K Number
K092257
Device Name
JALOSKIN
Date Cleared
2010-01-26

(182 days)

Product Code
Regulation Number
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
JALOSKIN is indicated for the management of superficial moderately exuding wounds including pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh's surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, skin tears) and first and second degree burns.
Device Description
JALOSKIN is a semi-permeable, transparent film dressing, composed of HYAFF® 11, a benzyl ester of hyaluronic acid. The hyaluronic acid is derived from bacterial fermentation.
More Information

Not Found

No
The description focuses on the material composition and intended use as a wound dressing, with no mention of AI or ML capabilities.

Yes
The device is indicated for the management of various wounds, including ulcers, surgical wounds, and burns, which are conditions that require therapeutic intervention for healing and recovery.

No

The device is described as a "semi-permeable, transparent film dressing" indicated for the "management of superficial moderately exuding wounds," which describes a treatment or wound care product, not a diagnostic tool.

No

The device description clearly states that JALOSKIN is a "semi-permeable, transparent film dressing," which is a physical, tangible product, not software.

Based on the provided information, JALOSKIN is not an IVD (In Vitro Diagnostic).

Here's why:

  • Intended Use: The intended use clearly states that JALOSKIN is a dressing for the management of superficial wounds. This is a therapeutic application, not a diagnostic one.
  • Device Description: The description details the composition and form of a wound dressing.
  • Lack of Diagnostic Elements: There is no mention of analyzing samples from the body (like blood, urine, tissue) or providing information for diagnosis.
  • Performance Studies: The performance studies focus on biocompatibility and safety as a wound dressing, not on diagnostic accuracy.

IVD devices are used to examine specimens derived from the human body to provide information for the diagnosis, prevention, monitoring, treatment, or alleviation of disease. JALOSKIN's function is to cover and manage wounds, which is a direct treatment/management function, not a diagnostic one.

N/A

Intended Use / Indications for Use

JALOSKIN is indicated for the management of superficial moderately exuding wounds including pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh's surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, skin tears) and first and second degree burns.

Product codes

FRO

Device Description

JALOSKIN is a semi-permeable, transparent film dressing, composed of HYAFF® 11, a benzyl ester of hyaluronic acid. The hyaluronic acid is derived from bacterial fermentation.

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

Not Found

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Not Found

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

K001508, K073251

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

N/A

0

K092257
1092

ATTACHMENT 2

510(k) SUMMARY

510(k) Owner:

Fidia Advanced Biopolymers S.r.l. Via Ponte dell Fabbrica 3/B 35031 Abano Terme PADOVA, ITALY

JAN 2 6 2010

| Contact: | Dr. Adriano Zanotti
Regulatory Affairs |
|----------|-------------------------------------------|
| Phone: | +39-049-82 32 650 |
| Fax: | +39-049082 32 345 |

Date Summary Prepared:

Device:

Common/Classification Name:

JALOSKIN Wound Dressing Product Code FRO

Unclassified

Classification:

Trade Name:

December 10, 2009

Predicate Devices:

HYALOMATRIX™ KC Fidia Advanced Biopolymers S.r.1. K001508

HYALOMATRIX PA®

Fidia Advanced Biopolymers S.r.l.

K073251 JALOSKIN is a semi-permeable, transparent film dressing, composed of

Device Description:

Intended Use:

derived from bacterial fermentation.

JALOSKIN is indicated for the management of superficial moderately exuding wounds including pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh's surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, skin tears) and first and second degree burns.

HY AFF® 11, a benzyl ester of hyaluronic acid. The hyaluronic acid is

1

Technological Characteristics:

JALOSKIN is substantially equivalent to the predicate devices with regard the intended use and/or technological characteristics. HYAFF 11 has been used in legally marketed predicate devices, and no new questions of safety or effectiveness are presented by the technological differences between JALOSKIN and its predicate devices.

Biocompatibility Data

In vitro cytotoxicity studies and a hemolysis study in rabbits demonstrate that HY AFF films are neither cytogenic nor hemolytic. Acute oral and dermal toxicity studies on HYAFF powder in rats and indicate that the lethal dose of HY AFF 11 is greater than 5,000 mg/kg and 2,000 mg/kg, respectively. Irritation studies in rabbits demonstrate that HYAFF 11 powder is not an ocular or dermal irritant, and a sensitization study in guinea pigs provides evidence for the lack of a sensitizing effect. No evidence of genotoxicity was observed in three in vitro assays or one in vivo study in mice. An implantation study of up to 1 year in rats found no evidence of treatmentrelated toxicity, and demonstrated that the HYAFF film was degraded within. 4 months.

2

DEPARTMENT OF HEALTH & HUMAN SERVICES

Image /page/2/Picture/1 description: The image shows the seal of the Department of Health & Human Services (HHS) of the United States. The seal features the department's name encircling a stylized emblem. The emblem consists of a caduceus-like symbol with a single snake entwined around a staff, accompanied by a stylized representation of an eagle's wing.

Public Health Service

Food and Drug Administration 10903 New Hampshire Avenue Document Control Room W-O66-0609 Silver Spring, MD 20993-0002

Fidia Advanced Biopolymers S.r.1. % Morgan, Lewis, & Bocklus LLP Sharon A. Segal, Ph.D. 1111 Pennsylvania Avenue, Northwest Washington, District of Columbia 20004

Re: K092257

Trade/Device Name: JALOSKIN Regulatory Class: Unclassified Product Code: FRO Dated: December 10, 2009 Received: December 10, 2009

Dear Dr. Segal:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food. Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to additional controls. Existing major regulations affecting your device can be found in the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); medical device reporting (reporting of medical device-related adverse events) (21 CFR 803); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

JAN 2 3 2010

3

Page 2 - Sharon A. Segal, Ph.D.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please go to http://www.ida.gov/AboutFDA/CentersOffices/CDRH/CDRHoffices/ucm115809.htm for the Center for Devices and Radiological Health's (CDRH's) Office of Compliance. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding the reporting of adverse events under the MDR regulation (21 CFR Part 803); please go to http://www.fda.gov/cdrh/mdr/ for the CDRH's Office of Surveillance and Biometrics/Division of Postmarket Surveillance.

You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 796-7100 or at its Internet address http://www.fda.gov/cdrh/industry/support/index.html.

Sincerely yours.

31 Mark N. Melkerson Director

Division of Surgical, Orthopedic and Restorative Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

4

Fidia Advanced Biopolymers S.r.1.

510(k) Submission JALOSKIN®

ATTACHMENT 1

Indications for Use

510(k) Number (if known):

92257

Device Name:

JALOSKIN

Indications for Use:

JALOSKIN is indicated for the management of superficial moderately exuding wounds including pressure ulcers, venous ulcers, diabetic ulcers, chronic vascular ulcers, surgical wounds (donor sites/grafts, post-Moh's surgery, post-laser surgery, podiatric, wound dehiscence), trauma wounds (abrasions, lacerations, skin tears) and first and second degree burns.

Daniel Keane

(Division Sign-Off) Division of Surgical, Orthopedic, and Restorative Devices

510(k) Number K092257

Prescription Use (Part 21 CFR 801 Subpart D) AND/OR

Over-The-Counter Use (21 CFR 801 Subpart C)

PLEASE DO NOT WRITE BELOW THIS LINE -- CONTINUE ON ANOTHER PAGE IF NEEDED

Concurrence of CDRH, Office of Device Evaluation (ODE)

CONFIDENTIAL