K Number
K051645
Date Cleared
2005-10-13

(115 days)

Product Code
Regulation Number
876.1500
Reference & Predicate Devices
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP AuthorizedThirdpartyExpeditedreview
Intended Use

The EVIS EXERA 160A system consists of Olympus camera heads, endoscopes, video system center, light source, monitors, endo-therapy accessories and other ancillary equipment. This system is intended for endoscopic diagnosis, treatment and video observation of the upper and lower digestive tract.

EVIS EXERA Xenon Light Source Olympus CLV-160A: This light source has been designed to be used with Olympus endoscopes, video system center, and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Video System Center Olympus CV-160A: This video system center has been designed to be used with Olympus camera heads, endoscopes, light source, monitors, endo-therapy accessories and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Gastrointestinal Videoscope XGIF-N160Y2: This instrument has been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for transoral or transnasal observation and surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

EVIS EXERA Gastrointestinal Videoscope XGIF-Q160Y5, XGIF-H160Y2: These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

EVIS EXERA Colonovideoscope XCF-Q160W6L, XCF-H160AY2L, XPCF-Q160AY2L: These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the lower digestive tract (including the anus, rectum, sigmoid colon, colon and ileocecal valve).

Device Description

The EVIS EXERA 160A System consists of Olympus camera heads, endoscopes, video system center, light source, monitors, endo-therapy accessories and other ancillary equipment. This system is intended for endoscopic diagnosis, treatment and video observation of the upper and lower digestive tract.

The primary components of the subject system, which are part of this submission, are:

  • EVIS EXERA Xenon Light Source Olympus CLV-160A,
  • EVIS EXERA Video System Center Olympus CV-160A,
  • EVIS EXERA Gastrointestinal Videoscopes XGIF-N160Y2, XGIF-Q160Y5, XGIF-H160Y2.
  • EVIS EXERA Colonovideoscopes XCF-Q160W6L, XCF-H160AY2L, XPCF-Q160AY2L

The EVIS EXERA Xenon Light Source Olympus CLV-160A is intended for endoscopic diagnosis, treatment and video observation. The CLV-160A is basically identical to the predicate device, EVIS Universal Light Source CLV-U40, with the exception that the CLV-160A has an optional filter which allows the user to enhance endoscopic white light images by selective processing of green and blue light. This feature, referred to as Narrow Band Imaging (NBI) employs an optical filter to filter the white light spectrum, changing it from a broad band to a narrow band. Both an endoscopic image by standard white light illumination and that by NBI illumination can be obtained. The user can select either the standard observation mode by pressing the scope switch on the scope or the NBI mode switch on the CLV-160A. In comparison to conventional white light observation provides greater visual contrast of the surface structure and fine capillary patterns of the mucous membranes.

The EVIS EXERA Video System Center Olympus CV-160A is a video processing system intended for use with Olympus endoscopes such as the subject endoscopes. The CV-160A Video System Center contains the video signal processing technology which enables the endoscope to illuminate, enhance, view, record and transmit video data of endoscopic images.

AI/ML Overview

The provided document is a 510(k) summary for the Olympus EVIS EXERA 160A System, which is a premarket notification to the FDA for medical devices. This type of document is intended to demonstrate substantial equivalence to a predicate device, rather than proving that a new device meets specific acceptance criteria through a clinical study with quantitative performance metrics.

Therefore, the document does not contain the acceptance criteria or a study that proves the device meets specific performance acceptance criteria in the way you've outlined for things like AI/ML models. It focuses on demonstrating that the new device is as safe and effective as previously cleared devices.

Here's why your requested information isn't present in this type of submission and what information is available:

  • Acceptance Criteria and Reported Device Performance: This document describes comparisons of specifications between the new device and its predicate devices (Tables 16-3 to 16-10). It highlights similarities in intended use, specifications, performance, and materials, with the key difference being the addition of the Narrow Band Imaging (NBI) function. It asserts that the clinical literature supports the safety and efficacy of NBI imaging in endoscopy, but it does not provide a specific table of acceptance criteria a new study had to meet for the overall system or its NBI function.
  • Sample size, data provenance, number of experts, adjudication method, MRMC study, standalone performance, type of ground truth, training set size, and training set ground truth: These details are typically associated with performance studies, especially for new diagnostic algorithms or AI/ML components. The provided document is for a hardware system (endoscopic video imaging system) and focuses on demonstrating substantial equivalence through comparison to existing products and referencing existing clinical literature. It does not describe a specific clinical performance study with these parameters for the EVIS EXERA 160A System itself. The NBI function is presented as an additional feature, and its safety and efficacy are supported by "clinical literatures" (plural), implying existing published research rather than a de novo study conducted for this 510(k).

Conclusion from the document:

The conclusion explicitly states: "When compared to the predicate devices, the EVIS EXERA 160A System does not incorporate any significant changes in intended use, method of operation, material, or design that could affect the safety or effectiveness of the system." This is the core of a 510(k) submission – to show that the new device is substantially equivalent to already legally marketed devices, rather than establishing entirely new performance metrics via a dedicated study.

In summary, the provided 510(k) summary is not a clinical study report that would answer your specific questions about acceptance criteria and performance study details. It is a regulatory submission for substantial equivalence.

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K05/645

OCT 1 3 2005

510(k) SUMMARY EVIS EXERA 160A SYSTEM

1. General Information

ApplicantOlympus Medical Systems Corp.
2951 Ishikawa-cho, Hachioji-shi,
Tokyo, 192-8507, Japan
Establishment Registration No.: 8010047

Laura Storms-Tyler I Official Correspondent Executive Director Regulatory Affairs & Quality Assurance Olympus America Inc. Two Corporate Center Drive, Melville, NY 11747-9058, USA Phone: 631-844-5688 FAX: 631-844-5554 Email: Laura.storms-tyler @olympus.com Establishment Registration No.: 2429304

■ Manufacturer

Light source/Video system center:Shirakawa Olympus Co., Ltd.
3-1, Aza-Ookamiyama, Ooaza-Odakura, Nishigo-mura,Nishishirakawa-gun, Fukushima, Japan 961-8061Establishment Registration No.: 3002808148
Gastrointestinal scope/Colonoscope:Aizu Olympus Co., Ltd.
500 Aza-Muranishi, Ooaza-Iidera, Monden-cho,Aizuwakamatsu-shi, Fukushima, Japan 965-8520Establishment Registration No.: 9610595

2. Device Identification

Device Name:EVIS EXERA 160A System
Common Name:Endoscopic Video Imaging System
  • il ■ Class:
  • Classification:
Table 16-1. Classification of the EVIS EXERA 160A System
RegulationNumberRegulation NameProduct CodeClassification Panel
876.1500Endoscope and accessoriesFDS- Gastroscope, Gastro-UrologyFDF- Colonoscope, Gastro-UrologyKOG- Endoscope and accessoriesGCT- Light Source, Endoscope,Xenon ArcGastroenterology &Urology

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3. Legally Marketed Device to which Substantial Equivalence is Claimed

The following table shows the primary components (part of this submission) of the EVIS EXERA 160A System and each device to which we claim substantial equivalence (predicate device).

Subject Device(Part of this Submission)Predicate DevicePD's 510(k) No.
EVIS EXERA Xenon Light SourceOlympus CLV-160AEVIS Universal Light Source CLV-U40K954451
EVIS EXERA Video System CenterOlympus CV-160AEVIS Video System Center CV-140K954451
EVIS EXERA GastrointestinalVideoscope XGIF-N160Y2XGIF-N200HGastrointestinal VideoscopeK001766
EVIS EXERA GastrointestinalVideoscope XGIF-Q160Y5EVIS EXERA GastrointestinalVideoscopeGIF-Q160ZK011151
EVIS EXERA GastrointestinalVideoscope XGIF-H160Y2
EVIS EXERA ColonovideoscopeXCF-Q160W6LEVIS EXERA Colonoscope CF-Q160AL
EVIS EXERA ColonovideoscopeXCF-H160AY2LK001241
EVIS EXERA ColonovideoscopeXPCF-Q160AY2LEVIS EXERA Colonovideoscope PCF-160AL

Table 16-2 Primary Components & Predicate Devices of the EVIS EXERA 160A System

4. Device Description

The EVIS EXERA 160A System consists of Olympus camera heads, endoscopes, video system center, light source, monitors, endo-therapy accessories and other ancillary equipment. This system is intended for endoscopic diagnosis, treatment and video observation of the upper and lower digestive tract.

The primary components of the subject system, which are part of this submission, are:

  • EVIS EXERA Xenon Light Source Olympus CLV-160A, •
  • EVIS EXERA Video System Center Olympus CV-160A, .
  • EVIS EXERA Gastrointestinal Videoscopes XGIF-N160Y2, XGIF-Q160Y5, . XGIF-H160Y2.
  • EVIS EXERA Colonovideoscopes XCF-Q160W6L, XCF-H160AY2L, ، XPCF-Q160AY2L

The EVIS EXERA Xenon Light Source Olympus CLV-160A is intended for endoscopic diagnosis, treatment and video observation. The CLV-160A is basically identical to the predicate device, EVIS Universal Light Source CLV-U40, with the exception that the CLV-160A has an optional filter which allows the user to enhance endoscopic white light images by selective processing of green and blue light. This feature, referred to as Narrow Band Imaging (NBI) employs an optical filter to filter the white light spectrum, changing it from a broad band to a narrow band. Both an endoscopic image by standard white light illumination and that by NBI illumination can be obtained. The user can select either the standard observation mode by pressing the scope switch on the scope or the NBI mode switch on the CLV-160A. In comparison to conventional white light observation provides greater visual contrast of the surface structure and fine capillary patterns of the mucous membranes.

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The EVIS EXERA Video System Center Olympus CV-160A is a video processing system intended for use with Olympus endoscopes such as the subject endoscopes. The CV-160A Video System Center contains the video signal processing technology which enables the endoscope to illuminate, enhance, view, record and transmit video data of endoscopic images. The CV-160A Video System Center is equivalent to predicate Olympusdevices which have the same basic functionality. Predicate Olympus devices include the EVIS Video System Center CV-140. The Video System Center CV-140 enabled the physician to utilize a variety of Olympus flexible endoscopes, including colonoscopes, gastroscopes, sigmoidscopes, duodenoscopes and bronchoscopes. The EVIS Video System Center CV-140 contains the video signal processor technology which allowed the various endoscopes to illuminate, enhance, view, record, and transmit video data of endoscopic images.

Compared to these predicate devices, the subject CV-160A incorporates the following changes: 1. The CV-160A is compatible with any specified Olympus flexible, both video and fiberoptic, and rigid endoscope.

    1. The CV-160A processes the NBI image, generated by the CLV-160A light source and captured by the endoscope's Charged Coupled Device (CCD), creating an enhanced image of the tissue's vasculature.
      Both the CLV-160A and CV-160A can be used with any specified Olympus flexible and rigid endoscope models, including gastroscopes, ultrasound gastroscopes, duodenoscopes, colonoscopes, sigmoidscopes, choledochoscopes, bronchoscopes, rhino-laryngoscopes, tracheal intubation scopes, transnasal esophago scopes, hysteroscopes, cystoscopes, ureterorenoscopes, laparo-thoracoscopes for conventional white light endoscopy. The flexible endoscopes which are the subject of this premarket notification are gastroscope and colonoscope models listed in Table 16-2.

Additionally, when they are combined with the new Gastrointestinal Videoscopes (XGIF-N160Y2, XGIF-Q160Y5, XGIF-H160Y2), and Colonovideoscopes (XCF-Q160W6L, XCF-H160AY2L, XPCF-Q160AY2L), both an endoscopic image by white light illumination and that by NBI illumination can be obtained. The user can select either the NBI mode or normal mode by pressing the scope switch on the scope or the NBI mode switch on the CLV-160A; the NBI filter in the CLV-160A is inserted on the light axis when the NBI mode is selected.

The new endoscopes are basically identical to each predicate device shown in Table 16-2 in intended use, and similar in specifications, performance and materials. The CV-160A identifies an NB+compatible scope when it is connected by using the Scope ID function provided with the scopes.

5. Indications for Use

The EVIS EXERA 160A system consists of Olympus camera heads, endoscopes, video system center, light source, monitors, endo-therapy accessories and other ancillary equipment. This system is intended for endoscopic diagnosis, treatment and video observation of the upper and lower digestive tract. The indications for use of each primary component are shown below.

EVIS EXERA Xenon Light Source Olympus CLV-160A

This light source has been designed to be used with Olympus endoscopes, video system center, and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Video System Center Olympus CV-160A

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This video system center has been designed to be used with Olympus camera heads, endoscopes, light source, monitors, endo-therapy accessories and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Gastrointestinal Videoscope XGIF-N160Y2

This instrument has been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for transoral or transnasal observation and surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

EVIS EXERA Gastrointestinal Videoscope XGIF-Q160Y5, XGIF-H160Y2

These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

EVIS EXERA Colonovideoscope XCF-Q160W6L, XCF-H160AY2L, XPCF-Q160AY2L

These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the lower digestive tract (including the anus, rectum, sigmoid colon, colon and ileocecal valve).

6. Comparison of Technological Characteristics

Each primary component of the EVIS EXERA160A System is basically identical to its predicate device in intended use, and similar in specifications except for the addition of the NBI function. Comparison between the subject and predicate devices is shown in Table 16-3 to 16-10. The clinical literatures provided in this submission supports the safety and efficacy of NBI imaging in endoscopy.

SpecificationsSuject DevePredicate Device CLV-U40
Power Supply100-240V~ ±10%,50/60Hz ± 1Hz120V~ ±10%,50/60Hz ± 1Hz
Over-current ProtectionFuse typeCircuit breaker type
Input Current500VA (at observation)6A ( at observation)8A ( at flash)
Size381(W) × 162(H) × 536(D)mm587(W) × 165(H) × 537(D)mm
Weight15.4kg20kg
Compatible EndoscopesVideoscopeFiberscopeRigid scopeVideoscopeFiberscopeRigid scope

Table 16-3. Comparison of Specifications Subject Device: EVIS EXERA Xenon Light Source Olympus CLV-160A Predicate Device: EVIS Universal Light Source CLV-U40 (K954451)

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Examination LampXenon short-arc lamp(ozone-free)300WXenon short-arc lamp(ozone-free)300W
Average Lamp LifeApproximately 500 hours ofcontinuous useApproximately 500 hours ofcontinuous use
Emergency LampHalogen lamp 12V 35WHalogen lamp(without mirror)24V 150W
Average Emergency LampLifeApproximately 500 hoursApproximately 500 hours
NBI FilterNBI filterNA
Brightness ControlAutomatic and ManualAutomatic and Manual
Automatic Exposure17 steps17 steps + F
Photography Function-Provided
Air Feeding4 levels available(off, low, mid, high)4 levels available(off, low, mid, high)
Air Feeding PumpDiaphragm type pumpLinear type pump
System ConnectorProvidedProvided
Foot Switch ConnectorProvidedProvided
CV ConnectorProvidedProvided
Cooling Air DirectionRearLeft side
Type of Protection againstElectric ShockClass?Class?
Degree of Protectionagainst Electric Shock ofApplied PartTYPE BF or CF applied part(Depend on applied part)TYPE BF applied part
Applicable StandardUL60601-1UL544
SpecificationsSubject device CV 160APredicate Device CV-140
Power Supply100-240V~ ±10%? 50/60Hz ±1Hz120V~ ±10%? 50/60Hz ± 1Hz
Over-current ProtectionFuse typeCircuit breaker type
Input Current150VA0.8A
Size370(W) $\times$ 91(H) $\times$ 462 (D)mm450(W) $\times$ 72(H) $\times$ 465(D)mm
Weight10.6 kg10 kg
Compatible Endoscopes· Fiber/rigid scope via camerahead· Videoscope· Gastro/colono/sigmoid/duodeno/broncho videoscope· Fiberscope via video converter
Video SignalOutputRGB:3 Y/C:4 VBS:4 HDTV:1RGB:3 Y/C:3 VBS:4
Auto WhitebalanceAutomatically adjusted using thewhite balance switch.At the time of connection with thescope in which Scope ID isprovided, compensation isperformed automatically.Automatically adjusted using thewhite balance switch
ObservationStandard ColorChart OutputColor bar imageColor bar image50% white
Color ToneAdjustmentR: ±8 stepsB: ±8 stepsCHROMA: ±8stepsR control: ±7 stepsB control: ±7stepsHSR control: ±7steps
AutomaticGain Control(AGC)ProvidedProvided
ImageEnhancementEdge enhancement: [OFF] [Low][Med] [High] 4 levels availableStructure enhancement:[OFF] [Low][Med] [High] 4 levels availableImage enhancement: [Low] [Med][High] 3 levels available
Iris ModeSelectionAUTO/ PEAK EXPOSUREElectrical shutterAVE/ PEAK
Optical Zoom$\times$ 1/ $\times$ 1.2 / $\times$ 1.5: 3-Mode
NBIObservationNBI function
Picture inPictureThe image of an external deviceconnected to this instrument isdisplayed on the main monitortogether with the endoscopic image.The frozen endoscopic image isdisplayed on the sub screen whenthe freeze mode is selected.
Communication with ScopeProvided
Foot Switch ConnectorProvided
Record to Memory CardProvided
Type of Protection againstElectric ShockClass?Class?
Degree of Protection againstTYPE BF or CF applied part(Depend on applied part)
Electric Shock of Applied PartTYPE BF applied part
Applicable StandardUL60601-1UL544

:

:

.

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Table 16-4. Comparison of Specifications Subject Device: EVIS EXERA Video System Center Olympus CV -160A Predicate Device: EVIS Video System Center CV-140 (K954451)

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Table 16-5. Comparison of Specifications Subject Device: EVIS EXERA Gastrointestinal Videoscope XGIF-N160Y2 Predicate Device: XGIF-N200H Gastrointestinal Videoscope (K001766)

SpecificationsSubject DeviceXGIF-N160Y2Predicate DeviceXGIF-N200H
Field of View120 °120 °
Depth of Field3-100mm3-100mm
Direction of Forward View0 °0 °
Type of CCDColorMonochrome
Outer Diameter of Distal End4.9mm6mm
Outer Diameter of Insertion Tube4.9mm6mm
Bending Section AngulationUP: 210 °DOWN:120 °UP: 180 °DOWN: 180 °RIGHT: 160 °LEFT: 160 °
Working Length1100mm925mm
Inner Diameter of InstrumentChannel2.0mm2.0mm

Table 16-6. Comparison of Specifications Subject Device: EVIS EXERA Gastrointestinal Videoscope XGIF-Q160Y5 Predicate Device: EVIS EXERA Gastrointestinal Videoscope GIF-Q160Z (K011151)

SpecificationsSubject DeviceXGIF-Q160Y5Predicate DeviceGIF-Q160Z
Field of View140 °140 ° (in WIDE position)75 ° (in TELE position)
Depth of Field3-100mm8-100mm (in WIDE position)1.5-3mm (in TELE position)
Direction of Forward View0 °0 °
Type of CCDColorColor
Outer Diameter of Distal End8.8mm10.8mm
Outer Diameter of Insertion Tube8.8mm10.9mm
Bending Section AngulationUP:210 °DOWN:90 °RIGHT:100 °LEFT:100 °UP: 210°DOWN: 90 °RIGHT:100 °LEFT:100 °
Working Length1030mm1030mm
Inner Diameter of InstrumentChannel2.8mm2.8mm
Zoom Magnification FunctionNoYes

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Table 16-7. Comparison of Specifications Subject Device: EVIS EXERA Gastrointestinal Videoscope XGIF-H160Y2 Predicate Device: EVIS EXERA Gastrointestinal Videoscope GIF-Q160Z (K011151)

SpecificationsSubject DeviceXGIF-H160Y2Predicate DeviceGIF-Q160Z
Field of View140 °140 ° (in WIDE position)75 ° (in TELE position)
Depth of Field2-100mm8-100mm (in WIDE position)1.5-3mm (in TELE position)
Direction of Forward View0 °0 °
Type of CCDColorColor
Outer Diameter of Distal End9.8mm10.8mm
Outer Diameter of Insertion Tube9.8mm10.9mm
Bending Section AngulationUP: 210 °DOWN: 90 °RIGHT:100 °LEFT:100 °UP: 210 °DOWN: 90 °RIGHT:100 °LEFT:100 °
Working Length1030mm
Inner Diameter of Instrument Channel2.8mm2.8mm
Zoom Magnification FunctionNoYes

Table 16-8. Comparison of Specifications Subject Device: EVIS EXERA Colonovideoscope XCF-Q160W6L Predicate Device: EVIS EXERA Colonovideoscope CF-Q160AL (K001241)

SpecificationsSubject DeviceXCF-Q160W6LPredicate DeviceCF-Q160AL
Field of View170 °140 °
Depth of Field3-100mm3 -100mm
Direction of Forward View0 °0 °
Type of CCDColorColor
Outer Diameter of Distal End13.2mm12.8mm
Outer Diameter of Insertion Tube12.8mm12.8mm
Bending Section AngulationUP: 180 °UP: 180 °
DOWN: 180 °DOWN: 180 °
RIGHT:160 °RIGHT:160 °
LEFT:160 °LEFT:160 °
Working Length1680mm1680mm
Inner Diameter of InstrumentChannel3.7mm3.7mm
Flexibility of Insertion TubeAdjustable by the user.Adjustable by the user.

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Table 16-9. Comparison of Specifications Subject Device: EVIS EXERA Colonovideoscope XCF-H160AY2L Predicate Device: EVIS EXERA Colonovideoscope CF-Q160AL (K001241)

SpecificationsSubject DeviceXCF-H160AY2LPredicate DeviceCF-Q160AL
Field of View170 °140 °
Depth of Field2 -100mm3 -100mm
Direction of Forward View0 °0 °
Type of CCDColorColor
Outer Diameter of Distal End13.9mm12.8mm
Outer Diameter of Insertion Tube12.8mm12.8mm
Bending Section AngulationUP: 180 °DOWN:180 °RIGHT:160 °LEFT:160 °UP: 180 °DOWN:180 °RIGHT:160 °LEFT:160 °
Working Length1680mm1680mm
Inner Diameter of InstrumentChannel3.7mm3.7mm
Flexibility of Insertion TubeAdjustable by the user.Adjustable by the user.

Table 16-10. Comparison of Specifications Subject Device: EVIS EXERA Colonovideoscope XPCF-Q160AY2L Predicate Device: EVIS EXERA Colonovideoscope PCF-160AL (K001241)

SpecificationsSubject DeviceXPCF-Q160Y2LPredicate DevicePCF-160AL
Field of View140 °140 °
Depth of Field3-100mm3-100mm
Direction of Forward View0 °0 °
Type of CCDColorColor
Outer Diameter of Distal End11.3mm11.3mm
Outer Diameter of Insertion Tube11.5mm11.5mm
Bending Section AngulationUP: 180 °UP: 180 °
DOWN: 180 °DOWN: 180 °
RIGHT:160 °RIGHT:160 °
LEFT:160 °LEFT:160 °
Working Length1680mm1680mm
Inner Diameter of InstrumentChannel3.2mm3.2mm
Flexibility of Insertion TubeAdjustable by the userAdjustable by the user

6. Conclusion

When compared to the predicate devices, the EVIS EXERA 160A System does not incorporate any significant changes in intended use, method of operation, material, or design that could affect the safety or effectiveness of the system.

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Image /page/9/Picture/1 description: The image shows a black and white logo of the Department of Health & Human Services. The logo is circular in shape, with the words "DEPARTMENT OF HEALTH & HUMAN SERVICES" written around the perimeter of the circle. Inside the circle is a stylized image of a bird with three lines extending from its body.

Public Health Service

Food and Drug Administration 9200 Corporate Boulevard Rockville MD 20850

OCT 1 3 2005

Ms. Laura Storms-Tyler Executive Director, Regulatory Affairs and Quality Assurance Olympus America, Inc. Two Corporate Center Drive MELVILLE NY 11747-3157

Re: K051645

Trade/Device Name: EVIS EXERA 160A System Regulation Number: 21 CFR §876.1500 Regulation Name: Endoscope and accessories Regulatory Class: II Product Codes: NWB, FDS and FDF Dated: September 2, 2005 Received: September 6, 2005

Dear Ms. Storms-Tyler:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act actively subjects to the for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (Premarket Approval), it may be subject to such additional controls. Existing major regulations affecting your I tpp. o tal), it the Code of Federal Regulations, Title 21, Parts 800 to 898. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the I or 's requirements, including, but not limited to registration and listing (21 CFR Part 807); labeling (21 CFR Part 801); good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820); and if applicable, the electronic product radiation control provisions (Sections 531-542 of the Act); 21 CFR 1000-1050.

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This letter will allow you to begin marketing your device as described in your Section 510(k) I ins icter with anow you're ought mains of substantial equivalence of your device to a legally prematication. "The I Drivination for your device and thus, permits your device to proceed to the market.

If you desire specific advice for your device on our labeling regulation (21 CFR Part 801), please If you desire specific actifice for your ac ween the following numbers, based on the regulation number at the top of this letter:

21 CFR 876.xxxx(Gastroenterology/Renal/Urology)240-276-0115
21 CFR 884.xxxx(Obstetrics/Gynecology)240-276-0115
21 CFR 892.xxxx(Radiology)240-276-0120
Other240-276-0100

Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21 CFR Also, picaso note the regulation entitled, formation on your responsibilities under the Act from the 807.97). Tou may obtain outer general missistance at its toll-free number (800) 638-2041 or (301) 443-6597 or at its Internet address http://www.fda.gov/cdrh/industry/support/index.html.

Sincerely yours,

Nancy C. Hogdon

Nancy C. Brogdon Director, Division of Reproductive, Abdominal, and Radiological Devices Office of Device Evaluation Center for Devices and Radiological Health

Enclosure

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Indications for Use

510(k) Number (if known): Device Name: EVIS EXERA 160A System Indications For Use:

EVIS EXERA Xenon Light Source Olympus CLV-160A

This light source has been designed to be used with Olympus endoscopes, video system center, and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Video System Center Olympus CV-160A.

This video system center has been designed to be used with Olympus camera heads, endoscopes, light source, monitors, endo-therapy accessories and other ancillary equipment for endoscopic diagnosis, treatment and video observation.

EVIS EXERA Gastrointestinal Videoscope XGIF-N160Y2

This instrument has been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for transoral or transnasal observation and surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

Prescription Use_ (Part 21 CFR 801 Subpart D) ANDIOR

Over-The-Counter Use_ (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation(ODE)

of Reproductive, Abdomin and Radiological Dev 510(k) Number

Page 1 of 2_

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Indications for Use

510(k) Number (if known):

Device Name: EVIS EXERA 160A System

Indications For Use:

EVIS EXERA Gastrointestinal Videoscope XGIF-Q160Y4, XGIF-Q160Y5, XGIF-H160Y1, XGIE-H160Y2

These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the upper digestive tract (including the esophagus, stomach and duodenum).

EVIS_EXERA_Colonovideoscope_XCF_Q160W3L,_XCF-Q160W6L,_XCF-H160AYL,_XCE-H160AY2L, XPCF-Q160AYL, XPCF-Q160AY2L

These instruments have been designed to be used with an Olympus video system center, light source, documentation equipment, video monitor, endo-therapy accessories (such as a biopsy forceps) and other ancillary equipment for endoscopy and endoscopic surgery within the lower digestive tract (including the anus, rectum, sigmoid colon, colon and ileocecal valve).

Prescription Use_ (Part 21 CFR 801 Subpart D)

AND/OR

Over-The-Counter Use_ (21 CFR 807 Subpart C)

(PLEASE DO NOT WRITE BELOW THIS LINE - CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

David A. Larson

(Division Sign-Off) Division of Reproductive, Abdomina and Radiological Device

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510(k) Number

§ 876.1500 Endoscope and accessories.

(a)
Identification. An endoscope and accessories is a device used to provide access, illumination, and allow observation or manipulation of body cavities, hollow organs, and canals. The device consists of various rigid or flexible instruments that are inserted into body spaces and may include an optical system for conveying an image to the user's eye and their accessories may assist in gaining access or increase the versatility and augment the capabilities of the devices. Examples of devices that are within this generic type of device include cleaning accessories for endoscopes, photographic accessories for endoscopes, nonpowered anoscopes, binolcular attachments for endoscopes, pocket battery boxes, flexible or rigid choledochoscopes, colonoscopes, diagnostic cystoscopes, cystourethroscopes, enteroscopes, esophagogastroduodenoscopes, rigid esophagoscopes, fiberoptic illuminators for endoscopes, incandescent endoscope lamps, biliary pancreatoscopes, proctoscopes, resectoscopes, nephroscopes, sigmoidoscopes, ureteroscopes, urethroscopes, endomagnetic retrievers, cytology brushes for endoscopes, and lubricating jelly for transurethral surgical instruments. This section does not apply to endoscopes that have specialized uses in other medical specialty areas and that are covered by classification regulations in other parts of the device classification regulations.(b)
Classification —(1)Class II (special controls). The device, when it is an endoscope disinfectant basin, which consists solely of a container that holds disinfectant and endoscopes and accessories; an endoscopic magnetic retriever intended for single use; sterile scissors for cystoscope intended for single use; a disposable, non-powered endoscopic grasping/cutting instrument intended for single use; a diagnostic incandescent light source; a fiberoptic photographic light source; a routine fiberoptic light source; an endoscopic sponge carrier; a xenon arc endoscope light source; an endoscope transformer; an LED light source; or a gastroenterology-urology endoscopic guidewire, is exempt from the premarket notification procedures in subpart E of part 807 of this chapter subject to the limitations in § 876.9.(2) Class I for the photographic accessories for endoscope, miscellaneous bulb adapter for endoscope, binocular attachment for endoscope, eyepiece attachment for prescription lens, teaching attachment, inflation bulb, measuring device for panendoscope, photographic equipment for physiologic function monitor, special lens instrument for endoscope, smoke removal tube, rechargeable battery box, pocket battery box, bite block for endoscope, and cleaning brush for endoscope. The devices subject to this paragraph (b)(2) are exempt from the premarket notification procedures in subpart E of part 807of this chapter, subject to the limitations in § 876.9.