystemEdge:Edge:M Series:
CharacteristicsBeamformer 128/128 using SABeamformer 128/128 using SABeamformer 128/128 using SA
(configurable)(configurable)(configurable)
Hand held display and controlHand held display and controlHand held display and control
Single 12.1" Liquid Crystal DisplaySingle 12.1" Liquid Crystal DisplaySingle 10.4" Liquid Crystal Display
(LCD)256 gray shades on LCD(LCD)256 gray shades on LCD(LCD)256 gray shades on LCD
Dimensions: 12.9"(W) x 12.4 (L) xDimensions: 12.9"(W) x 12.4 (L) xDimensions: 10.9"(W) x 11.8 (L) x
2.5"(H)2.5"(H)3.0"(H)
Weight: 8.5 lbsWeight: 8.5 lbsWeight: 8.3 lbs
Battery operated (1.5 - 4 hourBattery operated (1.5 - 4 hourBattery operated (1.5 - 4 hour
operation per charge)operation per charge)operation per charge)operation per charge)operation per charge)operation per charge)

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SonoSite EdgeSonoSite EdgeSonoSite M-Turbo (Maxx
Ultrasound SystemUltrasound SystemSeries) Ultrasound
Feature(This Submission)(K113156)System
(K130173)
100 - 240V options, 50/60 Hz,15VDC output100 - 240V options, 50/60 Hz,15VDC output100 - 240V options, 50/60 Hz
Various obstetrical, cardiac,
Various obstetrical, cardiac.volume, M-mode, PW and CWVarious obstetrical, cardiac,volume, M-mode, PW and CWvolume, M-mode, PW and CWDoppier measurement and
Doppler measurement andcalculation packagesDoppler measurement andcalculation packagescalculation packages
ECG acquisition and display
ECG acquisition and displaycapabilitiesECG acquisition and displaycapabilitiescapabilitiesCW/PW Doppler Audio
CW/PW Doppler AudioCWIPW Doppler AudioSpectral Doppler Audio and image
Spectral Doppler Audio and imageSpectral Doppler Audio and imagestorage on removable media
storage on removable mediastorage on removable mediaMeasurement on Recalledlmages.
Wireless 802 11 (a\b\g) support forimage transferWireless 802.11 (a\b\g) support forimage transferWireless 802.11 {a\b\q} support forimage transfer and Bluetooth® 20.for voice activated remote control.
S Series:
Beamformer 128/128 using SA
(configurable)Hand held display and control
Single 10.4" Liquid Crystal Display
(LCD)256 gray shades on LCD
Dimensions: 11.5"(W) x 14.8 (L) x2.8"(H)
Weight: 8.5 Ibs
Battery operated (1.5 - 4 houroperation per charge)
100 - 240V options, 50/60 Hz
Various obstetrical, cardiac.
volume, and M-modemeasurement and calculation
packages
ECG acquisition and display
capabilitiesImage storage on removable
media
Measurement on recalled images
Wireless 802.11 {a\b\g} support for
image transfer and Bluetooth® 2.0for voice activated remote control
510(k) TrackTrack 3Track 3Track 3

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7) Determination of Substantial Equivalence:

Summary of Non-Clinical Tests:

The SonoSite Edge Ultrasound System has been evaluated for electrical, thermal, mechanical and EMC safety. Additionally, cleaning/disinfection, biocompatibility, and acoustic output have been evaluated, and the device has been found to conform to all applicable mandatory medical device safety standards. Assurance of quality was established by employing the following elements of product development: Design Phase Reviews, Risk Assessment, Requirements Development, System and Software Verification, Hardware Verification, Safety Compliance Verification, Clinical Validation, Human Factors Validation. All patient contact materials are biocompatible. Reports for these elements of product development are referenced in Attachment 6.

Reference No.Title
AAMI/ANSI/ISO 10993-1ISO 10993-1:2009, Biological evaluation of medical devices -- Part 1: Evaluation andtesting within a risk management process
IEC 60601-1AAMI / ANSI ES60601-1:2005/(R)2012 and A1:2012,, C1:2009/(R)2012 andA2:2010/(R)2012 (Consolidated Text) Medical electrical equipment - Part 1: Generalrequirements for basic safety and essential performance (IEC 60601-1:2005, MOD)
IEC 60601-1-2IEC 60601-1-2:2007, Medical electrical equipment - Part 1-2: General requirementsfor basic safety and essential performance - Collateral standard: Electromagneticcompatibility - Requirements and tests (Edition 3)
IEC 60601-2-37IEC 60601-2-37:2007, Particular Requirements for the basic safety and essentialperformance of ultrasonic medical diagnostic and monitoring equipment
ISO 14971ISO 14971: 2007, Medical devices - Application of risk management to medical

The Edge Ultrasound System is designed to comply with the following voluntary standards.

NEMA UD 2-2004 Acoustic Output Measurement Standard for Diagnostic Ultrasound Equipment NEMA UD 3-2004 Standard for Real-Time Display of Thermal and Mechanical Acoustic Output Indices on Diagnostic Ultrasound Equipment, American Institute of Ultrasound in Medicine NEMA PS 3.15 NEMA Ps 3.15.2011, Digital Imaging and Communications in Medicine (DICOM), Part 15: Security and System Management Profiles

Summary of Clinical Tests:

devices

The SonoSite Edge Ultrasound System and transducers did not require clinical studies to support the determination of substantial equivalence.

Conclusion: 8)

Intended uses and other key features are consistent with traditional clinical practice and FDA guidance. The Edge and predicate device both conform to applicable electromedical device safety standards with compliance verified through independent evaluation. The Edge and predicate device both meet FDA requirements for Track 3 devices, share indications for use, have biosafety equivalence, and are manufactured using the same ISO 13485 quality system. FUJIFILM SonoSite, Inc. believes that the Edge Ultrasound System is substantially equivalent with regard to safety and effectiveness to the predicate device.

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DEPARTMENT OF HEALTH & HUMAN SERVICES

Image /page/6/Picture/1 description: The image shows the logo for the Department of Health & Human Services USA. The logo consists of a stylized eagle with three lines representing its wings, and the text "DEPARTMENT OF HEALTH & HUMAN SERVICES USA" arranged in a circular fashion around the eagle. The text is in all caps and is oriented to follow the curve of the circle.

Public Health Service

Food and Drug Administration 10903 New Hampshire Avenue Document Control Center - WO66-G609 Silver Spring, MD 20993-0002

December 16, 2013

FUJIFILM SonoSite, Inc. % Mr. Mark Job Responsible Third Party Official Regulatory Technology Services LLC 1394 25th Street NW BUFFALO MN 55313

Re: K133454

Trade/Device Name: Sonosite Edge® Ultrasound System Regulation Number: 21 CFR 892.1550 Regulation Name: Ultrasonic pulsed doppler imaging system Regulatory Class: II Product Code: IYN, IYO, ITX Dated: November 11, 2013 Received: November 12, 2013

Dear Mr. Job:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration. Please note: CDRH does not evaluate information related to contract liability warranties. We remind you, however, that device labeling must be truthful and not misleading.

This determination of substantial equivalence applies to the following transducers intended for use with the Edge® Diagnostic Ultrasound System, as described in your premarket notification:

Transducer Model Number

C8x/8-5 MHzC11x/8-5 MHzD2x/2 MHz
C60x/5-2 MHzHFL38x/13-6 MHzHFL50x/15-6 MHz
ICTx/8-5 MHzL25x/13-6 MHzL38xi/10-5 MHz
L38x/10-5 MHzP10x/8-4 MHzP11x/10-5 MHz
P21x/5-1 MHzSLAx/13-6 MHzTEEX/8-3 MHz

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be

{7}------------------------------------------------

Page 2-Mr. Job

found in the Code of Federal Regulations. Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events} (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Division of Small Manufacturers, International and Consumer Assistance at its tollfree number (800) 638 2041 or (301) 796-7100 or at its Internet address a

http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm. Also, please note the regulation entitled. "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803), please go to

http://www.fda.gov/MedicalDevices/Safety/ReportaProblem/default.htm for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You mav obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers. International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/MedicalDevices/ResourcesforYou/Industry/default.htm.

Sincerely yours,

Smh)

for

Janine M. Morris Director, Division of Radiological Health Office of In Vitro Diagnostics and Radiological Health Center for Devices and Radiological Health

Enclosure

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DEPARTMENT OF HEALTH AND HUMAN SERVICES Food and Drug Administration

Indications for Use

510(k) Number (if known) TBD K133454

Device Name

SonoSite Edge Ultrasound System

Indications for Use (Describe)

The SonoSite Edge Ultrasound System is a general purpose ultrasound system intended for use by a qualified physician for evaluation by ultrasound imaging or fluid flow analysis of the human body. Specific clinical applications and exam types include:

Ophthalmic Fetal - OB/GYN Abdominal Intra-operative (abdominal organs and vascular) Intra-operative (Neuro.) Pediatric Small Organ (breast, thyroid, testicle, prostate) Neonatal Cephalic Adult Cephalic Trans-rectal Trans-vaginal Musculo-skeletal (Conventional) Musculo-skeletal (Superficial) Cardiac Adult Cardiac Pediatric Trans-esophageal (cardiac) Peripheral Vessel

Type of Use (Select one or both, as applicable)

🇿 Prescription Use (Part 21 CFR 801 Subpart D)

[ Over-The-Counter Use (21 CFR 801 Subpart C)

Form Approved: OMB No. 0910-0120

Expiration Date: December 31, 2013

See PRA Statement on last page.

PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON A SEPARATE PAGE IF NEEDED.

FOR FDA USE ONLY *

Concurrence of Center for Devices and Radiological Health (CDRH) (Signature)

Page 8 of 30

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Table 1.3-1 Diagnostic Ultrasound Indications for Use Form – FUJIFILM SonoSite Edge Ultrasound System

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:N/A
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of the humanbody as follows:
Clinical ApplicationBMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
OphthalmicPPPPB+M; B+PWD;B+CDNote 1
FetalPPPPB+M; B+PWD;B+CDNote 1
AbdominalPPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Intra-operative (Abdominalorgans and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)LaparoscopicPPPPB+M; B+PWD;B+CDNote 1
PediatricSmall Organ (breast, thyroid,testicles, prostate)PPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Neonatal CephalicPPPPB+M; B+PWD;B+CDNote 1
Adult CephalicPPPPB+M; B+PWD;B+CDNote 1
Trans-rectalPPPPB+M; B+PWD;B+CDNote 1
Trans-vaginalPPPPB+M; B+PWD;B+CDNote 1
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac AdultPPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Cardiac PediatricPPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Trans-esophageal (card.)Other (spec.)PPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:C8x/8-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of
the human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
FetalPPPPB+M; B+PWD;B+CDNote 1
Abdominal
Intra-operative (Abdominal organs and vascular)
Intra-operative (Neuro.)
Laparoscopic
Pediatric
Small Organ (breast, thyroid, testicles, prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectalPPPPB+M; B+PWD;B+CDNote 1
Trans-vaginalPPPPB+M; B+PWD;B+CDNote 1
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vessel
Other (spec.)

Additional Comments :-

All items marked "P" were previously cleared in 510(k) K113156.

ﺍﻟﻤﻮﺍﺻﻞ ﺍﻟﻤﺮﺍﺣﻞ ﺍﻟﻤﺴﺎﻋﺔ ﺍﻟﻤﺘﻮﺳﻂ ﺍﻟﻤﺴﺎﻋﺔ ﺍﻟﻤﺴﺎﻋﺪ ﺍﻟﻤﺴﺎﻋﺪ ﺍﻟﻤﻮﺿﻮﻉ ﺍﻟﻤﻮﺿﻮﻉ ﺍﻟﻤﻮﺿﻮﻉ ﺍﻟﻤﻮﺿﻮﻉ ﺍﻟﻤﻮﺿﻮﻋﺎﺕ ﺍﻟﺴﻮﺍﺭﻱ ﺍﻟﻤﺴﺎﻋﺪ ﺍﻟﺴﻴﺎﺳﻲ ﺍﻟﺴﻴﺎﺳﻲ ﺍﻟﺴﻴﺎﺳﻲ ﺍﻟﺴﻴﺎﺳﻲ ﺍﻟﺴﻴﺎﺳﻲ ﺍﻟﻤﺘﻮﺳﻂ. ﺍﻟﻤﺘﻮﺳﻂ ﺍﻟ

{10}------------------------------------------------

Table 1.3-2 Diagnostic Ultrasound Indications for Use Form - C8x/8-5 Transducer

N= new indication; P= previously cleared by FDA; E= added under this appendix

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoMBIMBe compund imaging itsue Dopler imaging (TD), inacing to guidance of biopsy and in the placement of needes and cathers in
vascular or other anatomical structures Color Dopler Mode includes color M-Mode.

All items marked "P" were previously cleared in 510(k) K071134 and K082098.

Prescription Use (Per 21 CFR 801.109)

Page 3 of 17

Page 10 of 30

{11}------------------------------------------------

Table 1.3-3 Diagnostic Ultrasound Indications for Use Form - C11x/8-5 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:C11x/8-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
AbdominalPPPPB+M; B+PWD:B+CWD; B+CDNote 1
Intra-operative (Abdominal organs andvascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)PPPPB+M; B+PWD;B+CDNote 1
Laparoscopic
PediatricPPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)B+M; B+PWD:B+CDNote 1
Neonatal CephalicPPPPB+M; B+PWD;B+CDNote 1
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac PediatricPPPPPB+M; B+PWD;B+CWD; B+CDNote 1
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

N= new indication: P= previously cleared by FDA; E= added under this appendix

Additional Comments:

Note 1 · Other includes color power Doppier, combined B and color power Doppler, issue harmonic imaging, SonoMBIMBe compound imaging, issue Doppler imaging (TDI), imaging guidance for penpheral herve block procedures, imaging to assist in the placement of needles and cather andomical stuctures. Color Doppler includes velocity color Dopler. Color
Dopler can be combined with any imaging mode. M-Mo

All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

Page 4 of 17

{12}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:D2x/2 MHz Dual Element Circular Array
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
Abdominal
Intra-operative (Abdominal organs and vascular)
Intra-operative (Neuro.)
Laparoscopic
Pediatric
Small Organ (breast, thyroid, testicles, prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac AdultP
Cardiac PediatricP
Trans-esophageal (card.)
Other (spec.)
Peripheral vessel
Other (spec.)

Table 1.3-4 Diagnostic Ultrasound Indications for Use Form – D2x/2 Transducer

N= new indication: P= previously cleared by FDA; E= added under this appendix

Additional Comments:

All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

Page 5 of 17

the first and the comments of the comments of the comments of the comments of the comments of the comments of the section of the section of the section of the section of the

{13}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:C60x/5-2 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
FetalPPPPB+M; B+PWD;B+CDNote 1
AbdominalPPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Table 1.3-5 Diagnostic Ultrasound Indications for Use Form – C60x/5-2 Transducer

Additional Comments:

Note 1: Other includes color power Dopler, combined B and color power Doppler, iissue harmonic imaging, SonoHD2 imaging, SonoMBIMBe room in may also potor inaging to block on por por and include maging, sondro condegrine commender
compund imaging (TD), maging bidane in period neve block groenent of spins anatomical structures. Color Doppler includes velocity color Doppler can be combined with any imaging mode. M-Made includes color M-Mode.

A STATE FOR FOR FOR BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK BOOK

Boor Taller France of the

All items marked "P" were previously cleared in 510(k) K071134.

{14}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:HFL38x/13-6 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
AbdominalPPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles, prostate)PPPPB+M; B+PWD;B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Table 1.3-6 Diagnostic Ultrasound Indications for Use Form -- HFL38x/13-6 Transducer

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoMBAMBe compund imaging tissue Dopler imaging (TD), imaging guideral nerve block procedures, imaging of spinal cord to povide guidence in vascular or the anatomical structures. Calor Doppler includes velocity color Doppier can be combined with any imaging mode. M-Mote includes cator M-Mode.

All items marked "P" were previously cleared in 510(k) K071134.


Prescription Use (Per 21 CFR 801.109)

ﻤﺴﻴﻨﻴﻨﻴﺔ

{15}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:HFL50x/15-6 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
AbdominalPPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD:B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWD:B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
B+M; B+PWD;
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Table 1.3-7 Diagnostic Ultrasound Indications for Use Form - HFL50x/15-6 Transducer

N= new indication; P= previously cleared by FDA; E= added under this appendix

ﻠﻴﻨﺖ ﺍﻟﻤﺴﺎ

Additional Comments:

Note 1: Other includes color power Doppler, combined B and cotor power Doptler, tissue harmonic imaging, SonoHD2 imaging, SonoMBIMBe compound imaging, tissue Doppler imaging gurdance for perioheral neve block procedures, imaging of spinal cord to provide guidance for central nerve block procedures, imaging to guidance of biopsy and imaging to assist in the placement of needler or other anatomical structures. Color Doppler includes velocity color Doppler can be combined with any maging mode. M-Mode includes color M-Mode.

and a wall and the most of the resear

ﺘﻌﺪﺩ ﺍﻟﻤﻌﻠﻴﺔ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ ﺍﻟﻤﺘﺤﺪﺓ

All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

and the same of the same of the same of the states of the same of the same of the

{16}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:ICTx/8-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of
the human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
FetalPPPPB+M; B+PWD:B+CDNote 1
Abdominal
Intra-operative (Abdominal organs and vascular)
Intra-operative (Neuro.)
Laparoscopic
Pediatric
Small Organ (breast, thyroid, testicles. prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectalPPPPB+M; B+PWD:B+CDNote 1
Trans-vaginalPPPPB+M; B+PWD:B+CDNote 1
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vessel
Other (spec.)

Table 1.3-8 Diagnostic Ultrasound Indications for Use Form -- ICTx/8-5 Transducer

N= new indication; P= previously cleared by FDA; E= added under this appendix

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, lissue harmonic imaging, SonoMBMBe compound imaging (TD). imaging (TDI). imaging for guidance of biopsy and imaging to assist in the placement of needles and catheters in offically in and copper magnig roy, magnig of gudance of bippy and minghis in the concerner of recors and cambres model.
vasular or the analomical stuctures. Coor Dopler in

All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

Page 9 of 17

SALE LA LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE LE L

Page 16 of 30

{17}------------------------------------------------

Table 1.3-9 Diagnostic Ultrasound Indications for Use Form - L25x/13-6 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:L25x/13-6 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
OphthalmicPPPB+M; B+CDNote 1
Fetal
AbdominalPPPB+M; B+CDNote 1
Intra-operative (Abdominal organs andvascular)PPPB+M; B+CDNote 1
Intra-operative (Neuro.)Laparoscopic
PediatricPPPB+M; B+CWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPB+M; B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPB+M; B+CDNote 1
Musculo-skel. (Superfic.)PPPB+M; B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPB+M; B+CDNote 1
Other (spec.)

Additional Comments:

Not 1: Ohe includes colo contined and color power Doper, issue harmoni, maging, Sondh24.
compund inaging tissue Dopler imaging golderes incontent inaging in guidance di cingi Doppler can be combined with any imaging mode. M-Mode includes color M-Mode.

All items marked "P" were previously cleared in 510(k) K071134 and K082098.

Prescription Use (Per 21 CFR 801,109)

ﻀﻤﻨﺸ

Page 10 of 17


Page 17 of 30

------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ﺘﺤﻘﻪ

==============================================================================================================================================================================

{18}------------------------------------------------

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:L38xi/10-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of
the human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
AbdominalPPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWD;B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec:)
Cardiac Adult
Cardiac PediatricTrans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Table 1.3-10 Diagnostic Ultrasound Indications for Use Form - L38xi/10-5 Transducer

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, iissue harmonic imaging, SonoHB/MB compound inaging, tissue Doppler imaging (TDI), imaging guidance for periores imaging of spinal cord to provide guidance for central nerve block procedures, imaging to gird inaging to assist in the placement of needles and cathers in vascular or other anatomical structures. Color Doppler includes velocity color Dopler can be combined with any imaging mode. M-Mode includes color M-Mode.



and and the state of the state of the state of the state of the states of the states of the states of the states of the states of the states of the states of the state of the

All items marked "P" were previously cleared in 510(k) K113156.

{19}------------------------------------------------

Table 1.3-11 Diagnostic Ultrasound Indications for Use Form - L38x/10-5
Transducer
System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:L38x/10-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of
the human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
AbdominalPPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWD;B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoHD2 imaging, SonoMBIMBe compound imaging, tissue Doppler imaging (TD)), imaging guidance for perinteral neve block procedures, imaging of spinal cord to provide guidance lor central neve block proceded to bopsy and integing to assis in the placement on needes and cathers in rascular or che M-Mode.

and and the same and think and the compress of the final comments and instruments of the while while would


All items marked "P" were previously cleared in 510(k) K071134.

all differentle to the block the election in the block and the block and and comments of the seat of the

{20}------------------------------------------------

Table 1.3-12 Diagnostic Ultrasound Indications for Use Form - P10x/8-4 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:P10x/8-4 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
FetalPPPPB+M; B+PWDB+CDNote 1
AbdominalPPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWDB+CDNote 1
Intra-operative (Neuro.)PPPPB+M; B+PWD; B+CDNote 1
Laparoscopic
PediatricPPPPB+M; B+PWDB+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWDB+CDNote 1
Neonatal CephalicPPPPB+M; B+PWD ,B+CDNote 1
Adult CephalicPPPPB+M; B+PWD; B+CDNote 1
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWDB+CDNote 1
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac AdultPPPPPB+M; B+PWD; B+CWD:B+CDNote 1
Cardiac PediatricPPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD; B+CDNote 1
Other (spec.)

N= new indication; P= previously cleared by FDA; E= added under this appendix

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoMB/MBe compound imaging, tissue Doppler imaging (TDI, imaging guidance for perioheral nerve block procedures, imaging for guidance of biopsy and imaging to assist in the placement of needler or vascular or other anatomical structures. Color Doppler includes velocity color and maging to assist in the placement of neceise in vasular of the mindinical shortined shortheres. Ook Door and mich

All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

Page 13 of 17

{21}------------------------------------------------

Table 1.3-13 Diagnostic Ultrasound Indications for Use Form - P11x/10-5 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:P11x/10-5 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis of the humanbody as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
Abdominal
Intra-operative (Abdominal organsand vascular)
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPB+M; B+CDNote 1
Small Organ (breast, thyroid,testicles. prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPB+M; B+CDNote 1
Other (spec.)

N= new indication; P= previously cleared by FDA; E= added under this appendix

Additional Comments:

Note 1: Other includes color power Dopler, combined B and color power Dopler, M-Mode, SonoHD2 imaging, SonoMBMBe compound imaging, wou'r. Online middles color popler, comained in model popier and inaging to assist in the placement of needes and catheters in vascular or other anatomical structures. Color Dopler can be combined with any imaging mode. Can be used with disposable kit cleared with K113680.

All items marked "P" were previously cleared in 510(k) K130173.

{22}------------------------------------------------

Table 1.3-14 Diagnostic Ultrasound Indications for Use Form – P21x/5-1 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:P21x/5-1 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
OphthalmicPPPPB+M; B+PWD; B+CDNote 1
FetalPPPPB+M; B+PWD;B+CDNote 1
AbdominalPPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD;B+CDNote 1
Intra-operative (Neuro.)
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWD;B+CDNote 1
Neonatal CephalicPPPPB+M; B+PWD;B+CDNote 1
Adult CephalicPPPPB+M; B+PWD; B+CDNote 1
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac AdultPPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Cardiac PediatricPPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD; B+CDNote 1
Other (spec.)

Additional Comments:

Note 1; Other includes color power Doppier, combined B and color power Doppler, tissue harmonic imaging, SonoMBIMBe compound imaging tissue Doppler imaging (TDI), color TDI, imaging to assist in the placement of needles and catheters in vascular or other anatomical structures. Color Dopter includes velocity color Doppler can be combined with any imaging mode M-Mode includes color M-Mode .___________________________________________________________________________________________________________________________________________ ﻟﺘﻘﺪﻳﻤﺔ ﺍﻟﻤﺴﺎ 174 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 ------------

All items marked "P" were previously cleared in 510(k) K071134.

{23}------------------------------------------------

Table 1.3-15 Diagnostic Ultrasound Indications for Use Form - SLAx/13-6 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:SLAx/13-6 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationMode of Operation
BMPWDCWDColorDopplerCombined(Spec.)Other(Spec.)
Ophthalmic
Fetal
Abdominal
Intra-operative (Abdominal organs and vascular)PPPPB+M; B+PWD:B+CDNote 1
Intra-operative (Neuro.)PPPPB+M; B+PWD:B+CDNote 1
Laparoscopic
PediatricPPPPB+M; B+PWD;B+CDNote 1
Small Organ (breast, thyroid, testicles. prostate)PPPPB+M; B+PWD:B+CDNote 1
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)PPPPB+M; B+PWD;B+CDNote 1
Musculo-skel. (Superfic.)PPPPB+M; B+PWD;B+CDNote 1
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)
Other (spec.)
Peripheral vesselPPPPB+M; B+PWD;B+CDNote 1
Other (spec.)

Additional Comments:

Note 1: Other includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoHD2 imaging, SonoMBMBe Noter in the minder collection on over por respect note hights in only of in an anyag condines
compuni maging listic magins con contribus no sections . incoln on guidance .

11 - 15 - 12 - 12 - 12 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 -

All items marked "P" were previously cleared in 510(k) K071134 and K082098. 『

{24}------------------------------------------------

Table 1.3-16 Diagnostic Ultrasound Indications for Use Form – TEEx/8-3 Transducer

System:FUJIFILM SonoSite Edge Ultrasound System
Transducer:TEEx/8-3 MHz Transducer
Intended Use:Diagnostic ultrasound imaging or fluid flow analysis ofthe human body as follows:
Clinical ApplicationBMPWDCWDColor DopplerCombined (Spec.)Other (Spec.)
Ophthalmic
Fetal
Abdominal
Intra-operative (Abdominal organs and vascular)
Intra-operative (Neuro.)
Laparoscopic
Pediatric
Small Organ (breast, thyroid, testicles. prostate)
Neonatal Cephalic
Adult Cephalic
Trans-rectal
Trans-vaginal
Trans-urethral
Trans-esoph. (non-Card.)
Musculo-skel. (Convent.)
Musculo-skel. (Superfic.)
Intra-luminal
Other (spec.)
Cardiac Adult
Cardiac Pediatric
Trans-esophageal (card.)PPPPPB+M; B+PWD; B+CWD;B+CDNote 1
Other (spec.)
Peripheral vessel
Other (spec.)

to any the this with a string world resident in all street and state and

Additional Comments:

Note 1: Qther includes color power Doppler, combined B and color power Doppler, tissue harmonic imaging, SonoMBIMBe compound imaging, tissue Doppler imaging (TDI, color TDI, imaging to guidance of biopsy and imaging to assist in the placement of needles and catheters in vascular or other analorical structures. Color Doppler. Color Dopler. Color Doppler can be combined with any imaging mode. M-Mode includes color M-Mode.

13 - 12 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 - 11 -


All items marked "P" were previously cleared in 510(k) K071134.

Prescription Use (Per 21 CFR 801.109)

And The Bank States

Page 17 of 17 Page 24 of 30

§ 892.1550 Ultrasonic pulsed doppler imaging system.

(a)
Identification. An ultrasonic pulsed doppler imaging system is a device that combines the features of continuous wave doppler-effect technology with pulsed-echo effect technology and is intended to determine stationary body tissue characteristics, such as depth or location of tissue interfaces or dynamic tissue characteristics such as velocity of blood or tissue motion. This generic type of device may include signal analysis and display equipment, patient and equipment supports, component parts, and accessories.(b)
Classification. Class II.