K Number
K040291
Device Name
EL-ANA PROFILES: ANTI-CHROMATIN
Date Cleared
2004-03-11

(34 days)

Product Code
Regulation Number
866.5100
AI/MLSaMDIVD (In Vitro Diagnostic)TherapeuticDiagnosticis PCCP Authorized
Intended Use
To aid in the diagnosis of systemic lupus erythematosus and related conditions.
Device Description
Not Found
More Information

Not Found

NotFound

No
The provided 510(k) summary contains no mention of AI, ML, image processing, or any other terms typically associated with AI/ML technologies in medical devices.

No
The intended use explicitly states "To aid in the diagnosis," not treatment or therapy.

Yes
The "Intended Use / Indications for Use" explicitly states, "To aid in the diagnosis of systemic lupus erythematosus and related conditions."

Unknown

The provided 510(k) summary is incomplete and lacks a device description, making it impossible to determine if the device is software-only.

Based on the provided information, specifically the Intended Use / Indications for Use, this device is likely an IVD (In Vitro Diagnostic).

Here's why:

  • "To aid in the diagnosis of systemic lupus erythematosus and related conditions." This statement directly indicates that the device is intended to be used in the diagnosis of a disease.
  • IVD devices are defined as those intended for use in the collection, preparation, and examination of specimens taken from the human body (such as blood, urine, or tissue) to obtain information for diagnostic purposes. While the description doesn't explicitly state it uses human specimens, the diagnostic intent strongly suggests this is the case.

The lack of other information like Device Description, Input Imaging Modality, or Anatomical Site doesn't negate the strong indication from the Intended Use.

Therefore, based solely on the provided text, the device's intended use aligns with the definition of an In Vitro Diagnostic device.

N/A

Intended Use / Indications for Use

To aid in the diagnosis of systemic lupus erythematosus and related conditions.

Product codes

LJM

Device Description

Not Found

Mentions image processing

Not Found

Mentions AI, DNN, or ML

Not Found

Input Imaging Modality

Not Found

Anatomical Site

Not Found

Indicated Patient Age Range

Not Found

Intended User / Care Setting

Not Found

Description of the training set, sample size, data source, and annotation protocol

Not Found

Description of the test set, sample size, data source, and annotation protocol

Not Found

Summary of Performance Studies (study type, sample size, AUC, MRMC, standalone performance, key results)

Not Found

Key Metrics (Sensitivity, Specificity, PPV, NPV, etc.)

Not Found

Predicate Device(s)

Not Found

Reference Device(s)

Not Found

Predetermined Change Control Plan (PCCP) - All Relevant Information

Not Found

§ 866.5100 Antinuclear antibody immunological test system.

(a)
Identification. An antinuclear antibody immunological test system is a device that consists of the reagents used to measure by immunochemical techniques the autoimmune antibodies in serum, other body fluids, and tissues that react with cellular nuclear constituents (molecules present in the nucleus of a cell, such as ribonucleic acid, deoxyribonucleic acid, or nuclear proteins). The measurements aid in the diagnosis of systemic lupus erythematosus (a multisystem autoimmune disease in which antibodies attack the victim's own tissues), hepatitis (a liver disease), rheumatoid arthritis, Sjögren's syndrome (arthritis with inflammation of the eye, eyelid, and salivary glands), and systemic sclerosis (chronic hardening and shrinking of many body tissues).(b)
Classification. Class II (performance standards).

0

DEPARTMENT OF HEALTH & HUMAN SERVICES

Image /page/0/Picture/1 description: The image shows the logo for the Department of Health & Human Services. The logo is a circular seal with the words "DEPARTMENT OF HEALTH & HUMAN SERVICES USA" around the perimeter. Inside the circle is an image of an eagle with its wings spread, with three lines extending from the eagle's body. The eagle is facing to the left.

Food and Drug Administration 2098 Gaither Road Rockville MD 20850

Marius Teodorescu, M.D., Ph.D. President and CEO TheraTest Laboratories 1111 North Main Street Lombard, Illinois 60148

MAR 1 1 2004

Re: K040291

Trade/Device Name: EL-ANA Profiles:anti-Chromatin Regulation Number: 21 CFR § 866.5100 Regulation Name: Antinuclear Antibody Immunological Test System Regulatory Class: II Product Code: LJM Dated: February 24, 2004 Received: February 27, 2004

Dear Dr. Teodorescu:

We have reviewed your Section 510(k) premarket notification of intent to market the device referenced above and have determined the device is substantially equivalent (for the indications for use stated in the enclosure) to legally marketed predicate devices marketed in interstate commerce prior to May 28, 1976, the enactment date of the Medical Device Amendments, or to devices that have been reclassified in accordance with the provisions of the Federal Food, Drug, and Cosmetic Act (Act) that do not require approval of a premarket approval application (PMA). You may, therefore, market the device, subject to the general controls provisions of the Act. The general controls provisions of the Act include requirements for annual registration, listing of devices, good manufacturing practice, labeling, and prohibitions against misbranding and adulteration.

If your device is classified (see above) into either class II (Special Controls) or class III (PMA), it may be subject to such additional controls. Existing major regulations affecting your device can be found in Title 21, Code of Federal Regulations (CFR), Parts 800 to 895. In addition, FDA may publish further announcements concerning your device in the Federal Register.

Please be advised that FDA's issuance of a substantial equivalence determination does not mean that FDA has made a determination that your device complies with other requirements of the Act or any Federal statutes and regulations administered by other Federal agencies. You must comply with all the Act's requirements, including, but not limited to: registration and listing (21 CFR Part 807); labeling (21 CFR Parts 801 and 809); and good manufacturing practice requirements as set forth in the quality systems (QS) regulation (21 CFR Part 820). This letter will allow you to begin marketing your device as described in your Section 510(k) premarket notification. The FDA finding of substantial equivalence of your device to a legally marketed predicate device results in a classification for your device and thus, permits your device to proceed to the market.

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If you desire specific information about the application of labeling requirements to your device, or questions on the promotion and advertising of your device, please contact the Office of In Vitro Diagnostic Device Evaluation and Safety at (301) 594-3084. Also, please note the regulation entitled, "Misbranding by reference to premarket notification" (21CFR Part 807.97). You may obtain other general information on your responsibilities under the Act from the Division of Small Manufacturers, International and Consumer Assistance at its toll-free number (800) 638-2041 or (301) 443-6597 or at its Internet address http://www.fda.gov/cdrh/dsma/dsmamain.html.

Sincerely yours,

Joseph L. Arlett

Joseph L. Hackett, Ph.D. Acting Director Division of Immunology and Hematology Devices Office of In Vitro Diagnostic Device Evaluation and Safety Center for Devices and Radiological Health

Enclosure

2

510(k) Number (if known) Devicc Name: EL-ANA Profiles: anti-Chromatin

Indications For Use:

ਸਾਰ ਸ਼ੁਰੂ ਕੀਤੀ ਸ

To aid in the diagnosis of systemic lupus erythematosus and related conditions.

(PLEASE DO NOT WRITE BELOW THIS LINE – CONTINUE ON ANOTHER PAGE IF NEEDED)

Concurrence of CDRH, Office of Device Evaluation (ODE)

Approve for m. Chan
(Division Sign-Off)

Division of Clinical Laboratory Devices

510(k) Number_________________________________________________________________________________________________________________________________________________________________

Prescription Use & (Per 2) CFR 801.109) OR

Over - The - Counter _________________________________________________________________________________________________________________________________________________________

Optional Format 1-2-96