K Number
K081527
Date Cleared
2009-04-01

(303 days)

Product Code
Regulation Number
866.3305
Reference & Predicate Devices
N/A
Predicate For
N/A
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The Light Diagnostics™ HSV 1/2 Typing DFA Kit is an in vitro diagnostic test for the qualitative detection and identification of herpes simplex virus type 1 and/or type 2 in direct specimens from patients with vesicular lesions and symptoms consistent with herpes infection and for culture confirmation by immunofluorescence. Negative results do not preclude an infection and should not be used as the sole basis for diagnosis, treatment or other management decisions. Specimens found negative on direct specimen detection should be confirmed by culture.

For In Vitro Diagnostic Use.

Device Description

Light Diagnostics™ HSV 1/2 Typing DFA Kit is a qualitative test that uses specific typing reagents and FITC filter fluorescence microscope to detect and differentiate herpes simplex viruses 1 and 2 in direct specimens from symptomatic patients with lesions and in specimens amplified by cell culture. The kit consists of HSV-1 Typing Reagent vial, HSV-2 Typing Reagent vial, two HSV Control Slides, Phosphate-Buffered Saline packet; Tween 20/Sodium Azide Solution (100X) vial, and Mounting Fluid vial. The kit utilizes specific reagents for the detection and identification of HSV-1 and HSV-2, therefore two cell spots on slides of specimens are required to identify the type of HSV. The HSV-1 Typing Reagent consists of two fluorescein-labeled monoclonal antibodies specific for HSV-1 glycoprotein C and ICP35 respectively. The HSV-2 Typing Reagent consists of two fluorescein-labeled monoclonal antibodies that specifically bind HSV-2 polypeptides. In Western blots these appear as two major bands with molecular weights of between 110-120 kD and between 78-82 kD and are consistent with the monoclonal antibodies recognizing epitopes within glycoprotein G of HSV-2. The typing reagents will bind to HSV-1 or HSV-2 infected cells fixed on microscope slides specifically. Separate cell spots on slides should be prepared for use with each reagent. Unbound reagent is removed by rinsing with phosphate-buffered saline (PBS). Illumination with ultraviolet light allows visualization of the antigen-antibody complexes by fluorescence microscopy. HSV-infected cells will exhibit apple-green fluorescence with the specific reagent while cells stain a dull red due to the presence of Evans blue in the typing reagents. The controls contained in this kit are acetone fixed slides with one well containing HSV-1 infected cells, one well containing HSV-2 infected cells, and one well containing uninfected cells to verify functioning of reagents, culture methodology and functioning of the microscope.

AI/ML Overview

Here's a summary of the acceptance criteria and the study that proves the device meets them, based on the provided text:

1. Table of Acceptance Criteria and Reported Device Performance

The document does not explicitly state pre-defined acceptance criteria (e.g., "Sensitivity must be >= X%"). Instead, it presents the performance characteristics found and concludes that they demonstrate substantial equivalence to the predicate device. The comparison studies were performed against "Culture Confirmation with HSV typing reagent," which served as the reference standard.

Performance MetricAcceptance Criteria (Implicit - based on predicate equivalence)Reported Device Performance (Light Diagnostics™ HSV 1/2 Typing DFA Kit)
Direct Specimen Testing
HSV-1 SensitivityComparable to predicate device/culture84% (87/104) (95% CI: 75-90%)
HSV-1 SpecificityComparable to predicate device/culture99% (331/334) (95% CI: 97-99%)
HSV-2 SensitivityComparable to predicate device/culture85% (57/67) (95% CI: 75-92%)
HSV-2 SpecificityComparable to predicate device/culture99% (367/369) (95% CI: 98-99%)
Culture Testing (Amplified Specimens)
HSV-1 SensitivityComparable to predicate device/culture100% (105/105) (95% CI: 97-100%)
HSV-1 SpecificityComparable to predicate device/culture100% (71/71) (95% CI: 95-100%)
HSV-2 SensitivityComparable to predicate device/culture100% (70/70) (95% CI: 97-100%)
HSV-2 SpecificityComparable to predicate device/culture100% (106/106) (95% CI: 97-100%)

2. Sample Size Used for the Test Set and Data Provenance

  • Sample Size for Direct Specimen Testing:
    • Total collected: 454 specimens
    • Excluded for HSV-1 direct analysis due to insufficient cells: 16 specimens
    • Excluded for HSV-2 direct analysis due to insufficient cells: 18 specimens
    • Culture results not recorded for: 3 specimens
    • Effective Sample Size (HSV-1 Direct): 438 specimens (454 - 16)
    • Effective Sample Size (HSV-2 Direct): 436 specimens (454 - 18)
  • Sample Size for Culture Testing (Amplified Specimens):
    • Total: 176 specimens (from the initial 454 specimens that grew on culture)
  • Data Provenance: Clinical specimens were collected from three sites in the United States: 258 samples from the Eastern region and 196 from the Southeastern region. The study explicitly states it was a "Clinical Evaluation" using "specimens collected from three sites from symptomatic patients with lesions," indicating a prospective collection of real-world patient samples.

3. Number of Experts Used to Establish the Ground Truth for the Test Set and Qualifications of Those Experts

The document does not specify the number or qualifications of experts involved in establishing the ground truth. It states that "Culture Confirmation with HSV typing reagent" was used as the reference standard. For direct specimen analysis, fluorescence microscopy was used to examine slides stained with the Light Diagnostics™ kit and a reference HSV typing reagent. For cell culture, observers would typically assess cytopathic effect (CPE) for the presence of HSV. The interpretation of these methods would usually be performed by trained laboratory personnel or clinical microbiologists, but no specific details on their number or qualifications are provided.

4. Adjudication Method for the Test Set

The document does not describe a formal adjudication method (e.g., 2+1, 3+1). The reference standard for comparison was "Culture Confirmation with HSV typing reagent." It implies a direct comparison of the investigational device's results against this established reference, rather than a multi-reader adjudication process for the ground truth itself.

5. If a Multi-Reader Multi-Case (MRMC) Comparative Effectiveness Study was Done

No, a multi-reader multi-case (MRMC) comparative effectiveness study was not explicitly described. The study focuses on evaluating the performance of the device against a predicate or reference method (cell culture with HSV typing reagent) rather than assessing human reader improvement with or without AI assistance. The device itself is an immunofluorescence assay kit, not an AI-based system.

6. If a Standalone (i.e., algorithm only without human-in-the-loop performance) Was Done

Yes, in a sense, a standalone performance was done. The Light Diagnostics™ HSV 1/2 Typing DFA Kit is an in vitro diagnostic test kit. Its "performance" is measured by its ability to detect and differentiate HSV-1 and HSV-2 antigens in patient samples via immunofluorescence without human "interpretation assistance" beyond standard laboratory procedures (e.g., slide reading under a microscope). The results presented (sensitivity and specificity) represent the performance of the kit itself when compared to the reference standard. There is no AI algorithm involved.

7. The Type of Ground Truth Used

The primary ground truth used was molecular/biological confirmation via cell culture (with HSV typing reagent). For direct specimen testing, the device's results were compared to "culture isolation." For culture testing (amplified specimens), the device's performance was compared against a "Predicate HSV typing reagent" used on culture-amplified specimens. This implies that the presence or absence and typing of HSV were determined by cell culture methods and confirmed with a reference HSV typing reagent.

8. The Sample Size for the Training Set

The document does not describe a "training set" in the context of machine learning or AI. This is a traditional in vitro diagnostic device, and thus, the concept of a training set for an algorithm is not applicable. The non-clinical evaluations involving reference strains and clinical isolates (e.g., 8 HSV-1 isolates, 7 HSV-2 isolates, other viruses, bacteria, and cell lines) served as an internal validation and specificity check (see "Non-clinical evaluation" section), rather than a training set for an algorithm.

9. How the Ground Truth for the Training Set Was Established

As there is no "training set" in the AI sense, this question is not applicable. For the non-clinical evaluation, the ground truth was established by using known reference strains (e.g., ATCC VR733/735 for HSV-1, ATCC VR734 for HSV-2) and "previously typed clinical isolates," indicating these were characterized and verified prior to being used in the specificity assessment.

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K081527

Image /page/0/Picture/1 description: The image shows the Millipore logo. The logo consists of a large letter "M" with the left half in black and the right half in a light color. To the right of the "M" is the word "MILLIPORE" in a vertical arrangement.

APR - 1 2009

510(k) Notification for Light Diagnostics™ HSV 1/2 Typing DFA Kit

510(k) SUMMARY

Submitter:Millipore Corp. (formerly Chemicon International, Inc.)28820 Single Oak DriveTemecula, CA 92590Tel: (951) 676-8080Fax: (951) 514-4482
Contact Name:Cindy Penny
Date Prepared:Tuesday, May 29, 2008
Product Name
Trade Name:Common Name:Classification Name:Light Diagnostics™ HSV 1/2 Typing DFA KitImmunofluorescence AssayHerpes simplex virus (21 CFR 866.3305, Product Code GOL)

Intended Use

The Light Diagnostics™ HSV 1/2 Typing DFA Kit is an in vitro diagnostic test for the qualitative detection and identification of herpes simplex virus type 1 and/or type 2 in direct specimens from patients with vesicular lesions and symptoms consistent with herpes infection and for culture confirmation by immunofluorescence. Negative results do not preclude an infection and should not be used as the sole basis for diagnosis, treatment or other management decisions. Specimens found negative on direct specimen detection should be confirmed by culture.

For In Vitro Diagnostic Use.

Predicate Device

    1. Cell Culture (used to detect the absence of the HSV 1 and/or HSV 2)
      Note: MRC-5 and HNF Cell Lines were used to assist clinicians in determining if the patient specimens were infected with HSV-1 and/or HSV-2 by cytopatic effect (CPE) observation. Culture grown from cells inoculated with patient specimens uses the presence of CPE in the cells to identify the presence or absence of HSV in the originating patient specimen.

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Image /page/1/Picture/0 description: The image shows the Millipore logo. The logo consists of a large, stylized letter "M" with the left half filled in black and the right half outlined. To the right of the "M" is the word "MILLIPORE" in a vertical arrangement, with the letters stacked on top of each other.

Device Description

Light Diagnostics™ HSV 1/2 Typing DFA Kit is a qualitative test that uses specific typing reagents and FITC filter fluorescence microscope to detect and differentiate herpes simplex viruses 1 and 2 in direct specimens from symptomatic patients with lesions and in specimens amplified by cell culture. The kit consists of HSV-1 Typing Reagent vial, HSV-2 Typing Reagent vial, two HSV Control Slides, Phosphate-Buffered Saline packet; Tween 20/Sodium Azide Solution (100X) vial, and Mounting Fluid vial. The kit utilizes specific reagents for the detection and identification of HSV-1 and HSV-2, therefore two cell spots on slides of specimens are required to identify the type of HSV. The HSV-1 Typing Reagent consists of two fluorescein-labeled monoclonal antibodies specific for HSV-1 glycoprotein C and ICP35 respectively. The HSV-2 Typing Reagent consists of two fluorescein-labeled monoclonal antibodies that specifically bind HSV-2 polypeptides. In Western blots these appear as two major bands with molecular weights of between 110-120 kD and between 78-82 kD and are consistent with the monoclonal antibodies recognizing epitopes within glycoprotein G of HSV-2. The typing reagents will bind to HSV-1 or HSV-2 infected cells fixed on microscope slides specifically. Separate cell spots on slides should be prepared for use with each reagent. Unbound reagent is removed by rinsing with phosphate-buffered saline (PBS). Illumination with ultraviolet light allows visualization of the antigen-antibody complexes by fluorescence microscopy. HSV-infected cells will exhibit apple-green fluorescence with the specific reagent while cells stain a dull red due to the presence of Evans blue in the typing reagents. The controls contained in this kit are acetone fixed slides with one well containing HSV-1 infected cells, one well containing HSV-2 infected cells, and one well containing uninfected cells to verify functioning of reagents, culture methodology and functioning of the microscope.

Technological Comparison of Methods

Comparison with Culture:

The performance characteristics of Light Diagnostics™ HSV 1/2 Typing DFA Kit will be established by direct evaluation of clinical specimens and smear made from culture specimens using the predicate device.

An FDA cleared direct immunofluorescence test for HSV-1 and HSV-2 was used in the study to confirm with the direct specimens testing, amplified culture material, and HSV typing. The reference device is a direct immunofluorescence test intended for the detection and identification of HSV-1 and HSV-2 following amplification in cell culture or by direct examination of clinical specimens prepared by cytospin. Specimens found to be negative on direct specimen examination was tested by cell culture.

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Image /page/2/Picture/0 description: The image shows the Millipore company logo. The logo consists of a stylized letter "M" with the left half in solid black and the right half in a textured gray. To the right of the "M" is the word "MILLIPORE" in a vertical arrangement. The letters are stacked on top of each other. The letters are in a sans-serif font, and the trademark symbol "TM" is located at the bottom left of the image.

Similarities
Light Diagnostics™ HSV 1/2 TypingDFA KitReference Device for HSV 1and HSV 2
Intended UseIn vitro diagnostic test for the qualitativedetection and identification of herpessimplex virus type 1 and/or type 2 indirect specimens from patients withvesicular lesions and symptoms consistentwith herpes infection and for cultureconfirmation by immunofluorescence.Negative results do not preclude aninfection and should not be used as thesole basis for diagnosis, treatment or othermanagement decisions. Specimens foundnegative on direct specimen detectionshould be confirmed by culture.In vitro diagnostic test fordirect immunofluorescence testintended for the detection andidentification of herpes simplexvirus type 1 (HSV-1) or herpessimplex virus type 2 (HSV-2)following amplification in cellculture or by directexamination of clinicalspecimens prepared bycytospin. Specimens found tobe negative on direct specimenexamination should be testedby cell culture.
MethodDirectly labeled fluorescent antibodiesspecific to HSV-1 and HSV-2 to identifythe presence of these viruses in patientspecimens.Directly labeled fluorescentantibodies specific to HSV-1and HSV-2 to identify thepresence of these viruses inpatient specimens.
HSV 1 AntibodyThe HSV-1 Typing Reagent consists oftwo fluorescein-labeled monoclonalantibodies specific for HSV-1glycoprotein C and ICP35 respectively.The primary componentspecific to HSV-1 will bind tothe glycoprotein C and acapsid-associated protein inHSV-1 infected cells
HSV 2 AntibodyThe HSV-2 Typing Reagent consists oftwo fluorescein-labeled monoclonalantibodies that specifically bind HSV-2polypeptides. In Western blots theseappear as two major bands with molecularweights of between 110-120 kD andbetween 78-82 kD and are consistent withthe monoclonal antibodies recognizingepitopes within glycoprotein G of HSV-2.The secondary component,specific for HSV-2, will bindto the glycoprotein G in HSV-2infected cells.
Instrumentsrequired, but notprovidedFluorescence microscope with 100 watt mercury or halogen lamp, appropriate filtercombination for FITC (excitation peak = 490nm, emission peak = 520nm), 100x, 200x and400x magnification (dry objective)Fluorescence microscope with 100watt mercury or halogen lamp,appropriate filter combination forFITC (excitation peak = 490 nm,emission peak = 520nm), 100x,200x and 400x magnification (dryobjective)
Light Diagnostics™ HSV 1/2Typing DFA KitReference Test for HSV 1and HSV 2
Labeling methodTwo separate reagents, each of whichcontains FITC-labeled monoclonalantibodies directed against either HSV-1 or HSV-2. Two separate wells arenecessary to detect and identify bothviruses in one sample. Illuminationwith ultraviolet light allowsvisualization of the antigen-antibodycomplexes by fluorescencemicroscopy. HSV-infected cells willexhibit apple-green fluorescence withthe specific reagent while cells stain adull red due to the presence of Evansblue in the typing reagents.One reagent contains specificmonoclonal antibodies directedagainst HSV-1 and HSV-2 andtagged with two differentfluorescent labels. This allowssimultaneous visualization andidentification of both HSV-1 andHSV-2-infected cells in one well.When an FITC filter set is used,HSV-1 infected cells will exhibitapple-green fluorescence andHSV-2 infected cells will exhibityellow-gold fluorescence. Theuninfected cells will stain a dullred due to the presence of Evansblue in the reagent.

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Image /page/3/Picture/0 description: The image shows a logo with the letter 'M' in two different styles. The left side of the 'M' is solid black, while the right side is a textured gray. To the right of the 'M' is the word 'MILLIPORE' in a vertical orientation, with the letters stacked on top of each other.

Differences

Performance Data for Light Diagnostics™ HSV 1/2 Typing DFA Kit

1) Non-clinical evaluation:

The specificity of the HSV-1 and HSV-2 Typing Reagents were examined on slides prepared from HSV-1 and HSV-2 reference strains and previously typed clinical isolates after cell culture. The table below shows the results. HSV-1 and HSV-2 Typing Reagents were type-specific, showing no cross-reaction. The Typing Reagents were also tested on slides prepared from a variety of other viruses, bacteria and cell lines and showed no cross-reaction.

Cross-reactivity against common viruses, bacteria, and cell lines

OrganismHSV-1 ReagentResultHSV-2Reagent Result
Herpes Viruses
Herpes simplex virus type 1; ATCC VR733/735 - Clinicalisolates (8)+-
Herpes simplex virus type 2; ATCC VR734 - Clinicalisolates(7)-+
Varicella zoster virus; Oka strain--
Cytomegalovirus; Clinical isolate 70-35--
Human herpes virus 6; strain Z-29--
Epstein-Barr virus; Human Lymph. P3HR1--
Other viruses
OrganismHSV-1 Reagent ResultHSV-2 Reagent Result
Adenovirus; CDC strains V5002--
Influenza A; Clinical isolate--
Influenza B Clinical isolate--
Mumps; CDC V5004--
Parainfluenza 1; CDC V6004--
Parainfluenza 2; CDC V7003--
Parainfluenza 3; CDC V5003--
Parainfluenza 4; ATCC strain VR-1378--
Respiratory syncytial virus; CDC strain A2--
Rubella; VR315 strain M-33--
Bacteria
Bordetella bronchiseptica--
Bordetella pertussis--
Branhamella catarrhalis--
Candida albicans--
Chlamydia pneumonia--
Chlamydia trachomatis--
Corynebacterium diptheriae--
E. coli--
Legionella micdadei--
Legionella pneumophila--
Mycobacterium tuberculosis--
Mycoplasma hominis--
Mycoplasma pneumoniae--
Neisseria Meningitidis--
Pneumocystis carinii pneumonia--
Staphylococcus aureus**
Staphylococcus epidermidis--
Streptococcus pneumonia--
Streptococcus pyogenes--
Trichomonas vaginalis--
Cell Lines
MRC-5--
A549--
Vero--
LLC-MK2--
Hep-2--

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Image /page/4/Picture/0 description: The image shows the Millipore logo. The logo consists of a large letter M, with the left half of the M in solid black and the right half in a lighter shade. To the right of the M, the word "MILLIPORE" is written vertically in a simple, sans-serif font.

510(k) Notification for Light Diagnostics™ HSV 1/2 Typing DFA Kit

*Protein A, produced by certain bacteria, will bind the Fc portion of the monoclonal antibodies used in the Light Diagnostics™ HSV 1/2 Typing DFA Kit HSV-1 and HSV-2 reagents. Staining, however, can be differentiated by size and morphology. The presence of Staphylococcus aureus, a Protein A producer, will result in small (0.8um) fluorescent spheres.

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Image /page/5/Picture/0 description: The image shows a logo with a large letter 'M'. The left half of the 'M' is solid black, while the right half is filled with a gray dot pattern. To the right of the 'M', the word 'MILLIPORE' is written vertically, with the letters stacked on top of each other. The letters are in a simple, sans-serif font.

2) Clinical Evaluation:

Specimens were collected from three sites from symptomatic patients with lesions. The comparison studies were performed using Light Diagnostics™ HSV 1/2 Typing DFA Kit on direct specimens and the predicate device on specimens that grew on culture. The comparison studies were also performed using both kits on specimens that grew on culture.

The results are summarized below.

A total of 454 specimens collected from 3 clinical sites were included in this study, 258 samples were from the Eastern region of the United States and 196 from the Southeastern region of the US. The specimens include fresh vesicular fluid from herpetic lesions collected from patients with lesions and exhibiting symptoms of HSV 1 or HSV 2 infections.

Clinical samples were submitted to each laboratory in viral transport media. Cells were washed in PBS, dropped onto slides, and fixed in acetone. Slides were stained with the Light Diagnostics™ HSV 1/2 Typing DFA Kit reagents, and another HSV typing reagent for reference, and examined using fluorescence microscopy. All specimens were placed in MRC-5 and/or HNF standard tubes for cell culture. Slides from positive cultures were stained with the Light Diagnostics™ HSV 1/2 Typing DFA Kit reagents, and reference HSV typing reagent and examined using fluorescence microscopy.

Sixteen specimens were excluded from HSV-1 direct specimen analysis and 18 specimens were excluded from HSV-2 direct specimen analysis, because of insufficient numbers of cells on the direct specimen slides. The results of the remaining direct specimen slides were compared to the results of culture isolation.

Culture results were not recorded for three specimens. Analysis was performed on the remaining specimens.

Compared to culture, direct specimen testing using the Light DiagnosticsTM HSV 1/2 Typing DFA Kit had a sensitivity of 84% (87/104) (95% Confidence Interval of 75-90%) and specificity of 99% (331/334) (95% Confidence Interval of 97% to 99%)for the detection of HSV-1; and a sensitivity of 85% (57/67) (95% Confidence Interval of 75-92%) and specificity of 99% (367/369)) (95% Confidence Interval of 98% to 99%) for the detection of HSV-2. Refer to Table 1 and Table 2.

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Image /page/6/Picture/0 description: The image shows a logo with a large letter 'M' split into two distinct halves. The left half of the 'M' is solid black, while the right half is textured with a gray pattern. To the right of the 'M', the word 'MILLIPORE' is written vertically, with the letters stacked on top of each other. The text is oriented so that it reads from bottom to top.

Data from all clinical sites was combined and summarized below.

Direct specimen testing results combined from all sites

Detection of HSV-1 in Direct Specimens using Light Diagnostics™ HSV 1/2 Table 1 Typing DFA Kit vs. Culture Confirmation with HSV typing reagent.

DETECTING HSV-1CultureConfirmation withPredicate HSVtyping reagentTotalComments
PositiveNegative
LightDiagnostics™Positive87390Sensitivity 84% (87/104)(75-90%) 95% CI
HSV 1/2Typing DFAKit on DirectSpecimensNegative17331348Specificity 99%(331/334)(97-99%) 95% CI
Total104334438

Table 2

Detection of HSV-2 in Direct Specimens using Light Diagnostics™ HSV 1/2 Typing DFA Kit vs. Culture Confirmation with HSV typing reagent.

DETECTING HSV-2CultureConfirmation withPredicate HSVtyping reagent
PositiveNegativeTotalComments
LightDiagnostics™HSV 1/2Typing DFAKit on DirectSpecimensPositive57259Sensitivity 85% (57/67)(75-92%) 95% CI
Negative10367377Specificity 99% (367/369)(98-99%) 95% CI
Total67369436

Culture testing using the Light Diagnostics™ HSV 1/2 Typing DFA Kit had a sensitivity of 100% (105/105) (95% Confidence Interval of 97-100%) and specificity of 100% (71/71) (95% Confidence Interval of 95% to 100%) for the detection of HSV-1; and a sensitivity of 100% (70/70) (95% Confidence Interval of 97-100%) and specificity of 100% (106/106))

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Image /page/7/Picture/0 description: The image shows a logo with a stylized letter "M" and the word "MILLPORE" written vertically on the right side. The left part of the "M" is solid black, while the right part has a dotted pattern. The letters in "MILLPORE" are arranged vertically, with each letter stacked on top of the other.

(95% Confidence Interval of 95% to 100%) for the detection of HSV-2. Refer to Table 5 and Table 6.

Culture testing results combined from all sites

Table 3

Detection of HSV-1 using Light Diagnostics™ HSV 1/2 Typing DFA Kit vs. HSV typing reagent in culture amplified specimens.

DETECTING HSV-1Predicate HSVtyping reagent
PositiveNegativeTotalComments
LightDiagnostics™HSV 1/2Typing DFAKit on CultureSpecimensPositive1050105Sensitivity 100%(105/105)(97-100%) 95% CI
Negative07171Specificity 100%(71/71)(95-100%) 95% CI
Total10571176

Table 4

Detection of HSV-2 using Light Diagnostics IM HSV 1/2 Typing DFA Kit vs. HSV typing reagent in culture amplified specimens.

DETECTING HSV-2Predicate HSV typing reagent
PositiveNegativeTotalComments
LightDiagnostics™HSV 1/2Typing DFAKit on CultureSpecimensPositive70070Sensitivity 100%(70/70)(95-100%) 95% CI
Negative0106106Specificity 100%(106/106)(97-100%) 95% CI
Total70106176

Conclusions Drawn from Evaluation:

Light Diagnostics™ HSV 1/2 Typing DFA Kit uses a standard direct immunofluorescence assay procedure for the detection of HSV type 1 and type 2 in patient specimens and in cell culture. The monoclonal antibodies used in the reagent have been characterized to ensure specificity and reliability of the product. In clinical evaluations, the performance

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Image /page/8/Picture/0 description: The image shows the Millipore logo. The logo consists of a stylized letter "M" with the left half in solid black and the right half in a lighter shade, possibly gray or a textured pattern. To the right of the "M", the word "MILLIPORE" is printed vertically in a simple, sans-serif font.

characteristics of the reagents were shown to be substantially equivalent to cell culture and the predicate reagent.

The characterization and clinical evaluation of the Light Diagnostics™ HSV 1/2 Typing DFA Kit demonstrates the safety and effectiveness of this product when used as intended as described in the product insert.

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DEPARTMENT OF HEALTH & HUMAN SERVICES

Public Health Service

Food and Drug Administration 2098 Gaither Road Rockville MD 20850

Cindy Penny Regulatory Affairs Manager Millipore Corporation 28820 Single Oak Drive Temecula, CA 92590

APR -1 2009

APR - 1 2009

Re: K081527

Trade/Device Name: Light Diagnostics™ HSV ½ Typing DFA Kit Regulation Number: 21 CFR 866.3305 Regulation Name: Herpes simplex virus serological reagents Regulatory Class: Class II Product Code: GQL Dated: February 27, 2009 Received: March 3, 2009

Dear Ms. Penny:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to such additional controls. Existing major regulations affecting your device can be found in Title 21, Code of Federal Regulations (CFR), Parts 800 to 895. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Parts 801 and 809); and good manufacturing practice requirements as set forth in the quality systems (OS) regulation (21 CFR Part 820).

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Page 2 -

This letter will allow you to begin marketing your device as described in your Section 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please contact the Office of In Vitro Diagnostic Device Evaluation and Safety at 240-276-0450. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). For questions regarding postmarket surveillance, please contact CDRH's Office of Surveillance and Biometric's (OSB's) Division of Postmarket Surveillance at 240-276-3474. For questions regarding the reporting of device adverse events (Medical Device Reporting (MDR)), please contact the Division of Surveillance Systems at 240-276-3464. You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or ' (240) 276-3150 or at its Internet address http://www.fda.gov/cdrh/industry/support/index.html.

Sincerely yours,

Sally attaym

Sally A. Hojvat, M.Sc., Ph.D. Director Division of Microbiology Devices Office of In Vitro Diagnostic Device Evaluation and Safety Center for Devices and Radiological Health

Enclosure

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Indication for Use

KD-81527 510(k) Number (if known): _

Device Name: Light Diagnostics™ HSV 1/2 Typing DFA Kit

Indication for Use:


The Light Diagnostics™ HSV 1/2 Typing DFA Kit is an in vitro diagnostic test for the qualitative detection and identification of herpes simplex virus type 2 in direct specimens from patients with vesicular lesions and symptoms consistent with herpes infection and for culture confirmation by immunofluorescence. Negative results do not preclude an infection and should not be used as the sole basis for diagnosis, treatment or other management decisions. Specimens found negative on direct specimen detection should be confirmed by culture.

Prescription Use __ · √ (21 CFR Part 801 Subpart D) And/Or

Over the Counter Use _ (21 CFR Part 801 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE; CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of In Vitro Diagnostic Device Evaluation and Safety (OIVD)

Uwe Schief

Division Sign-Off Office of In Vitro Diagnostic Device Evaluation and Safety

510(k): K081527

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§ 866.3305 Herpes simplex virus serological assays.

(a)
Identification. Herpes simplex virus serological assays are devices that consist of antigens and antisera used in various serological tests to identify antibodies to herpes simplex virus in serum. Additionally, some of the assays consist of herpes simplex virus antisera conjugated with a fluorescent dye (immunofluorescent assays) used to identify herpes simplex virus directly from clinical specimens or tissue culture isolates derived from clinical specimens. The identification aids in the diagnosis of diseases caused by herpes simplex viruses and provides epidemiological information on these diseases. Herpes simplex viral infections range from common and mild lesions of the skin and mucous membranes to a severe form of encephalitis (inflammation of the brain). Neonatal herpes virus infections range from a mild infection to a severe generalized disease with a fatal outcome.(b)
Classification. Class II (special controls). The device is classified as class II (special controls). The special control for the device is FDA's revised guidance document entitled “Class II Special Controls Guidance Document: Herpes Simplex Virus Types 1 and 2 Serological Assays.” For availability of the guidance revised document, see § 866.1(e).